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View article: Structural covariance network in the striatum is modulated by non-suicidal self-injury in adolescents with major depressive disorder
Structural covariance network in the striatum is modulated by non-suicidal self-injury in adolescents with major depressive disorder Open
The corticostriatal circuit, vital for emotional processing, appears pivotal in the early stages of adolescents with MDD. Our findings underscore the critical effects of NSSI on neurophysiological alterations in these patients.
View article: Sex Differences in Brain Activity and Connectivity in Late-Life Depression
Sex Differences in Brain Activity and Connectivity in Late-Life Depression Open
Background There are notable sex differences in the symptoms and treatment response of late-life depression (LLD); however, the underlying static and dynamic abnormalities in brain function that may drive these disparities remain poorly un…
View article: Correction: Rapid treatment center for depression in China: constructive reflections and transnational implications
Correction: Rapid treatment center for depression in China: constructive reflections and transnational implications Open
[This corrects the article DOI: 10.3389/fpsyt.2025.1582312.].
View article: FerrDb V3: expanding the manually curated resource for regulators and disease associations from ferroptosis to regulated cell death
FerrDb V3: expanding the manually curated resource for regulators and disease associations from ferroptosis to regulated cell death Open
Regulated cell death (RCD) is essential to both physiological homeostasis and numerous diseases. FerrDb is a curated database for ferroptosis regulators and ferroptosis–disease associations. Though widely used, FerrDb is limited by its sin…
View article: Transient other-perspective contextual cueing in a visuospatial perspective-taking task
Transient other-perspective contextual cueing in a visuospatial perspective-taking task Open
Human beings inhabit a world abundant in environmental contexts, and our cognitive processing is invariably influenced by the contextual information surrounding us. Previous research has examined how contextual information is processed and…
View article: CX3CR1–TLR4 Axis as a Shared Neuroimmune Target in COVID-19 and Epilepsy: Integrative Transcriptomics and Gabapentin Repositioning
CX3CR1–TLR4 Axis as a Shared Neuroimmune Target in COVID-19 and Epilepsy: Integrative Transcriptomics and Gabapentin Repositioning Open
Introduction: Neuroinflammation is a common pathological hallmark of Coronavirus Disease 2019 (COVID-19) and epilepsy; however, their shared immunogenomic mechanisms remain poorly defined. This study explores shared immune-inflammatory tra…
View article: Update on neurodegenerative markers in isolated rapid eye movement sleep behavior disorder
Update on neurodegenerative markers in isolated rapid eye movement sleep behavior disorder Open
α-synucleinopathy, as represented by Parkinson’s disease and dementia with Lewy bodies, is a group of common neurodegenerative diseases that have insidious onset and irreversible progression. Therefore, identifying markers related to neuro…
View article: Multi-kingdom microbial changes and their associations with the clinical characteristics in schizophrenia patients
Multi-kingdom microbial changes and their associations with the clinical characteristics in schizophrenia patients Open
Accumulating evidence has highlighted alterations in the gut microbiome in schizophrenia (SZ); however, the role of multi-kingdom microbiota in SZ remains inadequately understood. In this study, we performed metagenomic sequencing of fecal…
View article: Rapid treatment center for depression in China: constructive reflections and transnational implications
Rapid treatment center for depression in China: constructive reflections and transnational implications Open
Enhancing the early diagnosis and standardized treatment of major depressive disorder (MDD), as advocated by the National Health Commission of China, is a key priority in the mental health initiatives of the nation. To achieve this, numero…
View article: Validation and Clinical Application of the Chinese Version of Rapid Response Scale
Validation and Clinical Application of the Chinese Version of Rapid Response Scale Open
Background Current assessment tools inadequately capture rapid symptom changes. This study aims to translate, validate and explore clinical application of the Chinese version of the McIntyre and Rosenblat Rapid Response Scale (CMRRRS) for …
View article: Exploring motherhood dilemmas and coping strategies among mothers of children with autism: a qualitative study in mainland China
Exploring motherhood dilemmas and coping strategies among mothers of children with autism: a qualitative study in mainland China Open
Background Under the traditional division of gender roles in China, mothers often shoulder more responsibilities for caring for children with autism. This article is the first attempt to explore the motherhood practices of mothers of autis…
View article: YTHDF1 differentiates the contributing roles of mTORC1 in aging
YTHDF1 differentiates the contributing roles of mTORC1 in aging Open
The mechanistic target of rapamycin (mTOR) serves as an essential hub in sensing metabolic stress and regulating aging, although the differential contributions of mTOR-regulated protein and cholesterol synthesis are unclear. Post-transcrip…
View article: The Impact of Childhood Maltreatment Experiences on the Structural Covariance Network of Amygdala Subregions in Adolescents with Major Depressive Disorder
The Impact of Childhood Maltreatment Experiences on the Structural Covariance Network of Amygdala Subregions in Adolescents with Major Depressive Disorder Open
Background Childhood maltreatment (CM) and the amygdala are pivotal in the etiology of adolescents with major depressive disorder (MDD), but the neurobiological processes linking them remain ambiguous. Methods This study employed voxel-bas…
View article: Revealing multiple biological subtypes of schizophrenia through a data-driven approach
Revealing multiple biological subtypes of schizophrenia through a data-driven approach Open
These findings show the potential to identify multiple biological subtypes with distinct biomarkers, thereby suggesting the possibility of personalized and precise treatment for SZ patients.
View article: Neural connectivity biotypes: predictors of clinical outcomes and improvement patterns of iTBS treatment in adolescents and young adults with depression
Neural connectivity biotypes: predictors of clinical outcomes and improvement patterns of iTBS treatment in adolescents and young adults with depression Open
Background The heterogeneity of depression limits the treatment outcomes of intermittent theta burst stimulation (iTBS) and hinders the identification of predictive factors. This study investigated functional network connectivity and predi…
View article: Abnormalities in large-scale brain network dynamics in late-life depression with suicidal ideation: an EEG microstate analysis
Abnormalities in large-scale brain network dynamics in late-life depression with suicidal ideation: an EEG microstate analysis Open
Background Patients with late-life depression (LLD) with suicidal ideation (SI) often have more explicit suicide plans, and suicide attempts among older adults are more highly lethal than in other age groups. Increasing evidence suggests t…
View article: The Restoration of Energy Pathways Indicates the Efficacy of Ketamine Treatment in Depression: A Metabolomic Analysis
The Restoration of Energy Pathways Indicates the Efficacy of Ketamine Treatment in Depression: A Metabolomic Analysis Open
Aims Despite the clinical benefits of ketamine in treating major depressive disorder (MDD), some patients exhibit drug resistance, and the intricate mechanisms underlying this await comprehensive explication. We used metabolomics to find b…
View article: Body mass index is associated with the antidepressant effects of intravenous ketamine in patients with depression
Body mass index is associated with the antidepressant effects of intravenous ketamine in patients with depression Open
Objectives We aimed to explore the correlation between baseline body mass index (BMI) and the antidepressant properties of intravenous ketamine in patients with depression. Methods We divided 135 patients diagnosed with either major depres…
View article: Device‐Measured Physical Activity, Sedentary Behaviour and Risk of Chronic Kidney Diseases Across Levels of Grip Strength
Device‐Measured Physical Activity, Sedentary Behaviour and Risk of Chronic Kidney Diseases Across Levels of Grip Strength Open
Background The study aimed to investigate whether the associations of accelerometer‐measured physical activity (PA) and sedentary behaviour (SB) with incident chronic kidney disease (CKD) vary based on different levels of hand grip strengt…
View article: Plasma p‐tau217 and p‐tau217/Aβ1‐42 are effective biomarkers for identifying CSF‐ and PET imaging‐diagnosed Alzheimer's disease: Insights for research and clinical practice
Plasma p‐tau217 and p‐tau217/Aβ1‐42 are effective biomarkers for identifying CSF‐ and PET imaging‐diagnosed Alzheimer's disease: Insights for research and clinical practice Open
INTRODUCTION With the advancement of disease‐modifying therapies for Alzheimer's disease (AD), validating plasma biomarkers against cerebrospinal fluid (CSF) and positron emission tomography (PET) standards is crucial in both research and …
View article: Proteomic patterns associated with ketamine response in major depressive disorders
Proteomic patterns associated with ketamine response in major depressive disorders Open
The study was registered in the Chinese Clinical Trials Registry (ChiCTR-OOC-17012239) on May 26, 2017.