Yoojun Nam
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View article: Clinical-grade iPSC-derived chondrogenic micropellets for treating advanced cartilage defects
Clinical-grade iPSC-derived chondrogenic micropellets for treating advanced cartilage defects Open
Induced pluripotent stem cell (iPSC)–derived chondrogenic tissues represent a promising alternative for treating cartilage defects in chronic degenerative joint conditions such as osteoarthritis (OA). Cartilage tissue has limited self-repa…
View article: Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications
Advances in the characterization of in vitro–generated red blood cells: from biophysical properties to functional applications Open
This review underscores both current advances and persistent challenges in characterizing in vitro-generated RBCs, and it proposes a translational framework that integrates multi-omics data into their development and evaluation. By explici…
View article: Advances in Cell and Gene Therapy for Rare Disease Treatment
Advances in Cell and Gene Therapy for Rare Disease Treatment Open
A rare disease is generally defined as a medical condition that affects a small proportion of the population, though specific thresholds vary across countries. Despite regional differences, these definitions consistently reflect the low pr…
View article: Advanced Animal Replacement Testing Strategies Using Stem Cell and Organoids
Advanced Animal Replacement Testing Strategies Using Stem Cell and Organoids Open
The increasing ethical concerns and regulatory restrictions surrounding animal testing have accelerated the development of advanced in vitro models that more accurately replicate human physiology. Among these, stem cell-based systems and o…
View article: iPSC‐Derived MSC Secretome as a Protective and Restorative Modality for Atopic Dermatitis
iPSC‐Derived MSC Secretome as a Protective and Restorative Modality for Atopic Dermatitis Open
Background Atopic dermatitis (AD) is a chronic inflammatory skin disease that significantly impacts quality of life. Reducing inflammation and restoring the skin barrier are key to its management. Objective This study aimed to investigate …
View article: Generation of hypoimmunogenic universal iPSCs through HLA-type gene knockout
Generation of hypoimmunogenic universal iPSCs through HLA-type gene knockout Open
Hypoimmunogenic universal induced pluripotent stem cells (iPSCs) were generated through the targeted disruption of key genes, including human leukocyte antigen (HLA)-A, HLA-B, and HLA-DR alpha (DRA), using the CRISPR/Cas9 system. This appr…
View article: Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model
Combination of induced pluripotent stem cell-derived motor neuron progenitor cells with irradiated brain-derived neurotrophic factor over-expressing engineered mesenchymal stem cells enhanced restoration of axonal regeneration in a chronic spinal cord injury rat model Open
Background Spinal cord injury (SCI) is a disease that causes permanent impairment of motor, sensory, and autonomic nervous system functions. Stem cell transplantation for neuron regeneration is a promising strategic treatment for SCI. Howe…
View article: Exploration of Efficient HLA Haplotypes by Comparing the Proportion of Applicable Populations
Exploration of Efficient HLA Haplotypes by Comparing the Proportion of Applicable Populations Open
With the aging population, the incidence of degenerative diseases such as dementia and arthritis is on the rise. To combat these diseases, cell therapies using induced pluripotent stem cells (iPSCs) are being developed worldwide. However, …
View article: Prochondrogenic effect of decellularized extracellular matrix secreted from human induced pluripotent stem cell-derived chondrocytes
Prochondrogenic effect of decellularized extracellular matrix secreted from human induced pluripotent stem cell-derived chondrocytes Open
Cartilage is mainly composed of chondrocytes and the extracellular matrix (ECM), which transmits important biochemical and biomechanical signals necessary for differentiation and homeostasis. Human articular cartilage has a low ability for…
View article: Differential effects of periodontal microbiome on the rheumatoid factor induction during rheumatoid arthritis pathogenesis
Differential effects of periodontal microbiome on the rheumatoid factor induction during rheumatoid arthritis pathogenesis Open
Association between exposure to periodontal bacteria and development of autoantibodies related to rheumatoid arthritis (RA) has been widely accepted; however, direct causal relationship between periodontal bacteria and rheumatoid factor (R…
View article: Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid
Mitigating Effect of Estrogen in Alzheimer’s Disease-Mimicking Cerebral Organoid Open
Alzheimer’s disease (AD) is the most common condition in patients with dementia and affects a large population worldwide. The incidence of AD is expected to increase in future owing to the rapid expansion of the aged population globally. R…
View article: Lupus Heart Disease Modeling with Combination of Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Lupus Patient Serum
Lupus Heart Disease Modeling with Combination of Induced Pluripotent Stem Cell-Derived Cardiomyocytes and Lupus Patient Serum Open
iPSC derived cardiomyocytes with patient-derived serum, and anti-Ro antibody treatment could serve in effective autoimmune disease modeling including SLE. We believe that the present study might briefly provide possibilities on the applica…
View article: Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis
Application of Induced Pluripotent Stem Cells for Disease Modeling and 3D Model Construction: Focus on Osteoarthritis Open
Since their discovery in 2006, induced pluripotent stem cells (iPSCs) have shown promising potential, specifically because of their accessibility and plasticity. Hence, the clinical applicability of iPSCs was investigated in various fields…
View article: Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated COL1A1 Gene in Osteogenesis Imperfecta
Restoration of Osteogenesis by CRISPR/Cas9 Genome Editing of the Mutated COL1A1 Gene in Osteogenesis Imperfecta Open
Osteogenesis imperfecta (OI) is a genetic disease characterized by bone fragility and repeated fractures. The bone fragility associated with OI is caused by a defect in collagen formation due to mutation of COL1A1 or COL1A2. Current strate…
View article: Minicircles for Investigating and Treating Arthritic Diseases
Minicircles for Investigating and Treating Arthritic Diseases Open
Gene delivery systems have become an essential component of research and the development of therapeutics for various diseases. Minicircles are non-viral vectors with promising characteristics for application in a variety of fields. With th…
View article: Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis
Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis Open
Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties. With high expectations, many ongoing clinical trials are investigat…
View article: Characterization of Early-Onset Finger Osteoarthritis-Like Condition Using Patient-Derived Induced Pluripotent Stem Cells
Characterization of Early-Onset Finger Osteoarthritis-Like Condition Using Patient-Derived Induced Pluripotent Stem Cells Open
Early osteoarthritis (OA)-like symptoms are difficult to study owing to the lack of disease samples and animal models. In this study, we generated induced pluripotent stem cell (iPSC) lines from a patient with a radiographic early-onset fi…
View article: The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression Open
Osteoarthritis (OA) is the most common joint disease that causes pain and disability in the adult population. OA is primarily caused by trauma induced by an external force or by age-related cartilage damage. Chondrocyte hypertrophy or chon…
View article: Chondrogenic Differentiation from Induced Pluripotent Stem Cells Using Non-Viral Minicircle Vectors
Chondrogenic Differentiation from Induced Pluripotent Stem Cells Using Non-Viral Minicircle Vectors Open
Human degenerative cartilage has low regenerative potential. Chondrocyte transplantation offers a promising strategy for cartilage treatment and regeneration. Currently, chondrogenesis using human pluripotent stem cells (hiPSCs) is accompl…
View article: Current Stem Cell Therapy for Osteoarthritis
Current Stem Cell Therapy for Osteoarthritis Open
Osteoarthritis is a musculoskeletal disease representative of an aging society. As medical conditions are usually complicated in an aging population, osteoarthritis becomes more frequently encountered in the physicianâs office. There is …
View article: Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration
Application of Cord Blood and Cord Blood-Derived Induced Pluripotent Stem Cells for Cartilage Regeneration Open
Regeneration of articular cartilage is of great interest in cartilage tissue engineering since articular cartilage has a low regenerative capacity. Due to the difficulty in obtaining healthy cartilage for transplantation, there is a need t…
View article: Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells
Establishment of a complex skin structure via layered co-culture of keratinocytes and fibroblasts derived from induced pluripotent stem cells Open
This study reveals that a human skin organoid generated using CBMC iPSCs is a novel tool for in-vitro and in-vivo dermatologic research.