Yongzhen Mo
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View article: Single-cell sequencing reveals MCAM+ MyCAFs as key pro-angiogenic cells interacting with endothelial cells in solid-type adenoid cystic carcinoma
Single-cell sequencing reveals MCAM+ MyCAFs as key pro-angiogenic cells interacting with endothelial cells in solid-type adenoid cystic carcinoma Open
Compared to non-solid-type ACC, CAFs in solid-type ACC are predominantly composed of melanoma cell adhesion molecule (MCAM)+ myofibroblastic cancer-associated fibroblasts (myCAFs). The transcriptional levels of pro-angiogenic fa…
View article: A versatile and efficient method for detecting tRNA-derived fragments
A versatile and efficient method for detecting tRNA-derived fragments Open
Recently, it has been discovered surprisingly that tRNA can be cleaved into specific small fragments under certain conditions. Most importantly, these tRNA-derived fragments (tRFs) participate in the regulation of gene expression, playing …
View article: METTL14 promotes lipid metabolism reprogramming and sustains nasopharyngeal carcinoma progression via enhancing m<sup>6</sup>A modification of ANKRD22 mRNA
METTL14 promotes lipid metabolism reprogramming and sustains nasopharyngeal carcinoma progression via enhancing m<sup>6</sup>A modification of ANKRD22 mRNA Open
Background N 6 ‐methyladenosine (m 6 A) modification is essential for modulating RNA processing as well as expression, particularly in the context of malignant tumour progression. However, the exploration of m 6 A modification in nasophary…
View article: RETRACTED: METTL14 Promotes Lipid Metabolism Reprogramming and Sustains Nasopharyngeal Carcinoma Progression via Enhancing m6A Modification of ANKRD22 mRNA
RETRACTED: METTL14 Promotes Lipid Metabolism Reprogramming and Sustains Nasopharyngeal Carcinoma Progression via Enhancing m6A Modification of ANKRD22 mRNA Open
The authors have requested that this preprint be removed from Research Square.
View article: Circular RNA circADARB1 enhances radiotherapy resistance in nasopharyngeal carcinoma via suppressing ferroptosis
Circular RNA circADARB1 enhances radiotherapy resistance in nasopharyngeal carcinoma via suppressing ferroptosis Open
Background Nasopharyngeal carcinoma (NPC) is a prevalent head and neck malignancy in Southeast Asia. Radiotherapy is the primary clinical treatment for NPC, but radiotherapy resistance stands as the fundamental reason for treatment failure…
View article: Spatially Resolved Transcriptomics Technology Facilitates Cancer Research
Spatially Resolved Transcriptomics Technology Facilitates Cancer Research Open
Single cell RNA sequencing (scRNA‐seq) provides a great convenience for studying tumor occurrence and development for its ability to study gene expression at the individual cell level. However, patient‐derived tumor tissues are composed of…
View article: Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway
Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the Hippo-YAP signaling pathway Open
View article: Overview and countermeasures of cancer burden in China
Overview and countermeasures of cancer burden in China Open
View article: Transfer RNA-derived small RNAs in tumor microenvironment
Transfer RNA-derived small RNAs in tumor microenvironment Open
Transfer RNAs (tRNAs) are a class of non-coding RNAs responsible for amino acid translocation during protein synthesis and are ubiquitously found in organisms. With certain modifications and under specific conditions, tRNAs can be sheared …
View article: Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
View article: Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the YAP/HIPPO signaling pathway
Circular RNA circRILPL1 promotes nasopharyngeal carcinoma malignant progression by activating the YAP/HIPPO signaling pathway Open
Background Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), but they have not been sufficiently studied. Methods The high expression of circRILPL1 in NPC tiss…
View article: Construction of a lncRNA–mRNA Co-Expression Network for Nasopharyngeal Carcinoma
Construction of a lncRNA–mRNA Co-Expression Network for Nasopharyngeal Carcinoma Open
Long non-coding RNAs (lncRNAs) widely regulate gene expression and play important roles in the pathogenesis of human diseases, including malignant tumors. However, the functions of most lncRNAs remain to be elucidated. In order to study an…
View article: Regulatory pathways and drugs associated with ferroptosis in tumors
Regulatory pathways and drugs associated with ferroptosis in tumors Open
View article: Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Background Circular RNAs play an important role in tumor genesis and progression, but they have not been sufficiently studied in patients with nasopharyngeal carcinoma (NPC). Methods The circular RNA, circCAMSAP1, was screened in NPC cells…
View article: Additional file 6 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 6 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 6: Supplemental Table 6. The potential β-TrCP-interacting proteins in CNE2 cells identified by LC-MS/MS spectrometry after pull-down with β-TrCP antibody.
View article: Additional file 3 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 3 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 3: Supplemental Table 3. Probes for fluorescence in situ hybridization and RNA pulldown, siRNAs, primers for qRT-PCR and vector construction.
View article: Additional file 7 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 7 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 7: Supplemental Table 7. Proteomic analysis of circPVT1-regulated proteins in CNE2 cells after transfected with the circPVT1overexpression or empty vectors, followed by LC-MS/MS spectrometry.
View article: Additional file 9 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 9 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 9: Supplemental Table 9. Clinicopathologicaldata of 30 paraffin-embedded NPC tissues for immunohistochemistry (IHC) and in situ hybridization (ISH).
View article: Additional file 4 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 4 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 4: Supplemental Table 4. List of antibodies for immunohistochemistry, western blotting, immunofluorescence, and RNA pull-down experiments.
View article: Additional file 2 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 2 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 2: Supplemental Table 2. Clinicopathological data of 159 paraffin-embedded NPC tissues and 29 non-neoplastic nasopharyngeal epithelialtissues for in situhybridization.
View article: Additional file 14 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 14 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 14: Table S4. List of antibodies for immunohistochemistry, western blotting, immunofluorescence, RNA pull-down, Co-immunoprecipitation, or ChIP analyses.
View article: Additional file 2 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 2 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 2: Figure S2. circCAMSAP1 promotes proliferation, migration, and invasion of NPC cells in vitro. A. The efficiency of overexpression or knockdown of circCAMSAP1 in NPC cell lines detected by RT-qPCR. *, p < 0.05; **, p < 0.…
View article: Additional file 12 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 12 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 12: Table S2. Clinicopathological data of 82 paraffin-embedded NPC tissues and 29 non-neoplastic NPE tissues for in situ hybridization.
View article: Additional file 16 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 16 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 16: Table S6. Mass spectrometry identification of proteins positively regulated by circCAMSAP1.
View article: Additional file 1 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 1 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 1: Supplemental Table 1. Clinicopathological data of 60 NPC and 26 NPE tissues measured by qRT-PCR.
View article: Additional file 13 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 13 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 13: Table S3: Probes for siRNAs, ISH, FISH, RNA pull-down and circRIP, and primers for circRIP, RIP, ChIP experiment, the overexpression vectors, the luciferase reporter vectors, and RT-qPCR.
View article: Additional file 11 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 11 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 11: Table S1. Clinicopathological data for 29 NPC tissues and 12 non-neoplastic NPE tissue samples used for RT-qPCR.
View article: Additional file 8 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop
Additional file 8 of Circular RNA circPVT1 promotes nasopharyngeal carcinoma metastasis via the β-TrCP/c-Myc/SRSF1 positive feedback loop Open
Additional file 8: Supplemental Table 8. Clinicopathological data of 3 NPC tissues measured by RNA pull-down.
View article: Additional file 15 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 15 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 15: Table S5. The top 20 circRNAs according to their RPM values in 41 NPC tissues from the GSE68799 database.
View article: Additional file 4 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop
Additional file 4 of Splicing factor derived circular RNA circCAMSAP1 accelerates nasopharyngeal carcinoma tumorigenesis via a SERPINH1/c-Myc positive feedback loop Open
Additional file 4: Figure S4. SERPINH1 promotes proliferation, migration, and invasion of NPC cells in vitro. A-B. The efficiency of SERPINH1 overexpression or knockdown in NPC cell lines examined by RT-qPCR and western blotting. *, p < 0.…