Yongping Lin
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View article: Higher viremia and pathogenesis of human adenovirus 7 is likely associated to enhanced disruption of junction integrity
Higher viremia and pathogenesis of human adenovirus 7 is likely associated to enhanced disruption of junction integrity Open
View article: Neutrophil-mediated effects of S100A12 on major adverse cardiovascular events: Insights from the UK biobank
Neutrophil-mediated effects of S100A12 on major adverse cardiovascular events: Insights from the UK biobank Open
Elevated S100A12 levels are independently associated with increased MACEs risk, with neutrophil count serving as a significant mediator.
View article: Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China
Genomic and clinical characterization of linezolid resistance in Enterococcus species from cancer patients in China Open
The prevalence of LRE in this centre was low (3.35%). The presence of optrA gene was the primary mechanism of acquired linezolid resistance, with ST16 being the most prevalent sequence type. These findings highlight the need for both conti…
View article: Prevalence and Molecular Characteristics of Klebsiella pneumoniae Harboring the Pks Island from Cancer Patients in China
Prevalence and Molecular Characteristics of Klebsiella pneumoniae Harboring the Pks Island from Cancer Patients in China Open
The distribution of pks-positive K. pneumoniae in different types of cancer combined with its hypervirulent determinants highlighted the potential pathogenicity of genotoxins, which requires close clinical attention and epide…
View article: Impact of Spartina alterniflora invasion and aquaculture reclamation on soil aggregate stability and carbon sequestration in Chinese coastal wetlands
Impact of Spartina alterniflora invasion and aquaculture reclamation on soil aggregate stability and carbon sequestration in Chinese coastal wetlands Open
View article: Correlation and predictive modeling of serum exosomal miRNAs and serological biomarkers for lymph node metastasis in gastric cancer
Correlation and predictive modeling of serum exosomal miRNAs and serological biomarkers for lymph node metastasis in gastric cancer Open
Serum exosomal miRNAs and serological biomarkers are significantly associated with lymph node metastasis in gastric cancer.
View article: High-Fidelity Telomerase Activity Assay Based on Light-Triggered Nucleic Acid Separation System for the Diagnosis of Bladder Cancer
High-Fidelity Telomerase Activity Assay Based on Light-Triggered Nucleic Acid Separation System for the Diagnosis of Bladder Cancer Open
View article: HAdV-7 and HAdV-3: A Comparative Study on Tropism, Replication, and Receptor Mediated Infection in Human Cell Lines
HAdV-7 and HAdV-3: A Comparative Study on Tropism, Replication, and Receptor Mediated Infection in Human Cell Lines Open
Background: To explore the tropism and replication proficiency of specific human adenoviruses, namely HAdV-7 and HAdV-3, across a spectrum of human cell lines, and to elucidate the relationship between viral infection and the levels of hDS…
View article: Advancements in understanding cardiotoxicity of EGFR- TKIs in non-small cell lung cancer treatment and beyond
Advancements in understanding cardiotoxicity of EGFR- TKIs in non-small cell lung cancer treatment and beyond Open
Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitors (EGFR-TKIs) are a class of oral targeted anticancer drugs that have been demonstrated to significantly inhibit tumor progression and improve clinical prognosis in patients diagnos…
View article: Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic
Mycoplasma pneumoniae infection outbreak in Guangzhou, China after COVID-19 pandemic Open
View article: Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in mycobacteria
Amino acid 17 in QRDR of Gyrase A plays a key role in fluoroquinolones susceptibility in mycobacteria Open
The polymorphism at amino acid 17 of quinolone resistance-determining region of GyrA has been stated with a potential role in fluoroquinolone susceptibility in different mycobacterial species. However, no study has provided dependable evid…
View article: Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay
Distribution of common and rare drug resistance patterns in Mycobacterium tuberculosis clinical isolates revealed by GenoType MTBDRplus and MTBDRsl assay Open
This study highlights the effectiveness of GenoType MTBDRplus and MTBDRsl assays as valuable tools for TB management. These assays enable rapid detection of resistance to RIF, INH, and fluoroquinolones (FQs) in Mtb clinical i…
View article: Metagenomic next-generation sequencing of bronchoalveolar lavage fluid assists in the diagnosis of pathogens associated with lower respiratory tract infections in children
Metagenomic next-generation sequencing of bronchoalveolar lavage fluid assists in the diagnosis of pathogens associated with lower respiratory tract infections in children Open
Worldwide, lower respiratory tract infections (LRTI) are an important cause of hospitalization in children. Due to the relative limitations of traditional pathogen detection methods, new detection methods are needed. The purpose of this st…
View article: The value of folate receptor‐positive circulating tumor cells in the diagnosis of lung cancer and its correlation with clinical characteristics
The value of folate receptor‐positive circulating tumor cells in the diagnosis of lung cancer and its correlation with clinical characteristics Open
Objective The aim of this research is to investigate the feasibility of folate receptor‐positive circulating tumor cells (FR+CTCs) as a biomarker for the diagnosis of malignant pulmonary nodules and the correlation between clinicopathologi…
View article: Molecular Epidemiology and Antibiotic Resistance Analysis of Non-Typeable Haemophilus influenzae (NTHi) in Guangzhou: A Representative City of Southern China
Molecular Epidemiology and Antibiotic Resistance Analysis of Non-Typeable Haemophilus influenzae (NTHi) in Guangzhou: A Representative City of Southern China Open
This study aimed to investigate the molecular epidemiology and antibiotic resistance of Haemophilus influenzae in Guangzhou, China. A total of 80 H. influenzae isolates were collected from the First Affiliated Hospital of Guangzhou Medical…
View article: Generation of a human induced pluripotent stem cell line (JSPHi003-A) from a patient with atrial fibrillation and ventricular tachycardia carrying LMNA frame shift mutation (c.1304_1307dup)
Generation of a human induced pluripotent stem cell line (JSPHi003-A) from a patient with atrial fibrillation and ventricular tachycardia carrying LMNA frame shift mutation (c.1304_1307dup) Open
The iPSC line was generated from the peripheral blood mononuclear cells (PBMCs) from a 53-year-old female patient carrying the LMNA gene mutation (c.1304_1307dup) diagnosed with atrial fibrillation and paroxysmal ventricular tachycardia. T…
View article: Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus
Arabinosyltransferase C Mediates Multiple Drugs Intrinsic Resistance by Altering Cell Envelope Permeability in Mycobacterium abscessus Open
Mycobacterium abscessus is intrinsically resistant to most antibiotics, and treatment of its infections is highly challenging. The mechanisms of its intrinsic resistance remain not fully understood.
View article: Development and evaluation of <scp>time‐resolved</scp> fluorescent immunochromatographic assay for quantitative detection of <scp>SARS‐CoV</scp>‐2 spike antigen
Development and evaluation of <span>time‐resolved</span> fluorescent immunochromatographic assay for quantitative detection of <span>SARS‐CoV</span>‐2 spike antigen Open
Background The spread of COVID‐19 worldwide caused by the severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) has necessitated efficient, sensitive diagnostic methods to identify infected people. We report on the development of a …
View article: Risk and predictive factors for severe dengue infection: A systematic review and meta-analysis
Risk and predictive factors for severe dengue infection: A systematic review and meta-analysis Open
Background Dengue is a major public health issue worldwide and severe dengue (SD) is life threatening. It is critical to triage patients with dengue infection in the early stage. However, there is limited knowledge on early indicators of S…
View article: Atrial Lesions in a Pedigree With PRKAG2 Cardiomyopathy: Involvement of Disrupted AMP-Activated Protein Kinase Signaling
Atrial Lesions in a Pedigree With PRKAG2 Cardiomyopathy: Involvement of Disrupted AMP-Activated Protein Kinase Signaling Open
PRKAG2 cardiomyopathy is a rare progressive disease characterized by increased ventricular wall thickness and preexcitation. Dysfunction of the protein 5′-AMP-activated protein kinase (AMPK) plays a decisive role in the progression of vent…
View article: A multi‐analyte cell‐free DNA–based blood test for early detection of hepatocellular carcinoma
A multi‐analyte cell‐free DNA–based blood test for early detection of hepatocellular carcinoma Open
The limited performance of guideline‐recommended abdominal ultrasound and serum alpha‐fetoprotein (AFP) highlights the urgent, unmet need for new biomarkers for more accurate detection of early hepatocellular carcinoma (HCC). To this end, …
View article: Clinical characteristics and viral analysis of severe influenza A [H1N1]pdm09 in Guangzhou, 2019
Clinical characteristics and viral analysis of severe influenza A [H1N1]pdm09 in Guangzhou, 2019 Open
To understand the clinical characteristics of and analyze viral genes in patients with severe pneumonia due to [H1N1]pdm09 influenza virus in Guangzhou, 2019. The clinical data of 120 inpatients with laboratory‐confirmed influenza A [H1N1]…
View article: Dried blood sample analysis by antibody array across the total testing process
Dried blood sample analysis by antibody array across the total testing process Open
View article: Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis
Cucurbitacin B enhances apoptosis in gefitinib resistant non‑small cell lung cancer by modulating the miR‑17‑5p/STAT3 axis Open
Tyrosine kinase inhibitors, such as gefitinib, are currently widely used as targeted therapeutics for non-small cell lung cancer (NSCLC). Although drug resistance has become a major obstacle to successful treatment, mechanisms underlying r…
View article: Antigenic Drift of the Hemagglutinin from an Influenza A (H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro
Antigenic Drift of the Hemagglutinin from an Influenza A (H1N1) pdm09 Clinical Isolate Increases its Pathogenicity In Vitro Open
View article: Photon Scattering Signal Amplification in Gold-Viral Particle Ligation Towards Fast Infection Screening
Photon Scattering Signal Amplification in Gold-Viral Particle Ligation Towards Fast Infection Screening Open
The polarization states of scattered photons can be used to map or image the anisotropic features of a nanostructure. However, the scattering strength depends heavily on the refractivity contrast in the near field under measurement, which …
View article: Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients
Immunological and inflammatory profiles during acute and convalescent phases of severe/ critically ill COVID-19 patients Open
View article: Establishment of an iPSC line (JSPHi001-A) from a patient with familial dilated cardiomyopathy and atrial fibrillation caused by LMNA missense mutation (c.1003C > T)
Establishment of an iPSC line (JSPHi001-A) from a patient with familial dilated cardiomyopathy and atrial fibrillation caused by LMNA missense mutation (c.1003C > T) Open
Peripheral blood mononuclear cells (PBMCs) were harvested and reprogramed to induced pluripotent stem cells (iPSCs) from a 46-year-old male patient with familial dilated cardiomyopathy and atrial fibrillation via a non-integrating system. …
View article: 407P Integrating histologic and genomic characteristics to predict tumour mutation burden of early-stage non-small cell lung cancer
407P Integrating histologic and genomic characteristics to predict tumour mutation burden of early-stage non-small cell lung cancer Open
View article: Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles
Lyn kinase regulates egress of flaviviruses in autophagosome-derived organelles Open
Among the various host cellular processes that are hijacked by flaviviruses, few mechanisms have been described with regard to viral egress. Here we investigate how flaviviruses exploit Src family kinases (SFKs) for exit from infected cell…