Yoonji Lee
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View article: MetaboGNN: predicting liver metabolic stability with graph neural networks and cross-species data
MetaboGNN: predicting liver metabolic stability with graph neural networks and cross-species data Open
The metabolic stability of a drug is a crucial determinant of its pharmacokinetic properties, including clearance, half-life, and oral bioavailability. Accurate predictions of metabolic stability can significantly streamline the drug disco…
View article: Recent advances in AI-based toxicity prediction for drug discovery
Recent advances in AI-based toxicity prediction for drug discovery Open
Toxicity, defined as the potential harm a substance can cause to living organisms, requires the implementation of stringent regulatory standards to ensure public safety. These standards involve comprehensive testing frameworks, including h…
View article: p21-Activated Kinase 4 and Ischemic Acute Kidney Injury in Mice and Humans
p21-Activated Kinase 4 and Ischemic Acute Kidney Injury in Mice and Humans Open
Key Points p21-activated kinase 4 (PAK4) phosphorylates and inactivates GSH peroxidase 3 in the kidney after ischemia-reperfusion. Mice lacking PAK4 or treated with PAK4 proteolysis-targeting chimera were protected from kidney damage cause…
View article: The anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC
The anticancer effect of metformin targets VDAC1 via ER-mitochondria interactions-mediated autophagy in HCC Open
Metformin (MetF) is used worldwide as a first-line therapy for type 2 diabetes. Recently, interest in the pleiotropic effects of MetF, such as its anticancer and antiaging properties, has increased. However, the molecular target of MetF an…
View article: PAK4 phosphorylates and inhibits AMPKα to control glucose uptake
PAK4 phosphorylates and inhibits AMPKα to control glucose uptake Open
Our recent studies have identified p21-activated kinase 4 (PAK4) as a key regulator of lipid catabolism in the liver and adipose tissue, but its role in glucose homeostasis in skeletal muscle remains to be explored. In this study, we find …
View article: Transient Plant Expression of Recombinant Rabies Virus Glycoprotein: A strategy for Vaccine Production
Transient Plant Expression of Recombinant Rabies Virus Glycoprotein: A strategy for Vaccine Production Open
The rabies virus causes neurological infections, resulting in the deaths of over 60,000 people worldwide each year. Currently available rabies vaccines are attenuated virus vaccines, which carry the risk of transmission among both humans a…
View article: The anticancer effect of Metformin targets VDAC1 via ER-mitochondria interaction-mediated autophagy in HCC
The anticancer effect of Metformin targets VDAC1 via ER-mitochondria interaction-mediated autophagy in HCC Open
Metformin (MetF) is widely used worldwide as a first-line therapy for type 2 diabetes. Recently, there has been increasing interest in the pleiotropic effects of MetF, such as its anti-cancer and anti-aging properties. However, the molecul…
View article: Kinetic model for the desensitization of G protein-coupled receptor
Kinetic model for the desensitization of G protein-coupled receptor Open
GPCR desensitization is a general regulatory mechanism adopted by biological organisms against overstimulation of G protein-coupled receptors. Although the details of mechanism aren extensively studied, it is not easy to gain an overarchin…
View article: Kinetic closures for unmagnetized and magnetized plasmas
Kinetic closures for unmagnetized and magnetized plasmas Open
Parallel and perpendicular closures with cyclotron resonance effects retained for the five-moment (density, temperature, and flow velocity) fluid equations are derived by solving the kinetic equation with the Bhatnagar–Gross–Krook operator…
View article: Glucose‐mediated mitochondrial reprogramming by cholesterol export at TM4SF5‐enriched mitochondria‐lysosome contact sites
Glucose‐mediated mitochondrial reprogramming by cholesterol export at TM4SF5‐enriched mitochondria‐lysosome contact sites Open
Background Transmembrane 4 L six family member 5 (TM4SF5) translocates subcellularly and functions metabolically, although it is unclear how intracellular TM4SF5 translocation is linked to metabolic contexts. It is thus of interests to und…
View article: Revolutionizing Medicinal Chemistry: The Application of Artificial Intelligence (AI) in Early Drug Discovery
Revolutionizing Medicinal Chemistry: The Application of Artificial Intelligence (AI) in Early Drug Discovery Open
Artificial intelligence (AI) has permeated various sectors, including the pharmaceutical industry and research, where it has been utilized to efficiently identify new chemical entities with desirable properties. The application of AI algor…
View article: A combined transcriptomic and physiological approach to understanding the adaptive mechanisms to cope with oxidative stress in <i>Fusarium graminearum</i>
A combined transcriptomic and physiological approach to understanding the adaptive mechanisms to cope with oxidative stress in <i>Fusarium graminearum</i> Open
In plant-pathogen interactions, oxidative bursts are crucial for plants to defend themselves against pathogen infections. Rapid production and accumulation of reactive oxygen species kill pathogens directly and cause local cell death, prev…
View article: Benzo[a]pyrene represses synaptic vesicle exocytosis by inhibiting P/Q-type calcium channels in hippocampal neurons
Benzo[a]pyrene represses synaptic vesicle exocytosis by inhibiting P/Q-type calcium channels in hippocampal neurons Open
Humans are exposed to the common carcinogen benzo[a]pyrene (BaP) by ingesting contaminated foods and water or inhaling polluted air. Given the enriched lipids and reduced antioxidative properties in the brain and the accumulation of BaP in…
View article: Characteristic Changes in First-Visit Patients with Peripheral Facial Palsy before and during COVID-19 Pandemic: A Single Center Retrospective Study
Characteristic Changes in First-Visit Patients with Peripheral Facial Palsy before and during COVID-19 Pandemic: A Single Center Retrospective Study Open
(1) Background: The COVID-19 pandemic has affected healthcare utilization rates on a global scale. This study aimed to analyze whether the COVID-19 pandemic affected the characteristics of first-visit patients with peripheral facial palsy …
View article: Supplementary Figures 1-4 from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades
Supplementary Figures 1-4 from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades Open
Supplementary Figures 1-4 from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades
View article: Data from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades
Data from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades Open
Farnesiferol C (FC) is one of the major compounds isolated from Ferula assafoetida, an Asian herbal spice used for cancer treatment as a folk remedy. Here, we examined the hypothesis that novel antiangiogenic activities of FC contribute to…
View article: Data from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades
Data from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades Open
Farnesiferol C (FC) is one of the major compounds isolated from Ferula assafoetida, an Asian herbal spice used for cancer treatment as a folk remedy. Here, we examined the hypothesis that novel antiangiogenic activities of FC contribute to…
View article: Supplementary Figures 1-4 from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades
Supplementary Figures 1-4 from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades Open
Supplementary Figures 1-4 from Herbal Compound Farnesiferol C Exerts Antiangiogenic and Antitumor Activity and Targets Multiple Aspects of VEGFR1 (Flt1) or VEGFR2 (Flk1) Signaling Cascades
View article: Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Open
Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
View article: Supplementary Figure Legends 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
Supplementary Figure Legends 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Open
Supplementary Figure Legends 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
View article: Data from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
Data from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Open
Capsiate, a nonpungent capsaicin analogue, and its dihydroderivative dihydrocapsiate are the major capsaicinoids of the nonpungent red pepper cultivar CH-19 Sweet. In this study, we report the biological actions and underlying molecular me…
View article: Supplementary Figure Legends 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
Supplementary Figure Legends 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Open
Supplementary Figure Legends 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
View article: Data from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
Data from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Open
Capsiate, a nonpungent capsaicin analogue, and its dihydroderivative dihydrocapsiate are the major capsaicinoids of the nonpungent red pepper cultivar CH-19 Sweet. In this study, we report the biological actions and underlying molecular me…
View article: Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity
Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity Open
Supplementary Figures 1-3 from Capsiate, a Nonpungent Capsaicin-Like Compound, Inhibits Angiogenesis and Vascular Permeability via a Direct Inhibition of Src Kinase Activity