Yongze Chen
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View article: NRF1-mediated innate immune response drives inflammaging
NRF1-mediated innate immune response drives inflammaging Open
Aberrant innate immune responses contribute significantly to cellular senescence, yet the precise interplay between innate immunity and senescence remains poorly characterized. Here, we elucidate the pivotal role of nuclear respiratory fac…
View article: Association between physical activity and diabetes mellitus: mediation analysis involving Systemic Immune-Inflammatory Index in a cross-sectional NHANES study
Association between physical activity and diabetes mellitus: mediation analysis involving Systemic Immune-Inflammatory Index in a cross-sectional NHANES study Open
Objectives In this study, we aimed to clarify the relationship between physical activity (PA) and diabetes mellitus (DM), as well as the mediating role of Systemic Immune-Inflammatory Index (SII) in the relationship. Design A cross-section…
View article: Bayesian network analysis of factors influencing type 2 diabetes, coronary heart disease, and their comorbidities
Bayesian network analysis of factors influencing type 2 diabetes, coronary heart disease, and their comorbidities Open
View article: Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis
Role of remnant cholesterol in the relationship between physical activity and diabetes mellitus: an intermediary analysis Open
Objective The purpose of this investigation was to evaluate the potential link between physical activity (PA) and the heightened susceptibility to diabetes mellitus (DM), by examining whether remnant cholesterol (RC) might act as a mediato…
View article: Association between systemic immune-inflammatory index and diabetes mellitus: mediation analysis involving obesity indicators in the NHANES
Association between systemic immune-inflammatory index and diabetes mellitus: mediation analysis involving obesity indicators in the NHANES Open
Background Inflammation and obesity have been widely recognized to play a key role in Diabetes mellitus (DM), and there exists a complex interplay between them. We aimed to clarify the relationship between inflammation and DM, as well as t…
View article: Genetically predicted lifestyle factors, socioeconomic status and risk of coronary artery disease in individuals with diabetes: a Mendelian randomization study
Genetically predicted lifestyle factors, socioeconomic status and risk of coronary artery disease in individuals with diabetes: a Mendelian randomization study Open
Background This study explores the causal links between genetically predicted lifestyle factors, socioeconomic status, and coronary artery disease (CAD) risk in individuals with diabetes using a bidirectional Mendelian-randomization approa…
View article: ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation
ATL I, Acts as a SIRT6 Activator to Alleviate Hepatic Steatosis in Mice via Suppression of NLRP3 Inflammasome Formation Open
Accumulating evidence has highlighted that sirtuin-6 (SIRT6) plays an important role in hepatic gluconeogenesis and lipogenesis. We aim to investigate the underlying mechanisms and pharmacological interventions of SIRT6 on hepatic steatosi…
View article: Asymmetric Cell Division and Tumor Heterogeneity
Asymmetric Cell Division and Tumor Heterogeneity Open
Asymmetric cell division (ACD) gives rise to two daughter cells with different fates after mitosis and is a fundamental process for generating cell diversity and for the maintenance of the stem cell population. The cancer stem cell (CSC) t…
View article: Molecular recognition of the interaction between ApoE and the TREM2 protein
Molecular recognition of the interaction between ApoE and the TREM2 protein Open
Alzheimer’s disease (AD) is the most common type of dementia. The ε4 allele of the apolipoprotein E ( ApoE ) gene is the strongest known genetic risk factor for late-onset AD. Triggering receptor expressed on myeloid cells 2 (TREM2) is ano…
View article: TGF-β Signaling and Resistance to Cancer Therapy
TGF-β Signaling and Resistance to Cancer Therapy Open
The transforming growth factor β (TGF-β) pathway, which is well studied for its ability to inhibit cell proliferation in early stages of tumorigenesis while promoting epithelial-mesenchymal transition and invasion in advanced cancer, is co…
View article: Transcription factor forkhead box K1 regulates miR‑32 expression and enhances cell proliferation in colorectal cancer
Transcription factor forkhead box K1 regulates miR‑32 expression and enhances cell proliferation in colorectal cancer Open
Increased microRNA (miR)-32 expression in colorectal cancer (CRC) tissues enhances CRC cell proliferation, migration, invasion and attenuates CRC cell apoptosis by repressing the expression of phosphatase and tensin homolog (PTEN). Forkhea…
View article: Downregulation of microRNA‑126 is inversely correlated with insulin receptor substrate‑1 protein expression in colorectal cancer and is associated with advanced stages of disease
Downregulation of microRNA‑126 is inversely correlated with insulin receptor substrate‑1 protein expression in colorectal cancer and is associated with advanced stages of disease Open
Colorectal cancer (CRC) is a common human malignant tumor, and the fourth most common cause of cancer-associated mortality in China. However, the pathogenesis of CRC is not yet fully understood. The present study aimed to investigate the e…