Yongke Lu
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View article: Phytol enhances catalase-dependent ethanol metabolism in liver independent of PPARα
Phytol enhances catalase-dependent ethanol metabolism in liver independent of PPARα Open
View article: Intracellular Distribution and Pparα Regulation of Acyl-Coa Oxidase 1 (Acox1) and Catalase in Mice
Intracellular Distribution and Pparα Regulation of Acyl-Coa Oxidase 1 (Acox1) and Catalase in Mice Open
View article: Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches
Cellular and molecular mechanisms of hepatic ischemia-reperfusion injury: The role of oxidative stress and therapeutic approaches Open
Ischemia-reperfusion (IR) or reoxygenation injury is the paradoxical exacerbation of cellular impairment following restoration of blood flow after a period of ischemia during surgical procedures or other conditions. Acute interruption of b…
View article: Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High-Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity Open
Obesity results in hepatic fat accumulation, i.e., steatosis. In addition to fat overload, impaired fatty acid β-oxidation also promotes steatosis. Fatty acid β-oxidation takes place in the mitochondria and peroxisomes. Usually, very long-…
View article: Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity
Hepatocyte-Specific PEX16 Abrogation in Mice Leads to Hepatocyte Proliferation, Alteration of Hepatic Lipid Metabolism, and Resistance to High Fat Diet (HFD)-Induced Hepatic Steatosis and Obesity Open
Obesity results in hepatic fat accumulation, i.e., steatosis. Besides the fat overload, impaired fatty acid β-oxidation also promotes steatosis. Fatty acid β-oxidation takes place in mitochondria and peroxisomes. Usually very lon…
View article: Interaction between fatty acid oxidation and ethanol metabolism in liver
Interaction between fatty acid oxidation and ethanol metabolism in liver Open
Fatty acid oxidation (FAO) releases the energy stored in fat to maintain basic biological processes. Dehydrogenation is a major way to oxidize fatty acids, which needs NAD + to accept the released H + from fatty acids and form NADH, which …
View article: Deep learning analysis of UPLC-MS/MS-based metabolomics data to predict Alzheimer's disease
Deep learning analysis of UPLC-MS/MS-based metabolomics data to predict Alzheimer's disease Open
View article: Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism
Under peroxisome proliferation acyl-CoA oxidase coordinates with catalase to enhance ethanol metabolism Open
View article: Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass
Alcoholic fatty liver is blunted by rFGF21 administration in mice lacking adipose FGFR1: The role of FGF21 in PPARα-mediated regulation of adipose tissue mass Open
View article: Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer’s Disease and Cardiovascular Diseases
Levels of Angiotensin-Converting Enzyme and Apolipoproteins Are Associated with Alzheimer’s Disease and Cardiovascular Diseases Open
Angiotensin-converting enzyme-1 (ACE1) and apolipoproteins (APOs) may play important roles in the development of Alzheimer’s disease (AD) and cardiovascular diseases (CVDs). This study aimed to examine the associations of AD, CVD, and endo…
View article: PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1 Open
View article: PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase
PPARα agonist WY-14,643 enhances ethanol metabolism in mice: Role of catalase Open
View article: Racial Differences in the Effect of APOE-ε4 Genotypes on Trail Making Test Part B in Alzheimer’s disease
Racial Differences in the Effect of APOE-ε4 Genotypes on Trail Making Test Part B in Alzheimer’s disease Open
The trail making test part B (TMT-B) evaluates "executive" functions, memory, and sensorimotor functions. No previous studies were found to examine the longitudinal effect of apolipoprotein E epsilon 4 (APOE-ε4) genotypes on the TMT-B scor…
View article: High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis
High-fat diet induces fibrosis in mice lacking CYP2A5 and PPARα: a new model for steatohepatitis-associated fibrosis Open
PPARα is upregulated in cyp2a5 −/− mice, but HFD-induced steatosis is still deteriorated. PPARα abrogation makes cyp2a5 −/− mice more sensitive to HFD-induced steatosis, liver inflammation, and fibrosis, suggesting that PPARα upregulation …
View article: Pyrosequencing analysis of IRS1 methylation levels in schizophrenia with tardive dyskinesia
Pyrosequencing analysis of IRS1 methylation levels in schizophrenia with tardive dyskinesia Open
Tardive dyskinesia (TD) is a serious side effect of certain antipsychotic medications that are used to treat schizophrenia (SCZ) and other mental illnesses. The methylation status of the insulin receptor substrate 1 (IRS1) gene is reported…
View article: Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice
Suppressed hepatocyte proliferation via a ROS-HNE-P21 pathway is associated with nicotine- and cotinine-enhanced alcoholic fatty liver in mice Open
View article: Transplanted adult human hepatic stem/progenitor cells prevent histogenesis of advanced hepatic fibrosis in mice induced by carbon tetrachloride.
Transplanted adult human hepatic stem/progenitor cells prevent histogenesis of advanced hepatic fibrosis in mice induced by carbon tetrachloride. Open
Transplantation of adult human hepatic stem/progenitor cells (hHSPCs) has been considered as an alternative therapy, replacing donor liver transplantation to treat liver cirrhosis. This study assessed the antifibrotic effects of hHSPCs in …
View article: Cytochrome P450S and Alcoholic Liver Disease
Cytochrome P450S and Alcoholic Liver Disease Open
Alcohol consumption causes liver diseases, designated as Alcoholic Liver Disease (ALD). Because alcohol is detoxified by alcohol dehydrogenase (ADH), a major ethanol metabolism system, the development of ALD was initially believed to be du…
View article: Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer’s Disease
Polymorphisms Within RYR3 Gene Are Associated With Risk and Age at Onset of Hypertension, Diabetes, and Alzheimer’s Disease Open
RYR3 variants are associated with hypertension, diabetes, and AD. Replication of these results of this gene in these 3 complex traits may help to better understand the genetic basis of calcium-signaling gene, RYR3 in association with risk …
View article: The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers
The adipokine C1q TNF related protein 3 (CTRP3) is elevated in the breast milk of obese mothers Open
Background C1q TNF related protein 3 (CTRP3) is a relatively novel hormonal factor primarily derived from adipose tissue and has anti-diabetic properties. To determine if CTRP3 could play a role in early childhood development, the purpose …
View article: Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice
Author Correction: Midbrain circuit regulation of individual alcohol drinking behaviors in mice Open
View article: Midbrain circuit regulation of individual alcohol drinking behaviors in mice
Midbrain circuit regulation of individual alcohol drinking behaviors in mice Open
View article: Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease
Osteopontin deletion drives hematopoietic stem cell mobilization to the liver and increases hepatic iron contributing to alcoholic liver disease Open
The aim of this study was to investigate the role of osteopontin (OPN) in hematopoietic stem cell (HPSC) mobilization to the liver and its contribution to alcoholic liver disease (ALD). We analyzed young (14‐16 weeks) and old (>1.5 years) …
View article: Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis
Alcoholic fatty liver is enhanced in CYP2A5 knockout mice: The role of the PPARα-FGF21 axis Open
View article: Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury
Signalling via the osteopontin and high mobility group box-1 axis drives the fibrogenic response to liver injury Open
Objective Liver fibrosis is associated with significant collagen-I deposition largely produced by activated hepatic stellate cells (HSCs); yet, the link between hepatocyte damage and the HSC profibrogenic response remains unclear. Here we …
View article: Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity
Autophagy Protects against CYP2E1/Chronic Ethanol-Induced Hepatotoxicity Open
Autophagy is an intracellular pathway by which lysosomes degrade and recycle long-lived proteins and cellular organelles. The effects of ethanol on autophagy are complex but recent studies have shown that autophagy serves a protective func…
View article: Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice
Absence of cytochrome P450 2A5 enhances alcohol-induced liver injury in mice Open