Yihui Shi
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View article: Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells
Oncometabolite fumarate impairs ATR-CHK1 signaling by succinating RPA1 in Fumarate Hydratase-deficient renal cell carcinoma cells Open
Abnormal accumulation of oncometabolite fumarate drives susceptibility in fumarate hydratase-deficient renal cell carcinoma (FH-dRCC), but the precise mechanisms remain not fully understood. In this study, we demonstrate that high fumarate…
View article: Letter to the editor: “Efficacy and safety of immunotherapy-based neoadjuvant regimens in LAGC: a meta-analysis”
Letter to the editor: “Efficacy and safety of immunotherapy-based neoadjuvant regimens in LAGC: a meta-analysis” Open
View article: Dose‐Dependent Effects of Dietary n‐3 Fatty Acids on Bowel Health: Plant‐Sourced <scp>ALA</scp> Modulates Diarrhea Risk While Marine‐Sourced <scp>DHA</scp> / <scp>EPA</scp> Prevent Constipation in <scp>NHANES</scp> 2005–2010
Dose‐Dependent Effects of Dietary n‐3 Fatty Acids on Bowel Health: Plant‐Sourced <span>ALA</span> Modulates Diarrhea Risk While Marine‐Sourced <span>DHA</span> / <span>EPA</span> Prevent Constipation in <span>NHANES</span> 2005–2010 Open
Although omega‐3 polyunsaturated fatty acid (n‐3PUFA) is generally considered to have positive effects on bowel health, the understanding of the impacts of n‐3PUFA on bowel function is limited. This study aimed to deeply investigate the as…
View article: Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade
Combinatorial therapy regimens targeting preclinical models of melanoma resistant to immune checkpoint blockade Open
Few effective therapeutic options exist after progression on immune checkpoint blockade (ICB) for melanoma. Here, we utilized a platform incorporating transcriptomic profiling, high-throughput drug screening, and murine models to demonstra…
View article: Yolov11-Rah: Recurrent Attention-Enhanced Object Detection for Power Transmission Line Insulator Inspection
Yolov11-Rah: Recurrent Attention-Enhanced Object Detection for Power Transmission Line Insulator Inspection Open
View article: Research on aerodynamic and ballistic characteristics of rotary wing type aerodynamic layout rocket
Research on aerodynamic and ballistic characteristics of rotary wing type aerodynamic layout rocket Open
Rockets with a rotating wing type pneumatic layout as the research object, using the method of numerical simulation of subsonic stage of the rocket was studied at different attack angles, Mach Numbers and aerodynamic characteristics under …
View article: RELT Is Upregulated in Breast Cancer and Induces Death in Breast Cancer Cells
RELT Is Upregulated in Breast Cancer and Induces Death in Breast Cancer Cells Open
Background: Receptor Expressed in Lymphoid Tissues (RELT) is a TNFRSF member that has two paralogs, RELL1 and RELL2; the three proteins are collectively referred to as RELT family members (RELTfms). Methods: We sought to evaluate RELT expr…
View article: Application of fuzzy comprehensive evaluation method in the identification of potential faults of high-voltage power cables
Application of fuzzy comprehensive evaluation method in the identification of potential faults of high-voltage power cables Open
To address the challenge of identifying hidden faults in high-voltage power cables, this study proposes a fuzzy comprehensive evaluation method. The method aims to provide a comprehensive and effective means of fault identification for ope…
View article: Porcine decellularized nerve matrix hydrogel attenuates neuroinflammation after peripheral nerve injury by inhibiting the TLR4/MyD88/NF-κB axis
Porcine decellularized nerve matrix hydrogel attenuates neuroinflammation after peripheral nerve injury by inhibiting the TLR4/MyD88/NF-κB axis Open
JOURNAL/nrgr/04.03/01300535-202603000-00045/figure1/v/2025-06-16T082406Z/r/image-tiff Peripheral nerve injury causes severe neuroinflammation and has become a global medical challenge. Previous research has demonstrated that porcine decell…
View article: miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK
miR-876-3p is a tumor suppressor on 9p21 that is inactivated in melanoma and targets ERK Open
Background While melanomas commonly harbor losses of 9p21, on which CDKN2A resides, the presence of additional tumor suppressor elements at this locus is incompletely characterized. Here we assess the expression levels and functional role …
View article: Surgical treatment of congenital adrenal hyperplasia with adenoma
Surgical treatment of congenital adrenal hyperplasia with adenoma Open
View article: Depicting Biomarkers for HER2-Inhibitor Resistance: Implication for Therapy in HER2-Positive Breast Cancer
Depicting Biomarkers for HER2-Inhibitor Resistance: Implication for Therapy in HER2-Positive Breast Cancer Open
HER2 (human epidermal growth factor receptor 2) is highly expressed in a variety of cancers, including breast, lung, gastric, and pancreatic cancers. Its amplification is linked to poor clinical outcomes. At the genetic level, HER2 is enco…
View article: Current Advancements in Anti-Cancer Chimeric Antigen Receptor T Cell Immunotherapy and How Nanotechnology May Change the Game
Current Advancements in Anti-Cancer Chimeric Antigen Receptor T Cell Immunotherapy and How Nanotechnology May Change the Game Open
Chimeric antigen receptor (CAR)-T cell immunotherapy represents a cutting-edge advancement in the landscape of cancer treatment. This innovative therapy has shown exceptional promise in targeting and eradicating malignant tumors, specifica…
View article: Analysis, Optimization, and Testing of a Tilt-Body Aircraft
Analysis, Optimization, and Testing of a Tilt-Body Aircraft Open
View article: Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy
Targeting Farnesoid X Receptor in Tumor and the Tumor Microenvironment: Implication for Therapy Open
The farnesoid-X receptor (FXR), a member of the nuclear hormone receptor superfamily, can be activated by bile acids (BAs). BAs binding to FXR activates BA signaling which is important for maintaining BA homeostasis. FXR is differentially …
View article: A case report of renal dysplasia with papillary adenoma
A case report of renal dysplasia with papillary adenoma Open
View article: Laparoscopic partial cystectomy for myofibroblastic cystitis: A case report
Laparoscopic partial cystectomy for myofibroblastic cystitis: A case report Open
View article: The RELT Family of Proteins: An Increasing Awareness of Their Importance for Cancer, the Immune System, and Development
The RELT Family of Proteins: An Increasing Awareness of Their Importance for Cancer, the Immune System, and Development Open
This review highlights Receptor Expressed in Lymphoid Tissues (RELT), a Tumor Necrosis Factor Superfamily member, and its two paralogs, RELL1 and RELL2. Collectively, these three proteins are referred to as RELTfms and have gained much int…
View article: RELT is overexpressed in human inflammatory bowel disease and breast cancer
RELT is overexpressed in human inflammatory bowel disease and breast cancer Open
Receptor Expressed in Lymphoid Tissues (RELT) is a human TNFR member that activates NF-kB and is implicated in several cancers. We therefore sought to characterize the association of RELT with inflammatory bowel disease (IBD) and breast ca…
View article: Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α Open
Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role i…
View article: Supplementary Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
Supplementary Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α Open
Supplementary Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
View article: Supplementary Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
Supplementary Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α Open
Supplementary Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
View article: Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α
Data from Metallothionein Induction by Hypoxia Involves Cooperative Interactions between Metal-Responsive Transcription Factor-1 and Hypoxia-Inducible Transcription Factor-1α Open
Mammalian metallothionein (MT) genes are transcriptionally activated by the essential metal zinc as well as by environmental stresses, including toxic metal overload and redox fluctuations. In addition to playing a key role i…
View article: An effective up-sampling approach for breast cancer prediction with imbalanced data: A machine learning model-based comparative analysis
An effective up-sampling approach for breast cancer prediction with imbalanced data: A machine learning model-based comparative analysis Open
Early detection of breast cancer plays a critical role in successful treatment that saves thousands of lives of patients every year. Despite massive clinical data have been collected and stored by healthcare organizations, only a small por…
View article: Emerging Novel Combined CAR-T Cell Therapies
Emerging Novel Combined CAR-T Cell Therapies Open
Chimeric antigen receptors (CAR) T cells are T cells engineered to express membrane receptors with high specificity to recognize specific target antigens presented by cancer cells and are co-stimulated with intracellular signals to increas…
View article: New and Emerging Targeted Therapies for Advanced Breast Cancer
New and Emerging Targeted Therapies for Advanced Breast Cancer Open
In the United States, breast cancer is among the most frequently diagnosed cancers in women. Breast cancer is classified into four major subtypes: human epidermal growth factor receptor 2 (HER2), Luminal-A, Luminal-B, and Basal-like or tri…
View article: Breast Cancer Predisposition Genes and Synthetic Lethality
Breast Cancer Predisposition Genes and Synthetic Lethality Open
BRCA1 and BRCA2 are tumor suppressor genes with pivotal roles in the development of breast and ovarian cancers. These genes are essential for DNA double-strand break repair via homologous recombination (HR), which is a virtually error-free…
View article: Chimeric antigen receptor T-cell immunotherapy in breast cancer: development and challenges
Chimeric antigen receptor T-cell immunotherapy in breast cancer: development and challenges Open
Chimeric antigen receptor (CAR) T-cell therapy is an innovative form of immunotherapy wherein autologous T-cells are genetically modified to express chimeric receptors encoding an antigen-specific single-chain variable fragment and costimu…
View article: RELT stains prominently in B-cell lymphomas and binds the hematopoietic transcription factor MDFIC
RELT stains prominently in B-cell lymphomas and binds the hematopoietic transcription factor MDFIC Open
View article: The metal-responsive transcription factor-1 protein is elevated in human tumors
The metal-responsive transcription factor-1 protein is elevated in human tumors Open
We previously identified metal-responsive transcription factor-1 (MTF-1) as a positive contributor to mouse fibrosarcoma growth through effects on cell survival, proliferation, tumor angiogenesis and extracellular matrix remodeling. In the…