Yongxian Lai
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View article: P.G-Omvs Promote Metastasis Via Pre-Metastatic Niche Formation
P.G-Omvs Promote Metastasis Via Pre-Metastatic Niche Formation Open
Aim or purpose: Porphyromonas gingivalis (P.g) has been shown to promote tumor growth and metastasis. Outer membrane vesicles (OMVs), secreted by gram-negative bacteria, mediate intercellular communication. However, whether P.g promotes me…
View article: Bioinformatics analysis of immune infiltration and cell cycle hub genes in atopic dermatitis
Bioinformatics analysis of immune infiltration and cell cycle hub genes in atopic dermatitis Open
View article: SIRI-MOGA-UNet: A Synergistic Framework for Subsurface Latent Damage Detection in ‘Korla’ Pears via Structured-Illumination Reflectance Imaging and Multi-Order Gated Attention
SIRI-MOGA-UNet: A Synergistic Framework for Subsurface Latent Damage Detection in ‘Korla’ Pears via Structured-Illumination Reflectance Imaging and Multi-Order Gated Attention Open
Bruising in ‘Korla’ pears represents a prevalent phenomenon that leads to progressive fruit decay and substantial economic losses. The detection of early-stage bruising proves challenging due to the absence of visible external characterist…
View article: The Diagnostic Value of High-Frequency Ultrasound in Unclarified Lesions at the End of Extremities
The Diagnostic Value of High-Frequency Ultrasound in Unclarified Lesions at the End of Extremities Open
Objectives: Unlike other body parts, unclarified lesions at the end of extremities have unique challenges due to their small size and interference. Traditional imaging methods struggle with low resolution. HFUS enhances resolution, offerin…
View article: Biological and Bioinspired Vesicles for Wound Healing: Insights, Advances and Challenges
Biological and Bioinspired Vesicles for Wound Healing: Insights, Advances and Challenges Open
Millions of people suffer traumatic injuries and surgical procedures each year, making effective wound management very important. Benign wound repair is essential for structural and functional recovery of damaged tissues. Natural biologica…
View article: <i>Porphyromonas gingivalis</i> -OMVs promote the epithelial-mesenchymal transition of oral squamous cell carcinoma by inhibiting ferroptosis through the NF-κB pathway
<i>Porphyromonas gingivalis</i> -OMVs promote the epithelial-mesenchymal transition of oral squamous cell carcinoma by inhibiting ferroptosis through the NF-κB pathway Open
P. g-OMVs promote OSCC progression by modulating the ferroptosis-related EMT through NF-κB signaling.
View article: Case Report: Comprehensive management of trichilemmal carcinoma of the lower leg in an elderly patient with comorbidities: a case study on integrated ALA-PDT and surgical excision
Case Report: Comprehensive management of trichilemmal carcinoma of the lower leg in an elderly patient with comorbidities: a case study on integrated ALA-PDT and surgical excision Open
Trichilemmal carcinoma (TC), a rare malignancy originating from hair follicle cells, typically affects sun-exposed skin in older individuals and necessitates differential diagnosis from other skin carcinomas. Here, we present one case of t…
View article: Identifying ATP-Binding Cassette Member B5 as a New Biomarker for Oral Squamous Cell Carcinoma
Identifying ATP-Binding Cassette Member B5 as a New Biomarker for Oral Squamous Cell Carcinoma Open
ABCB5 promotes the migration, invasion, and EMT of OSCC. ABCB5 might be a new biomarker and potential therapeutic target for OSCC.
View article: Corrigendum: Comparative study of alginate and type I collagen as biomaterials for cartilage stem/progenitor cells to construct tissue-engineered cartilage in vivo
Corrigendum: Comparative study of alginate and type I collagen as biomaterials for cartilage stem/progenitor cells to construct tissue-engineered cartilage in vivo Open
[This corrects the article DOI: 10.3389/fbioe.2022.1057199.].
View article: Untargeted metabolomics yields insight into extramammary Paget’s disease mechanisms
Untargeted metabolomics yields insight into extramammary Paget’s disease mechanisms Open
Background Extramammary Paget’s disease (EMPD) is a rare cutaneous malignancy, commonly affecting the external genitalia and perianal area of the elderly with unclear pathogenesis. Metabolomics provides a novel perspective for uncovering t…
View article: A deep learning fusion network trained with clinical and high-frequency ultrasound images in the multi-classification of skin diseases in comparison with dermatologists: a prospective and multicenter study
A deep learning fusion network trained with clinical and high-frequency ultrasound images in the multi-classification of skin diseases in comparison with dermatologists: a prospective and multicenter study Open
This work was supported in part by the National Natural Science Foundation of China and the Clinical research project of Shanghai Skin Disease Hospital.
View article: Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo
Multiple gene-drug prediction tool reveals Rosiglitazone based treatment pathway for non-segmental vitiligo Open
View article: Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation
Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation Open
This study initially revealed the biological mechanism of RSV for treating DW through multi-target and multi-pathway. AGE-RAGE, FoxO, MAPK, PI3K-AKT and other signalling pathways may be the main pathways of RSV in treating DW. RSV reduces …
View article: Whole genome methylation sequencing reveals epigenetic landscape and abnormal expression of FABP5 in extramammary Paget's disease
Whole genome methylation sequencing reveals epigenetic landscape and abnormal expression of FABP5 in extramammary Paget's disease Open
Background Extramammary Paget's disease (EMPD) is a rare cutaneous malignant tumor with a high recurrence rate after surgery. However, the genetic and epigenetic alterations underlying its pathogenesis remain unknown. DNA methylation is an…
View article: Enhanced activation of mechanistic target of rapamycin complex 1 signaling in eruptive xanthomas
Enhanced activation of mechanistic target of rapamycin complex 1 signaling in eruptive xanthomas Open
To the Editor: Eruptive xanthomas are benign skin lesions involving excessive lipid deposition in the dermis.1Xu M. Liu Y. Eruptive xanthomas.N Engl J Med. 2022; 386: e58Crossref PubMed Scopus (2) Google Scholar It is characterized by loca…
View article: An epidemiological study on skin tumors of the elderly in a community in Shanghai, China
An epidemiological study on skin tumors of the elderly in a community in Shanghai, China Open
The morbidity of skin tumors (ST) in China is a great concern as the population ages. No epidemiological survey on ST in elderly communities in China has been reported. A questionnaire survey was conducted among the residents over 60 years…
View article: Comparative study of alginate and type I collagen as biomaterials for cartilage stem/progenitor cells to construct tissue-engineered cartilage in vivo
Comparative study of alginate and type I collagen as biomaterials for cartilage stem/progenitor cells to construct tissue-engineered cartilage in vivo Open
With the help of biomaterials, cartilage stem/progenitor cells (CSPCs) derived from cartilage tissue present a promising choice for cartilage regeneration. In our previous study, we investigated whether CSPCs could be ideal seeding cells f…
View article: Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation
Mechanisms of resveratrol against diabetic wound by network pharmacology and experimental validation Open
Resveratrol (RSV) that possesses anti-oxidative, anti-inflammatory, and pro-angiogenic effects is an effective drug for diabetic wound (DW), while its pharmacological mechanism remains to be elucidated. In this study, we apply network phar…
View article: Identification of key candidate genes involved in melanoma metastasis
Identification of key candidate genes involved in melanoma metastasis Open
Metastasis is the most lethal stage of cancer progression. The present study aimed to investigate the underlying molecular mechanisms of melanoma metastasis using bioinformatics. Using the microarray dataset GSE8401 from the Gene Expressio…
View article: Characteristics of human papillomaviruses infection in men with genital warts in Shanghai
Characteristics of human papillomaviruses infection in men with genital warts in Shanghai Open
Human papillomaviruses (HPV) infected men causes continued transmission of HPV to women. The prevalence of 15 high-risk HPV strains (HPV16, 18, 31, 33, 35, 39, 45, 51, 52, 53, 56, 58, 59, 66 and 68) and 6 low-risk HPV strains (HPV6, 11, 42…
View article: Microwave-Assisted Synthesis of Glutathione-Capped CdTe/CdSe Near-Infrared Quantum Dots for Cell Imaging
Microwave-Assisted Synthesis of Glutathione-Capped CdTe/CdSe Near-Infrared Quantum Dots for Cell Imaging Open
These glutathione (GSH)-conjugated CdTe/CdSe core/shell quantum dot (QD) nanoparticles in aqueous solution were synthesized using a microwave-assisted approach. The prepared type II core/shell QD nanoparticles were characterized by UV–Vis …