Yong‐ho Lee
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View article: Efficacy and Safety of HD-6277, a Novel G Protein-Coupled Receptor 40 Agonist, in Individuals with Type 2 Diabetes Mellitus: a Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 2 Clinical Trial
Efficacy and Safety of HD-6277, a Novel G Protein-Coupled Receptor 40 Agonist, in Individuals with Type 2 Diabetes Mellitus: a Double-Blind, Randomized, Placebo-Controlled, Parallel-Group, Multicenter Phase 2 Clinical Trial Open
HD-6277 at 50 and 100 mg improved glycemic control and was well-tolerated in adults with T2DM inadequately managed with diet and exercise. GPR40 agonists may offer a promising new therapeutic option for T2DM.
Lactate-Induced Lipid Accumulation in Hepatocytes through GPR81 Activation Open
Our findings demonstrate that lactate promotes hepatic steatosis primarily via the GPR81-AMPK signaling axis. GPR81 activation enhances lipogenesis and lipid uptake, independent of MCT1-mediated transport. These results position GPR81 as a…
View article: Protective Role of Serum β-Hydroxybutyrate in Early Diabetic Kidney Disease: A Longitudinal Study
Protective Role of Serum β-Hydroxybutyrate in Early Diabetic Kidney Disease: A Longitudinal Study Open
Higher baseline fasting serum βHB levels are linked to a lower risk of proteinuria in newly diagnosed type 2 diabetes, suggesting its potential as a protective metabolic marker in early diabetic kidney disease.
Comprehensive approaches to diabetes in the elderly: adapting to evolving trends Open
Background/Aims: The prevalence of diabetes mellitus (DM) is increasing worldwide owing to aging. This nationwide study aimed to investigate the prevalence of DM and its management status among elderly Koreans.Methods: We analyzed data fro…
Correction: Hemodynamic predictors of rupture in abdominal aortic aneurysms: a case series using computational fluid dynamics Open
[This corrects the article DOI: 10.3389/fcvm.2025.1633938.].
View article: The Impact of Ketogenic Capacity on Lipid Profile in Individuals with Prediabetes or Newly Diagnosed Type 2 Diabetes
The Impact of Ketogenic Capacity on Lipid Profile in Individuals with Prediabetes or Newly Diagnosed Type 2 Diabetes Open
In individuals with non-adipogenic traits and enhanced ketogenic capacity, plasma triglyceride (TG) levels are typically low, while low-density lipoprotein cholesterol (LDL-C) levels often exceed the normal range, complicating cardiovascul…
Hemodynamic predictors of rupture in abdominal aortic aneurysms: a case series using computational fluid dynamics Open
Background Abdominal aortic aneurysm (AAA) rupture is a life-threatening event traditionally predicted by aneurysm diameter. However, many clinical observations have revealed that rupture can occur even in small aneurysms, suggesting the i…
Association of temporal MASLD with type 2 diabetes, cardiovascular disease and mortality Open
Background We investigated the risk of type 2 diabetes (T2DM) and related comorbidities including cardiovascular disease (CVD), and mortality, based on changes in metabolic dysfunction associated steatotic liver disease (MASLD). Methods We…
Pathway Complexity in Supramolecular Polymerization of Porphyrin Dyads for Kinetic Control of Helicity Open
The supramolecular polymerization of porphyrin dyad ( PD ) shows the pathway complexity leading to the formation of kinetically metastable nanoparticles ( PD Particle ) through rapid cooling and thermodynamically stable fibrous supramolecu…
View article: Association of lean metabolic dysfunction‐associated steatotic liver disease with carotid plaque progression in patients with type 2 diabetes mellitus
Association of lean metabolic dysfunction‐associated steatotic liver disease with carotid plaque progression in patients with type 2 diabetes mellitus Open
Introduction We aimed to investigate whether lean metabolic dysfunction‐associated steatotic liver disease (MASLD) is associated with the progression of carotid atherosclerosis in patients with type 2 diabetes mellitus. Materials and Metho…
Estimation of Fractal Dimensions and Classification of Plant Disease with Complex Backgrounds Open
Accurate classification of plant disease by farming robot cameras can increase crop yield and reduce unnecessary agricultural chemicals, which is a fundamental task in the field of sustainable and precision agriculture. However, until now,…
View article: Potential Impact of Choline Alphoscerate on Depressive Symptoms in Association with Insulin Resistance in Elderly Patients with Type 2 Diabetes
Potential Impact of Choline Alphoscerate on Depressive Symptoms in Association with Insulin Resistance in Elderly Patients with Type 2 Diabetes Open
Background/Objectives: The aim of this study was to investigate whether Gliatamin (choline alphoscerate), an acetylcholine precursor originally used to treat dementia, improves depressive symptoms in patients with type 2 diabetes. Methods:…
Prevalence of Mortality and Vascular Complications in Older Patients with Diabetes in Korea Open
Background: This study investigated the prevalence of diabetes mellitus (DM) and impaired fasting glucose, as well as their management and comorbidities among older Korean adults.Methods: Data from 269,447 individuals aged 65 years and old…
View article: Meeting Physical Activity Guidelines: Impact on Chronic Kidney Disease Prevalence in Diabetic Individuals
Meeting Physical Activity Guidelines: Impact on Chronic Kidney Disease Prevalence in Diabetic Individuals Open
Meeting PA and RE guidelines are associated with reduced prevalence of CKD in individuals with diabetes. These findings underscore the potential benefits of LPA and RE in the prevention of CKD in individuals with diabetes.
Nutriomics and artificial intelligence nutrition obesity cohort (NAINOC): a design paper for a prospective cohort for nutrition and obesity research Open
The strength of this cohort will be as follows. First, the cohort will enable the integration of nutritional intake data with other multiomics data for a comprehensive analysis. Second, inclusion of both obese individuals with various meta…
View article: Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Review and Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association
Metabolic Dysfunction-Associated Steatotic Liver Disease in Type 2 Diabetes Mellitus: A Review and Position Statement of the Fatty Liver Research Group of the Korean Diabetes Association Open
Since the role of the liver in metabolic dysfunction, including type 2 diabetes mellitus, was demonstrated, studies on non-alcoholic fatty liver disease (NAFLD) and metabolic dysfunction-associated fatty liver disease (MAFLD) have shown as…
Effect of nelonemdaz for patients with out-of-hospital cardiac arrest: the AWAKE phase II randomised clinical trial Open
Background Hypoxic brain injury is a major hurdle that limits the survival of out-of-hospital cardiac arrest (OHCA). Nelonemdaz is a dual-target neuroprotectant, serving as a moderate NR2B-selective N-methyl-D-aspartate (NMDA) receptor ant…
View article: Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin in Patients with Type 2 Diabetes and Modifiable Cardiovascular Risk Factors (ENSEMBLE)
Study Design and Protocol for a Randomized Controlled Trial to Assess Long-Term Efficacy and Safety of a Triple Combination of Ezetimibe, Fenofibrate, and Moderate-Intensity Statin in Patients with Type 2 Diabetes and Modifiable Cardiovascular Risk Factors (ENSEMBLE) Open
Background: Atherogenic dyslipidemia, which is frequently associated with type 2 diabetes (T2D) and insulin resistance, contributes to the development of vascular complications. Statin therapy is the primary approach to dyslipidemia manage…
Relationship between Change in Physical Activity and Risk of Metabolic Syndrome: A Prospective Cohort Study Open
Changes in physical activity levels are associated with risk of metabolic syndrome. These results provide important insights for future investigations into the link between physical activity changes and disease occurrence.
Efficacy and tolerability of initial triple combination therapy with metformin, dapagliflozin and saxagliptin compared with stepwise add‐on therapy in drug‐naïve patients with type 2 diabetes ( <span>TRIPLE</span> ‐ <span>AXEL</span> study): A multicentre, randomized, 104‐week, open‐label, active‐controlled trial Open
Aim To evaluate the efficacy and tolerability of an initial triple combination therapy (TCT) compared with conventional stepwise add‐on therapy (SAT) in patients with newly diagnosed type 2 diabetes (T2D). Materials and Methods This multic…
Enhancement of Indoor Air Quality with a Displacement Ventilation System Comprising a 4-Way Fan Coil Unit and Multiple Air Purifiers Open
In indoor spaces without mechanical ventilation systems, a common approach involves using a ceiling-mounted 4-way fan coil unit (4WFCU) to regulate indoor temperature and placing floor-level air purifiers (APs) to remove indoor pollutants.…