Yanhan Dong
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View article: Single‐cell RNA sequencing reveals the niche transitions in the non‐small cell lung cancer microenvironment mediated by piR‐hsa‐164586 during the invasive and metastatic processes
Single‐cell RNA sequencing reveals the niche transitions in the non‐small cell lung cancer microenvironment mediated by piR‐hsa‐164586 during the invasive and metastatic processes Open
Screening of tumor‐specific markers and targeted therapy has achieved significant clinical efficacy in recent years. PIWI‐interacting RNAs (piRNAs), which are crucial in the progression of tumors, are anticipated to be significant targets …
View article: Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration
Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration Open
View article: Nr4a1 modulates inflammation and heart regeneration in zebrafish
Nr4a1 modulates inflammation and heart regeneration in zebrafish Open
Recent findings have highlighted the complex role of inflammation in zebrafish heart regeneration, demonstrating that although inflammation is essential for initiating transient fibrosis and tissue repair, chronic inflammation, and unresol…
View article: Charting Postnatal Heart Development Using <i>In Vivo</i> Single-Cell Functional Genomics
Charting Postnatal Heart Development Using <i>In Vivo</i> Single-Cell Functional Genomics Open
The transition at birth, marked by increased circulatory demands and rapid growth, necessitates extensive remodeling of the heart’s structure, function, and metabolism. This transformation requires precise spatial and temporal coordination…
View article: Repairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals
Repairing Effect and Mechanism of the 4-Dimensionally Printed Limbal Stem Cell Strategy on Corneal Alkali Burns in Large Animals Open
Alkali burn of corneas can induce corneal stromal fibrosis and limbal stem cell deficiency, which destroys corneal epithelial homeostasis, leading to scarring and impaired vision. Although stem cell therapy has shown potential therapeutic …
View article: Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg Open
View article: Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells
Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells Open
Cardiac regeneration requires coordinated participation of multiple cell types whereby their communications result in transient activation of proregenerative cell states. Although the molecular characteristics and lineage origins of these …
View article: Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg
Direct conversion of cardiac fibroblasts into endothelial-like cells using Sox17 and Erg Open
Endothelial cells are a heterogeneous population with various organ-specific and conserved functions that are critical to organ development, function, and regeneration. Here we report a Sox17 - Erg direct reprogramming approach that uses c…
View article: Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells
Single-cell chromatin profiling reveals genetic programs activating proregenerative states in nonmyocyte cells Open
Cardiac regeneration requires coordinated participation of multiple cell types whereby their communications result in transient activation of proregenerative cell states. Although the molecular characteristics and lineage origins of these …
View article: The application of a 4D-printed chitosan-based stem cell carrier for the repair of corneal alkali burns
The application of a 4D-printed chitosan-based stem cell carrier for the repair of corneal alkali burns Open
Background Corneal alkali burns can lead to ulceration, perforation, and even corneal blindness due to epithelial defects and extensive cell necrosis, resulting in poor healing outcomes. Previous studies have found that chitosan-based in s…
View article: Serum-derived piR-hsa-164586 of extracellular vesicles as a novel biomarker for early diagnosis of non-small cell lung cancer
Serum-derived piR-hsa-164586 of extracellular vesicles as a novel biomarker for early diagnosis of non-small cell lung cancer Open
Non-small cell lung cancer (NSCLC) is a major cause of death in those with malignant tumors. To achieve the early diagnosis of NSCLC, we investigated serum-derived Piwi-interacting RNA (piRNA) of extracellular vesicles to filter diagnostic…
View article: The Long Noncoding RNA <i>LINC00963</i> Inhibits Corneal Fibrosis Scar Formation by Targeting <i>miR-143-3p</i>
The Long Noncoding RNA <i>LINC00963</i> Inhibits Corneal Fibrosis Scar Formation by Targeting <i>miR-143-3p</i> Open
Corneal fibrosis is a complication of severe corneal injury, one of the major causes of vision loss. The formation of myofibroblasts has emerged as a key stimulative factor of corneal fibrosis. In the current study, we focused on the role …
View article: Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration
Functional coordination of non‐myocytes plays a key role in adult zebrafish heart regeneration Open
View article: ExpressHeart: Web Portal to Visualize Transcriptome Profiles of Non-Cardiomyocyte Cells
ExpressHeart: Web Portal to Visualize Transcriptome Profiles of Non-Cardiomyocyte Cells Open
Unveiling the molecular features in the heart is essential for the study of heart diseases. Non-cardiomyocytes (nonCMs) play critical roles in providing structural and mechanical support to the working myocardium. There is an increasing am…
View article: piR-hsa-211106 Inhibits the Progression of Lung Adenocarcinoma Through Pyruvate Carboxylase and Enhances Chemotherapy Sensitivity
piR-hsa-211106 Inhibits the Progression of Lung Adenocarcinoma Through Pyruvate Carboxylase and Enhances Chemotherapy Sensitivity Open
Although the importance of PIWI-interacting RNAs (piRNAs) in cancer has recently been recognized, studies on the role and functional mechanism of piRNAs in lung adenocarcinoma (LUAD) development and progression are limited. In this study, …
View article: Molecular and cellular basis of embryonic cardiac chamber maturation
Molecular and cellular basis of embryonic cardiac chamber maturation Open
View article: Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities
Exosomal circRNAs as novel cancer biomarkers: Challenges and opportunities Open
Identifying high specificity and sensitivity biomarkers has always been the focus of research in the field of non-invasive cancer diagnosis. Exosomes are extracellular vesicles with a lipid bilayer membrane that can be released by all type…
View article: Sirt6-Mediated Endothelial-to-Mesenchymal Transition Contributes Toward Diabetic Cardiomyopathy via the Notch1 Signaling Pathway
Sirt6-Mediated Endothelial-to-Mesenchymal Transition Contributes Toward Diabetic Cardiomyopathy via the Notch1 Signaling Pathway Open
Yan Zhang,1,* Yuan Dong,1,* Zhenyu Xiong,1,* Zhengru Zhu,2 Fanya Gao,3 Tingting Wang,1 Wanrong Man,1 Dong Sun,1 Jie Lin,1 Tongbin Li,1 Congye Li,1 Zhijing Zhao,1 Min Shen,1 Dongdong Sun,1 Yanhong Fan1 1Department of Cardiology, Xijing Hosp…
View article: Effects of REDOX in Regulating and Treatment of Metabolic and Inflammatory Cardiovascular Diseases
Effects of REDOX in Regulating and Treatment of Metabolic and Inflammatory Cardiovascular Diseases Open
Reduction oxidation (REDOX) reaction is crucial in life activities, and its dynamic balance is regulated by ROS. Reactive oxygen species (ROS) is associated with a variety of metabolic diseases involving in multiple cellular signalling in …
View article: Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application
Poly(N-Isopropyl-Acrylamide)/Poly(γ-Glutamic Acid) Thermo-Sensitive Hydrogels Loaded with Superoxide Dismutase for Wound Dressing Application Open
Yunsheng Dong,1 Huahong Zhuang,1 Yan Hao,1 Lin Zhang,1 Qiang Yang,2 Yufei Liu,1 Chunxiao Qi,1 Shufang Wang1 1State Key Laboratory of Medicinal Chemical Biology, The Key Laboratory of Bioactive Materials, The College of Life Science, Nankai…
View article: Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer
Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer Open
As the most common type of cancer in female patients, the morbidity and mortality rates of breast cancer (BC) are high, and its incidence is gradually increasing worldwide. However, the underlying molecular and genetic mechanisms involved …
View article: Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer
Analysis of circular RNA‑associated competing endogenous RNA network in breast cancer Open
View article: Correction: The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae
Correction: The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae Open
Correction: The bZIP Transcription Factor MoAP1 Mediates the Oxidative Stress Response and is Critical for Pathogenicity of the Rice Blast Fungus Magnaporthe oryzae
View article: The emerging role of the piRNA/piwi complex in cancer
The emerging role of the piRNA/piwi complex in cancer Open
View article: Long non‐coding <scp>RNA</scp>s in ocular diseases: new and potential therapeutic targets
Long non‐coding <span>RNA</span>s in ocular diseases: new and potential therapeutic targets Open
Long non‐coding RNAs (lnc RNA s) are non‐protein coding transcripts containing more than 200 nucleotides. In the past, lnc RNA s were considered as ‘transcript noise’ or ‘pseudogenes’ and were thus ignored. However, in recent years, lnc RN…
View article: Red yeast rice ameliorates high-fat diet-induced atherosclerosis in <i>Apoe</i><sup>−/−</sup> mice in association with improved inflammation and altered gut microbiota composition
Red yeast rice ameliorates high-fat diet-induced atherosclerosis in <i>Apoe</i><sup>−/−</sup> mice in association with improved inflammation and altered gut microbiota composition Open
Red yeast rice could significantly protect against atherosclerosis, which were possibly associated with the alterations in the gut microbiota composition.
View article: Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases
Reactive Oxygen Species Related Noncoding RNAs as Regulators of Cardiovascular Diseases Open
Reactive oxygen species (ROS) are a class of reactive molecules that have been implicated in a variety of cardiovascular diseases, accompanied by disorder of multiple signaling events. As cardiomyocytes maintain abundant of mitochondria, w…
View article: The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease
The Potential Markers of Circulating microRNAs and long non-coding RNAs in Alzheimer's Disease Open
Alzheimer's disease (AD) is a neurodegenerative disorder and one of the leading causes of disability and mortality in the late life with no curative treatment currently. Thus, it is urgently to establish sensitive and non-invasive biomarke…
View article: An <i>in situ</i> hydrogel based on carboxymethyl chitosan and sodium alginate dialdehyde for corneal wound healing after alkali burn
An <i>in situ</i> hydrogel based on carboxymethyl chitosan and sodium alginate dialdehyde for corneal wound healing after alkali burn Open
There is currently no optimal scaffold for the transplantation of limbal stem cells (LSCs) to induce corneal reconstruction after corneal alkali burns. This study attempts to fabricate a novel in situ Alginate‐Chitosan hydrogel (ACH) for L…
View article: The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway
The circular RNA ACR attenuates myocardial ischemia/reperfusion injury by suppressing autophagy via modulation of the Pink1/ FAM65B pathway Open