Explanipedia

Whole Exome Sequencing Reveals Novel Genetic Variants Associated with Atrial Septal Defect in a Tibetan Patient Cohort Open

Hongwei Li, Yongjun He, Zhengyao Cai, Qianqiu Che, Yonghong Wu , et al. · 2025

This first WES-based study of Tibetan ASD patients reveals population-specific genetic determinants. The nine novel candidate variants, particularly in C5, CRYAB, PIWIL1, and TSC1, provide preliminary insights into ASD etiolo…

Association between copper exposure and renal fibrosis in patients with chronic kidney disease: evidence from Mendelian randomization and a retrospective study Open

Kaixiang Liu, Min Yu, Yongjun He, Ting Wang, Honghua Hu , et al. · 2025

Background Chronic kidney disease (CKD), a global health challenge, is closely linked to renal fibrosis progression. Copper, an essential trace element, influences cellular functions, yet its role in CKD-related fibrosis remains unclear. T…

Telitacicept versus mycophenolate mofetil in IgA nephropathy: a real-world comparative study of efficacy, renal outcomes and safety Open

Yongjun He, Shasha Chen, Kaixiang Liu, Xirong Wu, Min Yu , et al. · 2025

Background This study aimed to evaluate the efficacy and safety of telitacicept versus mycophenolate mofetil (MMF) in high-risk progressive immunoglobulin A nephropathy (IgAN). Methods This retrospective, multicentre cohort study included …

LncRNA <i>C5orf64</i> polymorphisms (rs12518552 and rs2950218) decreases pulmonary tuberculosis susceptibility Open

Shilin Xu, Baoping Hu, Dongfeng Zhang, Jing Wang, Xue He , et al. · 2025

C5orf64 polymorphisms, particularly rs12518552 and rs2950218, are associated with a reduced risk of PTB. These findings suggest that C5orf64 polymorphisms contribute to genetic susceptibility to PTB, with implications for PTB target…

Generating Crop Type Labels from Historical Annual Crop Inventory Data with an Ensemble Learning Method Open

Yue Wu, Xin Chen, Chunhua Liao, Xuanhong Xu, Yongjun He , et al. · 2024

Confusing finding of quantitative fluorescent polymerase chain reaction analysis in invasive prenatal genetic diagnosis: A case report Open

Chen Cui, Tao Tang, Qiling Song, Yongjun He, Yan Cai · 2023

β cells are the main cells responsible for the hypoglycemic function of pancreatic islets, and the insulin secreted by these cells is the only hormone that lowers blood glucose levels in the human body. β cells are regulated by various fac…

The Association of Methylation Level in the CYP39A1 Gene with High Altitude Pulmonary Edema in the Chinese Population Open

Pingyi Wang, Hongyan Lu, Hao Rong, Yuhe Wang, Li Wang , et al. · 2023

The methylation level of CYP39A1 was associated with a risk of HAPE in the Chinese population, which provided new perspective for preventing and diagnosing of HAPE.

NOTCH2, ATIC, MRI1, SLC6A13, ATP13A2 Genetic Variations are Associated with Ventricular Septal Defect in the Chinese Tibetan Population Through Whole-Exome Sequencing Open

Xiaohui Zhang, Da Zhen, Xue-Mei Li, Faling Yi, Zhanhao Zhang , et al. · 2023

This study demonstrated that NOTCH2, ATIC, MRI1, SLC6A13, ATP13A2 gene variants were potentially associated with VSD in Chinese Tibetan population.

Genetic polymorphisms of MRPS30-DT and NINJ2 may influence lung cancer risk Open

Shouchun Yan, Shouzhen Wu, Jia Wu, Qinlu Zhang, Yongjun He , et al. · 2023

Lung cancer is one of the malignant tumors, and genetic background is a risk factor in lung cancer that cannot be neglected. In this study, we aimed to find out the effect of MRPS30-DT and NINJ2 variants on lung cancer risk. In this study,…

Effect of Rare-Earth-Containing Inhibitors on the Low-Temperature Oxidation Characteristics and Thermodynamic Properties of Coal Open

Yongjun He, Jun Deng, Xin Yi, Yang Xiao, Yin Deng , et al. · 2023

Genome-Wide Association Study on the Hematological Phenotypic Characteristics of the Han Population from Northwest China Open

Wei Yang, He Xue, Yuying Yao, Hongyan Lu, Yuliang Wang , et al. · 2022

The GWAS identified a total of 90 genetic variants significantly associated with hematological phenotypic indicators. In particular, rs1331309 (HBS1 L-MYB) is expected to be a biomarker for monitoring the dynamics of MCH levels. This study…

Association of SLC11A1 Polymorphisms With Tuberculosis Susceptibility in the Chinese Han Population Open

Baoping Hu, Yuhe Wang, Zhongtao Wang, He Xue, Li Wang , et al. · 2022

Tuberculosis (TB) is an important health issue in the world. Although the relation of SLC11A1 polymorphisms with TB risk has been extensively studied, it has not been reported in the northwest Chinese Han population. Therefore, this study …

Decentralized Training of Foundation Models in Heterogeneous Environments Open

Binhang Yuan, Yongjun He, Jared Quincy Davis, Tianyi Zhang, Tri Dao , et al. · 2022

Training foundation models, such as GPT-3 and PaLM, can be extremely expensive, often involving tens of thousands of GPUs running continuously for months. These models are typically trained in specialized clusters featuring fast, homogeneo…

Fine-tuning Language Models over Slow Networks using Activation Compression with Guarantees Open

Jue Wang, Binhang Yuan, Luka Rimanić, Yongjun He, Tri Dao , et al. · 2022

Communication compression is a crucial technique for modern distributed learning systems to alleviate their communication bottlenecks over slower networks. Despite recent intensive studies of gradient compression for data parallel-style tr…

Research on Structural Design and Parametric Modeling of Trestle of Material Ropeway of Transmission Line Open

Chen Liu, Jian Qin, Yongjun He, Guolei Sun, Liang Qiao · 2022

Aiming at the trestle of material ropeway of transmission line, the structural design of components was carried out with the combination of 3D design software. Parametric modeling method was adopted to carry out the modeling of components …

The Role of Problematic Smartphone Uses and Psychological Distress in the Relationship Between Sleep Quality and Disordered Eating Behaviors Among Chinese College Students Open

Ruipeng Wu, Lan Guo, Hao Rong, Jingming Shi, Wenyan Li , et al. · 2021

Background: Sleep problems and eating disorders (EDs) are both serious public health concerns often seen in young adults. Yet, the underlying mechanisms for such associations are largely unknown. This study aims to examine potential serial…

Uncovering The Mechanism of Shiwuwei Luodimingmu Wan On Cataract Via Network Pharmacology Open

Zhanhao Zhang, Yuliang Wang, Hongyan Lu, Yongjun He, Li Wang , et al. · 2021

Cataract is one of the most common eye diseases. The purpose of this study was to screen the active components and potential targets of Shiwuwei Luodimingmu Wan, then to explore the mechanism of Shiwuwei Luodimingmu Wan in the treatment of…

Fc receptor-like 1, 3, and 6 variants are associated with rheumatoid arthritis risk in the Chinese Han population Open

Yonghui Yang, Dandan Li, Chunjuan He, Linna Peng, Shishi Xing , et al. · 2021

Impacts of LOC105371267 Variants on Breast Cancer Susceptibility in Northern Chinese Han Females: A Population-Based Case-Control Study Open

Linna Peng, Congmei Huang, Shishi Xing, Dandan Li, Chunjuan He , et al. · 2021

Background. LOC105371267, also known as PR-lncRNA1, was reported to be a p53-regulated long noncoding RNA (lncRNA), which played an essential role in the pathogenesis of breast cancer (BC). We aimed to observe the potential association bet…

Network pharmacology and molecular docking analysis on mechanisms of Tibetan Hongjingtian (Rhodiola crenulata) in the treatment of COVID-19 Open

Li Wang, Yuhe Wang, Wei Yang, Xue He, Shilin Xu , et al. · 2021

Introduction. Coronavirus disease 2019 (COVID-19) is a highly contagious disease and ravages the world. Hypothesis/Gap Statement. We proposed that R. crenulata might have potential value in the treatment of COVID-19 patients by regulating …

The Impacts of IL1R1 and IL1R2 Genetic Variants on Rheumatoid Arthritis Risk in the Chinese Han Population: A Case–Control Study Open

Xiaoli Liu, Linna Peng, Dandan Li, Chunjuan He, Shishi Xing , et al. · 2021

We determined SNPs (rs3917318, rs956730, rs1049057) of IL1R1 and SNPs (rs3218977, rs719250, rs4851527, rs3218896, rs2072472) of IL1R2 were correlated with the RA susceptibility in the Chinese Han population.

Age- and gender-dependent association of SLC11A1 polymorphisms with tuberculosis susceptibility Open

Yuhe Wang, Zhongtao Wang, Xue He, Li Wang, Mei Bai , et al. · 2021

Background: Tuberculosis (TB) is an important health issue in our world. It is reported that various factors may effect on its pathogenesis. In this current study, we aimed to investigate the association between SLC11A1 polymorphism and th…

PTPN9 Genes Polymorphism as a Protect Factor in Lumbar Disc Herniation Development Open

Dandan Li, Huqiang Mai, Yuhe Wang, Li Wang, Xiaoli Liu , et al. · 2021

Background: Lumbar disc herniation (LDH) is a high incidence spinal disease caused by disc degeneration, nuclear pulse displacement or fiber ring degeneration. This study aimed to explore the correlation between PTPN9 susceptibility and lu…

Analysis of <i>CYP2J2</i> mutations in the Chinese Uyghur population. Open

Haiyue Li, Yongjun He, Li Wang, Shishi Xing, Linna Peng , et al. · 2021

Genetic characteristics of CYP2J2 in different populations may be helpful to explore interethnic variability in drug response and disease susceptibility. There is no information about the genetic profile of CYP2J2 in the Chin…

CoroBase Open

Yongjun He, Jiacheng Lu, Tianzheng Wang · 2020

Data stalls are a major overhead in main-memory database engines due to the use of pointer-rich data structures. Lightweight coroutines ease the implementation of software prefetching to hide data stalls by overlapping computation and asyn…

CoroBase: Coroutine-Oriented Main-Memory Database Engine Open

Yongjun He, Jiacheng Lu, Tianzheng Wang · 2020

Data stalls are a major overhead in main-memory database engines due to the use of pointer-rich data structures. Lightweight coroutines ease the implementation of software prefetching to hide data stalls by overlapping computation and asyn…

Functional Characterization of SmbHLH13 in Anthocyanin Biosynthesis and Flowering in Eggplant Open

Haochun Xi, Yongjun He, Huoying Chen · 2020

Endocytosis Is a Key Mode of Interaction between Extracellular β-Amyloid and the Cell Membrane Open

Jingming Shi, Li Zhu, Xi Lan, Duan-Wei Zhao, Yongjun He , et al. · 2020

Evaluation of Association of LOC105371267 Polymorphisms and Breast Cancer Susceptibility Open

Xiaoli Liu, Dandan Li, Chunjuan He, Linna Peng, Shishi Xing , et al. · 2020

Background : LOC105371267 (also known as PR-lncRNA1) was reported to be a p53-regulated lncRNA, which played essential roles in the pathogenesis of breast cancer (BC). We aimed to investigate the potential associations between LOC105371267…

Influence of COL9A1 and COL19A1 Polymorphisms on Kaschin-Beck Disease Risk Open

Xue He, Jianwen Zheng, Dongya Yuan, Yuhe Wang, Yongjun He , et al. · 2020

Objective: We aimed to determine whether COL9A1 and COL19A1 polymorphisms were associated with Kaschin-Beck disease (KBD) risk. Methods: Five single nucleotide polymorphisms (SNPs) in COL9A1 and COL19A1 were genotyped in 316 KBD patients a…

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