Yongqiong Deng
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View article: Nursing Care in Obstetrics and Breastfeeding Practices in Gestational Diabetic Mothers in China: A Systematic Review and Meta-Analysis
Nursing Care in Obstetrics and Breastfeeding Practices in Gestational Diabetic Mothers in China: A Systematic Review and Meta-Analysis Open
Background: Despite the fact that nursing care and breastfeeding practices are among the most important aspects of effective GDM management, the impact of these practices is still underexplored. We aimed to assess the effectiveness of obst…
View article: Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation
Uncovering novel biomarkers and drug targets for androgenetic alopecia via metabolite regulation and multi-tissue validation Open
Our integrative multi-omics analysis identified 10 potential therapeutic targets and biomarkers for AGA. SOD1 and KL stand out as strong candidates, offering promising directions for future AGA therapies.
View article: The effect of isotretinoin combined with omega-3 fatty acids on lipid metabolism in acne vulgaris: A Randomized Controlled Trial
The effect of isotretinoin combined with omega-3 fatty acids on lipid metabolism in acne vulgaris: A Randomized Controlled Trial Open
Backgroud :Acne vulgaris is a common chronic inflammatory skin disease, and its pathogenesis may related to dyslipidemia. Omega-3 fatty acids regulate lipid metabolism and reduce inflammation, but its effect on blood lipids in Acne vulgari…
View article: Evaluation of the Efficacy of Metformin in the Treatment of Acne Vulgaris and Its Effects on Serum Lipid Metabolism
Evaluation of the Efficacy of Metformin in the Treatment of Acne Vulgaris and Its Effects on Serum Lipid Metabolism Open
Background Acne vulgaris (AV) is a common inflammatory skin disease during adolescence. Metformin (MET) has recently been found to have the effects of regulating lipid disorders, suggesting its potential benefits in the treatment of AV pat…
View article: Efficacy of Vaginal Drug Administration for Pain in Patients Undergoing Intrauterine Device Insertion: A Randomized Controlled Systematic Review and Network Meta-Analysis
Efficacy of Vaginal Drug Administration for Pain in Patients Undergoing Intrauterine Device Insertion: A Randomized Controlled Systematic Review and Network Meta-Analysis Open
View article: From Eruptive Xanthoma to Acute Pancreatitis: Clinical Warning and Implications of Rapid Disease Progression
From Eruptive Xanthoma to Acute Pancreatitis: Clinical Warning and Implications of Rapid Disease Progression Open
Xanthoma is a common cutaneous manifestation typically associated with abnormal lipid metabolism, particularly hyperlipidemia. Both hyperlipidemia and hyperglycemia are significant components of metabolic syndrome and can elevate the risk …
View article: A Case of Intense Pulsed Light Aggravated Rosacea Successfully Treated by Abrocitinib
A Case of Intense Pulsed Light Aggravated Rosacea Successfully Treated by Abrocitinib Open
Rosacea is a chronic inflammatory skin condition characterized by facial erythema, papules, pustules, telangiectasia, and flushing. Currently, various treatment options are available, but no definitive cure has been established. Photothera…
View article: Severe Unilateral Alopecia in a Long-Term Surviving Male Adolescent Glioblastoma Multiforme Patient
Severe Unilateral Alopecia in a Long-Term Surviving Male Adolescent Glioblastoma Multiforme Patient Open
The prevention and treatment of RIA remain poorly understood, and this clinical scenario urgently necessitates the exploration of novel therapeutic strategies.
View article: Efficacy and Safety of Combined Platelet‐Rich Plasma With Fractional Laser for Adult Patients With Vitiligo: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials
Efficacy and Safety of Combined Platelet‐Rich Plasma With Fractional Laser for Adult Patients With Vitiligo: A Systematic Review and Meta‐Analysis of Randomized Controlled Trials Open
Objective Platelet‐rich plasma (PRP) is a novel treatment option for vitiligo. It has been reported to be effective in combination with other methods, such as fractional laser. However, there is no consensus on the specific combined use of…
View article: Targeting gut microbiota and its associated metabolites as a potential strategy for promoting would healing in diabetes
Targeting gut microbiota and its associated metabolites as a potential strategy for promoting would healing in diabetes Open
Impaired healing of diabetic wounds is one of the most important complications of diabetes, often leading to lower limb amputations and incurring significant economic and psychosocial costs. Unfortunately, there are currently no effective …
View article: Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis
Tryptophan, an important link in regulating the complex network of skin immunology response in atopic dermatitis Open
Atopic dermatitis (AD) is a common chronic relapsing inflammatory skin disease, of which the pathogenesis is a complex interplay between genetics and environment. Although the exact mechanisms of the disease pathogenesis remain unclear, th…
View article: Lactobacillus rhamnosus ameliorates acne vulgaris in SD rats via changes in gut microbiota and associated tryptophan metabolism
Lactobacillus rhamnosus ameliorates acne vulgaris in SD rats via changes in gut microbiota and associated tryptophan metabolism Open
Background The depletion of beneficial bacteria in the gut has been found in patients with acne vulgaris, and in previous studies, the supplement of Lactobacillus rhamnosus led to the improvement of adult acne. Nevertheless, the potential …
View article: The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris
The adjuvant treatment role of ω-3 fatty acids by regulating gut microbiota positively in the acne vulgaris Open
Objectives: We aimed to explore the potential role of omega-3 (ω-3) fatty acids on acne vulgaris by modulating gut microbiota. Materials and Methods: We randomly divided the untreated acne patients into two groups with or wit…
View article: Analysis and prediction of protein-energy malnutrition in children aged 8-10 years
Analysis and prediction of protein-energy malnutrition in children aged 8-10 years Open
The study identified key independent risk factors for PEM in children and established a robust nomogram model for clinical risk assessment. The model's high predictive accuracy and clinical applicability suggest it may be a valuable tool f…
View article: Metformin Contributes to the Therapeutic Effects of Acne Vulgaris by Modifying the Gut Microbiome
Metformin Contributes to the Therapeutic Effects of Acne Vulgaris by Modifying the Gut Microbiome Open
Background . Considering the increasing side effects of the first‐line treatment for acne vulgaris, metformin was developed to be an effective adjunct therapy, but its mechanism of action is poorly defined. Recent evidence shows that the g…
View article: Cellular Senescence: Ageing and Androgenetic Alopecia
Cellular Senescence: Ageing and Androgenetic Alopecia Open
Androgenetic alopecia (AGA) is the most common type of hair loss and features progressive miniaturization of hair follicles. Generally, the occurrence of AGA has long been thought to be driven by genetic and androgen predisposition. Howeve…
View article: Signet-Ring Cutaneous Metastasis Presenting with Huge Bunches of Grapes
Signet-Ring Cutaneous Metastasis Presenting with Huge Bunches of Grapes Open
Signet-ring cell (SRC) is a histologic type in which cells show unique features under the microscope. We mainly found signet-ring cells (SRCs) in gastrointestinal and breast tumors. Cutaneous metastasis from internal carcinomas was an unco…
View article: Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris
Potential roles of gut microbial tryptophan metabolites in the complex pathogenesis of acne vulgaris Open
Acne vulgaris is a chronic inflammatory skin disease in which the influence of gut microbiota has been implicated but without clarification of mechanisms. Gut microbiota may exert such an influence via metabolites, particularly those of tr…
View article: Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking
Exploring the Mechanisms and Molecular Targets of Taohong Siwu Decoction for the Treatment of Androgenetic Alopecia Based on Network Analysis and Molecular Docking Open
The results indicated that the effects of THSWD against AGA may be related to anti-inflammation and anti-oxidation properties of the compounds through the specific biological processes and the related pathways.
View article: Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis
Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis Open
Objective The aim of this research was to systematically investigate the effects of endothelial mesenchymal transition (EndMT) induced by hypoxia on the skin microvascular remodeling of systemic sclerosis (SSc) and the underlying mechanism…
View article: Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis
Hypoxia-induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic sclerosis Open
Objective The aim of this research was to systematically investigate the effects of endothelial mesenchymal transition (EndMT) induced by hypoxia on the skin microvascular remodeling of systemic sclerosis (SSc) and the underlying mechanism…
View article: A Traditional Chinese Herb Citri Reticulatae Pericarpium Induced Melanonychia
A Traditional Chinese Herb Citri Reticulatae Pericarpium Induced Melanonychia Open
Shiyu Jiang, Jixiang Xu, Xia Xiong, Yongqiong Deng Department of Dermatology & STD, The Affiliated Hospital of Southwest Medical University, Luzhou, Sichuan, People’s Republic of ChinaCorrespondence: Yongqiong DengDepartment of Dermatology…
View article: The Effect of Intense Pulsed Light on the Skin Microbiota and Epidermal Barrier in Patients with Mild to Moderate Acne Vulgaris
The Effect of Intense Pulsed Light on the Skin Microbiota and Epidermal Barrier in Patients with Mild to Moderate Acne Vulgaris Open
Background and Objectives The skin microbiota partly determined by epidermal barrier plays an important role in acne vulgaris and intense pulsed light (IPL) has been verified as a safe and effective therapeutic option for this disease. Nev…
View article: External application of Ruyi Jinhuang powder for phlebitis: A systematic review and meta-analysis
External application of Ruyi Jinhuang powder for phlebitis: A systematic review and meta-analysis Open
Purpose: To systematically review the effectiveness of the external application, Ruyi Jinhuang powder, on phlebitis
Methods: Relevant literature was retrieved from Medline, Embase, China National Knowledge Infrastructure database (CNKI), …
View article: Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris
Gender-Specific Differences in Gut Microbiota Composition Associated with Microbial Metabolites for Patients with Acne Vulgaris Open
The disorder of gut microbiota and metabolism in acne vulgaris was gender-specific, which supported the potential role of gender difference in the pathogenesis of this disease.
View article: Hypoxia induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic scleroderma
Hypoxia induced interstitial transformation of microvascular endothelial cells by mediating HIF-1α/VEGF signaling in systemic scleroderma Open
Background: Endothelial mesenchymal transition (EndMT) is a key pathological event for vasculopathy, and is one of the early features and hallmarks of systemic scleroderma (SSc). It has been well-established that hypoxia contributes to End…
View article: Hypoxia induced interstitial transformation of microvascular endothelial cells through mediating HIF-1α/VEGF signaling in systemic scleroderma
Hypoxia induced interstitial transformation of microvascular endothelial cells through mediating HIF-1α/VEGF signaling in systemic scleroderma Open
Background: Endothelial mesenchymal transition (EndMT) is a key pathological event for vasculopathy which is one of the early features and hallmarks of systemic scleroderma (SSc). It is well established that hypoxia contributes to EndMT, h…
View article: M2IA: a web server for microbiome and metabolome integrative analysis
M2IA: a web server for microbiome and metabolome integrative analysis Open
Motivation Microbiome–metabolome association studies have experienced exponential growth for an in-depth understanding of the impact of microbiota on human health over the last decade. However, analyzing the resulting multi-omics data and …
View article: A novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis
A novel benzoxazinone derivative YLT-LL-11 inhibits diffuse large B-cell lymphoma growth via inducing cell cycle arrest and apoptosis Open
Diffuse large B-cell lymphoma (DLBCL) is a clinically aggressive B-cell non-Hodgkin’s lymphoma (NHL) with high treatment difficulty and high relapse rate. The bromodomain and extra-terminal (BET) proteins play significant roles in supporti…
View article: Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris
Association of brain-derived neurotrophic factor levels and depressive symptoms in young adults with acne vulgaris Open