Yoshiharu Matsuura
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View article: Identification of claudin-3 as an entry factor for rat hepacivirus
Identification of claudin-3 as an entry factor for rat hepacivirus Open
Approximately 58 million people worldwide are believed to be infected with hepatitis C virus (HCV), a major causative agent of chronic liver diseases. Hepacivirus ratti strain rn-1, which was discovered from Rattus norvegicus (Norway rat) …
View article: Rational design of a covalent <scp>ACE2</scp> decoy receptor that broadly neutralizes <scp>SARS</scp>‐<scp>CoV</scp>‐2 variants
Rational design of a covalent <span>ACE2</span> decoy receptor that broadly neutralizes <span>SARS</span>‐<span>CoV</span>‐2 variants Open
The ongoing evolution of severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) and the emergence of variants that evade existing vaccines and antibody therapies necessitate novel, potent, and broad‐spectrum antiviral strategies. Enh…
View article: SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase
SFTSV utilizes AXL/GAS6 for entry via PI3K-PLC-dependent macropinocytosis activated by AXL-kinase Open
Severe fever with thrombocytopenia syndrome (SFTS) is a significant public health concern caused by SFTS virus (SFTSV), a tick-borne RNA virus. Previous studies have identified DC-SIGN and related C-type lectins as receptors of SFTSV infec…
View article: Development of in vitro plaque-based assay for assessment of antibody-dependent enhancement in SARS-CoV-2 infection
Development of in vitro plaque-based assay for assessment of antibody-dependent enhancement in SARS-CoV-2 infection Open
Antibody-dependent enhancement (ADE) of infection is a concerning phenomenon in SARS-CoV-2 infection, since it may develop disease severity. Although ADE has been demonstrated in animal models, the pathogenic mechanism has not been fully e…
View article: Establishment of a green fluorescent protein (GFP)-based reporter for picornaviral 3C proteases
Establishment of a green fluorescent protein (GFP)-based reporter for picornaviral 3C proteases Open
Picornaviruses represent a diverse group of plus-stranded RNA viruses, many of which have been linked to severe diseases in both humans and animals. The viral 3C protease is essential for the maturation of viral proteins and the propagatio…
View article: Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization
Modulating Immunogenicity and Reactogenicity in mRNA-Lipid Nanoparticle Vaccines through Lipid Component Optimization Open
Messenger RNA (mRNA) vaccines effectively induce antibody production and T cell responses. However, adverse reactions, such as fatigue and fever, following administration remain a key challenge. To modulate the immunogenicity and reactogen…
View article: Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2
Evolutionary dynamics of heparan sulfate utilization by SARS-CoV-2 Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron variants have acquired enhanced infectivity compared to earlier variants. To elucidate the underlying molecular mechanisms, we conducted CRISPR library screening to ident…
View article: Orthologs of Branching Enzymes from Cyanobacteria Accumulating Distinct Types of α-Glucans Share Common Reaction Product Specificity
Orthologs of Branching Enzymes from Cyanobacteria Accumulating Distinct Types of α-Glucans Share Common Reaction Product Specificity Open
Cyanobacteria generally accumulate glycogen in their cells as a photosynthetic product. Interestingly, several unicellular diazotrophic species accumulate insoluble branched polysaccharide called cyanobacterial starch. Branching enzymes (B…
View article: NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs.
NEDD4-binding protein 1 suppresses hepatitis B virus replication by regulating viral RNAs. Open
Chronic infection with hepatitis B virus (HBV) (chronic HBV infection) places patients at increased risk for liver cirrhosis and hepatocellular carcinoma. Although nucleos(t)ide analogues are mainly used for the treatment of HBV, they requ…
View article: Identification of claudin-3 as an entry factor for rat hepacivirus
Identification of claudin-3 as an entry factor for rat hepacivirus Open
Approximately 58 million people worldwide are believed to be infected with hepatitis C virus (HCV), a major causative agent of chronic liver diseases. Hepacivirus ratti strain rn-1, which was discovered from Rattus norvegicus (Norway rat) …
View article: Development of a Plaque Assay System for in Vitro Assessment of Antibody-Dependent Enhancement in Sars-Cov-2 Infection
Development of a Plaque Assay System for in Vitro Assessment of Antibody-Dependent Enhancement in Sars-Cov-2 Infection Open
View article: BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis
BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis Open
Introduction The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients. Materials and methods In this study, we used single-cell RN…
View article: HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1
HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1 Open
We previously reported that hepatitis C virus (HCV) infection or HCV core protein expression induces HOX gene expression by impairing histone H2A monoubiquitination via a proteasome-dependent reduction in the level of RNF2, a key catalytic…
View article: Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients
Clonal landscape of autoantibody-secreting plasmablasts in COVID-19 patients Open
Whereas severe COVID-19 is often associated with elevated autoantibody titers, the underlying mechanism behind their generation has remained unclear. Here we report clonal composition and diversity of autoantibodies in humoral response to …
View article: Regulation viral RNA transcription and replication by higher-order RNA structures within the nsp1 coding region of MERS coronavirus
Regulation viral RNA transcription and replication by higher-order RNA structures within the nsp1 coding region of MERS coronavirus Open
View article: Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production
Importin-7-dependent nuclear translocation of the Flavivirus core protein is required for infectious virus production Open
Flaviviridae is a family of positive-stranded RNA viruses, including human pathogens, such as Japanese encephalitis virus (JEV), dengue virus (DENV), Zika virus (ZIKV), and West Nile virus (WNV). Nuclear localization of the viral core prot…
View article: Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1
Enterovirus 3A protein disrupts endoplasmic reticulum homeostasis through interaction with GBF1 Open
Enteroviruses are single-stranded, positive-sense RNA viruses causing endoplasmic reticulum (ER) stress to induce or modulate downstream signaling pathways known as the unfolded protein responses (UPR). However, viral and host factors invo…
View article: BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis
BCR, not TCR, repertoire diversity is associated with favorable COVID-19 prognosis Open
The SARS-CoV-2 pandemic has had a widespread and severe impact on society, yet there have also been instances of remarkable recovery, even in critically ill patients. In this study, we used single-cell RNA sequencing to analyze the immune …
View article: HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1
HCV infection activates the proteasome via PA28γ acetylation and heptamerization to facilitate the degradation of RNF2, a catalytic component of polycomb repressive complex 1 Open
We previously reported that hepatitis C virus (HCV) infection or HCV core protein expression induces HOX gene expression by impairing histone H2A monoubiquitination via a proteasome-dependent reduction in the level of RNF2, a key catalytic…
View article: JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice
JAK inhibition during the early phase of SARS-CoV-2 infection worsens kidney injury by suppressing endogenous antiviral activity in mice Open
Patients frequently present with acute kidney injury or abnormal urinary findings after severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Here, we investigated how the kidneys respond during SARS-CoV-2 infection using…
View article: Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution
Genes involved in the limited spread of SARS-CoV-2 in the lower respiratory airways of hamsters may be associated with adaptive evolution Open
Novel respiratory viruses can cause a pandemic and then evolve to coexist with humans. The Omicron strain of severe acute respiratory syndrome coronavirus 2 has spread worldwide since its emergence in late 2021, and its sub-lineages are no…
View article: Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection
Akaluc bioluminescence offers superior sensitivity to track in vivo dynamics of SARS-CoV-2 infection Open
Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue tropism. Because the gene size of RNA viruses is typically small, NanoLuc is the primary choice for accommodation within viral genome. Howev…
View article: Characterization of a neutralizing antibody that recognizes a loop region adjacent to the receptor-binding interface of the SARS-CoV-2 spike receptor-binding domain
Characterization of a neutralizing antibody that recognizes a loop region adjacent to the receptor-binding interface of the SARS-CoV-2 spike receptor-binding domain Open
Although the global crisis caused by the coronavirus disease 2019 (COVID-19) pandemic is over, the global epidemic of the disease continues. Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of COVID-19, initiates inf…
View article: Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage
Vero cell-adapted SARS-CoV-2 strain shows increased viral growth through furin-mediated efficient spike cleavage Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) utilizes several host proteases to cleave the spike (S) protein to enter host cells. SARS-CoV-2 S protein is cleaved into S1 and S2 subunits by furin, which is closely involved i…
View article: Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19
Amino acid catabolite markers for early prognostication of pneumonia in patients with COVID-19 Open
Effective early-stage markers for predicting which patients are at risk of developing SARS-CoV-2 infection have not been fully investigated. Here, we performed comprehensive serum metabolome analysis of a total of 83 patients from two coho…
View article: Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies
Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies Open
The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2). Certain human antibodies, which target the spike N-terminal domain (NTD…
View article: Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses
Intranasal immunization with an RBD-hemagglutinin fusion protein harnesses preexisting immunity to enhance antigen-specific responses Open
Intranasal vaccines are anticipated to be powerful tools for combating many infectious diseases, including SARS-CoV-2, because they induce not only systemic immunity but also mucosal immunity at the site of initial infection. However, they…
View article: Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation
Electrolyzed hypochlorous acid water exhibits potent disinfectant activity against various viruses through irreversible protein aggregation Open
It is essential to employ efficient measures to prevent the transmission of pathogenic agents during a pandemic. One such method involves using hypochlorous acid (HClO) solution. The oxidative properties of HClO water (HAW) can contribute …
View article: Akaluc bioluminescence offers superior sensitivity to track<i>in vivo</i>dynamics of SARS-CoV-2 infection
Akaluc bioluminescence offers superior sensitivity to track<i>in vivo</i>dynamics of SARS-CoV-2 infection Open
Summary Monitoring in vivo viral dynamics can improve our understanding of pathogenicity and tissue tropism. For positive-sense, single-stranded RNA viruses, several studies have attempted to monitor viral kinetics in vivo using reporter g…
View article: 2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses
2-thiouridine is a broad-spectrum antiviral nucleoside analogue against positive-strand RNA viruses Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infections are causing significant morbidity and mortality worldwide. Furthermore, over 1 million cases of newly emerging or re-emerging viral infections, specifically dengue vir…