Yongwei Jiang
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View article: Differential Effects of High Methionine Diet on Biochemical Parameters in Normal and Diabetic Rat Models
Differential Effects of High Methionine Diet on Biochemical Parameters in Normal and Diabetic Rat Models Open
This study investigated the organ-specific effects of a high-methionine (HM) diet in streptozotocin (STZ)-induced diabetic rats, focusing on hepatic and renal metabolic adaptations. Male Wistar rats were divided into four groups (n=8/group…
View article: Association Between DNA Methylation of <i>MTHFR</i> and Diabetic Kidney Disease
Association Between DNA Methylation of <i>MTHFR</i> and Diabetic Kidney Disease Open
Objective: The objective of this study is to explore the association between MTHFR DNA methylation and diabetic kidney disease (DKD). Methods: This study involved 120 healthy people, 200 diabetes mellitus (DM) patients, and 200 DKD patient…
View article: The Association of Lipoic Acid Synthase ( <i>LIAS</i> ) Gene Methylation With Diabetic Kidney Disease
The Association of Lipoic Acid Synthase ( <i>LIAS</i> ) Gene Methylation With Diabetic Kidney Disease Open
Background Diabetic kidney disease (DKD) is a leading cause of end‐stage renal disease (ESRD). The dysregulation of lipoic acid synthase ( LIAS ) gene, which plays an essential role in the maintenance of mitochondrial function, was reporte…
View article: The Analysis of Plasma Proteomics for Luminal A Breast Cancer
The Analysis of Plasma Proteomics for Luminal A Breast Cancer Open
Background Breast cancer is the prevailing malignancy among women, exhibiting a discernible escalation in incidence within our nation; hormone receptor‐positive (HR+) human epidermal growth factor receptor 2‐negative (HER2−) breast cancer …
View article: Retrospective study on the characteristics of common urogenital tract pathogens in Beijing
Retrospective study on the characteristics of common urogenital tract pathogens in Beijing Open
Background: This study aims to investigate the infection status of Mycoplasma genitalium (MG), Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Ureaplasma urealyticum (UU) among male and female patients in Beijing, with the obje…
View article: The analysis of plasma proteomics for hormone receptor-positive HER2-negative breast cancer
The analysis of plasma proteomics for hormone receptor-positive HER2-negative breast cancer Open
Background Breast cancer (BC) is the prevailing malignancy among women, exhibiting a discernible escalation in incidence within our nation, hormone receptor-positive (HR+) human epidermal growth factor receptor 2-negative (HER2-) breast ca…
View article: Development of a Novel Multiplex PCR Method for the Rapid Detection of SARS-CoV-2, Influenza A Virus, and Influenza B Virus
Development of a Novel Multiplex PCR Method for the Rapid Detection of SARS-CoV-2, Influenza A Virus, and Influenza B Virus Open
Objective. A sensitive and specific multiplex fluorescence rapid detection method was established for simultaneous detection of SARS-CoV-2, influenza A virus, and influenza B virus in a self-made device within 30 min, with a minimum detect…
View article: Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney
Tangshen formula improves diabetic nephropathy in STZ-induced diabetes rats fed with hyper-methionine by regulating the methylation status of kidney Open
Background The objective of this study was to examine and analyze differential methylation profiles in order to investigate the influence of hyper-methioninemia (HM) on the development of diabetic nephropathy (DN). Male Wistar rats, aged e…
View article: Hyper-methionine Feeding Influence diabetes nephropathy (DN) by regulating the methylation status of kidney in STZ-induced diabetes rats
Hyper-methionine Feeding Influence diabetes nephropathy (DN) by regulating the methylation status of kidney in STZ-induced diabetes rats Open
This study aimed to investigate the impact of hyper-methionine (HM) feeding on diabetic nephropathy (DN) pathogenesis by examining and analyzing differential methylation profiles. Eight-week-old male Wistar rats (250–300g) were randomly di…
View article: Role of HLA class I and II alleles in susceptibility to ankylosing spondylitis in Chinese Han
Role of HLA class I and II alleles in susceptibility to ankylosing spondylitis in Chinese Han Open
Objective The objective of the study was to clarify the associations of HLA class I and II alleles with ankylosing spondylitis (AS) among Chinese Han. Methods We performed HLA genotyping and Sanger sequencing for 68 HLA‐B*27(−), 62 HLA‐B*2…
View article: Discrimination of SARS-CoV-2 omicron variant and its lineages by rapid detection of immune-escape mutations in spike protein RBD using asymmetric PCR-based melting curve analysis
Discrimination of SARS-CoV-2 omicron variant and its lineages by rapid detection of immune-escape mutations in spike protein RBD using asymmetric PCR-based melting curve analysis Open
View article: Fast and Sensitive Detection of SARS-CoV-2 Nucleic Acid Using a Rapid Detection System Free of RNA Extraction
Fast and Sensitive Detection of SARS-CoV-2 Nucleic Acid Using a Rapid Detection System Free of RNA Extraction Open
Objectives. To establish and evaluate the analytical and clinical performance of the Flash20 SARS-CoV-2 nucleic acid rapid detection system free of RNA extraction. Methods. The limit of detection (LoD) was determined using a negative nasop…
View article: Rapid detection of the irinotecan‐related <i>UGT1A1</i>*28 polymorphism by asymmetric PCR melting curve analysis using one fluorescent probe
Rapid detection of the irinotecan‐related <i>UGT1A1</i>*28 polymorphism by asymmetric PCR melting curve analysis using one fluorescent probe Open
Background Determination of UGT1A1 (TA) n polymorphism prior to irinotecan therapy is necessary to avoid severe adverse drug effects. Thus, accurate and reliable genotyping methods for (TA) n polymorphism are highly desired. Here, we prese…
View article: A novel method for early detection of colorectal cancer based on detection of methylation of two fragments of syndecan-2 (SDC2) in stool DNA
A novel method for early detection of colorectal cancer based on detection of methylation of two fragments of syndecan-2 (SDC2) in stool DNA Open
Background Methylated SDC2 has been proved as a diagnostic marker for human colorectal cancer (CRC), noninvasive stool DNA-based methylation testing also emerges as a novel approach for detecting CRC. The aim of this study was to evaluate …
View article: A Novel Stool Methylation Test for the Non-Invasive Screening of Gastric and Colorectal Cancer
A Novel Stool Methylation Test for the Non-Invasive Screening of Gastric and Colorectal Cancer Open
Background Because of poor compliance or low sensitivity, existing diagnostic approaches are unable to provide an efficient diagnosis of patients with gastric and colorectal cancer. Here, we developed the ColoCaller test, which simultaneou…
View article: Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan
Association of AGTR1 A1166C and CYP2C9∗3 Gene Polymorphisms with the Antihypertensive Effect of Valsartan Open
Background. The differences in the antihypertensive treatment with angiotensin type II receptor blockers (ARBs) may be attributed to polymorphisms in genes involving drug-targeted receptor and drug metabolism. The present study aimed to in…
View article: Susceptibility of ApoB and PCSK9 Genetic Polymorphisms to Diabetic Kidney Disease Among Chinese Diabetic Patients
Susceptibility of ApoB and PCSK9 Genetic Polymorphisms to Diabetic Kidney Disease Among Chinese Diabetic Patients Open
This study aimed to investigate the susceptibility of 8 polymorphisms in ApoB and PCSK9 genes to diabetic kidney disease (DKD) in Chinese patients with type 2 diabetes mellitus. This is a case-control association study, including 575 DKD c…
View article: Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese
Association of Epoxide Hydrolase 2 Gene Arg287Gln with the Risk for Primary Hypertension in Chinese Open
Background . Epoxide hydrolase 2 ( EPHX2 ) gene coding for soluble epoxide hydrolase is a potential candidate in the pathogenesis of hypertension. Objectives . We aimed to assess the association of a missense mutation, R287Q, in EPHX2 gene…
View article: Genetically elevated circulating homocysteine concentrations increase the risk of diabetic kidney disease in Chinese diabetic patients
Genetically elevated circulating homocysteine concentrations increase the risk of diabetic kidney disease in Chinese diabetic patients Open
Diabetic kidney disease (DKD) is a devastating and frequent complication of diabetes mellitus. Here, we first adopted methylenetetrahytrofolate reductase ( MTHFR ) gene C677T polymorphism as an instrument to infer the possible causal relev…
View article: Protein kinase C and protein kinase A are involved in the protection of recombinant human glucagon‐like peptide‐1 on glomeruli and tubules in diabetic rats
Protein kinase C and protein kinase A are involved in the protection of recombinant human glucagon‐like peptide‐1 on glomeruli and tubules in diabetic rats Open
Aims/Introduction Blockade or reversal the progression of diabetic nephropathy is a clinical challenge. The aim of the present study was to examine whether recombinant human glucagon‐like peptide‐1 (rh GLP ‐1) has an effect on alleviating …
View article: Distribution of Human Papillomavirus Genotypes (2014–2016) in Women With Genital Warts at a Sexually Transmitted Disease Clinic in Beijing, China
Distribution of Human Papillomavirus Genotypes (2014–2016) in Women With Genital Warts at a Sexually Transmitted Disease Clinic in Beijing, China Open
Aim: The aim of this study was to analyze the distribution of human papillomavirus (HPV) genotypes among women with genital warts in the Beijing region of China. Methods: A total of 350 women diagnosed with genital warts between 2014 and 2…
View article: Association of <i>EPHX2</i> R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients
Association of <i>EPHX2</i> R287Q Polymorphism with Diabetic Nephropathy in Chinese Type 2 Diabetic Patients Open
The aim of this study was to investigate the relationship between EPHX2 rs751141 (R287Q polymorphism) and diabetic nephropathy (DN) in Chinese type 2 diabetes (T2D). This case-control study explored the association between EPHX2 rs751141 a…
View article: Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy
Transplantation of human fetal pancreatic progenitor cells ameliorates renal injury in streptozotocin-induced diabetic nephropathy Open
DN may be reversed by transplantation of human fetal pancreatic progenitor cell-derived islets. And fetal pancreatic progenitor cells offer potential resources for cell replacement therapy.
View article: Synergistic Effect of the<i> MTHFR</i> C677T and<i> EPHX2</i> G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients
Synergistic Effect of the<i> MTHFR</i> C677T and<i> EPHX2</i> G860A Polymorphism on the Increased Risk of Ischemic Stroke in Chinese Type 2 Diabetic Patients Open
The aim of this study was to investigate the relationship between the combined effect of MTHFR C677T (rs1801133) and EPHX2 G860A (rs751141) polymorphism and ischemic stroke in Chinese T2DM patients. This case-control study included a total…
View article: Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients
Effects of Apolipoprotein E Isoforms in Diabetic Nephropathy of Chinese Type 2 Diabetic Patients Open
Diabetic nephropathy (DN) is one of the major chronic complications of diabetes. Genetic polymorphism of Apolipoprotein E (ApoE) has been proposed to participating in DN. The purpose of the study was to evaluate the relationship between Ap…