Yoo‐Jin Kim
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View article: MRD-guided outcome analysis of ponatinib plus hyper-CVAD versus historical imatinib in ph-positive ALL: Impact of early response and dose-adjusted ponatinib
MRD-guided outcome analysis of ponatinib plus hyper-CVAD versus historical imatinib in ph-positive ALL: Impact of early response and dose-adjusted ponatinib Open
Background : The treatment strategies and outcomes of Philadelphia chromosome (Ph)-positive ALL have markedly improved with the development of tyrosine kinase inhibitors (TKIs), particularly with the introduction of ponatinib. Hyper-CVAD p…
View article: Revisiting the role of second allogeneic HCT for post-transplant relapse in acute lymphoblastic leukemia: Comparative outcomes in the era of targeted therapies
Revisiting the role of second allogeneic HCT for post-transplant relapse in acute lymphoblastic leukemia: Comparative outcomes in the era of targeted therapies Open
Background: Relapse after allogeneic hematopoietic cell transplantation (HCT) remains the leading cause of treatment failure in adult patients with acute lymphoblastic leukemia (ALL). Historically, a second HCT has been considered the stan…
View article: Clinical outcomes of WHO 2022 and ICC MDS entities with risk stratification by IPSS-R and IPSS-M
Clinical outcomes of WHO 2022 and ICC MDS entities with risk stratification by IPSS-R and IPSS-M Open
Not available.
View article: Ponatinib Monotherapy in Adult Patients with Relapsed or Refractory Philadelphia-Positive Acute Lymphoblastic Leukemia: A Real-World Retrospective Analysis Including Measurable Residual Disease Relapse
Ponatinib Monotherapy in Adult Patients with Relapsed or Refractory Philadelphia-Positive Acute Lymphoblastic Leukemia: A Real-World Retrospective Analysis Including Measurable Residual Disease Relapse Open
Introduction: The treatment of relapsed or refractory (R/R) Philadelphia chromosome (Ph)-positive acute lymphoblastic leukemia (ALL) remains challenging after failure to several tyrosine kinase inhibitors. This study evaluated the clinical…
View article: Atypical features of hepatic veno-occlusive disease/sinusoidal obstruction syndrome after inotuzumab ozogamicin in adult patients with acute lymphoblastic leukemia
Atypical features of hepatic veno-occlusive disease/sinusoidal obstruction syndrome after inotuzumab ozogamicin in adult patients with acute lymphoblastic leukemia Open
View article: Claudins in vulvar cancer – from epithelial barrier to potential tumor-agnostic cancer therapy
Claudins in vulvar cancer – from epithelial barrier to potential tumor-agnostic cancer therapy Open
The immunohistochemical expression of various members of the claudin family has already been studied in pathological affections of the vulva whether to differentiate precancerous lesions from vulvar squamous cell carcinoma or in inflammato…
View article: Hematopoietic stem cell transplantation to improve prognosis in aggressive monomorphic epitheliotropic intestinal T-cell lymphoma
Hematopoietic stem cell transplantation to improve prognosis in aggressive monomorphic epitheliotropic intestinal T-cell lymphoma Open
Introduction Monomorphic epitheliotropic intestinal T-cell lymphoma (MEITL) is a rare, aggressive subtype of primary gastrointestinal T-cell lymphoma. Owing to the absence of symptoms characteristic of MEITL, diagnosis can be challenging, …
View article: Impact of an antimicrobial stewardship programme on antibiotic utilization and resistance burden in patients with acute leukaemia: an 11-year longitudinal cohort study using interrupted time-series analysis
Impact of an antimicrobial stewardship programme on antibiotic utilization and resistance burden in patients with acute leukaemia: an 11-year longitudinal cohort study using interrupted time-series analysis Open
Background Antimicrobial resistance (AMR), driven by inappropriate and overuse of antibiotics, poses a significant threat, especially to patients with acute leukaemia. Objectives To evaluate the impact of antimicrobial stewardship programm…
View article: Classification and prognostic stratification based on genomic features in myelodysplastic neoplasms, myeloproliferative neoplasms, and their overlapping conditions
Classification and prognostic stratification based on genomic features in myelodysplastic neoplasms, myeloproliferative neoplasms, and their overlapping conditions Open
In this study, we analyzed clinical and genomic data from 1,585 patients diagnosed with myeloid neoplasms (MNs), including myeloproliferative neoplasms (MPN, n = 715), myelodysplastic neoplasms (MDS, n = 698), MDS/MPN (n = 94), and aplasti…
View article: Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation Open
DEAD box helicase 41 (DDX41) mutations are the most prevalent predisposition to familial myelodysplastic syndrome (MDS). However, the precise roles of these variants in the pathogenesis of MDS have yet to be elucidated. Here, we discovered…
View article: Prognostic Role Of Physical Function in Older Adults with Acute Myeloid Leukemia Treated by Lower-Intensity Therapy: A Prospective Cohort Study
Prognostic Role Of Physical Function in Older Adults with Acute Myeloid Leukemia Treated by Lower-Intensity Therapy: A Prospective Cohort Study Open
View article: Reduced toxicity (FluBu3) versus myeloablative (BuCy) conditioning in acute myeloid leukemia patients who received first allogeneic hematopoietic stem cell transplantation in measurable residual disease-negative CR1
Reduced toxicity (FluBu3) versus myeloablative (BuCy) conditioning in acute myeloid leukemia patients who received first allogeneic hematopoietic stem cell transplantation in measurable residual disease-negative CR1 Open
In the present study, reduced toxicity (FluBu3) and myeloablative (BuCy) conditioning were compared in patients with AML who received first allogeneic HSCT in MRD-negative CR1. The study included 124 adult patients who underwent HSCT from …
View article: Dynamic changes in physical function during intensive chemotherapy affect transplant outcomes in older adults with AML
Dynamic changes in physical function during intensive chemotherapy affect transplant outcomes in older adults with AML Open
Introduction Intensive chemotherapy (IC) can affect all geriatric assessment (GA) domains in older adults with acute myeloid leukemia (AML), but data on the effects of these changes on transplant outcomes are lacking. Methods Therefore, we…
View article: The salvage role of allogeneic hematopoietic stem-cell transplantation in relapsed/refractory diffuse large B cell lymphoma
The salvage role of allogeneic hematopoietic stem-cell transplantation in relapsed/refractory diffuse large B cell lymphoma Open
View article: Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation
Impaired binding affinity of YTHDC1 with METTL3/METTL14 results in R-loop accumulation in myelodysplastic neoplasms with DDX41 mutation Open
DEAD box helicase 41 (DDX41) mutations are the most prevalent predisposition to familial myelodysplastic syndrome (MDS). However, the precise roles of these variants in the pathogenesis of MDS have yet to be elucidated. Here, we discovered…
View article: Cytomegalovirus Infection after Allogeneic Hematopoietic Cell Transplantation under 100-Day Letermovir Prophylaxis: A Real-World 1-Year Follow-Up Study
Cytomegalovirus Infection after Allogeneic Hematopoietic Cell Transplantation under 100-Day Letermovir Prophylaxis: A Real-World 1-Year Follow-Up Study Open
The prevention and management of cytomegalovirus (CMV) reactivation is important to improve the outcomes of allogeneic hematopoietic cell transplantation (allo-HCT) recipients. The aim of this study was to analyze real-world data regarding…
View article: Cytomegalovirus Infection after Allogeneic Hematopoietic Cell Transplantation under 100-day Letermovir Prophylaxis: a Real-world, 1-year Follow-up Study
Cytomegalovirus Infection after Allogeneic Hematopoietic Cell Transplantation under 100-day Letermovir Prophylaxis: a Real-world, 1-year Follow-up Study Open
Prevention and management of cytomegalovirus (CMV) reactivation is important to improve outcome of allogeneic hematopoietic cell transplantation (allo-HCT) recipients. The aim of this study was to analyze real-world data for incidence and …
View article: Efficacy of ex vivo purging with CD34+ selection to maximize the effects of autologous stem cell transplantation in peripheral T-cell lymphoma patients
Efficacy of ex vivo purging with CD34+ selection to maximize the effects of autologous stem cell transplantation in peripheral T-cell lymphoma patients Open
CD34+ selective purging in PTCL patients undergoing HDT/ASCT improved survival outcomes and reduced relapse risk. The procedure increased NK cell counts and post-ASCT LMR. CD34+ selective purging may minimize autograft tumor cell contamina…
View article: Efficacy and safety of mucous fistula refeeding in preterm infants: an exploratory randomized controlled trial
Efficacy and safety of mucous fistula refeeding in preterm infants: an exploratory randomized controlled trial Open
View article: A Successful Bridge Therapy Combining Hypomethylating Agents with Venetoclax for Adult Patients with Newly Diagnosed or Relapsed/Refractory Acute Myeloid Leukemia
A Successful Bridge Therapy Combining Hypomethylating Agents with Venetoclax for Adult Patients with Newly Diagnosed or Relapsed/Refractory Acute Myeloid Leukemia Open
Recently, the combination of VEN-HMA has been shown to achieve durable responses in patients with both newly diagnosed (ND) and R/R-AML. We retrospectively evaluated the post-allo-HCT outcomes of 50 patients who received VEN-HMA therapy. I…
View article: Haploidentical versus Double-Cord Blood Stem Cells as a Second Transplantation for Relapsed Acute Myeloid Leukemia
Haploidentical versus Double-Cord Blood Stem Cells as a Second Transplantation for Relapsed Acute Myeloid Leukemia Open
There are limited data on second stem cell transplantation (SCT2) outcomes with alternative donors for relapsed AML after the first stem cell transplantation (SCT1). We analyzed the outcomes of 52 adult AML patients who received SCT2 from …
View article: Superior survival outcome of blinatumomab compared with conventional chemotherapy for adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia: a propensity score–matched cohort analysis
Superior survival outcome of blinatumomab compared with conventional chemotherapy for adult patients with relapsed or refractory B-cell precursor acute lymphoblastic leukemia: a propensity score–matched cohort analysis Open
Background: Blinatumomab showed a higher complete remission (CR) rate and a safe bridging to allogeneic hematopoietic cell transplantation (allo-HCT) in adults with relapsed or refractory B-cell precursor acute lymphoblastic leukemia (R/R …
View article: Venetoclax with decitabine versus decitabine monotherapy in elderly acute myeloid leukemia: a propensity score-matched analysis
Venetoclax with decitabine versus decitabine monotherapy in elderly acute myeloid leukemia: a propensity score-matched analysis Open
View article: Higher prevalence of rotavirus infection among out-born newborns transferred to a regional neonatal intensive care unit in Korea
Higher prevalence of rotavirus infection among out-born newborns transferred to a regional neonatal intensive care unit in Korea Open
View article: Efficacy of ex vivo Purging with CD34+ Selection to Maximize the Effects of Autologous Stem Cell Transplantation in Peripheral T-cell Lymphoma Patients
Efficacy of ex vivo Purging with CD34+ Selection to Maximize the Effects of Autologous Stem Cell Transplantation in Peripheral T-cell Lymphoma Patients Open
Background: Autologous stem cell transplantation (ASCT) is the standard treatment for peripheral T-cell lymphomas (PTCLs). Strategies that reduce the relapse rate and treatment-related mortality are essential for successful ASCT. Because i…
View article: Clinical Features, Gene Alterations, and Outcomes in Prefibrotic and Overt Primary and Secondary Myelofibrotic Patients
Clinical Features, Gene Alterations, and Outcomes in Prefibrotic and Overt Primary and Secondary Myelofibrotic Patients Open
The Philadelphia-negative myeloproliferative neoplasms (MPNs) are divided in three major groups: polycythemia vera (PV), essential thrombocythemia (ET), and primary myelofibrosis (PMF). The 2016 WHO classification incorporates also prefibr…
View article: Long-term treatment outcome of Castleman’s disease: A real-world experience
Long-term treatment outcome of Castleman’s disease: A real-world experience Open
Background Castleman disease (CD), classified as unicentric CD (UCD) or multicentric CD (MCD), is a rare non-neoplastic lymphoproliferative disorder of unknown origin. Owing to its rarity, the clinical characteristics, therapeutic modaliti…
View article: Treatment for relapsed acute promyelocytic leukemia: what is the best post-remission treatment?
Treatment for relapsed acute promyelocytic leukemia: what is the best post-remission treatment? Open
Post-remission treatment outcomes of patients with relapsed APL were not significantly different, regardless of the treatment option, suggesting the feasibility of ATO-based treatment without HSCT in mCR2. Allogeneic HSCT may be an effecti…
View article: Efficacy and safety of mucous fistula refeeding in preterm infants: An exploratory randomized controlled trial
Efficacy and safety of mucous fistula refeeding in preterm infants: An exploratory randomized controlled trial Open
Background: This study aimed to evaluate whether mucous fistula refeeding (MFR) is safe and beneficial for the growth and intestinal adaptation of preterm infants with enterostomies. Methods: This exploratory randomized controlled trial en…
View article: Depth of Response to Intensive Chemotherapy Has Significant Prognostic Value among Acute Myeloid Leukemia (AML) Patients Undergoing Allogeneic Hematopoietic Stem-Cell Transplantation with Intermediate or Adverse Risk at Diagnosis Compared to At-Risk Group According to European Leukemia Net 2017 Risk Stratification
Depth of Response to Intensive Chemotherapy Has Significant Prognostic Value among Acute Myeloid Leukemia (AML) Patients Undergoing Allogeneic Hematopoietic Stem-Cell Transplantation with Intermediate or Adverse Risk at Diagnosis Compared to At-Risk Group According to European Leukemia Net 2017 Risk Stratification Open
We evaluated the prognostic efficiency of the European Leukemia Net (ELN) 2017 criteria on the post-transplant outcomes of 174 patients with intermediate (INT; n = 108, 62%) or adverse (ADV) risk (n = 66, 38%) of acute myeloid leukemia; th…