Yorick Post
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View article: Mimicking Block Copolymer Self‐Assembly with One‐Pot Synthesized Polyphosphoester Gradient Copolymers
Mimicking Block Copolymer Self‐Assembly with One‐Pot Synthesized Polyphosphoester Gradient Copolymers Open
The development of sustainable and especially (bio)degradable nanomaterials is an important aspect of addressing environmental concerns of persistent commodity polymers. This study explores the synthesis of degradable amphiphilic polyphosp…
View article: WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency
WNT Mimetic-Induced Lacrimal Gland Regeneration Reverses Aqueous Tear Deficiency Open
Our novel WNT mimetic platform offers a promising alternative to symptom-focused treatments by actively stimulating acinar cell proliferation and restoration.
View article: Ternary Microphase Diagram of <scp>SBM</scp> Triblock Terpolymer Morphologies in Spherical Confinement
Ternary Microphase Diagram of <span>SBM</span> Triblock Terpolymer Morphologies in Spherical Confinement Open
Block copolymers are a versatile class of soft materials, as they combine different chemical and physical properties within the same macromolecule. Triblock terpolymers are of particular interest because of the numerous morphologies they c…
Ternary Microphase Diagram of SBM Triblock Terpolymer Morphologies in Spherical Confinement Open
Block copolymers are a versatile class of soft materials, as they combine different chemical and physical properties within the same macromolecule. Triblock terpolymers are of particular interest because of the numerous morphologies they c…
View article: Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles
Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles Open
Responsive nanomaterials that can undergo reversible changes in morphology are interesting for the development of functional materials that interact with and respond to their environment. Amphiphilic block copolymers are well known for the…
View article: Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles
Photoresponsive block copolymer nanostructures through implementation of arylazopyrazoles Open
Responsive nanomaterials that can undergo reversible changes in morphology are interesting for the development of functional materials that interact with and respond to their environment. Amphiphilic block copolymers are well known for the…
View article: Unravelling Competitive Interactions between Polymer Side Chains and End Groups with β‐Cyclodextrin
Unravelling Competitive Interactions between Polymer Side Chains and End Groups with β‐Cyclodextrin Open
This study investigates unexpected competitive host–guest interactions of β‐cyclodextrin (β‐CD), which can occur with polymers in aqueous solution, using the examples of the two polymers poly(oligo(ethylene glycol) methyl ether methacrylat…
View article: Unravelling competitive interactions between polymer side chains and end groups with β-cyclodextrin
Unravelling competitive interactions between polymer side chains and end groups with β-cyclodextrin Open
This study investigates unexpected competitive host-guest interactions of β-cyclodextrin which can occur with polymers in aqueous solution, using the examples of the two polymers poly(oligo(ethylene glycol) methyl ether methacrylate) (POEG…
A WNT mimetic with broad spectrum FZD-specificity decreases fibrosis and improves function in a pulmonary damage model Open
Background Wnt/β-catenin signaling is critical for lung development and AT2 stem cell maintenance in adults, but excessive pathway activation has been associated with pulmonary fibrosis, both in animal models and human diseases such as idi…
View article: BRAIDing receptors for cell-specific targeting
BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
View article: Reviewer #2 (Public Review): BRAIDing receptors for cell-specific targeting
Reviewer #2 (Public Review): BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
View article: Reviewer #1 (Public Review): BRAIDing receptors for cell-specific targeting
Reviewer #1 (Public Review): BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
View article: Author Response: BRAIDing receptors for cell-specific targeting
Author Response: BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
View article: BRAIDing receptors for cell-specific targeting
BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
View article: BRAIDing receptors for cell-specific targeting
BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
View article: BRAIDing receptors for cell specific targeting
BRAIDing receptors for cell specific targeting Open
Systemic toxicity is a major challenge to therapeutic development, consequently, cell-type specific targeting is highly desirable to improve on-target cell efficacy while reducing off-target toxicity. Here, we describe a cell targeting sys…
View article: BRAIDing receptors for cell-specific targeting
BRAIDing receptors for cell-specific targeting Open
Systemic toxicity is a major challenge in the development of therapeutics. Consequently, cell-type-specific targeting is needed to improve on-target efficacy while reducing off-target toxicity. Here, we describe a cell-targeting system we …
Helical bias in supramolecular polymers accounts for different stabilities of kinetically trapped states Open
The idea to synthesize and self‐assemble nano‐graphenes with structural precision into supramolecular polymers is just one of Klaus Müllen's many pioneering contributions to the chemical sciences. To honor his impact in the field of polyme…
MODELING VERTEBRATE ADULT STEM CELLS AND THEIR PROGENY Open
The adult human body consists of trillions of cells. These cells are the building blocks for every organ and tissue in the body. During our lifetime, cells are constantly lost at different speeds due to natural turnover or damage. Extreme …
Profiling proliferative cells and their progeny in damaged murine hearts Open
The significance of cardiac stem cell (CSC) populations for cardiac regeneration remains disputed. Here, we apply the most direct definition of stem cell function (the ability to replace lost tissue through cell division) to interrogate th…