Yongrui Liu
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View article: Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies
Integrative analysis of ferroptosis in the hypoxic microenvironment of gastric cancer unveils the immune landscape and personalized therapeutic strategies Open
Background Ferroptosis is a cell death mode caused by excessive accumulation of lipid peroxides caused by disturbance of intracellular metabolic pathway, which is closely related to iron and cholesterol metabolism homeostasis. Its regulati…
View article: Structural basis for C. elegans pairing center DNA binding specificity by the ZIM/HIM-8 family proteins
Structural basis for C. elegans pairing center DNA binding specificity by the ZIM/HIM-8 family proteins Open
Pairing center (PC) on each chromosome of Caenorhabditis elegans is crucial for homolog pairing and initiating synapsis. Within each PC, clusters of 11/12 bp DNA motif recruit one of four paralogous meiosis-specific proteins: ZIM-1, ZIM-2,…
View article: Phase separation of hnRNPA1 and TERRA regulates telomeric stability
Phase separation of hnRNPA1 and TERRA regulates telomeric stability Open
Telomeres are the complexes composed of repetitive DNA sequences and associated proteins located at the end of chromatin. As a result of the DNA replication ending issue, telomeric DNA shortens during each cell cycle. The shelterin protein…
View article: Systems biology-based analysis exploring shared biomarkers and pathogenesis of myocardial infarction combined with osteoarthritis
Systems biology-based analysis exploring shared biomarkers and pathogenesis of myocardial infarction combined with osteoarthritis Open
Background More and more evidence supports the association between myocardial infarction (MI) and osteoarthritis (OA). The purpose of this study is to explore the shared biomarkers and pathogenesis of MI complicated with OA by systems biol…
View article: De novo design of cavity-containing proteins with a backbone-centered neural network energy function
De novo design of cavity-containing proteins with a backbone-centered neural network energy function Open
View article: Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling
Xuebijing Injection Attenuates Heat Stroke-Induced Brain Injury through Oxidative Stress Blockage and Parthanatos Modulation via PARP-1/AIF Signaling Open
Heat stroke (HS) is a potentially fatal acute condition caused by an interplay of complex events including inflammation, endothelial injury, and coagulation abnormalities that make its pharmacological treatment a challenging problem. The t…
View article: Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3
Structural Insights Uncover the Specific Phosphoinositide Recognition by the PH1 Domain of Arap3 Open
Arap3, a dual GTPase-activating protein (GAP) for the small GTPases Arf6 and RhoA, plays key roles in regulating a wide range of biological processes, including cancer cell invasion and metastasis. It is known that Arap3 is a PI3K effector…
View article: De novo Design of Cavity-Containing Proteins with a Backbone-Centered Neural Network Energy Function
De novo Design of Cavity-Containing Proteins with a Backbone-Centered Neural Network Energy Function Open
View article: Design of Cotton Recovery Device and Operation Parameters Optimization
Design of Cotton Recovery Device and Operation Parameters Optimization Open
This research aims to optimize the working parameters of the sawtooth-type recovery device for cotton fallen on the ground to enhance cotton’s recovery effect. Firstly, the cotton-picking mechanism and cotton unloading mechanism of the cot…
View article: Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study
Multi-marker approach using C-reactive protein, procalcitonin, neutrophil CD64 index for the prognosis of sepsis in intensive care unit: a retrospective cohort study Open
Background We aimed to explore the prognostic utilities of C-reactive protein (CRP), procalcitonin (PCT), neutrophil CD64 (nCD64) index, in combination or alone, in septic patients. Methods We retrospectively included 349 septic patients (…
View article: Vav2 is a novel APP-interacting protein that regulates APP protein level
Vav2 is a novel APP-interacting protein that regulates APP protein level Open
Amyloid precursor protein (APP) is a transmembrane protein that plays critical role in the pathogenesis of Alzheimer's disease (AD). It is also involved in many types of cancers. Increasing evidence has shown that the tyrosine phosphorylat…
View article: Structural insights reveal the specific recognition of meiRNA by the Mei2 protein
Structural insights reveal the specific recognition of meiRNA by the Mei2 protein Open
In the fission yeast Schizosaccharomyces pombe, Mei2, an RNA-binding protein essential for entry into meiosis, regulates meiosis initiation. Mei2 binds to a specific non-coding RNA species, meiRNA, and accumulates at the sme2 gene locus, w…
View article: Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122
Regression of Castration-Resistant Prostate Cancer by a Novel Compound HG122 Open
Prostate cancer (PCa) is a common aggressive disease worldwide which usually progresses into incurable castration-resistant prostate cancer (CRPC) in most cases after 18–24 months treatment. Androgen receptor (AR) has been considered as a …
View article: Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B
Structural Insights into ceNAP1 Chaperoning Activity toward ceH2A-H2B Open
View article: TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells
TRIM66 reads unmodified H3R2K4 and H3K56ac to respond to DNA damage in embryonic stem cells Open
View article: Application of fast track surgery in routine nursing for patient with colorectal cancer
Application of fast track surgery in routine nursing for patient with colorectal cancer Open
Objective: To investigate the clinical effect of fast track surgery (FTS) in perioperative nursing of colorectal cancer surgery. Background: In recent years, many complicated surgery began to develop in the direction of low i…
View article: Detection of plasmid-mediated AmpC β-lactamase in Escherichia coli
Detection of plasmid-mediated AmpC β-lactamase in Escherichia coli Open
Escherichia coli (E. coli) is a common opportunistic pathogen for nosocomial infection. The aim of the study was to examine the phenotype, genotype and epidemiology of plasmid-mediated AmpC β-lactamases in E. coli. In …
View article: Detection of AmpC β-lactamases in Acinetobacter baumannii in the Xuzhou region and analysis of drug resistance
Detection of AmpC β-lactamases in Acinetobacter baumannii in the Xuzhou region and analysis of drug resistance Open
The aim of the present study was to determine the prevalence and related drug resistance of AmpC β-lactamases in Acinetobacter baumannii in tertiary-level hospitals in the Xuzhou region in China. A total of 134 clinical isolates of …