Explanipedia

Multi-modal characterization of metabolic and immune gene clusters in adrenocortical carcinoma treatment Open

Wenjun Hao, Luhan Yao, Yanlong Wang, Junjie Wan, Yuyan Zhu , et al. · 2025

Editorial: Molecular mechanisms and treatment of MYCN-driven tumors, volume II Open

Yuyan Zhu, Yusuke Suenaga · 2025

Multi-omics analysis of bidirectional liquid–liquid phase separation signatures reveals immunotherapy response and prognosis in renal cell carcinoma Open

Zheyu Wang, Hongze Li, Xiaolong Hou, Senyu Zhang, Kai Deng , et al. · 2025

Integrating Multiomics and Machine Learning: Senescence-Regulated ALMS1-IT1/miR-7c-5p/HMGA2 Axis as a Novel Therapeutic Target for Head and Neck Squamous Cell Carcinoma Open

Yuyan Zhu, Zhan Yang, Yaxian Luo, Luying Qin, Yixuan Ma , et al. · 2025

Head and neck squamous cell carcinoma (HNSCC) is distinguished by the absence of definitive diagnostic markers and effective treatment modalities, which results in its poor clinical outcomes. Although senescence-targeted therapies have eme…

A tiny Cambrian stem-mandibulate reveals independent evolution of limb tagmatization and specialization in early euarthropods Open

Yao Liu, Han Zeng, Fangchen Zhao, Yuyan Zhu, Yimeng Li , et al. · 2025

Generation of self-organized neuromusculoskeletal tri-tissue organoids from human pluripotent stem cells Open

Yin Yao, Wei Zhou, Jinkui Zhu, Ziling Chen, Linlin Jiang , et al. · 2024

The human body function requires crosstalk between different tissues. An essential crosstalk is in the neuromusculoskeletal (NMS) axis involving neural, muscular, and skeletal tissues, which is challenging to model using human cells. Here,…

Comprehensive multi-omics analysis reveals a combination of lncRNAs that synergistically regulate glycolysis and immunotherapeutic effects in renal clear cell carcinoma Open

Yuchen Li, Bowen Hou, Yan Xu, Hongze Li, Yuyan Zhu , et al. · 2024

The identified risk profiles can accurately assess the prognosis of patients with clear cell renal carcinoma and identify patient populations that would benefit from immunotherapy, providing valuable insights and therapeutic targets for th…

Integration of multi-omics and clinical treatment data reveals bladder cancer therapeutic vulnerability gene combinations and prognostic risks Open

Yan Xu, Xiaoyu Sun, Guangxu Liu, Hongze Li, Meng Yu , et al. · 2024

Background Bladder cancer (BCa) is a common malignancy of the urinary tract. Due to the high heterogeneity of BCa, patients have poor prognosis and treatment outcomes. Immunotherapy has changed the clinical treatment landscape for many adv…

Cellulose as a sustainable scaffold material in cultivated meat production Open

Yunan Tang, Chenchen Shi, Yuyan Zhu, Ming Yang, Kuichuan Sheng , et al. · 2024

Cancer-keeper genes as therapeutic targets Open

Xizhe Zhang, Chunyu Pan, Xinru Wei, Meng Yu, Shuangjie Liu , et al. · 2023

HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma Open

Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei , et al. · 2023

Identification of a glutamine metabolism reprogramming signature for predicting prognosis, immunotherapy efficacy, and drug candidates in bladder cancer Open

Yan Xu, Zhixiu Xia, Xiaoyu Sun, Baojun Wei, Yang Fu , et al. · 2023

Background Bladder cancer is the most common malignancy of the urinary system. However, patient prognosis and treatment outcomes in bladder cancer are difficult to predict owing to high tumor heterogeneity. Given that abnormal glutamine me…

Additional file 3 of HES1-mediated down-regulation of miR-138 sustains NOTCH1 activation and promotes proliferation and invasion in renal cell carcinoma Open

Shuangjie Liu, Lei Dou, Miao Miao, Xiaojun Man, Baojun Wei , et al. · 2023

Additional file 3.

Identification of a novel ferroptosis-related gene signature associated with prognosis, the immune landscape, and biomarkers for immunotherapy in ovarian cancer Open

Yilong Liu, Suya Du, Mengying Yuan, Xia He, Changyu Zhu , et al. · 2022

Ferroptosis has been implicated in tumor progression and immunoregulation. Identification of ferroptosis-related prognostic gene is important for immunotherapy and prognosis in ovarian cancer (OV). We assessed the potential predictive powe…

Identification of SNHG16 and Its Derived Tumor Immune Gene Signatures for Predicting Prognosis and Efficacy of Immunotherapy in Bladder Cancer Open

Yuchen Li, Yuyan Zhu, Yang Fu, Dan‐Yang Guo, Meng Yu , et al. · 2022

Background In the era of individualized therapy,there is a great need to incorporate lncRNAs into preclinical models to develop prognostic or therapeutic biomarkers.We sought to apply the tumor immune-associated lncRNA – SNHG16 to develop …

Honokiol Improves Acne-like Lesions in a Rabbit Ear Model by Alleviating Hyperkeratosis and Sebum Secretion Open

Yuyan Zhu, Lixia Zhang, Xiyuan Zhou · 2022

The prevalence of acne vulgaris is high, but the topical retinoids used as the foundation of treatment have teratogenic and photosensitivity properties. Previous studies have suggested that honokiol, a small-molecule compound extracted fro…

Oridonin attenuates lung inflammation and fibrosis in silicosis via covalent targeting iNOS Open

Jingyan Gao, Chao Li, Xialu Wang, Xiaojie Sun, Rong Zhang , et al. · 2022

Cancer-keeping genes as therapeutic targets Open

Xizhe Zhang, Chunyu Pan, Xinru Wei, Meng Yu, Shuangjie Liu , et al. · 2022

Finding cancer-driver genes – the genes whose mutations may transform normal cells into cancerous ones – remains a central theme of cancer research. We took a different perspective; instead of considering normal cells, we focused on cancer…

Identification of cancer-keeping genes as therapeutic targets by finding network control hubs Open

Xizhe Zhang, Chunyu Pan, Xinru Wei, Meng Yu, Shuangjie Liu , et al. · 2022

Finding cancer driver genes has been a focal theme of cancer research and clinical studies. One of the recent approaches is based on network structural controllability that focuses on finding a control scheme and driver genes that can stee…

[corrigendum] Knockdown of SNHG15 suppresses renal cell carcinoma proliferation and EMT by regulating the NF‑κB signaling pathway Open

Yang Du, Chuize Kong, Yuyan Zhu, Meng Yu, Zeliang Li , et al. · 2022

Subsequently to the publication of the above article, the authors have realized that, on p. 390, the data selected for the siRNA‑1 and siRNA‑2 experiments for the ACHN and 786-O cell lines concerning both the invasion and the migration ass…

Editorial: Molecular Mechanisms and Treatment of MYCN-Driven Tumors Open

Yusuke Suenaga, Christer Einvik, Atsushi Takatori, Yuyan Zhu · 2021

EDITORIAL article Front. Oncol., 30 November 2021Sec. Molecular and Cellular Oncology Volume 11 - 2021 | https://doi.org/10.3389/fonc.2021.803443

Construction of a Macrophage Infiltration Regulatory Network and Related Prognostic Model of High-Grade Serous Ovarian Cancer Open

Hua Chang, Yuyan Zhu, Jiahui Zheng, Lian Chen, Jiaxing Lin , et al. · 2021

Background. High-grade serous ovarian cancer (HGSOC) carries the highest mortality in the gynecological cancers; however, therapeutic outcomes have not significantly improved in recent decades. Macrophages play an essential role in the occ…

OLFML2B Is a Robust Prognostic Biomarker in Bladder Cancer Through Genome-Wide Screening: A Study Based on Seven Cohorts Open

Jiaxing Lin, Xiao Xu, Tian‐Ren Li, Jihang Yao, Meng Yu , et al. · 2021

Background Bladder cancer lacks useful and robust prognostic markers to stratify patients at risk. Our study is to identify a robust prognostic marker for bladder cancer. Methods The transcriptome and clinical data of bladder cancer were d…

Correction: UNC5B mediates G2/M phase arrest of bladder cancer cells by binding to CDC14A and P53 Open

Yexiang Huang, Yuyan Zhu, Zhe Zhang, Zhenhua Li, Chuize Kong · 2021

Exogenous melatonin prevents type 1 diabetes mellitus–induced bone loss, probably by inhibiting senescence Open

Zimu Gong, Wacili Da, Yihao Tian, Rui Zhao, Shui Qiu , et al. · 2021

Multidimensional Analyses of Tumor Immune Microenvironment Reveal the Possible Rationality of Immunotherapy and Identify High Immunotherapy Response Subtypes for Renal Papillary Cell Carcinoma Open

Baojun Wei, Meng Yu, Jihang Yao, Mingzhe Jiang, Jun An , et al. · 2021

Kidney renal papillary cell carcinoma (KIRP), the second most common subtype of renal cell carcinoma, still lacks effective treatment regimens for individualized immunotherapy because of the heterogeneity of its elusive immune microenviron…

Metabolic classification of bladder cancer based on multi-omics integrated analysis to predict patient prognosis and treatment response Open

Chaozhi Tang, Meng Yu, Jiakang Ma, Yuyan Zhu · 2021

Background Currently, no molecular classification is established for bladder cancer based on metabolic characteristics. Therefore, we conducted a comprehensive analysis of bladder cancer metabolism-related genes using multiple publicly ava…

Control Analysis of Protein-Protein Interaction Network Reveals Potential Regulatory Targets for MYCN Open

Chunyu Pan, Yuyan Zhu, Meng Yu, Yongkang Zhao, Changsheng Zhang , et al. · 2021

Background MYCN is an oncogenic transcription factor of the MYC family and plays an important role in the formation of tissues and organs during development before birth. Due to the difficulty in drugging MYCN directly, revealing the molec…

SNHG12 promotes carcinogenesis of human renal cell cancer via functioning as a competing endogenous RNA and sponging miR‐30a‐3p Open

Hongyuan Yu, Junlong Liu, Zhe Zhang, Yuyan Zhu, Jianbin Bi , et al. · 2021

Small nucleolar RNA host gene 12 (SNHG12) has been indicated in the tumorigenesis of various human cancers, including clear cell renal cell carcinoma (ccRCC). However, the underlying mechanisms of SNHG12 driving progression of ccRCC remain…

TRIB3 Promotes the Malignant Progression of Bladder Cancer: An Integrated Analysis of Bioinformatics and in vitro Experiments Open

Jieping Yang, Jiaxing Lin, Jun An, Yongkang Zhao, Siyang Jing , et al. · 2021

Background Bladder cancer is a common malignant tumor characterized by high mortality and high management costs; however, it lacks useful molecular prognostic markers. Tribbles pseudokinase 3 (TRIB3) is a pseudokinase that participates in …

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