Explanipedia

Structural basis of the RNA-mediated Retron-Eco2 oligomerization Open

Yanjing Wang, Chen Wang, Yongqi Yin, Yongqing Cui, Zhikang Dai , et al. · 2025

In the evolutionary arms race between bacteria and viruses, retrons have emerged as distinctive antiphage defense systems. Here, we elucidate the structure and function of Retron-Eco2, which comprises a non-coding RNA (ncRNA) that encodes …

Bacterial Hachiman complex executes DNA cleavage for antiphage defense Open

Yongqing Cui, Zhikang Dai, Yifang Ouyang, Chunyang Fu, Yanjing Wang , et al. · 2025

DNA methylation activates retron Ec86 filaments for antiphage defense Open

Yanjing Wang, Chen Wang, Zeyuan Guan, Jie Cao, Jia Xu , et al. · 2024

Retrons are a class of multigene antiphage defense systems typically consisting of a retron reverse transcriptase, a non-coding RNA, and a cognate effector. Although triggers for several retron systems have been discovered recently, the co…

Defense mechanism of a bacterial retron supramolecular assembly Open

Yanjing Wang, Chen Wang, Zeyuan Guan, Jie Cao, Xu Jia , et al. · 2023

Summary Retrons are a class of multigene antiphage defense system typically consisting of a retron reverse transcriptase, a non-coding RNA, and a cognate effector. Although the triggers for several retron systems have been discovered recen…

Bacterial MazF/MazE toxin-antitoxin suppresses lytic propagation of arbitrium-containing phages Open

Yongqing Cui, Xiang Su, Chen Wang, Han Xu, Delei Hu , et al. · 2022

Temperate phages dynamically switch between lysis and lysogeny in their full life cycle. Some Bacillus-infecting phages utilize a quorum-sensing-like intercellular communication system, the "arbitrium," to mediate lysis-lysogeny decisions.…

DeepMeshFlow: Content Adaptive Mesh Deformation for Robust Image Registration Open

Nianjin Ye, Chuan Wang, Shuaicheng Liu, Lanpeng Jia, Jue Wang , et al. · 2019

Image alignment by mesh warps, such as meshflow, is a fundamental task which has been widely applied in various vision applications(e.g., multi-frame HDR/denoising, video stabilization). Traditional mesh warp methods detect and match image…

Structural insights into DNA recognition by AimR of the arbitrium communication system in the SPbeta phage Open

Zeyuan Guan, Kai Pei, Jing Wang, Yongqing Cui, Xiang Zhu , et al. · 2019

A newly identified arbitrium communication system regulates the lysis-to-lysogeny decision in a Bacillus bacteriophage. This system contains an arbitrium hexapeptide as a signal, the cellular receptor AimR, and the lysogenic negative regul…

Crystal structure of AimR in complex with arbitrium peptide Open

Zeyuan Guan, Kai Pei, Jing Wang, Yongqing Cui, Xiang Zhu , et al. · 2019

A newly identified arbitrium communication system regulates the lysis-to-lysogeny decision in a Bacillus bacteriophage. This system contains an arbitrium hexapeptide as a signal, the cellular receptor AimR, and the lysogenic negativ…

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