Yongkyu Park
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View article: Supplementary Table 1 from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia
Supplementary Table 1 from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia Open
Timing of CSF collection relative to Leukemia Treatment Phases for patients treated on DFCI protocol 16-001
View article: Supplementary Figure 2 from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia
Supplementary Figure 2 from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia Open
Linear regression between CSF 8OHdG and CSF tau at each of five timepoints.
View article: Supplementary Figure 1 from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia
Supplementary Figure 1 from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia Open
Exploratory analysis of the effect of Cranial Radiation on CSF 8OHdG among patients on DFCI 16-001 and 11-001.
View article: Data from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia
Data from Treatment-Related Changes in Cerebrospinal Fluid Markers of Oxidative Stress and Neurodegeneration during Therapy for Childhood Acute Lymphoblastic Leukemia Open
Background:Survivors of childhood acute lymphoblastic leukemia (ALL) frequently exhibit treatment-related neurocognitive impairment, although there is substantial interpatient variability in this outcome. Analysis of biomarkers that reflec…
View article: Tau, Glial Fibrillary Acidic Protein, and Neurofilament Light Chain as Brain Protein Biomarkers in Cerebrospinal Fluid and Blood for Diagnosis of Neurobiological Diseases
Tau, Glial Fibrillary Acidic Protein, and Neurofilament Light Chain as Brain Protein Biomarkers in Cerebrospinal Fluid and Blood for Diagnosis of Neurobiological Diseases Open
Neurological damage is the pathological substrate of permanent disability in various neurodegenerative disorders. Early detection of this damage, including its identification and quantification, is critical to preventing the disease’s prog…
View article: Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex
Celf4 controls mRNA translation underlying synaptic development in the prenatal mammalian neocortex Open
View article: Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs
Extrinsic Regulators of mRNA Translation in Developing Brain: Story of WNTs Open
Extrinsic molecules such as morphogens can regulate timed mRNA translation events in developing neurons. In particular, Wingless-type MMTV integration site family, member 3 (Wnt3), was shown to regulate the translation of Foxp2 mRNA encodi…
View article: Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development
Translational derepression of Elavl4 isoforms at their alternative 5′ UTRs determines neuronal development Open
View article: Blepharoptosis among Korean adults: age-related prevalence and threshold age for evaluation
Blepharoptosis among Korean adults: age-related prevalence and threshold age for evaluation Open
Background To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation. Methods The Korean Na…
View article: Blepharoptosis among Korean adults: Age-related prevalence and threshold age for evaluation
Blepharoptosis among Korean adults: Age-related prevalence and threshold age for evaluation Open
Purpose: To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation. Methods: The Korean Nat…
View article: Blepharoptosis among Korean adults: Age-related prevalence and threshold age for evaluation
Blepharoptosis among Korean adults: Age-related prevalence and threshold age for evaluation Open
Background: To evaluate the prevalence of blepharoptosis among Korean adults and the characteristics of blepharoptosis patients, and to determine an appropriate age threshold for recommending blepharoptosis evaluation.Methods: The Korean N…
View article: Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA
Longer lifespan in the Rpd3 and Loco signaling results from the reduced catabolism in young age with noncoding RNA Open
Downregulation of Rpd3 (histone deacetylase) or Loco (regulator of G-protein signaling protein) extends Drosophila lifespan with higher stress resistance. We found rpd3-downregulated long-lived flies genetically interact with…
View article: Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway
Stress resistance and lifespan enhanced by downregulation of antimicrobial peptide genes in the Imd pathway Open
Biological behaviors and longevity of ectothermic animals are remarkably influenced by ambient temperature. Development at 18°C significantly enhances the stress resistance of adult flies with more accumulation of nutrients (especially fat…
View article: Gender-specific relationship between alcohol consumption and injury in the South Korean adults
Gender-specific relationship between alcohol consumption and injury in the South Korean adults Open
Alcohol-related injuries have been concerned worldwide. However, there have been no large cross-sectional epidemiologic studies. The aim of this study was to investigate the association between alcohol and the prevalence of injury accordin…
View article: Socioeconomic Disparities in the Prevalence of Blepharoptosis in the South Korean Adult Population Based on a Nationwide Cross-Sectional Study
Socioeconomic Disparities in the Prevalence of Blepharoptosis in the South Korean Adult Population Based on a Nationwide Cross-Sectional Study Open
Socioeconomic disparities in the prevalence of blepharoptosis were found among women. Indeed, future research using a prospective design to determine the causal relationship between SES and blepharoptosis may identify SES as a risk factor …
View article: Heart-specific Rpd3 downregulation enhances cardiac function and longevity
Heart-specific Rpd3 downregulation enhances cardiac function and longevity Open
Downregulation of Rpd3, a homologue of mammalian Histone Deacetylase 1 (HDAC1), extends lifespan in Drosophila melanogaster. Once revealed that long-lived fruit flies exhibit limited cardiac decline, we investigated whether Rpd3 downregula…
View article: miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival
miR-206 Mediates YAP-Induced Cardiac Hypertrophy and Survival Open
Rationale: In Drosophila , the Hippo signaling pathway negatively regulates organ size by suppressing cell proliferation and survival through the inhibition of Yorkie, a transcriptional cofactor. Yes-associated protein (YAP), the mammalian…