Yongwei Sun
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View article: Analysis of hepatitis B virus integration identifies <i>KMT2B</i> as a novel cancer‐related gene in pancreatic cancer
Analysis of hepatitis B virus integration identifies <i>KMT2B</i> as a novel cancer‐related gene in pancreatic cancer Open
Background Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy with few well‐established risk factors. Emerging epidemiological evidence suggests a link between hepatitis B virus (HBV) infection and PDAC. However, the…
View article: Serum microRNA-24-based nomogram predicts prognosis for patients with resected pancreatic cancer
Serum microRNA-24-based nomogram predicts prognosis for patients with resected pancreatic cancer Open
View article: TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis
TMEM105 modulates disulfidptosis and tumor growth in pancreatic cancer via the β-catenin-c-MYC-GLUT1 axis Open
Background: Pancreatic cancer (PCa) is one of the most malignant diseases in the world. Different from ferroptosis and apoptosis, disulfidptosis is a novel type of cell death. The role of disulfidptosis in PCa remains uncovered. …
View article: Fault Location in Distribution Networks with Multi-Lateral Branches Based on Time-Domain Difference
Fault Location in Distribution Networks with Multi-Lateral Branches Based on Time-Domain Difference Open
View article: Fault Location in Distribution Networks with Multi-Lateral Branches Based on Time-Domain Difference
Fault Location in Distribution Networks with Multi-Lateral Branches Based on Time-Domain Difference Open
View article: Bibliometric analysis of research trends and advancements in medicinal plant microbiome
Bibliometric analysis of research trends and advancements in medicinal plant microbiome Open
Medicinal plants and microorganisms are closely linked, with microorganisms boosting plant growth, offering pest control, and enhancing secondary compound production. However, there’s a lack of systematic research, detailed molecular studi…
View article: Risk factors affecting cervical spondylotic myelopathy complicated with traumatic central cord syndrome and the efficacy of different treatment options
Risk factors affecting cervical spondylotic myelopathy complicated with traumatic central cord syndrome and the efficacy of different treatment options Open
View article: Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma
Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma Open
Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma(PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemcit…
View article: SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer
SIN3B Loss Heats up Cold Tumor Microenvironment to Boost Immunotherapy in Pancreatic Cancer Open
Despite progress significant advances in immunotherapy for some solid tumors, pancreatic ductal adenocarcinoma (PDAC) remains unresponsive poorly responsive to such interventions, largely due to its highly immunosuppressive tumor microenvi…
View article: A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer Open
Pancreatic ductal adenocarcinoma (PDAC) features substantial matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, the complex interplay between these traits and their impact on tumor advancement …
View article: The lncRNA LINC01605 promotes the progression of pancreatic ductal adenocarcinoma by activating the mTOR signaling pathway
The lncRNA LINC01605 promotes the progression of pancreatic ductal adenocarcinoma by activating the mTOR signaling pathway Open
View article: Mechanical cues of extracellular matrix determine tumor innervation
Mechanical cues of extracellular matrix determine tumor innervation Open
Peripheral tumors can establish local autonomic and sensory nerve networks, termed as tumor innervation (TIN), to support tumorigenesis and metastasis. While nerve dependence in cancers is well-established, the mechanisms governing TIN rem…
View article: Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study
Development of a Serum-Based MicroRNA Signature for Early Detection of Pancreatic Cancer: A Multicenter Cohort Study Open
A panel of four serum miRNAs was developed showing remarkably discriminative ability of early stage PCa from either healthy controls or other pancreatic diseases, suggesting it may be developed as a novel, noninvasive approach for early sc…
View article: Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma.
Oncogenic GALNT5 confers FOLFIRINOX resistance via activating the MYH9/ NOTCH/ DDR axis in pancreatic ductal adenocarcinoma. Open
Chemotherapy resistance has been a great challenge in pancreatic ductal adenocarcinoma (PDAC) treatments. Current first-line chemotherapy regimens for PDAC include gemcitabine-based regimens such as AG regimen (albumin paclitaxel and gemci…
View article: The lncRNA LINC01605 promotes the progression of pancreatic ductal adenocarcinoma by activating the mTOR signaling pathway
The lncRNA LINC01605 promotes the progression of pancreatic ductal adenocarcinoma by activating the mTOR signaling pathway Open
Background This study investigated the molecular mechanism of long intergenic non-protein coding RNA 1605 (LINC01605) in the process of tumor growth and liver metastasis of pancreatic ductal adenocarcinoma (PDAC). Methods LINC01605 was fil…
View article: A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer Open
BACKGROUND & AIMS PDAC is characterized by significant matrix stiffening and reprogrammed glucose metabolism, particularly the Warburg effect. However, it is not clear the connection between matrix stiffness and the Warburg effect and the …
View article: Development of a serum-based miRNA signature for early detection of pancreatic cancer: a multicenter cohort study
Development of a serum-based miRNA signature for early detection of pancreatic cancer: a multicenter cohort study Open
Background A grim prognosis of pancreatic cancer (PCa) was attributed to the difficulty in early diagnosis of the disease. Identifying novel biomarkers for early detection of PCa is thus urgent to improve the overall survival rates of pati…
View article: Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms
Chinese Medical Association consensus for standardized diagnosis and treatment of pancreatic neuroendocrine neoplasms Open
Pancreatic neuroendocrine neoplasms (pNENs) are rare and highly heterogeneous tumors originating from pluripotent stem cells with neuroendocrine differentiation in the pancreas, constituting approximately 3% of all pancreatic tumors.[1] Th…
View article: Three-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification
Three-dimensional visualization and evaluation of hilar cholangiocarcinoma resectability and proposal of a new classification Open
View article: An unusual case of isolated serum γ-glutamyl transferase elevation: slight abnormality also should not be taken lightly
An unusual case of isolated serum γ-glutamyl transferase elevation: slight abnormality also should not be taken lightly Open
A 75-year-old man was admitted to our hospital for isolated serum γ-glutamyl transpeptidase (GGT, 147 U/L) elevation, with fluctuation in the past 2 years ([Fig. 1]). His alanine aminotransferase, glutamic transaminase, bilirubin level, an…
View article: Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma
Coadaptation fostered by the SLIT2-ROBO1 axis facilitates liver metastasis of pancreatic ductal adenocarcinoma Open
View article: Ociad2，A Potential Biomarker: From Pan-Cancer Analysis to Pancreatic Adenocarcinoma Validation via Glycolysis
Ociad2，A Potential Biomarker: From Pan-Cancer Analysis to Pancreatic Adenocarcinoma Validation via Glycolysis Open
View article: Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis
Tumor Cell‐Intrinsic SETD2 Deficiency Reprograms Neutrophils to Foster Immune Escape in Pancreatic Tumorigenesis Open
Genetic and epigenetic alterations play central roles in shaping the immunosuppressive tumor microenvironment (TME) to evade immune surveillance. The previous study shows that SETD2‐H3K36me3 loss promotes KRAS‐induced pancreatic tumorigene…
View article: A Magnetically and Thermally Controlled Liquid Metal Variable Stiffness Material
A Magnetically and Thermally Controlled Liquid Metal Variable Stiffness Material Open
Smart materials that can actively tune their stiffness are of great interest to many fields, including the construction industry, medical devices, industrial machines, and soft robotics. However, developing a material that can offer a larg…
View article: Exploitation and Verification of a Stroma- and Metastasis-Associated Risk Prognostic Signature in Pancreatic Adenocarcinoma
Exploitation and Verification of a Stroma- and Metastasis-Associated Risk Prognostic Signature in Pancreatic Adenocarcinoma Open
Pancreatic adenocarcinoma (PAAD), one of the most malignant tumors, not only has abundant mesenchymal components, but is also characterized by an extremely high metastatic risk. The purpose of this study was to construct a model of stroma-…
View article: The protective effects of nesfatin‐1 in neurological dysfunction after spinal cord injury by inhibiting neuroinflammation
The protective effects of nesfatin‐1 in neurological dysfunction after spinal cord injury by inhibiting neuroinflammation Open
Aims Spinal cord injury (SCI) is one of the most severe neurological diseases. However, there is still no effective treatment for it. Nesfatin, a precursor neuropeptide derived from nucleobindin 2 (NUCB2), has displayed a wide range of pro…
View article: GJB3 promotes pancreatic cancer liver metastasis by enhancing the polarization and survival of neutrophil
GJB3 promotes pancreatic cancer liver metastasis by enhancing the polarization and survival of neutrophil Open
Connexins are membrane expressed proteins, which could assemble into hexamers to transfer metabolites and secondary messengers. However, its roles in pancreatic cancer metastasis remains unknown. In this study, by comparing the gene expres…
View article: Influence Of Electromagnetic Field On Crystallization Of Tunnel Drainage Pipes
Influence Of Electromagnetic Field On Crystallization Of Tunnel Drainage Pipes Open
The salts contained in hard groundwater often lead to crystallization and blockage of tunnel drainage pipes. In this paper, based on the principle of scale removal and inhibition, indoor tests were implemented so as to study the influence …
View article: Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of pancreatic cancer
Chinese Society of Clinical Oncology (CSCO): Clinical guidelines for the diagnosis and treatment of pancreatic cancer Open
View article: Modeling of cancer-related body-wide effects identifies LTB4 as a diagnostic biomarker for pancreatic cancer
Modeling of cancer-related body-wide effects identifies LTB4 as a diagnostic biomarker for pancreatic cancer Open