Yongsan Yang
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View article: Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry
Genetic architecture of hypertrophic cardiomyopathy in individuals of Chinese and United Kingdom ancestry Open
Background No studies have explored the genetic differences between the Chinese and other ethnic hypertrophic cardiomyopathy (HCM) populations. Methods This cross-sectional study included Chinese patients (n = 593) with HCM and controls (n…
View article: KDASDB: A comprehensive and user-friendly database of alternative splicing dedicated to kidney diseases
KDASDB: A comprehensive and user-friendly database of alternative splicing dedicated to kidney diseases Open
Kidney disease has long been a major public health concern, making it crucial to understand its causes, pathogenesis and progression for the development of effective prevention and treatment strategies. Alternative splicing (AS), an import…
View article: LncPepAtlas: a comprehensive resource for exploring the translational landscape of long non-coding RNAs
LncPepAtlas: a comprehensive resource for exploring the translational landscape of long non-coding RNAs Open
Long non-coding RNAs were commonly viewed as non-coding elements. However, they are increasingly recognized for their ability to be translated into proteins, thereby playing a significant role in various cellular processes and diseases. Wi…
View article: Summary data‐based Mendelian randomization and single‐cell <scp>RNA</scp> sequencing analyses identify immune associations with low‐level <scp>LGALS9</scp> in sepsis
Summary data‐based Mendelian randomization and single‐cell <span>RNA</span> sequencing analyses identify immune associations with low‐level <span>LGALS9</span> in sepsis Open
Sepsis is one of the major challenges in intensive care units, characterized by the complexity of the host immune status. To gain a deeper understanding of the pathogenesis of sepsis, it is crucial to study the phenotypic changes in immune…
View article: TFTG: A comprehensive database for human transcription factors and their targets
TFTG: A comprehensive database for human transcription factors and their targets Open
Transcription factors (TFs) are major contributors to gene transcription, especially in controlling cell-specific gene expression and disease occurrence and development. Uncovering the relationship between TFs and their target genes is cri…
View article: DASES: a database of alternative splicing for esophageal squamous cell carcinoma
DASES: a database of alternative splicing for esophageal squamous cell carcinoma Open
Esophageal carcinoma ranks as the sixth leading cause of cancer-related mortality globally, with esophageal squamous cell carcinoma (ESCC) being particularly prevalent among Asian populations. Alternative splicing (AS) plays a pivotal role…
View article: CanMethdb: a database for genome-wide DNA methylation annotation in cancers
CanMethdb: a database for genome-wide DNA methylation annotation in cancers Open
Motivation DNA methylation within gene body and promoters in cancer cells is well documented. An increasing number of studies showed that cytosine–phosphate–guanine (CpG) sites falling within other regulatory elements could also regulate t…
View article: TF-Marker: A comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human.
TF-Marker: A comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human. Open
Here, we developed the TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/) which is committed to a comprehensive manual curation of TFs and related markers with experimental evidence in specific cell and tissue types in human.…
View article: TF-Marker: A comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human.
TF-Marker: A comprehensive manually curated database for transcription factors and related markers in specific cell and tissue types in human. Open
Here, we developed the TF-Marker database (TF-Marker, http://bio.liclab.net/TF-Marker/) which is committed to a comprehensive manual curation of TFs and related markers with experimental evidence in specific cell and tissue types in human.…
View article: TcoFBase: a comprehensive database for decoding the regulatory transcription co-factors in human and mouse
TcoFBase: a comprehensive database for decoding the regulatory transcription co-factors in human and mouse Open
Transcription co-factors (TcoFs) play crucial roles in gene expression regulation by communicating regulatory cues from enhancers to promoters. With the rapid accumulation of TcoF associated chromatin immunoprecipitation sequencing (ChIP-s…
View article: OUP accepted manuscript
OUP accepted manuscript Open
Transcription factors (TFs) play key roles in biological processes and are usually used as cell markers. The emerging importance of TFs and related markers in identifying specific cell types in human diseases increases the need for a compr…
View article: LncSEA: a platform for long non-coding RNA related sets and enrichment analysis
LncSEA: a platform for long non-coding RNA related sets and enrichment analysis Open
Long non-coding RNAs (lncRNAs) have been proven to play important roles in transcriptional processes and various biological functions. Establishing a comprehensive collection of human lncRNA sets is urgent work at present. Using reference …