Yongren Wang
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View article: Rapidly progressing after umbilical cord blood transplantation in a boy with acute myeloid leukemia with KAT6A::EP300 fusion transcript
Rapidly progressing after umbilical cord blood transplantation in a boy with acute myeloid leukemia with KAT6A::EP300 fusion transcript Open
View article: Early detection of right atrial dysfunction in patients with hypertrophic cardiomyopathy using cardiac magnetic resonance feature tracking
Early detection of right atrial dysfunction in patients with hypertrophic cardiomyopathy using cardiac magnetic resonance feature tracking Open
Patients with HCM exhibit impaired RA reservoir, conduit, and booster pump function even in the presence of normal RA volumes. CMR-FT-derived RA strain and strain rate may serve as more sensitive indicators than traditional RAEF metrics fo…
View article: Durable Molecular Remission in TCF3::HLF-Positive Pediatric B-ALL Using Post-Transplant Azacitidine, DLI and Blinatumomab
Durable Molecular Remission in TCF3::HLF-Positive Pediatric B-ALL Using Post-Transplant Azacitidine, DLI and Blinatumomab Open
Background: TCF3::HLF-positive B-cell acute lymphoblastic leukemia (B-ALL) is a rare, aggressive pediatric cancer characterized by chemotherapy resistance and high relapse rates following hematopoietic stem cell transplantation (HSCT), lea…
View article: Shared chromatin remodeling mutations drive concurrent rhabdomyosarcoma and leukemia in a pediatric patient
Shared chromatin remodeling mutations drive concurrent rhabdomyosarcoma and leukemia in a pediatric patient Open
The co-occurrence of rhabdomyosarcoma (RMS) and B-cell acute lymphoblastic leukemia (B-ALL) has been rarely reported, and the shared molecular drivers remain unidentified. This case report describes a pediatric patient diagnosed with both …
View article: Pediatric Mixed Phenotype Acute Leukemia With <i>ETV6</i>::<i>ARNT</i> Fusion Gene Successfully Treated by Allogeneic Hematopoietic Stem Cell Transplantation
Pediatric Mixed Phenotype Acute Leukemia With <i>ETV6</i>::<i>ARNT</i> Fusion Gene Successfully Treated by Allogeneic Hematopoietic Stem Cell Transplantation Open
View article: Modified SMILE (mSMILE) is active in the treatment of pediatric Epstein-Barr virus-associated natural killer/T-cell lymphoma: a single center experience, case series
Modified SMILE (mSMILE) is active in the treatment of pediatric Epstein-Barr virus-associated natural killer/T-cell lymphoma: a single center experience, case series Open
Based on our clinical experience, the mSMILE appears to be a safe and effective treatment option for EBV + NK/T-cell lymphoma, meriting further investigation in late-phase clinical trials.
View article: Severe Vincristine-Induced Neuropathic Pain: A Case Report with Pharmacogenetic Analysis and Literature Review
Severe Vincristine-Induced Neuropathic Pain: A Case Report with Pharmacogenetic Analysis and Literature Review Open
Vincristine-induced peripheral neuropathy (VIPN) is a common adverse effect of vincristine (VCR) for which there is no preventative or curative treatment. Here, we report a case of a patient suffering from severe VCR-related neurotoxicity.…
View article: Vincristine-Induced Peripheral Neuropathy in Childhood Acute Lymphoblastic Leukemia: Genetic Variation as a Potential Risk Factor
Vincristine-Induced Peripheral Neuropathy in Childhood Acute Lymphoblastic Leukemia: Genetic Variation as a Potential Risk Factor Open
Vincristine (VCR) is the first-line chemotherapeutic medication often co-administered with other drugs to treat childhood acute lymphoblastic leukemia. Dose-dependent neurotoxicity is the main factor restricting VCR’s clinical application.…
View article: Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion of RARA Into FIP1L1: The Clinical Utility of NGS and Bioinformatic Analyses
Myeloid Sarcoma Type of Acute Promyelocytic Leukemia With a Cryptic Insertion of RARA Into FIP1L1: The Clinical Utility of NGS and Bioinformatic Analyses Open
Background Acute promyelocytic leukemia (APL) is characterized by the presence of coagulopathy at onset and translocation t (15; 17) (q22; 21), meanwhile, other translocation variants of APL have also been reported. The FIP1L1–RARA fusion …
View article: The Value of Susceptibility-Weighted Imaging (SWI) in Evaluating the Ischemic Penumbra of Patients with Acute Cerebral Ischemic Stroke
The Value of Susceptibility-Weighted Imaging (SWI) in Evaluating the Ischemic Penumbra of Patients with Acute Cerebral Ischemic Stroke Open
SWI-DWI mismatch can prevent the injection of contrast agents and make an accurate diagnosis of acute stroke ischemic penumbra, which helps guide the selection of the clinical therapeutic plan.
View article: Tumor-Derived Autophagosomes (DRibbles) Activate Human B Cells to Induce Efficient Antigen-Specific Human Memory T-Cell Responses
Tumor-Derived Autophagosomes (DRibbles) Activate Human B Cells to Induce Efficient Antigen-Specific Human Memory T-Cell Responses Open
We have reported that tumor-derived autophagosomes (DRibbles) were efficient carriers of tumor antigens and DRibbles antigens could be present by DRibbles-activated B cells to stimulate effect and naïve T cells in mice. However, the effect…
View article: Primary testicular T-lymphoblastic lymphoma in a child
Primary testicular T-lymphoblastic lymphoma in a child Open
Rationale: Primary non-Hodgkin lymphoma (NHL) of the testes is rare, representing about 9% of testicular neoplasms and 1% to 2% of non-Hodgkin lymphomas. Patient concerns: A previously healthy 47-month-old boy came to our institution for 3…
View article: Personalized nanomedicine: a rapid, sensitive, and selective UV&ndash;vis spectrophotometry method for the quantification of nanostructured PEG-asparaginase activity in children&rsquo;s plasma
Personalized nanomedicine: a rapid, sensitive, and selective UV–vis spectrophotometry method for the quantification of nanostructured PEG-asparaginase activity in children’s plasma Open
This study proved that the Nessler method is well validated and can be successfully applied in the determination of plasma samples in the clinical setting for patients with ALL. It takes personalized nanomedicine to an entirely new level.
View article: rs61991156 in miR-379 is associated with low capability of glycolysis of gastric cancer by enhanced regulation of PKM2
rs61991156 in miR-379 is associated with low capability of glycolysis of gastric cancer by enhanced regulation of PKM2 Open
View article: MOESM1 of rs61991156 in miR-379 is associated with low capability of glycolysis of gastric cancer by enhanced regulation of PKM2
MOESM1 of rs61991156 in miR-379 is associated with low capability of glycolysis of gastric cancer by enhanced regulation of PKM2 Open
Additional file 1: Table S1. Raw data for proliferation determination for MKN-45 and AGS with different treatment. Table S2. Raw data for luciferase assay. Table S3. Raw data for metabolites determination for various genotypes. Table S4. S…