Yoonbae Oh
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View article: Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode
Improved longevity and in vivo performance of neurotransmitter detection using 30 µm cone-shaped carbon fiber microelectrode Open
Fast Scan Cyclic Voltammetry (FSCV) is a widely used electrochemical technique to detect rapid extracellular dopamine transients in vivo . It employs carbon fiber microelectrodes (CFMEs), but conventional 7 µm diameter CFMEs often suffer f…
View article: Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model
Application of a human stereotactic system for image-guided deep brain stimulation neurosurgery in a swine model Open
View article: High-Frequency Stimulation of the Ventral Tegmental Area Rescues Respiratory Failure
High-Frequency Stimulation of the Ventral Tegmental Area Rescues Respiratory Failure Open
View article: Micromagnetic Stimulation (μMS) Controls Dopamine Release: An in vivo Study Using WINCS Harmoni
Micromagnetic Stimulation (μMS) Controls Dopamine Release: An in vivo Study Using WINCS Harmoni Open
Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the in vivo changes …
View article: Real-Time Monitoring of Electrode Surface Changes in Fast-Scan Cyclic Voltammetry Using Fourier Transform Electrochemical Impedance Spectroscopy
Real-Time Monitoring of Electrode Surface Changes in Fast-Scan Cyclic Voltammetry Using Fourier Transform Electrochemical Impedance Spectroscopy Open
Fast-scan cyclic voltammetry (FSCV) is a widely used electrochemical technique to measure the phasic response of neurotransmitters in the brain. It has the advantage of reducing tissue damage to the brain due to the use of carbon fiber mic…
View article: A Multimodal Platform for Real-Time Neurochemical and Electrophysiologic Monitoring for Intraoperative Neurosurgical Applications
A Multimodal Platform for Real-Time Neurochemical and Electrophysiologic Monitoring for Intraoperative Neurosurgical Applications Open
View article: Expansion of stereotactic work envelope using transformation matrices and geometric algebra for neurosurgery
Expansion of stereotactic work envelope using transformation matrices and geometric algebra for neurosurgery Open
View article: Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry
Toward Precise Modeling of Dopamine Release Kinetics: Comparison and Validation of Kinetic Models Using Voltammetry Open
Dopamine (DA) is a neurotransmitter present within the animal brain that is responsible for a wide range of physiologic functions, including motivation, reward, and movement control. Changes or dysfunction in the dynamics of DA release are…
View article: Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning
Resolution of tonic concentrations of highly similar neurotransmitters using voltammetry and deep learning Open
View article: Understanding the different effects of fouling mechanisms on working and reference electrodes in fast-scan cyclic voltammetry for neurotransmitter detection
Understanding the different effects of fouling mechanisms on working and reference electrodes in fast-scan cyclic voltammetry for neurotransmitter detection Open
The distinct impacts of fouling mechanisms on a carbon fiber microelectrode and an Ag/AgCl reference electrode, affecting their performance in neurotransmitter detection via Fast-scan Cyclic Voltammetry.
View article: Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements
Improved circuitry and post-processing for interleaved fast-scan cyclic voltammetry and electrophysiology measurements Open
The combination of electrophysiology and electrochemistry acquisition methods using a single carbon fiber microelectrode (CFM) in the brain has enabled more extensive analysis of neurochemical release, neural activity, and animal behavior.…
View article: Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods
Techniques for Measurement of Serotonin: Implications in Neuropsychiatric Disorders and Advances in Absolute Value Recording Methods Open
Serotonin (5-HT) is a monoamine neurotransmitter in the peripheral, enteric, and central nervous systems (CNS). Within the CNS, serotonin is principally involved in mood regulation and reward-seeking behaviors. It is a critical regulator i…
View article: Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation
Oxycodone-induced dopaminergic and respiratory effects are modulated by deep brain stimulation Open
Introduction: Opioids are the leading cause of overdose death in the United States, accounting for almost 70,000 deaths in 2020. Deep brain stimulation (DBS) is a promising new treatment for substance use disorders. Here, we hypothesized t…
View article: Micromagnetic Stimulation (μMS) Controls Dopamine Release: An<i>in vivo</i>Study Using WINCS<i>Harmoni</i>
Micromagnetic Stimulation (μMS) Controls Dopamine Release: An<i>in vivo</i>Study Using WINCS<i>Harmoni</i> Open
Objective Research into the role of neurotransmitters in regulating normal and pathologic brain functions has made significant progress. Yet, clinical trials that aim to improve therapeutic interventions do not take advantage of the in viv…
View article: Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission
Deep brain stimulation alleviates tics in Tourette syndrome via striatal dopamine transmission Open
Tourette syndrome is a childhood-onset neuropsychiatric disorder characterized by intrusive motor and vocal tics that can lead to self-injury and deleterious mental health complications. While dysfunction in striatal dopamine neurotransmis…
View article: High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens
High frequency deep brain stimulation can mitigate the acute effects of cocaine administration on tonic dopamine levels in the rat nucleus accumbens Open
Cocaine’s addictive properties stem from its capacity to increase tonic extracellular dopamine levels in the nucleus accumbens (NAc). The ventral tegmental area (VTA) is a principal source of NAc dopamine. To investigate how high frequency…
View article: Software for near-real-time voltammetric tracking of tonic neurotransmitter levels in vivo
Software for near-real-time voltammetric tracking of tonic neurotransmitter levels in vivo Open
Tonic extracellular neurotransmitter concentrations are important modulators of central network homeostasis. Disruptions in these tonic levels are thought to play a role in neurologic and psychiatric disease. Therefore, ways to improve the…
View article: Deep Brain Stimulation for Addictive Disorders—Where Are We Now?
Deep Brain Stimulation for Addictive Disorders—Where Are We Now? Open
In the face of a global epidemic of drug addiction, neglecting to develop new effective therapies will perpetuate the staggering human and economic costs of substance use. This review aims to summarize and evaluate the preclinical and clin…
View article: Table of Contents
Table of Contents Open
View article: Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens
Cocaine increases stimulation-evoked serotonin efflux in the nucleus accumbens Open
Serotonin plays a vital role in drug addiction. Here, using N-shaped fast-scan cyclic voltammetry, we demonstrated the effect of cocaine on the phasic release of serotonin at the nucleus accumbens core. To the best of our knowledge, this h…
View article: Tonic Serotonin Measurements<i>In Vivo</i>Using N-Shaped Multiple Cyclic Square Wave Voltammetry
Tonic Serotonin Measurements<i>In Vivo</i>Using N-Shaped Multiple Cyclic Square Wave Voltammetry Open
Here, we present the development of a novel voltammetric technique, N-shaped multiple cyclic square wave voltammetry (N-MCSWV) and its application in vivo. It allows quantitative measurements of tonic extracellular levels of seroton…
View article: Enhanced Dopamine Sensitivity Using Steered Fast-Scan Cyclic Voltammetry
Enhanced Dopamine Sensitivity Using Steered Fast-Scan Cyclic Voltammetry Open
Fast-scan cyclic voltammetry (FSCV) is a technique for measuring phasic release of neurotransmitters with millisecond temporal resolution. The current data are captured by carbon fiber microelectrodes, and non-Faradaic current is subtracte…
View article: Feasibility of Applying Fourier Transform Electrochemical Impedance Spectroscopy in Fast Cyclic Square Wave Voltammetry for the<i>In Vivo</i>Measurement of Neurotransmitters
Feasibility of Applying Fourier Transform Electrochemical Impedance Spectroscopy in Fast Cyclic Square Wave Voltammetry for the<i>In Vivo</i>Measurement of Neurotransmitters Open
We previously reported on the use of fast cyclic square wave voltammetry (FCSWV) as a new voltammetric technique. Fourier transform electrochemical impedance spectroscopy (FTEIS) has recently been utilized to provide information that enabl…
View article: Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study
Development and validation of a rapidly deployable CT-guided stereotactic system for external ventricular drainage: preclinical study Open
View article: Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo
Cocaine-Induced Changes in Tonic Dopamine Concentrations Measured Using Multiple-Cyclic Square Wave Voltammetry in vivo Open
For over 40 years, in vivo microdialysis techniques have been at the forefront in measuring the effects of illicit substances on brain tonic extracellular levels of dopamine that underlie many aspects of drug addiction. However, the size o…
View article: Biomarkers for Deep Brain Stimulation in Animal Models of Depression
Biomarkers for Deep Brain Stimulation in Animal Models of Depression Open
View article: Symptom-specific differential motor network modulation by deep brain stimulation in Parkinson’s disease
Symptom-specific differential motor network modulation by deep brain stimulation in Parkinson’s disease Open
OBJECTIVE Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is an established neurosurgical treatment for the motor symptoms of Parkinson’s disease (PD). While often highly effective, DBS does not always yield optimal therapeut…
View article: Automatic and Reliable Quantification of Tonic Dopamine Concentrations <i>In Vivo</i> Using a Novel Probabilistic Inference Method
Automatic and Reliable Quantification of Tonic Dopamine Concentrations <i>In Vivo</i> Using a Novel Probabilistic Inference Method Open
Dysregulation of the neurotransmitter dopamine (DA) is implicated in several neuropsychiatric conditions. Multiple-cyclic square-wave voltammetry (MCSWV) is a state-of-the-art technique for measuring tonic DA levels with high sensitivity (…
View article: The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans
The development of an implantable deep brain stimulation device with simultaneous chronic electrophysiological recording and stimulation in humans Open
View article: A compact stereotactic system for image-guided surgical intervention
A compact stereotactic system for image-guided surgical intervention Open
Objective . Stereotactic technology enables fine navigation to small structures in the human body. While current stereotactic systems facilitate accurate targeting, they are mechanically cumbersome and limited in scope. Here, we hypothesiz…