Yongsheng Shi
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View article: Correction: Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021
Correction: Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 Open
View article: The competition between splicing and 3′ processing shapes the human transcriptome
The competition between splicing and 3′ processing shapes the human transcriptome Open
SUMMARY Eukaryotic pre-mRNA processing steps, including splicing and 3′ processing, are tightly coordinated, yet the underlying mechanisms remain incompletely understood. U1 snRNP has been proposed to inhibit 3′ processing at intronic poly…
View article: LENG8 mediates RNA nuclear retention and degradation in eukaryotes
LENG8 mediates RNA nuclear retention and degradation in eukaryotes Open
In eukaryotes, incompletely processed and misprocessed mRNAs as well as numerous noncoding RNAs are retained in the nucleus and often degraded. However, the mechanisms for this critical quality control pathway remain poorly understood. Her…
View article: Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021
Global burden of atrial fibrillation and atrial flutter due to high alcohol use from 1990 to 2021: estimates from the global burden of disease study 2021 Open
View article: Emerging Roles of Biomolecular Condensates in Pre‐<scp>mRNA</scp> 3′ End Processing
Emerging Roles of Biomolecular Condensates in Pre‐<span>mRNA</span> 3′ End Processing Open
Biomolecular condensates are membraneless assemblies of proteins and nucleic acids, often formed through liquid–liquid phase separation. They selectively concentrate specific biomolecules and play essential roles in diverse cellular proces…
View article: Table S4 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Table S4 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
Detailed sources and information for each cell line
View article: Table S2 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Table S2 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
Sequences of primers and sgRNA, sgiRNA, shRNA, tet-on shRNA (TO-shRNA)
View article: Figure S2 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S2 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
The efficiency of TUT1 deletion in vivo
View article: Figure S7 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S7 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
TUT1 uridylyltransferase activity is important for splicing regulation
View article: Figure S5 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S5 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
TUT1 does not regulate cell-cycle related genes in the normal pancreas
View article: Figure S1 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S1 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
TUT1 maintains PDAC cell survival
View article: Table S1 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Table S1 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
CRISPR screening of RNA binding proteins
View article: Data from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Data from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
Pancreatic ductal adenocarcinoma (PDAC) is highly aggressive and lacks effective therapeutic options. Cancer cells frequently become more dependent on splicing factors than normal cells due to increased rates of transcription. Terminal uri…
View article: Figure S4 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S4 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
TUT1 does not inhibit DNA damage and promotes splicing of exons with weak splice sites
View article: Figure S6 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S6 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
TUT1 promotes tri-snRNP assembly
View article: Table S3 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Table S3 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
Result of TUT1 co-IP-mass spectrometry
View article: Figure S3 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival
Figure S3 from Targeting TUT1 Depletes Tri-snRNP Pools to Suppress Splicing and Inhibit Pancreatic Cancer Cell Survival Open
TUT1 does not regulate mRNA polyadenylation in PDAC cells
View article: RNA-binding proteins: it's better to play in a band
RNA-binding proteins: it's better to play in a band Open
Alternative splicing (AS) is regulated by a myriad of RNA-binding proteins (RBPs) in a coordinated manner. However, most studies characterize RBPs individually. In this issue of Genes & Development , Peyda and colleagues (doi:10.1101/gad.3…
View article: Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts
Distinct plasmablast developmental intermediates produce graded expression of IgM secretory transcripts Open
Differentiation into plasma cells (PCs) enables secretion of ∼10,000 immunoglobulin molecules per second. This extraordinary capacity requires the upregulation of PC transcriptional determinants that specify PC fate, increase immunoglobuli…
View article: Enhancing Cognitive Performance and Physiological Benefit in Workspaces Through Patterns of Biophilic Design: A Restorative Approach
Enhancing Cognitive Performance and Physiological Benefit in Workspaces Through Patterns of Biophilic Design: A Restorative Approach Open
Contact with nature is believed to enhance mental health through the process of human psychological restoration. However, prolonged indoor living limits individuals’ exposure to nature, potentially hindering the timely alleviation of stres…
View article: Decoding biology with massively parallel reporter assays and machine learning
Decoding biology with massively parallel reporter assays and machine learning Open
Massively parallel reporter assays (MPRAs) are powerful tools for quantifying the impacts of sequence variation on gene expression. Reading out molecular phenotypes with sequencing enables interrogating the impact of sequence variation bey…
View article: A nuclear RNA degradation code for eukaryotic transcriptome surveillance
A nuclear RNA degradation code for eukaryotic transcriptome surveillance Open
SUMMARY The RNA exosome plays critical roles in eukaryotic RNA degradation, but it remains unclear how the exosome specifically recognizes its targets. The PAXT connection is an adaptor that recruits the exosome to polyadenylated RNAs in t…
View article: The Competition between Splicing and 3′ Processing Shapes the Human Transcriptome
The Competition between Splicing and 3′ Processing Shapes the Human Transcriptome Open
View article: Mechanochromic Luminescence And Excitation Wavelength-Dependent Emission Oftetra(1h-Benzo[D]Imidazol-2-Yl)Ethene Zn (Ii) Complexes and Their Applications
Mechanochromic Luminescence And Excitation Wavelength-Dependent Emission Oftetra(1h-Benzo[D]Imidazol-2-Yl)Ethene Zn (Ii) Complexes and Their Applications Open
View article: The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery
The anticancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery Open
JTE-607 is an anticancer and anti-inflammatory compound and its active form, compound 2, directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre-messenger RNA (pre-mRNA) 3' processing. Surprisingly, compound 2-…
View article: Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation
Nuclear RNA catabolism controls endogenous retroviruses, gene expression asymmetry, and dedifferentiation Open
Endogenous retroviruses (ERVs) are remnants of ancient parasitic infections and comprise sizable portions of most genomes. Although epigenetic mechanisms silence most ERVs by generating a repressive environment that prevents their expressi…
View article: CCDC 2233766: Experimental Crystal Structure Determination
CCDC 2233766: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2233768: Experimental Crystal Structure Determination
CCDC 2233768: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: CCDC 2233767: Experimental Crystal Structure Determination
CCDC 2233767: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery
The anti-cancer compound JTE-607 reveals hidden sequence specificity of the mRNA 3′ processing machinery Open
JTE-607 is a small molecule compound with anti-inflammation and anti-cancer activities. Upon entering the cell, it is hydrolyzed to Compound 2, which directly binds to and inhibits CPSF73, the endonuclease for the cleavage step in pre-mRNA…