Yongzhi Huang
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View article: Integrating Single‐Cell and Spatial Transcriptomics Reveals NK Cell Subpopulations Associated With Immunotherapy for Melanoma
Integrating Single‐Cell and Spatial Transcriptomics Reveals NK Cell Subpopulations Associated With Immunotherapy for Melanoma Open
Immune checkpoint inhibitors (ICI) have demonstrated prolonged efficacy in certain melanoma patients, yet a significant portion of patients do not experience clinical improvement, with the mechanisms underlying this resistance still not fu…
View article: Disrupting the SHOC2-RAS Nexus: a new frontier in targeting RAS-Driven cancers
Disrupting the SHOC2-RAS Nexus: a new frontier in targeting RAS-Driven cancers Open
View article: Sleep stage can be selectively modulated through targeted deep brain stimulation of brainstem circuits
Sleep stage can be selectively modulated through targeted deep brain stimulation of brainstem circuits Open
View article: Transcription factor SP1-Mediated Upregulation of B-Myb Promotes Glioma Aggression Through Transcriptomic Mechanism
Transcription factor SP1-Mediated Upregulation of B-Myb Promotes Glioma Aggression Through Transcriptomic Mechanism Open
Background Given the limited therapeutic options for gliomas, identifying molecules with therapeutic potential remains critical. This study aimed to investigate the functional significance and regulatory mechanisms of B-Myb in glioma progr…
View article: Summary of Evidence on the Safety Management of Non‐Suicidal Self‐Injury Behaviors in Adolescents in General Hospitals
Summary of Evidence on the Safety Management of Non‐Suicidal Self‐Injury Behaviors in Adolescents in General Hospitals Open
The current study was conducted to summarize the evidence related to the safety management of non‐suicidal self‐injury behaviors in adolescents in general hospitals, providing a basis for clinical medical staff to carry out appropriate saf…
View article: Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment
Targeting ferroptosis in cancer stem cells: A novel strategy to improve cancer treatment Open
Ferroptosis, a distinct regulated cell death process characterized by iron retention and lipid peroxidation, plays a crucial role in the survival of cancer stem cells (CSCs), key contributors to cancer initiation, progression, and recurren…
View article: Telitacicept monotherapy for refractory idiopathic membranous nephropathy: a case report and literature review
Telitacicept monotherapy for refractory idiopathic membranous nephropathy: a case report and literature review Open
Background Patients with refractory membranous nephropathy (MN) face risks of progressive renal decline and end-stage renal disease (ESRD), with limited treatment efficacy. Telitacicept, a novel humanized recombinant fusion protein effecti…
View article: Unveiling fundamental principles: visualizing T cell immunity with explainable artificial intelligence
Unveiling fundamental principles: visualizing T cell immunity with explainable artificial intelligence Open
View article: Enhanced Spatial Division Multiple Access BCI Performance via Incorporating MEG With EEG
Enhanced Spatial Division Multiple Access BCI Performance via Incorporating MEG With EEG Open
Spatial division multiple access (SDMA) is a way of encoding BCI systems based on spatial distribution of brain signal characteristics. However, SDMA-BCI based on EEG had poor system performance limited by spatial resolution. MEG-EEG fusio…
View article: Secure Color Traffic Image Transmission Through Enhanced Visual Encryption
Secure Color Traffic Image Transmission Through Enhanced Visual Encryption Open
With the rapid advancement of intelligent transportation systems (ITS), secure processing of color traffic images has become critical for traffic management, safety monitoring, and flow analysis. However, ITS are increasingly susceptible t…
View article: The Trap of Complexity in Experimentation
The Trap of Complexity in Experimentation Open
View article: Integrated Molecular and Clinical Profiling of 335 Primary Gliomas in Adolescents and Young Adults
Integrated Molecular and Clinical Profiling of 335 Primary Gliomas in Adolescents and Young Adults Open
View article: Fiscal Event Geometry An X-Axis / Y-Axis Coordinate Framework for Cross-Jurisdiction and Intergenerational Analysis
Fiscal Event Geometry An X-Axis / Y-Axis Coordinate Framework for Cross-Jurisdiction and Intergenerational Analysis Open
View article: Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation
Revolutionizing treatment for disorders of consciousness: a multidisciplinary review of advancements in deep brain stimulation Open
View article: [Current progress on characteristics of intracranial electrophysiology related to prolonged disorders of consciousness].
[Current progress on characteristics of intracranial electrophysiology related to prolonged disorders of consciousness]. Open
Prolonged disorders of consciousness (pDOC) are pathological conditions of alterations in consciousness caused by various severe brain injuries, profoundly affecting patients' life ability and leading to a huge burden for both the family a…
View article: Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors
Particulate matter induces depression-like behavior through systemic inflammation and brain-derived neurotrophic factors Open
Particulate matter (PM) has always received widespread attention, PM2.5 pollution is associated with many adverse effects, including cardiovascular, respiratory and metabolic diseases and mood disorders. However, the underlying mechanisms …
View article: The L1CAM‐positive extracellular vesicle‐based biomarker as a promising predictor of Parkinson's disease
The L1CAM‐positive extracellular vesicle‐based biomarker as a promising predictor of Parkinson's disease Open
Parkinson's disease (PD) is a multifaceted neurodegenerative disorder characterized by a prolonged prodromal phase followed by the onset of clinical motor symptoms. The development of reliable biomarkers for individuals at risk of developi…
View article: MetaBCI: An open-source platform for brain–computer interfaces
MetaBCI: An open-source platform for brain–computer interfaces Open
MetaBCI can greatly lower the BCI's technical threshold for BCI beginners and can save time and cost to build up a practical BCI system. The source code is available at https://github.com/TBC-TJU/MetaBCI, expecting new contributions from t…
View article: Biosensing strategies for amyloid‐like protein aggregates
Biosensing strategies for amyloid‐like protein aggregates Open
Protein aggregate species play a pivotal role in the pathology of various degenerative diseases. Their dynamic changes are closely correlated with disease progression, making them promising candidates as diagnostic biomarkers. Given the pr…
View article: Tailoring Human Sleep: selective alteration through Brainstem Arousal Circuit Stimulation
Tailoring Human Sleep: selective alteration through Brainstem Arousal Circuit Stimulation Open
Brainstem nuclei, such as the pedunculopontine nucleus, send activating projections to cortex, modulating states of sleep, wakefulness and arousal levels. Surgical modulation of subcortical activity using deep brain stimulation (DBS) is ut…
View article: Metabci: An Open-Source Platform for Brain-Computer Interfaces
Metabci: An Open-Source Platform for Brain-Computer Interfaces Open
View article: Paired Acute Invasive/Non-invasive Stimulation (PAINS) study: A phase I/II randomized, sham-controlled crossover trial in chronic neuropathic pain
Paired Acute Invasive/Non-invasive Stimulation (PAINS) study: A phase I/II randomized, sham-controlled crossover trial in chronic neuropathic pain Open
Our results indicate that a single session of tDCS alongside DRGS is safe and can significantly reduce pain acutely in neuropathic pain patients. Paired invasive/non-invasive neuromodulation is a promising new treatment strategy for pain m…
View article: Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus
Gait-Phase Modulates Alpha and Beta Oscillations in the Pedunculopontine Nucleus Open
The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed as an eme…
View article: Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer
Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer Open
View article: Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients
Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients Open
Lateral habenula is believed to encode negative motivational stimuli and plays key roles in the pathophysiology of psychiatric disorders. However, how habenula activities are modulated during the processing of emotional information is stil…
View article: LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer
LAMA3 DNA methylation and transcriptome changes associated with chemotherapy resistance in ovarian cancer Open
Objective LAMA3 is a widely studied methylated gene in multiple tumors, but the relationship between chemotherapy resistance in ovarian cancer is unclear. In this study, LAMA3 methylation was predicted by bioinformatics, and the ability of…
View article: Author response: Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients
Author response: Increased theta/alpha synchrony in the habenula-prefrontal network with negative emotional stimuli in human patients Open
Article Figures and data Abstract Introduction Results Discussion Materials and methods Data availability References Decision letter Author response Article and author information Metrics Abstract Lateral habenula is believed to encode neg…
View article: Dosimetric effects of supine immobilization devices on the skin in intensity-modulated radiation therapy for breast cancer: a retrospective study
Dosimetric effects of supine immobilization devices on the skin in intensity-modulated radiation therapy for breast cancer: a retrospective study Open
View article: Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus
Gait-phase modulates alpha and beta oscillations in the pedunculopontine nucleus Open
Backgroud The pedunculopontine nucleus (PPN) is a reticular collection of neurons at the junction of the midbrain and pons, playing an important role in modulating posture and locomotion. Deep brain stimulation of the PPN has been proposed…
View article: Additional file 1 of Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer
Additional file 1 of Abnormal methylation characteristics predict chemoresistance and poor prognosis in advanced high-grade serous ovarian cancer Open
Additional file 1. Table S1. Amplification primers and sequencing primers for Pyrosequencing. Table S2. Primers sequence for QRT-PCR. Table S3. Pathway analysis of different methylation sites between sensitive and resistant patients in KEG…