Yongya Li
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View article: Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay
Amplified detection of nucleic acids and proteins using an isothermal proximity CRISPR Cas12a assay Open
Herein, we develop an isothermal proximity CRISPR Cas12a assay that harnesses the target-induced collateral cleavage activity of Cas12a for the quantitative profiling of gene expression and detection of proteins with high sensitivity and s…
View article: Development of Universal Biosensing Platforms Based on CRISPR/Cas12a systems
Development of Universal Biosensing Platforms Based on CRISPR/Cas12a systems Open
CRISPR/Cas technologies possess the promising potential to affect biosensing field by providing a sensitive, precise, rapid, versatile and cost-effective method for diverse target detections. This thesis focusses on the development of CRIS…
View article: Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants
Simulation-guided engineering of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants Open
Development of an enzyme-powered three dimensional DNA nanomachine for discriminating single nucleotide variants through simulation-guided engineering and noncovalent DNA catalysis.