Explanipedia

Multi-modal virtual reality system for tinnitus treatment methods and validation Open

Hojun Aan, Kang Hyeon Lim, Jihoo Kim, Han Jo Kim, Ye Hwan Lee , et al. · 2025

Virtual reality (VR) has been utilized in clinical treatment because it can efficiently simulate situations that are difficult to control in the real world. In this study, we evaluated the efficacy of VR in patients with chronic subjective…

Protective Effects of Fasudil Against Cisplatin-Induced Ototoxicity in Zebrafish: An In Vivo Study Open

Kang Hyeon Lim, Saemi Park, Eun‐Jung Han, Hyun woo Baek, Kyungtae Hyun , et al. · 2024

While cisplatin is an effective anti-tumor treatment, it induces ototoxicity through mechanisms involving DNA damage, oxidative stress, and programmed cell death. Rho-associated coiled-coil-containing protein kinase (ROCK) is essential for…

Evaluating Prediction Models with Hearing Handicap Inventory for the Elderly in Chronic Otitis Media Patients Open

Hee Soo Yoon, Minjin Kim, Kang Hyeon Lim, Min Suk Kim, Byung Jae Kang , et al. · 2024

Background: This retrospective, cross-sectional study aimed to assess the functional hearing capacity of individuals with Chronic Otitis Media (COM) using prediction modeling techniques and the Hearing Handicap Inventory for the Elderly (H…

Association of the protective effect of telmisartan on hearing loss among patients with hypertension Open

Jung-Joon Cha, Yunjin Yum, Yong Hyun Kim, Eung Ju Kim, Yoon Chan Rah , et al. · 2024

Aim Hearing loss, affecting a significant portion of the global population, is prevented with peroxisome proliferator-activated receptor γ agonism. Understanding potential protective treatments is crucial for public health. We examine the …

Contralateral Hearing Loss in Temporal Bone Fractures: A Potential Association with Combined Intracranial Injury Open

Bumjoon J. Kim, Insik Song, June Choi, Yoon Chan Rah · 2024

BACKGROUND: Temporal bone (TB) fractures are frequently accompanied by intracranial injury. This study aimed to analyze combined intracranial injuries in relation to functional changes in the inner ear, including those of the contralateral…

Long Term Changes of Facial Nerve Schwannoma Open

Hee Soo Yoon, Sang Yeop Kim, June Choi, Yoon Chan Rah · 2024

Facial nerve schwannoma is a benign tumor which can emerge at any point along the facial nerve's course. It is characterized by its slow growth and a wide spectrum of symptoms, ranging from asymptomatic cases to involvement of lower crania…

Electrophysiological Changes Associated with the Progression of Noise-Induced Hearing Loss Open

Young‐Soo Chang, Insik Song, JungHyun Han, June Choi, Yoon Chan Rah · 2023

BACKGROUND: The aim of this study is to evaluate the clinical characteristics and electrophysiological changes in patients with different degrees of noise-induced hearing loss compared with those of normal controls to elucidate the progres…

Prediction of Hearing Prognosis After Intact Canal Wall Mastoidectomy With Tympanoplasty Using Artificial Intelligence Open

Sung Jin Lim, Eun‐Tae Jeon, Namyoung Baek, Young Han Chung, Sang Yeop Kim , et al. · 2023

Objective To evaluate the performance of a machine learning model and the effects of major prognostic factors on hearing outcomes following intact canal wall (ICW) mastoidectomy with tympanoplasty. Study Design Retrospective cross‐sectiona…

Hydrophilic and lipophilic statin use and risk of hearing loss in hyperlipidemia using a Common Data Model: multicenter cohort study Open

Insik Song, Minjin Kim, Hangseok Choi, Jeong Hwan Kim, Kang Hyeon Lim , et al. · 2023

Hearing impairment, the third largest health burden worldwide, currently lacks definitive treatments or preventive drugs. This study compared the effects of hydrophilic and lipophilic statin on hearing loss using a common database model. T…

A Multicenter Cohort Study on the Association between Metformin Use and Hearing Loss in Patients with Type 2 Diabetes Mellitus Using a Common Data Model Open

Minjin Kim, Dong Hyun Park, Hangseok Choi, Insik Song, Kang Hyeon Lim , et al. · 2023

We attempted to explore the association between metformin use and hearing loss in in a large-scale study. This retrospective multicenter cohort study assessed the data of patients with type 2 diabetes mellitus (DM) aged over 40 years using…

Clonazepam Usage Improves Chronic Tinnitus and Sleep Quality: A Prospective Cohort Study Open

Hyeon Geun Kim, Ho young Lee, Euyhyun Park, June Choi, Yoon Chan Rah , et al. · 2022

Background and Objectives Tinnitus, although being a common chronic disease, can be an intractable disease that causes depression and insomnia. This study aimed to analyze the results of the Tinnitus Handicap Inventory (THI), Beck Depressi…

Functional Outcomes of Single-Stage Ossiculoplasty in Chronic Otitis Media With or Without Cholesteatoma* Open

Seongbin Park, Kang Hyeon Lim, Sung Jin Lim, Dong Hyun Park, Yoon Chan Rah , et al. · 2022

BACKGROUND: Two-stage ossiculoplasty has been widely used for hearing improvement in chronic otitis media with or without cholesteatoma. However, the outcomes of single-stage ossiculoplasty have not been fully clarified.The aim of this stu…

Analysis of Confirmatory Auditory Responses in Unilateral Tinnitus Patients with Normal Hearing Open

Yong Jun Jeong, Kyoung Ho Oh, Sung Jin Lim, Dong Hyun Park, Yoon Chan Rah , et al. · 2022

In patients with unilateral tinnitus with normal hearing, several studies have compared the ipsilateral and contralateral ears; however, few studies have investigated its relationship with the duration of tinnitus. We compared the auditory…

Prediction of hearing recovery in unilateral sudden sensorineural hearing loss using artificial intelligence Open

Min Kyu Lee, Eun‐Tae Jeon, Namyoung Baek, Jeong Hwan Kim, Yoon Chan Rah , et al. · 2022

A Comprehensive Characterization of Temporal Rheotactic Behaviors in Lateral Line Damaged Zebrafish Larvae Open

Eun‐Jung Han, Yun Jae Choi, Saemi Park, Yoon Chan Rah, Hae‐Chul Park , et al. · 2022

Pupil responses associated with the perception of gravitational vertical under directional optic flows Open

Joo Hyun Park, Sung Ik Cho, June Choi, JungHyun Han, Yoon Chan Rah · 2021

Surgical Outcomes of Pure-Fat Myringoplasty for Small Tympanic Membrane Perforations: A Retrospective Study and Summary of the Literature in the Last 10 Years Open

Min Kyu Lee, Tae Min Kim, Sung Jin Lim, Dong Hyun Park, Yoon Chan Rah , et al. · 2021

Background and Objectives Fat myringoplasty is a simple, fast, and effective procedure for repairing tympanic membrane (TM) perforations. The aim of this study is to evaluate the surgical outcomes of pure-fat myringoplasty for small TM per…

The Need to Consider Vestibular Function in Cochlear Implantation Open

Yoon Chan Rah · 2021

Association between the severity of hearing loss and the risk of dementia within the 2010–2017 national insurance service survey in South Korea Open

Young‐Soo Chang, Yoon Chan Rah, Min Kyu Lee, Seongbin Park, Bongseong Kim , et al. · 2020

Hearing loss and dementia are highly prevalent neurologic conditions in older adults that can considerably impact the quality of life and create social and familial burdens. To investigate the impact of hearing loss on the risk of developi…

Analysis of Auditory Brainstem Response Change, according to Tinnitus Duration, in Patients with Tinnitus with Normal Hearing Open

Jae Woo Joo, Yong Jun Jeong, Mun Soo Han, Young‐Soo Chang, Yoon Chan Rah , et al. · 2020

OBJECTIVES: The purpose of this study was to analyze auditory brainstem response (ABR) waveforms of patients with tinnitus with normal hearing, according to tinnitus duration, and demonstrate the possible pathophysiological mechanisms of t…

Clinical Characteristics and Treatment Outcomes of Congenital Cholesteatoma Open

In Sik Song, Won Gue Han, Kang Hyeon Lim, Kuk Jin Nam, Myung Hoon Yoo , et al. · 2019

OBJECTIVES: Since its introduction in 2002, the staging system for congenital cholesteatoma, as defined by Potsic, has been used widely owing to its simplicity and predictability. The aim of the present study was to analyze the clinical ch…

The Effect of Natural Ocean Sound Exposure and Ocean-Side Relaxation on Chronic Tinnitus Patients: A Pilot Study in Korea Open

Kang Hyeon Lim, Kuk Jin Nam, Yoon Chan Rah, Jaehyung Cha, Sung Jae Lee , et al. · 2019

Sound therapy is a treatment modality for tinnitus patients by increasing the background neuronal activity in the auditory system and inducing relative alleviation of the tinnitus. This study was performed to evaluate the efficacy of natur…

Evaluation of Ototoxicity of an Antifog Agent and the Suspected Underlying Mechanisms: An Animal Study Open

Jihye Rhee, Eun‐Jung Han, Yoon Chan Rah, Saemi Park, Soonil Koun , et al. · 2019

Use of rigid endoscopes has become widespread in middle ear surgeries, thereby attracting attention to the safety of antifog agents. However, few studies on the ototoxicity of antifog agents have been conducted. The purpose of this study w…

Comparisons among Vestibular Examinations and Symptoms of Vertigo in Sudden Sensorineural Hearing Loss Patients Open

Kang Hyeon Lim, Yong Jun Jeong, Mun Soo Han, Yoon Chan Rah, Jaehyung Cha , et al. · 2018

Objective Vertigo in sudden sensorineural hearing loss (SSNHL) is hypothesized as an extension of the disease caused by the anatomical proximity of the cochlea and vestibule. The present study aimed to demonstrate the association of vestib…

Impact of Nicotine Exposure on Hair Cell Toxicity and Embryotoxicity During Zebrafish Development Open

Myung Hoon Yoo, Yoon Chan Rah, Saemi Park, Soonil Koun, Gi Jung Im , et al. · 2018

The current results suggest that nicotine induces dose-dependent hair cell toxicity in embryos by promoting apoptosis and mitochondrial and structural damage.

Questionnaires in Patients with Unilateral Sudden Sensorineural Hearing Loss Open

Gyu Ho Hwang, Jae Woo Joo, In Sik Song, Yoon Chan Rah, June Choi · 2017

OBJECTIVE: In this study, we evaluated the prognostic value of the Dizziness Handicap Inventory (DHI) and the Tinnitus Handicap Inventory (THI) in patients with unilateral sudden sensorineural hearing loss (SSNHL). MATERIALS and METHODS: I…

Analysis of Eustachian Tube Dysfunction by Dynamic Slow Motion Video Endoscopy and Eustachian Tube Dysfunction Questionnaire in Chronic Otitis Media Open

Won Gue Han, Jun Hwan Yoo, Yoon Chan Rah, Jiwon Chang, Gi Jung Im , et al. · 2017

DSVE and ETDQ-7 can provide information regarding preoperative status of eustachian tube dysfunction by measuring dynamic structural changes of the eustachian tube in combination with other diagnostic tests.

Clinical Correlation between Perverted Nystagmus and Brain MRI Abnormal Findings Open

Won-gue Han, Hee-Chul Yoon, Tae Min Kim, Yoon Chan Rah, June Choi · 2016

Perverted nystagmus was considered to the abnormalities at brain lesions, especially cerebellum, but neurologic symptoms and further evaluation were needed for exact diagnosis of central originated vertigo.

Sodium Selenite Acts as an Otoprotectant against Neomycin-Induced Hair Cell Damage in a Zebrafish Model Open

Jiwon Chang, June Choi, Yoon Chan Rah, Myung Hoon Yoo, Kyoung Ho Oh , et al. · 2016

Sodium selenite is a trace element essential for many physiological functions in the body. It is involved in various biological processes; it acts as a cofactor for antioxidant enzymes that protect against free radicals and is reported to …

Effect of Cadmium on Human Middle Ear Epithelial Cells Open

Jae‐Jun Song, Ju Yeon Kim, An‐Soo Jang, Shin Hye Kim, Yoon Chan Rah , et al. · 2016

OBJECTIVE: Cadmium (Cd2+) exposure can occur through passive smoking, ambient air pollution, and food. Even low exposure can affect hearing and cause lung disease. Here we investigated whether cadmium causes cytotoxicity, induces inflammat…

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