Yongning Xin
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View article: Efficacy and Safety of Entecavir, Tenofovir Disoproxil Fumarate, and Tenofovir Alafenamide Fumarate in Treating Acute-on-Chronic Liver Failure with Hepatitis B Virus: A Network Meta-analysis
Efficacy and Safety of Entecavir, Tenofovir Disoproxil Fumarate, and Tenofovir Alafenamide Fumarate in Treating Acute-on-Chronic Liver Failure with Hepatitis B Virus: A Network Meta-analysis Open
View article: Relationship between stress hyperglycemia ratio of one-year mortality in patients with heart failure: Analysis of the MIMIC-IV database
Relationship between stress hyperglycemia ratio of one-year mortality in patients with heart failure: Analysis of the MIMIC-IV database Open
Background Stress Hyperglycemia Ratio (SHR) has been confirmed to be a predictor for adverse outcomes in cardiovascular diseases in recent years. However, the impact of SHR on one-year mortality in patients diagnosed with heart failure (HF…
View article: Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study
Chiglitazar in MASLD with hypertriglyceridemia and insulin resistance: A phase II, randomized, double-blind, placebo-controlled study Open
Background and Aims: Metabolic dysfunction–associated steatotic liver disease (MASLD) can progress to severe forms such as metabolic dysfunction–associated steatohepatitis (MASH). Effective treatments for MASH are urgently needed. This stu…
View article: The association of dietary nutrients consumption with hepatic steatosis and fibrosis from NHANES 2017–2020
The association of dietary nutrients consumption with hepatic steatosis and fibrosis from NHANES 2017–2020 Open
Background/objectives Hepatic steatosis and fibrosis represent significant and growing global health burdens. There is an urgent need to seek strategies for early prevention and control of hepatic steatosis and fibrosis. This study attempt…
View article: Intestinal Depletion of TM6SF2 Exacerbates High-fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis
Intestinal Depletion of TM6SF2 Exacerbates High-fat Diet-induced Metabolic Dysfunction-associated Steatotic Liver Disease through the Gut-liver Axis Open
TM6SF2 GKO aggravates liver lipid accumulation and liver injury in MASLD mice. TM6SF2 may play an important role in regulating intestinal flora and the progression of MASLD through the gut-liver axis.
View article: Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-κB-mediated inflammation by regulating the PI3K/AKT/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model
Fucoidan ameliorates lipid accumulation, oxidative stress, and NF-κB-mediated inflammation by regulating the PI3K/AKT/Nrf2 signaling pathway in a free fatty acid-induced NAFLD spheroid model Open
View article: MiR-146a-5p-enriched exosomes inhibit M1 macrophage activation and inflammatory response by targeting CD80
MiR-146a-5p-enriched exosomes inhibit M1 macrophage activation and inflammatory response by targeting CD80 Open
This study demonstrated that miR-146a-5p-enriched exosomes can inhibit the M1 macrophages activation and reduce the release of pro-inflammatory factors by targeting CD80.
View article: Salidroside may target PPARα to exert preventive and therapeutic activities on NASH
Salidroside may target PPARα to exert preventive and therapeutic activities on NASH Open
Background Salidroside (SDS), a phenylpropanoid glycoside, is an antioxidant component isolated from the traditional Chinese medicine Rhodiola rosea and has multifunctional bioactivities, particularly possessing potent hepatoprotective fun…
View article: Renal and bone side effects of long-term use of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide fumarate in patients with Hepatitis B: a network meta-analysis
Renal and bone side effects of long-term use of entecavir, tenofovir disoproxil fumarate, and tenofovir alafenamide fumarate in patients with Hepatitis B: a network meta-analysis Open
View article: Alfosbuvir plus Daclatasvir for Treatment of Chronic Hepatitis C Virus Infection in China
Alfosbuvir plus Daclatasvir for Treatment of Chronic Hepatitis C Virus Infection in China Open
View article: Two Novel Variants of Undetermined Significance in the <i>ABCC2</i> Gene Were Identified in a Patient with Dubin-Johnson Syndrome
Two Novel Variants of Undetermined Significance in the <i>ABCC2</i> Gene Were Identified in a Patient with Dubin-Johnson Syndrome Open
Dubin-Johnson syndrome (DJS), also known as chronic idiopathic jaundice, black liver-jaundice syndrome, etc. most often develops in adolescents or young adults, and is more common in males, with clinical manifestations of asymptomatic long…
View article: Methylenetetrahydrofolate Reductase <i>Gene rs1801131</i> and <i>rs1801133</i> Polymorphisms were Associated with Susceptibility to Coronary Artery Disease and Nonalcoholic Fatty Liver Disease
Methylenetetrahydrofolate Reductase <i>Gene rs1801131</i> and <i>rs1801133</i> Polymorphisms were Associated with Susceptibility to Coronary Artery Disease and Nonalcoholic Fatty Liver Disease Open
Background and objectivesMethylenetetrahydrofolate Reductase (MTHFR) is the critical enzyme in folate and 1-carbon metabolism. MTHFR polymorphisms may result in increased homocysteine levels, and be associated with abnormal lipid metabolis…
View article: Alfosbuvir plus Daclatasvir for Treatment of Chronic Hepatitis C Virus Infection in China
Alfosbuvir plus Daclatasvir for Treatment of Chronic Hepatitis C Virus Infection in China Open
Background and aims A pan-genotypic and effective treatment regimen for patients with chronic hepatitis C virus (HCV) infection remains an unmet medical need in China. Alfosbuvir is a novel potent HCV NS5B polymerase inhibitor in developme…
View article: Elevated Serum Alpha-fetoprotein Levels in Non-alcoholic Steatohepatitis: Possible Molecular Mechanisms and Potential Clinical Significance
Elevated Serum Alpha-fetoprotein Levels in Non-alcoholic Steatohepatitis: Possible Molecular Mechanisms and Potential Clinical Significance Open
With the improvement of living standards in recent years, up to 90% of obese patients have nonalcoholic fatty liver disease (NAFLD). The number of nonalcoholic steatohepatitis (NASH)-related deaths will gradually increase, and NASH is expe…
View article: Renal and bone side effects of Entecavir, tenofovir disoproxil fumarate, tenofovir alafenamide fumarate in patients with hepatitis B: a network meta- analysis
Renal and bone side effects of Entecavir, tenofovir disoproxil fumarate, tenofovir alafenamide fumarate in patients with hepatitis B: a network meta- analysis Open
Background As the first-line treatment for chronic hepatitis B virus infection, the long-term effects of nucleoside analogues on kidney and bone tissue damage need to be further investigated. Methods Two investigators independently searche…
View article: Chronic Infection Considerations in Nonalcoholic Fatty Liver Disease Patients
Chronic Infection Considerations in Nonalcoholic Fatty Liver Disease Patients Open
Nonalcoholic fatty-liver disease (NAFLD) has become one of the most common and important chronic liver diseases worldwide. Some chronic infectious diseases are associated with the risk of NAFLD. These can induce abnormal glucose and lipid …
View article: Predictive effect and clinical significance of exosome-related genes for Nonalcoholic fatty liver disease-related hepatocellular carcinoma
Predictive effect and clinical significance of exosome-related genes for Nonalcoholic fatty liver disease-related hepatocellular carcinoma Open
Nonalcoholic fatty liver disease (NAFLD) is a multifactorial metabolic syndrome which could develop into hepatocellular carcinoma (HCC). Exosomes could mediate intercellular communications and play key roles in the occurrence and developme…
View article: Chaetomorpha linum polysaccharides alleviate NAFLD in mice by enhancing the PPARα/CPT-1/MCAD signaling
Chaetomorpha linum polysaccharides alleviate NAFLD in mice by enhancing the PPARα/CPT-1/MCAD signaling Open
View article: Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver
Serum 25-hydroxyvitamin D levels and the risk of non-alcoholic fatty liver Open
Background: Accumulated studies have shown that low expression of 25-hydroxyvitamin D [25(OH)D] was significantly associated with the risk of non-alcoholic fatty liver disease (NAFLD). However, the exact causality is still unknown. The aim…
View article: Establishment of a Prognostic Model for Hepatocellular Carcinoma Based on Bioinformatics and the Role of NR6A1 in the Progression of HCC
Establishment of a Prognostic Model for Hepatocellular Carcinoma Based on Bioinformatics and the Role of NR6A1 in the Progression of HCC Open
An effective prognostic model for HCC, based on a novel signature of 10 immune-related genes, was established. NR6A1 was up-regulated in HCC and was associated with a poor prognosis of HCC. NR6A1 promoted cell proliferation, …
View article: Association between the LRP5 rs556442 gene polymorphism and the risks of NAFLD and CHD in a Chinese Han population
Association between the LRP5 rs556442 gene polymorphism and the risks of NAFLD and CHD in a Chinese Han population Open
Background Multiple studies have demonstrated the involvement of low-density lipoprotein receptor-related protein 5 (LRP5) in metabolism-related diseases. This study explored the relationship between the LRP5 rs556442 gene polymorphism and…
View article: MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway
MiR-146a-5p, targeting ErbB4, promotes 3T3-L1 preadipocyte differentiation through the ERK1/2/PPAR-γ signaling pathway Open
View article: Efficacy and safety of alfosbuvir plus daclatasvir in Chinese patients with hepatitis C virus genotypes 1, 2, 3, and 6 infection: An open‐label, phase 2 study
Efficacy and safety of alfosbuvir plus daclatasvir in Chinese patients with hepatitis C virus genotypes 1, 2, 3, and 6 infection: An open‐label, phase 2 study Open
Alfosbuvir is a novel potent HCV NS5B polymerase inhibitor in development for the treatment of chronic HCV infection. Our previous studies indicated that alfosbuvir monotherapy was well‐tolerated and druggable in healthy subjects and HCV‐i…
View article: Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study
Relationship of circulating total bilirubin, UDP-glucuronosyltransferases 1A1 and the development of non-alcoholic fatty liver disease: a cross-sectional study Open
View article: A Novel Model for the Screening of Varices in Patients With Compensated Cirrhosis: An International Multicenter Study
A Novel Model for the Screening of Varices in Patients With Compensated Cirrhosis: An International Multicenter Study Open
View article: Relationship between <i>AGT</i> rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population
Relationship between <i>AGT</i> rs2493132 polymorphism and the risk of coronary artery disease in patients with NAFLD in the Chinese Han population Open
Objective To investigate the relationship between angiotensin ( AGT) rs2493132 gene polymorphism and the risk of developing non-alcoholic fatty liver disease (NAFLD) and coronary artery disease (CAD) in the Chinese Han population. Methods …
View article: Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis
Serum Resistin Levels in Adult Patients with Nonalcoholic Fatty Liver Disease: A Systematic Review and Meta-analysis Open
This meta-analysis investigated the serum resistin levels in adult patients with NAFLD comprehensively. Patients with NAFLD had higher serum resistin levels and patients with NASH had lower serum resistin levels than healthy controls. Seru…
View article: Tenofovir Alafenamide Fumarate, Tenofovir Disoproxil Fumarate and Entecavir: Which is the Most Effective Drug for Chronic Hepatitis B? A Systematic Review and Meta-analysis
Tenofovir Alafenamide Fumarate, Tenofovir Disoproxil Fumarate and Entecavir: Which is the Most Effective Drug for Chronic Hepatitis B? A Systematic Review and Meta-analysis Open
The virological response in TDF-treated CHB patients was superior to that in ETV-treated CHB patients, but there was no significant difference between TAF and TDF. In addition, the therapeutic effect of TDF+ETV was superior to TDF alone.
View article: Association of LDLR rs1433099 with the Risk of NAFLD and CVD in Chinese Han Population
Association of LDLR rs1433099 with the Risk of NAFLD and CVD in Chinese Han Population Open
Our study demonstrated that the LDLR rs1433099 polymorphism is not a risk factor of NAFLD. The LDLR rs1433099 polymorphism may increase the risk of CVD through a mechanism involving alkaline phosphatase and gamma-glutamyl transpeptidase.
View article: Diagnostic accuracy assessment of molecular prediction model for the risk of NAFLD based on MRI-PDFF diagnosed Chinese Han population
Diagnostic accuracy assessment of molecular prediction model for the risk of NAFLD based on MRI-PDFF diagnosed Chinese Han population Open