Explanipedia

A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas Open

Jeffrey R. Gehlhausen, Eric Hawley, Benjamin M. Wahle, Yongzheng He, Donna M. Edwards , et al. · 2025

Schwannomas are common, highly morbid and medically untreatable tumors that can arise in patients with germ line as well as somatic mutations in neurofibromatosis type 2 (NF2). These mutations most commonly result in the loss of function o…

Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial Open

Michael J. Fisher, Chie‐Schin Shih, Steven D. Rhodes, Amy E. Armstrong, Pamela L. Wolters , et al. · 2025

Respiratory Syncytial Virus Risk Profile in Hospitalized Infants and Comparison with Influenza and COVID-19 Controls in Valladolid, Spain, 2010–2022 Open

Mariana Haeberer, Martin Mengel, Rong Fan, Marina Toquero-Asensio, Alejandro Martín-Toribio , et al. · 2024

RSV Risk Profile in Hospitalized Adults and Comparison with Influenza and COVID-19 Controls in Valladolid, Spain, 2010–2022 Open

Mariana Haeberer, Martin Mengel, Rong Fan, Marina Toquero-Asensio, Alejandro Martín-Toribio , et al. · 2024

RSV especially affects those with comorbidities, coinfections, and living in care institutions. RSV vaccination could have an important public health impact in this population.

Clostridium butyricum regulates intestinal barrier function via trek1 to improve behavioral abnormalities in mice with autism spectrum disorder Open

Simeng Liu, Huayuan Xi, Xia Xue, Xiangdong Sun, Huang Huang , et al. · 2024

Brigatinib causes tumor shrinkage in both NF2-deficient meningioma and schwannoma through inhibition of multiple tyrosine kinases but not ALK Open

Long‐Sheng Chang, Janet L. Oblinger, Abbi E. Smith, Marc Ferrer, Steven P. Angus , et al. · 2021

Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic syndrome caused by mutations in the NF2 tumor suppressor gene resulting in multiple schwannomas and meningiomas. There are no FDA approved therapies for these tumors and their…

Cabozantinib for neurofibromatosis type 1–related plexiform neurofibromas: a phase 2 trial Open

Michael J. Fisher, Chie‐Schin Shih, Steven D. Rhodes, Amy E. Armstrong, Pamela L. Wolters , et al. · 2021

Characterization of the Tumor Microenvironment of Neurofibromatosis Type I Plexiform Neurofibromas Open

Abigail Chmiel, Steven D. Rhodes, Steven P. Angus, Yongzheng He, Quingbo Lu , et al. · 2020

Background/Objective: Neurofibromatosis type 1 (NF1) is a cancer predisposition syndrome caused by mutations in the NF1 tumor suppressor gene. Patients with NF1 develop tumors of the peripheral nervous system called plexiform neurofibromas…

Correction: Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17 Open

Julie A. Mund, SuJung Park, Abbi E. Smith, Yongzheng He, Li Jiang , et al. · 2020

Schwannoma development is mediated by Hippo pathway dysregulation and modified by RAS/MAPK signaling Open

Zhiguo Chen, Stephen Li, Juan Mo, Eric Hawley, Yong Wang , et al. · 2020

Schwannomas are tumors of the Schwann cells that cause chronic pain, numbness, and potentially life-threatening impairment of vital organs. Despite the identification of causative genes, including NF2 (Merlin), INI1/SMARCB1, and LZTR1, the…

Genetic disruption of the small GTPase RAC1 prevents plexiform neurofibroma formation in mice with neurofibromatosis type 17 Open

Julie A. Mund, SuJung Park, Abbi E. Smith, Yongzheng He, Li Jiang , et al. · 2020

Cdkn2a (Arf) loss drives NF1-associated atypical neurofibroma and malignant transformation Open

Steven D. Rhodes, Yongzheng He, Abbi E. Smith, Jiang Li, Qingbo Lu , et al. · 2019

Plexiform neurofibroma (PN) tumors are a hallmark manifestation of neurofibromatosis type 1 (NF1) that arise in the Schwann cell (SC) lineage. NF1 is a common heritable cancer predisposition syndrome caused by germline mutations in the NF1…

EXTH-13. REDUCTION OF TUMOR BURDEN AND HEARING LOSS WITH A MULTIPLE RECEPTOR TYROSINE KINASE INHIBITOR BRIGATINIB IN A GENETICALLY ENGINEERED MOUSE MODEL OF NEUROFIBROMATOSIS TYPE 2 Open

Abbi E. Smith, Waylan Bessler, Li Jiang, Xiaohong Li, Qingbo Lu , et al. · 2018

Neurofibromatosis Type 2 (NF2) is an autosomal dominant genetic disorder caused by germline mutations in the tumor suppressor gene NF2, which encodes the protein Merlin. Patients with NF2 may develop bilateral vestibular schwannomas, which…

A proteasome-resistant fragment of NIK mediates oncogenic NF-κB signaling in schwannomas Open

Jeffrey R. Gehlhausen, Eric Hawley, Benjamin M. Wahle, Yongzheng He, Donna M. Edwards , et al. · 2018

Schwannomas are common, highly morbid and medically untreatable tumors that can arise in patients with germ line as well as somatic mutations in neurofibromatosis type 2 (NF2). These mutations most commonly result in the loss of function o…

Chemopreventative celecoxib fails to prevent schwannoma formation or sensorineural hearing loss in genetically engineered murine model of neurofibromatosis type 2 Open

Benjamin M. Wahle, Eric Hawley, Yongzheng He, Abbi E. Smith, Jin Yuan , et al. · 2017

Mutations in the tumor suppressor gene NF2 lead to Neurofibromatosis type 2 (NF2), a tumor predisposition syndrome characterized by the development of schwannomas, including bilateral vestibular schwannomas with complete penetrance.…

Improving Combination Osteoporosis Therapy in a Preclinical Model of Heightened Osteoanabolism Open

Shaoqing Yu, Selene Hernandez-Buquer, Paul Childress, Keith R. Stayrook, Marta Alvarez , et al. · 2017

Combining anticatabolic agents with parathyroid hormone (PTH) to enhance bone mass has yielded mixed results in osteoporosis patients. Toward the goal of enhancing the efficacy of these regimens, we tested their utility in combination with…

An abnormal bone marrow microenvironment contributes to hematopoietic dysfunction in Fanconi anemia Open

Yuan Zhou, Yongzheng He, Wen Xing, Peng Zhang, Hui Shi , et al. · 2017

Fanconi anemia is a complex heterogeneous genetic disorder with a high incidence of bone marrow failure, clonal evolution to acute myeloid leukemia and mesenchymal-derived congenital anomalies. Increasing evidence in Fanconi anemia and oth…

ASXL1 interacts with the cohesin complex to maintain chromatid separation and gene expression for normal hematopoiesis Open

Zhaomin Li, Peng Zhang, Aimin Yan, Zhengyu Guo, Yuguang Ban , et al. · 2017

Asxl1 loss–induced myeloid malignancies are mediated partially through impaired ASXL1 cohesin interaction and cohesin functions.

Loss of Asxl1 Alters Self-Renewal and Cell Fate of Bone Marrow Stromal Cells, Leading to Bohring-Opitz-like Syndrome in Mice Open

Peng Zhang, Cai-Hong Xing, Steven D. Rhodes, Yongzheng He, Kai Deng , et al. · 2016

De novo ASXL1 mutations are found in patients with Bohring-Opitz syndrome, a disease with severe developmental defects and early childhood mortality. The underlying pathologic mechanisms remain largely unknown. Using Asxl1-targeted murine …

Genome-Wide Mapping and Interrogation of the Nmp4 Antianabolic Bone Axis Open

Paul Childress, Keith R. Stayrook, Marta Alvarez, Zhiping Wang, Shaoqing Yu , et al. · 2015

PTH is an osteoanabolic for treating osteoporosis but its potency wanes. Disabling the transcription factor nuclear matrix protein 4 (Nmp4) in healthy, ovary-intact mice enhances bone response to PTH and bone morphogenetic protein 2 and pr…

Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells Open

Yuan Zhou, Yongzheng He, Richa Sharma, Wen Xing, Selina A. Estwick , et al. · 2015

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the NF1 tumor suppressor gene, which affect approximately 1 out of 3000 individuals. Patients with NF1 suffer from a range of malignant and nonmalignant…

Hyperactive RAS/PI3-K/MAPK Signaling Cascade in Migration and Adhesion of Nf1 Haploinsufficient Mesenchymal Stem/Progenitor Cells Open

Yuan Zhou, Yongzheng He, Richa Sharma, Wen Xing, Selina A. Estwick , et al. · 2015

Neurofibromatosis type 1 (NF1) is an autosomal dominant disease caused by mutations in the NF1 tumor suppressor gene, which affect approximately 1 out of 3000 individuals. Patients with NF1 suffer from a range of malignant and nonmalignant…

<i>Nf1</i> Haploinsufficiency Alters Myeloid Lineage Commitment and Function, Leading to Deranged Skeletal Homeostasis Open

Steven D. Rhodes, Hao Yang, Ruizhi Dong, K.M.J. Menon, Yongzheng He , et al. · 2015

Although nullizygous loss of NF1 leads to myeloid malignancies, haploinsufficient loss of NF1 (Nf1) has been shown to contribute to osteopenia and osteoporosis which occurs in approximately 50% of neurofibromatosis type 1 (NF1) patients. B…

Yongzheng He YOU? Author Swipe