Yongqing Liu
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View article: Zeb1 Facilitates Nitrogen Mustard–Induced Corneal Epithelial Wound Healing by Maintaining Epithelial Renewability
Zeb1 Facilitates Nitrogen Mustard–Induced Corneal Epithelial Wound Healing by Maintaining Epithelial Renewability Open
Zeb1 facilitates NM-induced corneal epithelial wound healing by maintaining epithelial renewability and thus is a potential therapeutic target to reduce acute mustard gas keratopathy in early ocular pathogenesis.
View article: Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative
Preclinical characterization and anti-RSV efficacy of an oral C-nucleoside derivative Open
View article: Computed tomography radiomics to predict microsatellite instability status and immunotherapy response in gastric cancer
Computed tomography radiomics to predict microsatellite instability status and immunotherapy response in gastric cancer Open
Objectives To develop and validate a CT radiomics model for predicting microsatellite instability (MSI) status in preoperative gastric cancer (GC) patients and to explore the underlying immune infiltration pattern of the radiomics model. M…
View article: The C-reactive protein-to-albumin ratio as a diagnostic biomarker for rheumatoid arthritis: a cross-sectional NHANES analysis
The C-reactive protein-to-albumin ratio as a diagnostic biomarker for rheumatoid arthritis: a cross-sectional NHANES analysis Open
Background Rheumatoid arthritis (RA) is a chronic inflammatory disorder that leads to joint damage, cartilage and bone destruction, and functional disability. The C-Reactive Protein to Albumin Ratio (CAR), an emerging biomarker reflecting …
View article: Metabolic regulation of visual acuity
Metabolic regulation of visual acuity Open
Photoreceptors signal ON and OFF pathways via a synapse with bipolar cells that are transmitted to retinal ganglion cells (RGCs) for luminance and contrast detection. Retinal neurons metabolize glucose whose transport is mediated by photor…
View article: Involvement of tdTomato-Tagged RPE cells in a mouse PVR model with enzymatically compromised retina
Involvement of tdTomato-Tagged RPE cells in a mouse PVR model with enzymatically compromised retina Open
View article: Prophylactic antibiotic use is associated with better clinical outcomes in gastric cancer patients receiving immunotherapy
Prophylactic antibiotic use is associated with better clinical outcomes in gastric cancer patients receiving immunotherapy Open
Background The relationship between antibiotic treatment and immunotherapy efficacy is complex. Methods This study was a single-center study. History of antibiotic use in gastric cancer (GC) patients within 1 or 3 months prior to immunothe…
View article: The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis
The beneficial effects of curcumin on aging and age-related diseases: from oxidative stress to antioxidant mechanisms, brain health and apoptosis Open
Aging and age-related disease are among the most common and challenging issues worldwide. During the aging process, the accumulation of oxidative stress, DNA damage, telomere dysfunction, and other related changes lead to cellular dysfunct…
View article: Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa
Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa Open
View article: Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack
Effects of colchicine adjuvant therapy on disease control, serum NALP3, sICAM-1, MMP-9 and MMP-13 in patients with coronary heart disease and acute gout attack Open
Background: To investigate the impact of colchicine adjuvant therapy on disease control and serum levels of nucleotide-binding oligomerization domain-like receptor (NALP) 3, soluble intercellular adhesion molecule (sICAM)-1, matrix metallo…
View article: Corneal injury repair and the potential involvement of ZEB1
Corneal injury repair and the potential involvement of ZEB1 Open
The cornea, consisting of three cellular and two non-cellular layers, is the outermost part of the eyeball and frequently injured by external physical, chemical, and microbial insults. The epithelial-to-mesenchymal transition (EMT) plays a…
View article: Conditional deletion of Zeb1 in Csf1r+ cells reduces inflammatory response of the cornea to alkali burn
Conditional deletion of Zeb1 in Csf1r+ cells reduces inflammatory response of the cornea to alkali burn Open
View article: KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3
KAT6A deficiency impairs cognitive functions through suppressing RSPO2/Wnt signaling in hippocampal CA3 Open
Intellectual disability (ID) affects ∼2% of the general population and is often genetic in origin. ID-associated genes are enriched for epigenetic factors, including those encoding the largest family of histone lysine acetyltransferases (K…
View article: Temporal trends in the incidence and mortality of road injuries in China: Current trends and future predictions
Temporal trends in the incidence and mortality of road injuries in China: Current trends and future predictions Open
View article: Identification of molecular pattern and prognostic risk model based on ligand-receptor pairs in liver cancer
Identification of molecular pattern and prognostic risk model based on ligand-receptor pairs in liver cancer Open
Introduction The tumor microenvironment of hepatocellular carcinoma is composed of multiple cells, and the interactive communication between cells drives tumor progression and characterizes the tumor. Communication between cells is mainly …
View article: Revalidation of the ATTRACTION-4 study in a real-world setting: a multicenter, retrospective propensity score matching study in China
Revalidation of the ATTRACTION-4 study in a real-world setting: a multicenter, retrospective propensity score matching study in China Open
Background Immune-checkpoint inhibitors (ICIs) combined with chemotherapy have been successfully used in clinical trials to treat advanced gastric cancer. However, the efficacy and safety of first-line immunotherapy combined with chemother…
View article: Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa
Metabolic transcriptomics dictate responses of cone photoreceptors to retinitis pigmentosa Open
View article: Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility
Zeb1 facilitates corneal epithelial wound healing by maintaining corneal epithelial cell viability and mobility Open
View article: Current Progress on Predictive Biomarkers for Response to Immune Checkpoint Inhibitors in Gastric Cancer: How to Maximize the Immunotherapeutic Benefit?
Current Progress on Predictive Biomarkers for Response to Immune Checkpoint Inhibitors in Gastric Cancer: How to Maximize the Immunotherapeutic Benefit? Open
Gastric cancer is the fifth most prevalent cancer and the fourth leading cause of cancer death globally. Delayed diagnosis and pronounced histological and molecular variations increase the complexity and challenge of treatment. Pharmacothe…
View article: Comparison of the curative effect of vertebroplasty with spiral and traditional pushrod injector in the treatment of osteoporotic vertebral fractures
Comparison of the curative effect of vertebroplasty with spiral and traditional pushrod injector in the treatment of osteoporotic vertebral fractures Open
Background Cement diffusion and cement leakage are key and contradictory problems in the vertebroplasty, so vertebroplasty instruments constantly develop to explore the optimal treatment. The purpose of this study was to evaluate and compa…
View article: Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA
Ventral tegmental area astrocytes modulate cocaine reward by tonically releasing GABA Open
View article: Mouse Corneal Epithelial and Stromal Cell Isolation and Culture
Mouse Corneal Epithelial and Stromal Cell Isolation and Culture Open
Corneal epithelium and stroma are the major cellular structures for ocular protection and vision accuracy; they play important roles in corneal wound healing and inflammation under pathological conditions. Unlike human, murine corneal and …
View article: Future perspective of stem cell-derived exosomes: Cell-free therapeutic strategies for retinal degeneration
Future perspective of stem cell-derived exosomes: Cell-free therapeutic strategies for retinal degeneration Open
With continued expansion of the aged population, the number of patients with retinal degeneration, which is a leading cause of vision loss worldwide, is growing. Stem cell therapies offer hope for regeneration and repair of damaged retinal…
View article: Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity
Opposing roles of ZEB1 in the cytoplasm and nucleus control cytoskeletal assembly and YAP1 activity Open
Epithelial-mesenchymal transition (EMT) facilitates cancer invasion and is initiated by mesenchyme-driving transcription factors and actin cytoskeletal assembly. We show a cytoplasmic-to-nuclear transport gradient of the EMT transcription …
View article: Spheroid-induced heterogeneity and plasticity of uveal melanoma cells
Spheroid-induced heterogeneity and plasticity of uveal melanoma cells Open
View article: Risk factors for cardiac rupture after acute ST-segment elevation myocardial infarction during the percutaneous coronary intervention era: a retrospective case-control study
Risk factors for cardiac rupture after acute ST-segment elevation myocardial infarction during the percutaneous coronary intervention era: a retrospective case-control study Open
Non-single lesions and preoperative and postoperative TIMI grades were risk factors for CR in patients who accepted PCI. In addition to previously reported indicators, we found that AMI in the high lateral wall maybe helpful in early and a…
View article: Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas
Zeb1 regulation of wound-healing-induced inflammation in alkali-damaged corneas Open
View article: Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement
Development of PDA Nanoparticles for H9N2 Avian Influenza BPP-V/BP-IV Epitope Peptide Vaccines: Immunogenicity and Delivery Efficiency Improvement Open
The protection of current influenza vaccines is limited due to the viral antigenic shifts and antigenic drifts. The universal influenza vaccine is a new hotspot in vaccine research that aims to overcome these problems. Polydopamine (PDA), …
View article: Immobilization of molybdenum-based complexes on dendrimer-functionalized graphene oxide and their catalytic activity for the epoxidation of alkenes
Immobilization of molybdenum-based complexes on dendrimer-functionalized graphene oxide and their catalytic activity for the epoxidation of alkenes Open
View article: The effects of short time hyperoxia on glutamate concentration and glutamate transporters expressions in brain of neonatal rats
The effects of short time hyperoxia on glutamate concentration and glutamate transporters expressions in brain of neonatal rats Open
Preterm infants often suffer from impaired postnatal brain development, and glutamate excitotoxicity is identified as a pivotal mechanism of hyperoxia-induced neurological abnormality. We aimed to investigate the effect of short time hyper…