Explanipedia

The VCPKMT-VCP-HDAC1 axis inhibits colorectal cancer by conferring sensitivity to ferroptosis Open

Cijun Huang, Jin-Long Lin, Shuidan Xu, Yongrui Lv, Jiewei Chen , et al. · 2025

Truncated APC impairs innate immune response by targeting MAVS on mitochondria in colorectal cancer Open

Siyu Li, Xin-Yi Wang, Jing Wang, Jinghua Cao, Yongrui Lv , et al. · 2025

NUDT21 lactylation reprograms alternative polyadenylation to promote cuproptosis resistance Open

Jinlong Lin, Yixin Yin, Jinghua Cao, Yiyang Zhang, Jie-Wei Chen , et al. · 2025

Alternative polyadenylation (APA) is critical for shaping transcriptome diversity and modulating cancer therapeutic resistance. While lactate is a well-established metabolic signal in cancer progression, its role in APA regulation remains …

Nudix Hydrolase 13 Impairs the Initiation of Colorectal Cancer by Inhibiting PKM1 ADP‐Ribosylation Open

Jinlong Lin, Yixin Yin, Jinghua Cao, Bingxu Zou, Kai Han , et al. · 2025

Metabolic dysregulation has been implicated as a key factor in colorectal cancer (CRC) initiation, however, the underlying driving forces and mechanisms remain poorly understood. Herein, transcriptome profiling of paired early‐stage CRCs a…

METTL3 confers oxaliplatin resistance through the activation of G6PD-enhanced pentose phosphate pathway in hepatocellular carcinoma Open

Xiaohan Jin, Yongrui Lv, Fengjie Bie, Jin‐Ling Duan, Chao Ma , et al. · 2024

Mex-3 RNA binding family member A (MEX3A)/circMPP6 complex promotes colorectal cancer progression by inhibiting autophagy Open

Rixin Chen, Shui-Dan Xu, Minhua Deng, Shi-Hui Hao, Jiewei Chen , et al. · 2024

RNA-binding proteins (RBPs)-RNA networks have contributed to cancer development. Circular RNAs (circRNAs) are considered as protein recruiters; nevertheless, the patterns of circRNA-protein interactions in colorectal cancer (CRC) are still…

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