Jung Tak Park
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View article: #1247 Prognostic significance of Soluble urokinase-type plasminogen activator receptor (suPAR) in patients with glomerulonephritis: association with renal outcomes
#1247 Prognostic significance of Soluble urokinase-type plasminogen activator receptor (suPAR) in patients with glomerulonephritis: association with renal outcomes Open
Background and Aims Studies determining the relation between soluble urokinase-type plasminogen activator receptor (suPAR) levels and clinical outcomes in glomerulonephritis (GN) are limited. In this study, we aimed to investigate the asso…
View article: Soluble receptor for advanced glycation end products attenuates sepsis-associated acute kidney injury
Soluble receptor for advanced glycation end products attenuates sepsis-associated acute kidney injury Open
These findings suggest that RAGE plays an important role in septic AKI, and its inhibition by sRAGE may be a potential therapeutic target for AKI in severe sepsis.
View article: Deep learning-based quantitative analysis of glomerular morphology in IgA nephropathy whole slide images and its prognostic implications
Deep learning-based quantitative analysis of glomerular morphology in IgA nephropathy whole slide images and its prognostic implications Open
Kidney pathology of immunoglobulin A nephropathy (IgAN), which is the key finding of both diagnosis and risk stratification, involves labor-intensive manual interpretation as well as unavoidable interpreter-dependent variabilities. We prop…
View article: Association between polygenic risk scores for hypertension and low-density lipoprotein cholesterol with incident chronic kidney disease
Association between polygenic risk scores for hypertension and low-density lipoprotein cholesterol with incident chronic kidney disease Open
This study showed that individuals with a higher genetic predisposition to HTN were more likely to develop CKD than those predisposed to a high LDL-C concentration. Additionally, higher genetic predispositions for these two factors did not…
View article: Impact of occupational death trauma on burnout among mental health professionals: the mediating role of secondary traumatic stress
Impact of occupational death trauma on burnout among mental health professionals: the mediating role of secondary traumatic stress Open
Introduction In response to growing evidence regarding the psychological burden of client deaths on mental health professionals (MHPs), this study investigates how occupational death trauma influences burnout, particularly through the medi…
View article: Childhood trauma is associated with perceived stress and hair cortisol levels characterized by the BDNF Val66Met genotype and sex
Childhood trauma is associated with perceived stress and hair cortisol levels characterized by the BDNF Val66Met genotype and sex Open
Introduction Childhood trauma increases the risk of mental disorders by affecting both psychological and physiological stress responses in adulthood, including perceived stress and long-term hypothalamic-pituitary-adrenal (HPA) axis activi…
View article: Twin glomeruli: a newly discovered marker of neonephrogenesis in the ischemia-reperfusion injured adult mouse kidney
Twin glomeruli: a newly discovered marker of neonephrogenesis in the ischemia-reperfusion injured adult mouse kidney Open
The renal glomerulus, a capillary plexus between two arterioles, is crucial for urine production in mammals. While partial glomerular regeneration after renal injury is well recognized, its precise mechanisms remain unclear. However, stere…
View article: Intent to Die and Suicide Attempts: Exploring Clinical and Circumstantial Correlates
Intent to Die and Suicide Attempts: Exploring Clinical and Circumstantial Correlates Open
Introduction Intent to die is a crucial factor in assessing the risk of suicide attempts, which is difficult to measure. Objectives This study examined the characteristics of suicide attempters based on intent to die and aimed to investiga…
View article: Expanded Hemodialysis with Theranova Dialyzer and Residual Kidney Function in Patients Starting Long-Term Hemodialysis
Expanded Hemodialysis with Theranova Dialyzer and Residual Kidney Function in Patients Starting Long-Term Hemodialysis Open
Key Points This randomized controlled trial evaluated the effect of expanded hemodialysis on preserving residual kidney function in patients starting treatment with long-term hemodialysis. The expanded hemodialysis group with Theranova dia…
View article: Phase Angle following Intradialytic Neuromuscular Electrical Stimulation and Oral Protein Supplementation in Patients undergoing Chronic Hemodialysis
Phase Angle following Intradialytic Neuromuscular Electrical Stimulation and Oral Protein Supplementation in Patients undergoing Chronic Hemodialysis Open
Background: Sarcopenia is a prevalent condition in patients undergoing chronic hemodialysis. Therefore, a convenient and reliable method of monitoring muscle health is required. This study identified the utility of the phase angle (PhA) to…
View article: The impact of shortening patient–doctor contact duration on early peritoneal dialysis-related infections
The impact of shortening patient–doctor contact duration on early peritoneal dialysis-related infections Open
Early peritoneal dialysis (PD)-related infection is a severe complication. This study investigated the relationship between patient-doctor contact (PDC) duration and early PD-related infection. In the Peritoneal Dialysis Outcomes and Pract…
View article: Significance of intrarenal vascular lesions in Ig A nephropathy prognosis
Significance of intrarenal vascular lesions in Ig A nephropathy prognosis Open
Background Immunoglobulin A (IgA) nephropathy is the predominant primary glomerulonephritis globally and remains a subject of active research with a focus on understanding its course and prognosis. Although vascular lesions are associated …
View article: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization Open
The gram-negative bacterium lipopolysaccharide (LPS) is frequently administered to generate models of systemic inflammation. However, there are several side effects and no effective treatment for LPS-induced systemic inflammation. PEGylate…
View article: Kidney function and bone mineral density in chronic kidney disease patients
Kidney function and bone mineral density in chronic kidney disease patients Open
Background Bone mineral density (BMD) predicts fracture risk in patients with chronic kidney disease (CKD) and in the general population. However, few studies have investigated risk factors for bone loss in patients with CKD. The aim of th…
View article: Author response: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1via regulation of macrophage M1/M2 polarization
Author response: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1via regulation of macrophage M1/M2 polarization Open
The gram-negative bacterium lipopolysaccharide (LPS) is frequently administered to generate models of systemic inflammation. In particular, both kidney and lung are more sensitive to acute injury caused by LPS-induced systemic inflammation…
View article: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1via regulation of macrophage M1/M2 polarization
LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1via regulation of macrophage M1/M2 polarization Open
The gram-negative bacterium lipopolysaccharide (LPS) is frequently administered to generate models of systemic inflammation. In particular, both kidney and lung are more sensitive to acute injury caused by LPS-induced systemic inflammation…
View article: Author response: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
Author response: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization Open
The gram-negative bacterium lipopolysaccharide (LPS) is frequently administered to generate models of systemic inflammation. In particular, both kidney and lung are more sensitive to acute injury caused by LPS-induced systemic inflammation…
View article: LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization
LPS-induced systemic inflammation is suppressed by the PDZ motif peptide of ZO-1 via regulation of macrophage M1/M2 polarization Open
The gram-negative bacterium lipopolysaccharide (LPS) is frequently administered to generate models of systemic inflammation. In particular, both kidney and lung are more sensitive to acute injury caused by LPS-induced systemic inflammation…
View article: Air quality and kidney health: Assessing the effects of PM10, PM2.5, CO, and NO2 on renal function in primary glomerulonephritis
Air quality and kidney health: Assessing the effects of PM10, PM2.5, CO, and NO2 on renal function in primary glomerulonephritis Open
Background: While extensive studies have elucidated the relationships between exposure to air pollution and chronic diseases, such as cardiovascular disorders and diabetes, the intricate effects on specific kidney diseases, notably primary…
View article: Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease
Triglyceride-glucose index is an independent predictor of coronary artery calcification progression in patients with chronic kidney disease Open
Background: Coronary artery calcification (CAC) is highly prevalent in patients with chronic kidney disease (CKD) and is associated with major adverse cardiovascular events and metabolic disturbances. The triglyceride-glucose index (TyGI),…