Yuanyuan Luo
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View article: Bladder paraganglioma presenting with atypical abdominal pain: A diagnostic challenge
Bladder paraganglioma presenting with atypical abdominal pain: A diagnostic challenge Open
View article: Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study [Corrigendum]
Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study [Corrigendum] Open
[This corrects the article DOI: 10.2147/DDDT.S500384.].
View article: Diagnosis and therapy of recurrent renal metastases after surgery for testicular seminoma: a rare case report and review of the literature
Diagnosis and therapy of recurrent renal metastases after surgery for testicular seminoma: a rare case report and review of the literature Open
Background Seminoma is a malignant tumor arising from testicular germ cells, with cryptorchidism recognized as a major risk factor for its development. Although retroperitoneal lymph node metastasis is common, renal metastasis is exceeding…
View article: Ficus pandurata Hance suppresses colorectal cancer by targeting PI3K/Akt/mTOR pathway: A network pharmacology-guided experimental validation
Ficus pandurata Hance suppresses colorectal cancer by targeting PI3K/Akt/mTOR pathway: A network pharmacology-guided experimental validation Open
Background: Ficus pandurata Hance (FPH), a traditional Chinese medicinal herb, is known for its antioxidant and anti-inflammatory activities. While its efficacy against ulcerative colitis has been reported, its potential role in colorectal…
View article: Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study
Pharmacokinetics and Safety of HRS-1780 in Renal Impaired Subjects: A Multicenter, Non-Randomized, Open-Label Study Open
HRS-1780 PK and safety profiles did not differ significantly between healthy and renal impairment subjects. This supports the drug dose regimen for renal impairment patients in clinical practice.
View article: Analysis of correlation between dietary fiber intake and risk of diabetic kidney disease in adults with type 2 diabetes mellitus: results from the United States National Health and Nutrition Examination Surveys 2009–2018
Analysis of correlation between dietary fiber intake and risk of diabetic kidney disease in adults with type 2 diabetes mellitus: results from the United States National Health and Nutrition Examination Surveys 2009–2018 Open
Dietary fiber intake was negatively correlated with the prevalence of DKD in T2DM patients.
View article: Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris
Expression level of miR-146a is associated with the coronary lesion severity and clinical prognosis in patients with unstable angina pectoris Open
View article: Riboflavin photochemical therapy triggered PANoptosis by inducing mitochondrial damage in circulating colorectal cancer cells
Riboflavin photochemical therapy triggered PANoptosis by inducing mitochondrial damage in circulating colorectal cancer cells Open
View article: Relaxin Inhibits Angiotensin II-Induced Cardiac Fibrosis by Activating NO/cGMP Signaling Pathway
Relaxin Inhibits Angiotensin II-Induced Cardiac Fibrosis by Activating NO/cGMP Signaling Pathway Open
Relaxin attenuates Ang II-induced cardiac fibroblast activation and fibrosis primarily through the NO/cGMP signaling pathway.
View article: Genetic analysis of 280 children with unexplained developmental delay or intellectual disability using whole exome sequencing
Genetic analysis of 280 children with unexplained developmental delay or intellectual disability using whole exome sequencing Open
View article: Application and new findings of scRNA-seq and ST-seq in prostate cancer
Application and new findings of scRNA-seq and ST-seq in prostate cancer Open
Prostate cancer is a malignant tumor of the male urological system with the highest incidence rate in the world, which seriously threatens the life and health of middle-aged and elderly men. The progression of prostate cancer involves the …
View article: Exploring the role of mitochondrial-associated and peripheral neuropathy genes in the pathogenesis of diabetic peripheral neuropathy
Exploring the role of mitochondrial-associated and peripheral neuropathy genes in the pathogenesis of diabetic peripheral neuropathy Open
Background Diabetic peripheral neuropathy (DPN) is a prevalent and serious complication of diabetes mellitus, impacting the nerves in the limbs and leading to symptoms like pain, numbness, and diminished function. While the exact molecular…
View article: The psychiatric symptoms in anti‐IgLON5 disease: Case report and literature review
The psychiatric symptoms in anti‐IgLON5 disease: Case report and literature review Open
Key Clinical Message Immunotherapy may be ineffective in the advanced stages of anti‐IgLON5 disease with psychiatric symptoms. The psychiatric symptoms in advanced stages of anti‐IgLON5 disease may be associated with neurodegeneration.
View article: Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress
Pyrroline-5-carboxylate reductase 1 reprograms proline metabolism to drive breast cancer stemness under psychological stress Open
Cancer stem-like cells (CSCs) contribute to cancer metastasis, drug resistance and tumor relapse, yet how amino acid metabolism promotes CSC maintenance remains exclusive. Here, we identify that proline synthetase PYCR1 is critical for bre…
View article: The Psychiatric Symptoms in Anti-IgLON5 Disease: Case Report and Literature Review
The Psychiatric Symptoms in Anti-IgLON5 Disease: Case Report and Literature Review Open
The Psychiatric Symptoms in Anti-IgLON5 Disease: Case Report and Literature ReviewKey Clinical MessageImmunotherapy may be ineffective in the advanced stages of anti-IgLON5 disease with psychiatric symptoms. The psychiatric symptoms in adv…
View article: SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury
SENP2-mediated SERCA2a deSUMOylation increases calcium overload in cardiomyocytes to aggravate myocardial ischemia/reperfusion injury Open
Background: Sarcoplasmic reticulum calcium ATPase 2a (SERCA2a) is a key protein that maintains myocardial Ca 2+ homeostasis. The present study aimed to investigate the mechanism underlying the SERCA2a-SUMOylation (small ubiquitin-like modi…
View article: Expression level of miR-146a correlates with the coronary lesion severity and clinical prognosis in UA patients
Expression level of miR-146a correlates with the coronary lesion severity and clinical prognosis in UA patients Open
Objective To investigate whether there is a connection between the plasma expression level of miR-146a and both the severity of coronary lesion and clinical prognosis in patients with unstable angina pectoris (UA). Methods : 100 unstable a…
View article: Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review
Research progress in the treatment of glioblastoma by an oncolytic virus: A narrative review Open
Glioblastoma is the most common malignant tumor in the adult primary central nervous system. It has a strong proliferative ability, high recurrence rate, and high malignant degree. Despite standard radiotherapy combined with temozolomide c…
View article: Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients
Comparison of Behavioral Risk Factors and Cardiometabolic Comorbidities of Psoriatic Arthritis and Psoriasis: A Case–Control Study in Chinese Patients Open
Qiaolin Wang,1– 3 Yan Luo,1– 3 Menglin Chen,1– 3 Xuanwei Zheng,1– 3 Wu Zhu,1– 3 Minxue Shen,1– 4 Yehong Kuang1– 3 1Department of Dermatology, Xiangya Hospital, Central South University, Changsha, 410008, People’s Republic of China; 2Nation…
View article: Long-term survival case of a non-small cell lung cancer bone metastasis patient treated with bone cement, radiation and gefitinib.
Long-term survival case of a non-small cell lung cancer bone metastasis patient treated with bone cement, radiation and gefitinib. Open
The median survival time for NSCLC patients with bone metastases is often less than 1 year. We reported the patient with more than eight years of survival, showed that some special cases can adopt the methods of local treatment including b…
View article: SERCA2a ameliorates cardiomyocyte T-tubule remodeling via the calpain/JPH2 pathway to improve cardiac function in myocardial ischemia/reperfusion mice
SERCA2a ameliorates cardiomyocyte T-tubule remodeling via the calpain/JPH2 pathway to improve cardiac function in myocardial ischemia/reperfusion mice Open
View article: Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms
Luteolin: A Flavonoid that Has Multiple Cardio-Protective Effects and Its Molecular Mechanisms Open
Cardiovascular disease (CVD) has become the leading cause of morbidity and mortality worldwide. A well-monitored diet with a sufficient intake of fruits and vegetables has been confirmed as a primary prevention of CVD. Plant constituents s…
View article: Effect of MicroRNA-30e on the Behavior of Vascular Smooth Muscle Cells via Targeting Ubiquitin-Conjugating Enzyme E2I
Effect of MicroRNA-30e on the Behavior of Vascular Smooth Muscle Cells via Targeting Ubiquitin-Conjugating Enzyme E2I Open
The results of this study indicated that miR-30e in VSMCs exerted an anti-atherosclerosis effect via inhibiting proliferation and migration, and promoting apoptosis of VSMCs. More specifically, it was demonstrated that miR-30e exhibited th…
View article: Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion
Luteolin Enhances Sarcoplasmic Reticulum Ca2+-ATPase Activity through p38 MAPK Signaling thus Improving Rat Cardiac Function after Ischemia/Reperfusion Open
Background/Aims: A major challenge for current therapeutic strategies against ischemia/reperfusion (I/R) is the lack of effective drugs. Considering luteolin enhances the activity of sarcoplasmic reticulum Ca2+-ATPase (SERCA2a) to improve …
View article: Outer Balloon Ligation Increases Success Rate of Ischemia-Reperfusion Injury Model in Mice
Outer Balloon Ligation Increases Success Rate of Ischemia-Reperfusion Injury Model in Mice Open
Compared with the classic method, our new method of inducing myocardial I/R injury has higher efficiency and less tissue damage in mice, but achieves the same modeling effects.
View article: JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention.
JNK/PI3K/Akt signaling pathway is involved in myocardial ischemia/reperfusion injury in diabetic rats: effects of salvianolic acid A intervention. Open
Recent studies have demonstrated that diabetes impairs the phosphatidylinositol 3-kinase/Akt (PI3K/Akt) pathway, while insulin resistance syndrome has been associated with alterations of this pathway in diabetic rats after ischemia/reperfu…
View article: Na(+)/Ca(2+) exchanger 1 (NCX-1) mediates the anti-apoptotic effect of Akt1 in neonatal rat cardiomyocytes during ischemia/reperfusion.
Na(+)/Ca(2+) exchanger 1 (NCX-1) mediates the anti-apoptotic effect of Akt1 in neonatal rat cardiomyocytes during ischemia/reperfusion. Open
The purpose of this study was to investigate the anti-apoptotic role of Akt1 gene in neonatal rat cardiomyocytes and the relationship with Na(+)/Ca(2+) exchanger 1 (NCX1) during ischemia/reperfusion (IR). The cultured original rat cardiomy…
View article: Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p
Luteolin Inhibits Ischemia/Reperfusion-Induced Myocardial Injury in Rats via Downregulation of microRNA-208b-3p Open
LUT pretreatment conveys anti-apoptotic effects after myocardial I/R injury by decreasing miR-208b-3p and increasing Ets1 expression levels.
View article: P0847 : Malachite-II: Phase 3b trial of ombitasvir/paritaprevir/r and dasabuvir + ribavirin or telaprevir + peginterferon/ribavirin in peginterferon/ribavirin treatment-experienced adults with HCV genotype 1
P0847 : Malachite-II: Phase 3b trial of ombitasvir/paritaprevir/r and dasabuvir + ribavirin or telaprevir + peginterferon/ribavirin in peginterferon/ribavirin treatment-experienced adults with HCV genotype 1 Open