Explanipedia

Hypoxia-induced RCOR2 promotes macrophage M2 polarization and CD8 <sup>+</sup> T-cell exhaustion by enhancing LIF transcription in hepatocellular carcinoma Open

Wenbo Jia, Jinyi Wang, Weiming Yang, Zhijie Ding, Litao Liang , et al. · 2025

Background The hypoxic microenvironment plays a crucial role in regulating the progression of hepatocellular carcinoma (HCC) and facilitating immune evasion. It is essential to gain a more comprehensive understanding of the pathways throug…

Anatomical resection is associated with reduced early recurrences in HCC: A machine learning analysis Open

Xiangpan Meng, Fang‐Ming Chen, Tianyu Tang, Tianyi Xia, Yu Qian , et al. · 2025

Causal forest modeling enables the detection of HTEs of AR in patients with HCC based on multiple clinical-radiological characteristics. Radiological tumor size ≤5 cm and non-smooth tumor margins were identified as significant modifiers an…

Combination of imaging features on pancreatic CT for predicting early recurrence after upfront pancreatoduodenectomy of pancreatic ductal adenocarcinoma Open

Shuanglin Zhang, Yixuan Guo, Guanghui Dai, Xiumin Qi, Hao Wang , et al. · 2025

A combination of two or more imaging features such as rim enhancement, tumor necrosis, peripancreatic tumor infiltration, and suspicious metastatic lymph nodes, could be used as a prognostic imaging marker for early recurrence, demonstrati…

Bibliometric analysis of global research trends in pancreatic cancer immunotherapy Open

Tong Fu, Yuqing Chen, Hao Wang, Linlin He, Jian Zhang , et al. · 2025

Pancreatic cancer is a highly malignant tumor with poor prognosis and limited treatments. Immunotherapy shows promise in improving outcomes, but bibliometric analyses in this field are scarce. Our work reveals emerging trends, identifies r…

GALNT7 promotes hepatocellular carcinoma progression by activating the PI3K/AKT signaling pathway via O-glycosylation of MUC13 Open

Litao Liang, Chao Xu, Yunfeng Wang, Yanzhi Feng, Wenbo Jia , et al. · 2025

Retraction Note: Upregulation of ARHGAP30 attenuates pancreatic cancer progression by inactivating the β-catenin pathway Open

Yongping Zhou, Zhiyuan Hua, Ye Zhu, Liying Wang, Fang‐Ming Chen , et al. · 2025

The effect of healthy eating index-2015 in the associations of biological aging and non-alcoholic fatty liver disease: an interaction and mediation analysis Open

Xiang Zhang, Zhijie Ding, Yong Yan, Weiming Yang, Xiaoming Ai , et al. · 2025

Predicting hepatocellular carcinoma outcomes and immune therapy response with ATP-dependent chromatin remodeling-related genes, highlighting MORF4L1 as a promising target Open

Chao Xu, Litao Liang, Guoqing Liu, Yanzhi Feng, Bin Xu , et al. · 2025

Background Hepatocellular carcinoma (HCC) continues to be a major cause of cancer-related death worldwide, primarily due to delays in diagnosis and resistance to existing treatments. Recent research has identified ATP-dependent chromatin r…

BAIAP2L2 promotes the malignancy of hepatocellular carcinoma via GABPB1-mediated reactive oxygen species imbalance Open

Wenbo Jia, Bin Xu, Liang Yu, Yanzhi Feng, Jinyi Wang , et al. · 2024

Hepatocellular carcinoma (HCC) is a common type of cancer worldwide and ranks as the fourth leading cause of cancer-related deaths. This research investigation identified an upregulation of BAI1-associated protein 2-like 2 (BAIAP2L2) in HC…

Circ_0007386 Promotes the Progression of Hepatocellular Carcinoma Through the miR-507/ CCNT2 Axis Open

Yanzhi Feng, Litao Liang, Wenbo Jia, Jinyi Wang, Chao Xu , et al. · 2024

Circ_0007386 advanced HCC progression and lenvatinib resistance through the miR-507/ CCNT2 axis. Meanwhile, circ_0007386 served as a potential biomarker and therapeutic target in HCC patients.

Biomimicking covalent organic frameworks nanocomposite coating for integrated enhanced anticorrosion and antifouling properties of a biodegradable magnesium stent Open

Rui Zan, Hao Wang, Sheng Shen, Shi Yang, Han Yu , et al. · 2024

The utilization of biodegradable magnesium (Mg) alloys in the fabrication of temporary non-vascular stents is an innovative trend in biomedical engineering. However, the heterogeneous degradation profiles of these biomaterials, together wi…

Corrigendum to ‘Predicting post-resection recurrence by integrating imaging-based surrogates of distinct vascular patterns of hepatocellular carcinoma’ (JHEP Reports 5 [2023] 100806) Open

Xiangpan Meng, Tianyu Tang, Yongping Zhou, Cong Xia, Tianyi Xia , et al. · 2024

Estimating Heterogeneous Treatment Effects of Anatomical Resection in Hepatocellular Carcinoma: A Causal Machine Learning Analysis Open

Xiangpan Meng, Fang‐Ming Chen, Tianyu Tang, Tianyi Xia, Qian Yu , et al. · 2024

Exosomal SOX21-AS1 Regulates EREG by Sponging miR-451a and Promotes the Malignancy of Pancreatic Ductal Adenocarcinoma Open

Yong Yan, Jinyi Wang, Bin Xu, Jianming Ni, Tu Dai , et al. · 2024

The incidence and mortality of pancreatic ductal adenocarcinoma (PDAC) have increased. Exosomes, as a regulatory mode of intercellular communication, contain lncRNAs. SOX21-AS1 has been studied in other cancers, and its expression is eleva…

HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA Open

Wenbo Jia, Yu Liang, Bin Xu, Yanzhi Feng, Jinyi Wang , et al. · 2024

Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with a poor prognosis. Extensive research has revealed the significant role of long noncoding RNAs (lncRNAs) in the regulation of tumor development. In this study, high-…

Nomograms for stratified prognosis prediction of gastric cancer by integrating programmed death ligand 1 and tumor-infiltrating immune cells Open

Xiumin Qi, Yixuan Guo, Jiayi Wan, Yan Xiao, Xiang Pan , et al. · 2023

Purpose To develop nomograms for predicting disease-free survival (DFS) and overall survival (OS) of gastric cancer (GC) by integrating programmed death ligand 1 (PD-L1) and tumor-infiltrating immune cells. Materials and methods Immunohist…

Cholecystectomy Significantly Alters Gut Microbiota Homeostasis and Metabolic Profiles: A Cross-Sectional Study Open

Fusheng Xu, Ruimin Chen, Chengcheng Zhang, Hao Wang, Zhijie Ding , et al. · 2023

Cholecystectomy (CCE) is a standard clinical treatment for conditions like gallstones and cholecystitis. However, its link to post-CCE syndrome, colorectal cancer, and nonalcoholic fatty liver disease has raised concerns. Additionally, stu…

HNF4A-AS1 inhibits the progression of hepatocellular carcinoma by promoting the ubiquitin-modulated degradation of PCBP2 and suppressing the stability of ARG2 mRNA Open

Wenzhou Ding, Wenbo Jia, Yu Liang, Bin Xu, Yanzhi Feng , et al. · 2023

Hepatocellular carcinoma (HCC) is a highly aggressive malignant tumor with a poor prognosis. Extensive research has revealed the significant role of long noncoding RNAs (lncRNAs) in the regulation of tumor development. In this particular s…

Predicting post-resection recurrence by integrating imaging-based surrogates of distinct vascular patterns of hepatocellular carcinoma Open

Xiangpan Meng, Tianyu Tang, Yongping Zhou, Cong Xia, Tianyi Xia , et al. · 2023

MVI and VETC are distinct vascular patterns of HCC associated with aggressive biological behaviour and poor outcomes. Our multicentre study provided a model incorporating imaging-based surrogates of these patterns for preoperatively predic…

A novel approach to PAAD patient care: A 9-cuproptosis-related differential expression lncRNAs model for prognosis prediction Open

Chao Xu, Yanzhi Feng, Yong Yan, Litao Liang, Lianbao Kong , et al. · 2023

Cuproptosis is a novel type of programmed cell death that is being linked to varied malignancy activities. Long non-coding RNAs (lncRNAs) are demonstrating an increasing ability to influence the progression of cancer and the immune microen…

Exosome-transported circHDAC1_004 Promotes Proliferation, Migration, and Angiogenesis of Hepatocellular Carcinoma by the miR-361-3p/NACC1 Axis Open

Bin Xu, Wenbo Jia, Yanzhi Feng, Jinyi Wang, Jing Wang , et al. · 2023

We found that circHDAC1_004 overexpression enhanced the proliferation, stemness, and metastasis of HCC via the miR-361-3p/NACC1 axis and promoted HCC angiogenesis through exosomes. Our findings may help develop a possible therapeutic strat…

A Multi-Feature Fusion Speech Emotion Recognition Method Based on Frequency Band Division and Improved Residual Network Open

Yi Guo, Yongping Zhou, Xuejun Xiong, Xin Jiang, Hanbing Tian · 2023

Addition of Lactic Acid Bacteria Modulates Microbial Community and Promotes the Flavor Profiles of Kombucha Open

Shuo Wang, Chuanwei Li, Wang Ying, Shuai Wang, Yongping Zhou , et al. · 2023

BAIAP2L2 is activated by NFκB1 and promotes the malignancy of hepatocellular carcinoma by suppressing the ubiquitin-mediated degradation of GABPB1 to activate TRET transcription Open

Wenbo Jia, Liang Yu, Bin Xu, Yanzhi Feng, Jinyi Wang , et al. · 2022

Hepatocellular carcinoma (HCC) is one of the most commonly diagnosed human cancers in the world and the fourth leading cause of cancer-related death. In this study, we found that BAI1-associated protein 2-like 2 (BAIAP2L2) was upregulated …

BAIAP2L2 Promotes the Malignancy of Hepatocellular Carcinoma by Suppressing the Ubiquitin-Mediated Degradation of GABPB1 Open

Wenbo Jia, Bin Xu, Liang Yu, Yanzhi Feng, Jinyi Wang , et al. · 2022

LncRNA DHRS4-AS1 ameliorates hepatocellular carcinoma by suppressing proliferation and promoting apoptosis via miR-522-3p/SOCS5 axis Open

Yongping Zhou, Kuan Li, Xuexia Zou, Zhiyuan Hua, Hao Wang , et al. · 2021

Recent years have seen much effect in revealing the pathological association between lncRNA and HCC. Herein, we identified lncRNA DHRS4-AS1 as a potential tumor suppressor in HCC. Firstly, it was discovered that DHRS4-AS1 was significantly…

Long non-coding RNA HCP5 functions as a sponge of miR-29b-3p and promotes cell growth and metastasis in hepatocellular carcinoma through upregulating DNMT3A Open

Yongping Zhou, Kuan Li, Tu Dai, Hong Wang, Zhiyuan Hua , et al. · 2021

Multiple studies have revealed that long non-coding RNA (lncRNAs) served as regulatory factors in modulating tumorigenesis of hepatocellular carcinoma (HCC). In the present study, we demonstrated that lncRNA HCP5 was overexpressed in HCC t…

LncRNA TTN-AS1 intensifies sorafenib resistance in hepatocellular carcinoma by sponging miR-16-5p and upregulation of cyclin E1 Open

Yongping Zhou, Huang Yonggang, Tu Dai, Zhiyuan Hua, Jian Xu , et al. · 2020

Drug resistance has always been an important problem affecting the therapeutic effect of hepatocellular carcinoma (HCC). To investigate the potential role of lncRNA TTN-AS1 in HCC cells with sorafenib (SOR) resistance, and explore the unde…

Radiomics-Assisted Presurgical Prediction for Surgical Portal Vein-Superior Mesenteric Vein Invasion in Pancreatic Ductal Adenocarcinoma Open

Fang‐Ming Chen, Yongping Zhou, Xiumin Qi, Rui Zhang, Xin Gao , et al. · 2020

The radiomics signature can predict surgical PV-SMV invasion in patients with PDAC and may have incremental value to the diagnostic performance of radiologists during imaging interpretation.

Long Non-Coding RNA HCP5 Functions as A Sponger of miR-29b-3p and Promotes Cell Growth and Metastasis in Hepatocellular Carcinoma Through Upregulating DNMT3A Open

Yongping Zhou, Kuan Li, Tu Dai, Hong Wang, Zhiyuan Hua , et al. · 2020

Background: Multiple researches have revealed that long non-coding RNA (lncRNAs) served as regulatory factor in modulating tumorigenesis of hepatocellular carcinoma (HCC). In this study, we demonstrated that lncRNA HCP5 was a tumor promoti…

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