Yongmin Chang
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View article: Tumor-Targeting T <sub>1</sub> MRI Contrast Agents with Antioxidant Effects: Gadolinium Oxide Nanoparticles Grafted with Polydopamine- and Polyserotonin-Conjugated Polyacrylic Acids
Tumor-Targeting T <sub>1</sub> MRI Contrast Agents with Antioxidant Effects: Gadolinium Oxide Nanoparticles Grafted with Polydopamine- and Polyserotonin-Conjugated Polyacrylic Acids Open
View article: Physicochemical and Multimodal Imaging Properties of Core–Shell Ln2O3@Carbon Nanoparticles (Ln = Tb and Ho)
Physicochemical and Multimodal Imaging Properties of Core–Shell Ln2O3@Carbon Nanoparticles (Ln = Tb and Ho) Open
In this study, core–shell Ln2O3@carbon nanoparticles (core = Ln2O3 and shell = carbon; Ln = Tb and Ho) were synthesized for the first time by preparing Ln2O3 nanoparticles through a polyol method, followed by carbon coating using D-glucose…
View article: Current Status and Future Aspects of Gadolinium Oxide Nanoparticles as Positive Magnetic Resonance Imaging Contrast Agents
Current Status and Future Aspects of Gadolinium Oxide Nanoparticles as Positive Magnetic Resonance Imaging Contrast Agents Open
Although numerous studies have investigated gadolinium oxide (Gd2O3) nanoparticles (NPs) as positive (T1) magnetic resonance imaging (MRI) contrast agents (CAs), comprehensive reviews on this topic remain scarce. Therefore, it is essential…
View article: Therapeutic Potential of a Gadolinium Chelate Complex Conjugated with Vanillic Acid for Alzheimer’s Disease
Therapeutic Potential of a Gadolinium Chelate Complex Conjugated with Vanillic Acid for Alzheimer’s Disease Open
Magnetic resonance imaging (MRI) is a widely used diagnostic tool for neurodegenerative diseases, including Alzheimer's disease. A gadolinium chelate conjugated with vanillic acid (Gd-DO3A-Va) serves as a contrast agent that specifically t…
View article: Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition
Magnetic Resonance Imaging and X-Ray Imaging Properties of Ultrasmall Lanthanide Oxide (Ln = Eu, Gd, and Tb) Nanoparticles Synthesized via Thermal Decomposition Open
Owing to their 4f electrons and high atomic numbers, lanthanide (Ln) elements impart lanthanide oxide (Ln2O3) nanoparticles with excellent biomedical imaging properties. This study reports synthesis for three types of ultrasmall and monodi…
View article: Surface Modification, Toxicity, and Applications of Carbon Dots to Cancer Theranosis: A Review
Surface Modification, Toxicity, and Applications of Carbon Dots to Cancer Theranosis: A Review Open
Cancer remains one of the leading causes of death worldwide, prompting extensive research into novel theranostic (combined word of diagnostic and therapeutic) strategies. Nanomedicine has emerged as a potential breakthrough in cancer thera…
View article: Effect of Chewing Hardness on Cognitive-Associated Brain Regions Activation
Effect of Chewing Hardness on Cognitive-Associated Brain Regions Activation Open
Our study shows that hard-chewing activates brain regions linked to cognitive function more than soft-chewing. This suggests that harder chewing could be used as a simple, non-invasive method to enhance cognitive processing. Incorporating …
View article: Synthesis, Characterization, Magnetic Properties, and Applications of Carbon Dots as Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents: A Review
Synthesis, Characterization, Magnetic Properties, and Applications of Carbon Dots as Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents: A Review Open
Carbon dots (CDs) are metal-free carbon-based nanoparticles. They possess excellent photoluminescent properties, various physical properties, good chemical stability, high water solubility, high biocompatibility, and tunable surface functi…
View article: Synthesis, Characterization, Magnetic Properties, and Applications of Carbon Dots as Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents: A Review
Synthesis, Characterization, Magnetic Properties, and Applications of Carbon Dots as Diamagnetic Chemical Exchange Saturation Transfer Magnetic Resonance Imaging Contrast Agents: A Review Open
Carbon dots (CDs) are metal-free carbon-based nanoparticles. They possess excellent photoluminescent properties, various physical properties, good chemical stability, high water solubility, high biocompatibility, and tunable surface functi…
View article: Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease
Modulating Neuroinflammation as a Prospective Therapeutic Target in Alzheimer’s Disease Open
The recent approval of lecanemab highlights that the amyloid beta (Aβ) protein is an important pathological target in Alzheimer’s disease (AD) and further emphasizes the significance of neuroinflammatory pathways in regulating Aβ accumulat…
View article: Evaluation of Glutathione <i>T</i><sub>2</sub> in the Human Brain Using J‐Difference MRS at 3 T: Multicenter Multivendor Study
Evaluation of Glutathione <i>T</i><sub>2</sub> in the Human Brain Using J‐Difference MRS at 3 T: Multicenter Multivendor Study Open
The need to quantify brain glutathione (GSH) accurately by J‐difference spectroscopy has stimulated assessment of the TE effects on GSH edited signals at the popular field strength 3 T. We performed multiple‐TE J‐difference MRS at two site…
View article: Effect of chewing hard material on boosting brain antioxidant levels and enhancing cognitive function
Effect of chewing hard material on boosting brain antioxidant levels and enhancing cognitive function Open
Introduction Chewing has been reported to enhance cognitive function through the increase in cerebral blood flow. However, the mechanisms linking cerebral blood flow increase to metabolic changes in the brain affecting cognition remain unc…
View article: High Quantum Yields and Biomedical Fluorescent Imaging Applications of Photosensitized Trivalent Lanthanide Ion-Based Nanoparticles
High Quantum Yields and Biomedical Fluorescent Imaging Applications of Photosensitized Trivalent Lanthanide Ion-Based Nanoparticles Open
In recent years, significant advances in enhancing the quantum yield (QY) of trivalent lanthanide (Ln3+) ion-based nanoparticles have been achieved through photosensitization, using host matrices or capping organic ligands as photosensitiz…
View article: Characterization of BMO spaces via commutators of some maximal operators on the slice spaces
Characterization of BMO spaces via commutators of some maximal operators on the slice spaces Open
In this paper, the main aim is to demonstrate the boundedness for commutators of (fractional) maximal function and sharp maximal function in the slice spaces, where the symbols of the commutators belong to the BMO space, whereby some new c…
View article: Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood–Brain Barrier
Hopping the Hurdle: Strategies to Enhance the Molecular Delivery to the Brain through the Blood–Brain Barrier Open
Modern medicine has allowed for many advances in neurological and neurodegenerative disease (ND). However, the number of patients suffering from brain diseases is ever increasing and the treatment of brain diseases remains an issue, as dru…
View article: Gadolinium-Based Magnetic Resonance Theranostic Agent with Gallic Acid as an Anti-Neuroinflammatory and Antioxidant Agent
Gadolinium-Based Magnetic Resonance Theranostic Agent with Gallic Acid as an Anti-Neuroinflammatory and Antioxidant Agent Open
Studies in the field have actively pursued the incorporation of diverse biological functionalities into gadolinium-based contrast agents, aiming at the amalgamation of MRI imaging and therapeutic capabilities. In this research, we present …
View article: Core-Shell Fe3O4@C Nanoparticles as Highly Effective T2 Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies
Core-Shell Fe3O4@C Nanoparticles as Highly Effective T2 Magnetic Resonance Imaging Contrast Agents: In Vitro and In Vivo Studies Open
Magnetite nanoparticles (Fe3O4 NPs) have been intensively investigated because of their potential biomedical applications due to their high saturation magnetization. In this study, core–shell Fe3O4@C NPs (core = Fe3O4 NPs and shell = amorp…
View article: Ultrasmall cerium oxide nanoparticles as highly sensitive X-ray contrast agents and their antioxidant effect
Ultrasmall cerium oxide nanoparticles as highly sensitive X-ray contrast agents and their antioxidant effect Open
Ultrasmall CeO 2 nanoparticles as highly sensitive radioprotective or theranostic X-ray contrast agents.
View article: Multi-functional GdEu<sub><i>x</i></sub>Tb<sub>1−<i>x</i></sub>O<sub>3</sub> (<i>x</i> = 0 to 1) nanoparticles: colour tuning optical properties, water proton spin relaxivities, and X-ray attenuation properties
Multi-functional GdEu<sub><i>x</i></sub>Tb<sub>1−<i>x</i></sub>O<sub>3</sub> (<i>x</i> = 0 to 1) nanoparticles: colour tuning optical properties, water proton spin relaxivities, and X-ray attenuation properties Open
Multi-functional properties of GdEu x Tb 1− x O 3 @PAA/PDA nanoparticles ( x = 0 to 1), i.e. , colour tuning, high water proton spin relaxivities, and high X-ray attenuation, suitable for various applications, were investigated.
View article: A case report of brain activity during mastication
A case report of brain activity during mastication Open
Objectives:The aim of this study was to evaluate brain activity in youth during chewing gum and wood stick using functional magnetic resonance imaging (fMRI).Methods: Two participants chewed wax gums and wood stick on the rhythm of 1 Hz du…
View article: Suboptimal hepatobiliary phase image in gadoxetic acid-enhanced liver MRI for the evaluation of the HCC: Predictive factors
Suboptimal hepatobiliary phase image in gadoxetic acid-enhanced liver MRI for the evaluation of the HCC: Predictive factors Open
To determine the relevant laboratory values for hepatobiliary phase (HBP) imaging and predictive factors for suboptimal HBP images on gadoxetic acid-enhanced liver magnetic resonance imaging (MRI) for the evaluation of hepatocellular carci…
View article: Heavy Metal-Based Nanoparticles as High-Performance X-ray Computed Tomography Contrast Agents
Heavy Metal-Based Nanoparticles as High-Performance X-ray Computed Tomography Contrast Agents Open
X-ray computed tomography (CT) contrast agents offer extremely valuable tools and techniques in diagnostics via contrast enhancements. Heavy metal-based nanoparticles (NPs) can provide high contrast in CT images due to the high density of …
View article: Heavy Metal-Based Nanoparticles as High-Performance X-Ray Computed Tomography Contrast Agents
Heavy Metal-Based Nanoparticles as High-Performance X-Ray Computed Tomography Contrast Agents Open
Contrast agents developed for X-ray computed tomography (CT) offer extremely valuable tools and techniques in diagnostics via contrast enhancements. Heavy metal-based nanoparticles (NPs) can provide high contrast in CT images. These result…
View article: Effects of Alterations in Resting-State Neural Networks on the Severity of Neuropathic Pain after Spinal Cord Injury
Effects of Alterations in Resting-State Neural Networks on the Severity of Neuropathic Pain after Spinal Cord Injury Open
Neuropathic pain (NP) following spinal cord injury (SCI) is refractory to pain control strategies, and the underlying neuronal mechanisms remain poorly understood. This study aimed to determine the brain regions engaged in maintaining a sp…
View article: Hemagglutination Assay via Optical Density Characterization in 3D Microtrap Chips
Hemagglutination Assay via Optical Density Characterization in 3D Microtrap Chips Open
Hemagglutination assay has been used for blood typing and detecting viruses, thus applicable for the diagnosis of infectious diseases, including COVID-19. Therefore, the development of microfluidic devices for fast detection of hemagglutin…
View article: Neural mechanisms of acceptance-commitment therapy for obsessive-compulsive disorder: a resting-state and task-based fMRI study
Neural mechanisms of acceptance-commitment therapy for obsessive-compulsive disorder: a resting-state and task-based fMRI study Open
Background There is growing evidence for the use of acceptance-commitment therapy (ACT) for the treatment of obsessive-compulsive disorder (OCD). However, few fully implemented ACT have been conducted on the neural mechanisms underlying it…
View article: Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents
Magnetic Nanoparticle-Based High-Performance Positive and Negative Magnetic Resonance Imaging Contrast Agents Open
In recent decades, magnetic nanoparticles (MNPs) have attracted considerable research interest as versatile substances for various biomedical applications, particularly as contrast agents in magnetic resonance imaging (MRI). Depending on t…
View article: Manganese (II) Complex of 1,4,7-Triazacyclononane-1,4,7-Triacetic Acid (NOTA) as a Hepatobiliary MRI Contrast Agent
Manganese (II) Complex of 1,4,7-Triazacyclononane-1,4,7-Triacetic Acid (NOTA) as a Hepatobiliary MRI Contrast Agent Open
Magnetic resonance imaging (MRI) is increasingly used to diagnose focal and diffuse liver disorders. Despite their enhanced efficacy, liver-targeted gadolinium-based contrast agents (GBCAs) raise safety concerns owing to the release of tox…
View article: Nonsteroidal Anti-Inflammatory Drug Conjugated with Gadolinium (III) Complex as an Anti-Inflammatory MRI Agent
Nonsteroidal Anti-Inflammatory Drug Conjugated with Gadolinium (III) Complex as an Anti-Inflammatory MRI Agent Open
Studies have been actively conducted to ensure that gadolinium-based contrast agents for magnetic resonance imaging (MRI) are accompanied by various biological functions. A new example is the anti-inflammatory theragnostic MRI agent to tar…
View article: Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers
Facile Synthesis and X-ray Attenuation Properties of Ultrasmall Platinum Nanoparticles Grafted with Three Types of Hydrophilic Polymers Open
Ultrasmall platinum nanoparticles (Pt-NPs) grafted with three types of hydrophilic and biocompatible polymers, i.e., poly(acrylic acid), poly(acrylic acid-co-maleic acid), and poly(methyl vinyl ether-alt-maleic acid) were synthesized using…