Yongxin Sun
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View article: Prognostic Value of Functional Incomplete Revascularization in Patients Undergoing Valve Surgery With Coronary Artery Disease
Prognostic Value of Functional Incomplete Revascularization in Patients Undergoing Valve Surgery With Coronary Artery Disease Open
Functional ICR in patients undergoing valve surgery with coronary artery disease is associated with increased MACE. These findings support using functional assessment to guide revascularization decisions.
View article: A Novel Open-Vascular Single-Branched Stent Graft in Total Arch Repair of Type a Aortic Dissection--One-Year Results of a Prospective Multicenter Randomized Controlled Study
A Novel Open-Vascular Single-Branched Stent Graft in Total Arch Repair of Type a Aortic Dissection--One-Year Results of a Prospective Multicenter Randomized Controlled Study Open
View article: Regional dynamic early warning model for rainfall-induced landslide in Fujian, China
Regional dynamic early warning model for rainfall-induced landslide in Fujian, China Open
Recent advances have significantly enhanced dynamic early warning systems for rainfall-induced landslides by integrating rainfall thresholds with susceptibility mapping. However, there is still room for optimizing these models for regional…
View article: Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and <i>in Vitro</i> Study
Prolonged Cadmium Exposure and Osteoclastogenesis: A Mechanistic Mouse and <i>in Vitro</i> Study Open
This in vivo and in vitro study supported the authors' hypothesis that Cd exposure caused bone loss, in which NRF2 and L-NRF1 responded to Cd and osteoclastogenic stimuli in a cooperative, but contradictive, manner to coordin…
View article: Research Progress on Multiple Effects and Clinical Application of Proprotein Convertase Subtilisin-kexin9 Inhibitors
Research Progress on Multiple Effects and Clinical Application of Proprotein Convertase Subtilisin-kexin9 Inhibitors Open
PCSK9 inhibitors (Proprotein convertase subtilisin-kexin9 inhibitors) not only have a good lipid-lowering effect but also have the effects of improving cardiovascular outcome, anti-inflammation, reducing oxidative stress and improving vasc…
View article: Prognostic Value of Quantitative Flow Ratio in Patients Undergoing Primary Valve Surgery Combined with Coronary Artery Disease
Prognostic Value of Quantitative Flow Ratio in Patients Undergoing Primary Valve Surgery Combined with Coronary Artery Disease Open
View article: Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms
Nrf2 Mitigates RANKL and M-CSF Induced Osteoclast Differentiation via ROS-Dependent Mechanisms Open
Nuclear factor-erythroid 2-related factor 2 (Nrf2) has been shown to be a negative regulator of osteoclast differentiation, but the precise mechanisms have not yet been established. We examined the precise roles of Nrf2 in regulating antio…
View article: HIF‐1α Contributes to Hypoxia‐induced VSMC Proliferation and Migration by Regulating Autophagy in Type A Aortic Dissection
HIF‐1α Contributes to Hypoxia‐induced VSMC Proliferation and Migration by Regulating Autophagy in Type A Aortic Dissection Open
Type A aortic dissection (AD) is a catastrophic cardiovascular disease. Hypoxia‐inducible factor‐1α (HIF‐1α) and autophagy are reported to be upregulated in the AD specimens. However, the interaction between HIF‐1α and autophagy in the pat…
View article: Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis
Acid sphingomyelinase mediates ferroptosis induced by high glucose via autophagic degradation of GPX4 in type 2 diabetic osteoporosis Open
View article: Influence of Horizontal Loading in Changing the Ultimate Uplift Bearing Capacity of Monopile Foundation of Offshore Wind Turbine
Influence of Horizontal Loading in Changing the Ultimate Uplift Bearing Capacity of Monopile Foundation of Offshore Wind Turbine Open
Throughout their lifespan, monopile foundations supporting offshore wind turbines inevitably experience horizontal loads from waves, winds, and currents, resulting in cumulative deformation. It has been believed that deformation caused by …
View article: Septuagenarians with acute type A aortic dissection undergoing extended aortic arch repair: A retrospective cohort study
Septuagenarians with acute type A aortic dissection undergoing extended aortic arch repair: A retrospective cohort study Open
Extended arch repair may be safely and effectively performed in septuagenarians with ATAAD, with in-hospital and midterm outcomes comparable to those obtained in patients aged less than 70 years.
View article: Spatial prediction of the geological hazard vulnerability of mountain road network using machine learning algorithms
Spatial prediction of the geological hazard vulnerability of mountain road network using machine learning algorithms Open
The current assessment index of the geological hazard vulnerability assessment for mountain road network is relatively simple, and the assessment methods used are subjective, complex, and inefficient. This study proposes a prediction model…
View article: Ciprofloxacin exacerbates dysfunction of smooth muscle cells in a microphysiological model of thoracic aortic aneurysm
Ciprofloxacin exacerbates dysfunction of smooth muscle cells in a microphysiological model of thoracic aortic aneurysm Open
Ciprofloxacin use may be associated with adverse aortic events. However, the mechanism underlying the effect of ciprofloxacin on the progression of thoracic aortic aneurysm (TAA) is not well understood. Using an in vitro microphysiological…
View article: Early postoperative organ dysfunction is highly associated with the mortality risk of patients with type A aortic dissection
Early postoperative organ dysfunction is highly associated with the mortality risk of patients with type A aortic dissection Open
OBJECTIVES This study assessed the impact of early postoperative organ dysfunction (EPOD) on in-hospital mortality of patients with type A aortic dissection (TAAD) after surgery. METHODS Patients with TAAD who underwent surgical repair req…
View article: Preoperative and intraoperative risk factors of postoperative stroke in total aortic arch replacement and stent elephant trunk implantation
Preoperative and intraoperative risk factors of postoperative stroke in total aortic arch replacement and stent elephant trunk implantation Open
View article: Immediate Recognition and Surgical Treatment of Iatrogenic Acute Type A Aortic Dissection Is Associated with Low Hospital Mortality and High Intermediate-Term Survival
Immediate Recognition and Surgical Treatment of Iatrogenic Acute Type A Aortic Dissection Is Associated with Low Hospital Mortality and High Intermediate-Term Survival Open
Background: To investigate short- and intermediate-term outcomes of immediate (on table) recognition and surgical treatment of iatrogenic acute type A aortic dissection (ATAD) that occurred during the course of the cardiac surgical procedu…
View article: Outcomes of thoracic endovascular aortic repair for penetrating aortic ulcers involving the left subclavian artery with the Castor single-branched stent graft
Outcomes of thoracic endovascular aortic repair for penetrating aortic ulcers involving the left subclavian artery with the Castor single-branched stent graft Open
Objects To acquire adequate proximal landing zones for penetrating aortic ulcers in the proximal descending aorta or aortic arch, the left subclavian artery (LSA) is usually covered during thoracic endovascular aortic repair. The Castor si…
View article: Different frequencies of repetitive transcranial magnetic stimulation combined with local injection of botulinum toxin type A for post-stroke lower limb spasticity: study protocol for a prospective, single-center, non-randomized, controlled clinical trial
Different frequencies of repetitive transcranial magnetic stimulation combined with local injection of botulinum toxin type A for post-stroke lower limb spasticity: study protocol for a prospective, single-center, non-randomized, controlled clinical trial Open
No definite consensus has currently been reached regarding the safety and efficacy of low- or high-frequency repetitive transcranial magnetic stimulation in the treatment of post-stroke muscle spasticity. The latest research indicates that…
View article: Preoperative and Intraoperative Risk Factors of Perioperative Stroke in Total Aortic Arch Replacement and Stent Elephant Trunk Implantation
Preoperative and Intraoperative Risk Factors of Perioperative Stroke in Total Aortic Arch Replacement and Stent Elephant Trunk Implantation Open
View article: Long-Term Outcomes of Surgical Treatment for Acute Type-A Aortic Dissection with Coronary Artery Involvement
Long-Term Outcomes of Surgical Treatment for Acute Type-A Aortic Dissection with Coronary Artery Involvement Open
The surgical strategies for acute type-A aortic dissection (aTAAD) with coronary artery involvement have been controversial, and its prognosis remains unclear. Thus, in this study, we aim to determine the characteristics, surgical strategi…
View article: Circulating soluble receptor of advanced glycation end product is associated with bicuspid aortic aneurysm progression via NF-κB pathway
Circulating soluble receptor of advanced glycation end product is associated with bicuspid aortic aneurysm progression via NF-κB pathway Open
OBJECTIVES Patients with bicuspid aortic valve (BAV) have a high risk of aortic dilation and adverse vascular events. Previous studies had reported soluble receptor for advanced glycation end products (sRAGE) to compete with receptor of ad…
View article: MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers
MicroRNAs involve in bicuspid aortic aneurysm: pathogenesis and biomarkers Open
The incidence of bicuspid aortic valves (BAV) is high in the whole population, BAV-related thoracic aortic aneurysm (TAA) is accompanied by many adverse vascular events. So far, there are two key points in dealing with BAV-related TAA. Fir…
View article: Plasma proteomic profiling reveals biomarkers associated with aortic dilation in patients with bicuspid aortic valve
Plasma proteomic profiling reveals biomarkers associated with aortic dilation in patients with bicuspid aortic valve Open
Our data reveal unique features in the proteomic architecture of stenotic BAV patients' plasma, and we propose the potential of Notch signaling proteins NOTCH3 and ADAM10 in predicting aortic dilation.
View article: Veno-Arterial Extracorporeal Membrane Oxygenation for Patients Undergoing Acute Type A Aortic Dissection Surgery: A Six-Year Experience
Veno-Arterial Extracorporeal Membrane Oxygenation for Patients Undergoing Acute Type A Aortic Dissection Surgery: A Six-Year Experience Open
Objectives: Acute type A aortic dissection (aTAAD) is usually lethal without emergency surgery. Although veno-arterial extracorporeal membrane oxygenation (VA-ECMO) is widely used in patients with cardiogenic shock following cardiac surger…
View article: MicroRNA Profiling of Plasma Extracellular Vesicles in Bicuspid Aortopathy
MicroRNA Profiling of Plasma Extracellular Vesicles in Bicuspid Aortopathy Open
Background: Bicuspid aortic valve (BAV) is the most common congenital cardiovascular disease and highly associated with ascending aortic dilation, i.e. , bicuspid aortopathy. When the maximal aortic diameter achieves a critical threshold, …
View article: Ciprofloxacin Exacerbates Dysfunction of Human Aortic Smooth Muscle Cells in a Microphysiological Model of Thoracic Aortic Aneurysm
Ciprofloxacin Exacerbates Dysfunction of Human Aortic Smooth Muscle Cells in a Microphysiological Model of Thoracic Aortic Aneurysm Open
View article: Early risk stratification of acute type A aortic dissection: development and validation of a predictive score
Early risk stratification of acute type A aortic dissection: development and validation of a predictive score Open
The ALICE score comprising four components might help bedside clinicians in early detection of the most severe aTAAD patients.
View article: Learning curve of mitral valve repair: cumulative sum failure analysis from single high-volume center
Learning curve of mitral valve repair: cumulative sum failure analysis from single high-volume center Open
The number of cases required to overcome the learning curve for repair rate is substantial, although there is marked variation among surgeons. Individuals' learning curves accelerate as the institution accumulates experience. MV repair is …
View article: Mitral valve repair for degenerative mitral regurgitation in patients with left ventricular systolic dysfunction: early and mid-term outcomes
Mitral valve repair for degenerative mitral regurgitation in patients with left ventricular systolic dysfunction: early and mid-term outcomes Open
View article: Quantifying the learning curve of emergent total arch replacement in acute type A aortic dissection
Quantifying the learning curve of emergent total arch replacement in acute type A aortic dissection Open
Although emergent total arch replacement for acute type A dissection is a complex scenario, surgeons well-trained in adult cardiac surgery are able to achieve acceptable results in their start-up period.