Yoshihide Asano
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View article: Three Cases of Advanced Melanoma With Severe irAE Colitis With Rapid Tumor Progression Following Infliximab Administration
Three Cases of Advanced Melanoma With Severe irAE Colitis With Rapid Tumor Progression Following Infliximab Administration Open
Immune checkpoint inhibitors (ICIs) have improved melanoma outcomes but can cause severe immune‐related colitis. Infliximab is often used for steroid‐refractory cases, yet its effect on tumor control remains uncertain. We describe three ad…
View article: Bullous pilomatricoma in young children
Bullous pilomatricoma in young children Open
Dear Editor, Pilomatricoma is a benign tumor characterized by differentiation from hair matrix cells to hair cortical cells. It commonly occurs on the head and neck in young individuals. Although blistering is rare, when present, it is typ…
View article: Microarteriovenous Fistulas Causing Refractory Skin Ulcers: Feasibility and Safety of Transcatheter Embolization
Microarteriovenous Fistulas Causing Refractory Skin Ulcers: Feasibility and Safety of Transcatheter Embolization Open
Purpose Microarteriovenous fistulas (m-AVFs) have been proposed as a potential cause of lower limb ulcers that are refractory to standard therapies. This study evaluated the feasibility and safety of transcatheter arterial embolization (TA…
View article: Racial Differences in Immunotherapy for Melanoma and Perspectives on the Development of Novel Treatments
Racial Differences in Immunotherapy for Melanoma and Perspectives on the Development of Novel Treatments Open
Since nivolumab became available in clinical practice in 2014, the treatment landscape for unresectable melanoma has changed dramatically, with anti-PD-1 antibodies becoming an anchor drug in melanoma treatment. However, in Japan, the effi…
View article: PAI-1 in Skin Malignancies: a Central Regulator of Tumor Progression and Therapeutic Resistance
PAI-1 in Skin Malignancies: a Central Regulator of Tumor Progression and Therapeutic Resistance Open
View article: Pharmacokinetic Profiling Using 3H-Labeled Eggshell Membrane and Effects of Eggshell Membrane and Lysozyme Oral Supplementation on DSS-Induced Colitis and Human Gut Microbiota
Pharmacokinetic Profiling Using 3H-Labeled Eggshell Membrane and Effects of Eggshell Membrane and Lysozyme Oral Supplementation on DSS-Induced Colitis and Human Gut Microbiota Open
Eggshell membrane (ESM) is composed of approximately 90% protein. Our previous studies in healthy adults demonstrated that two months of daily ESM intake improved respiratory function, zigzag walking speed, and skin elasticity. The present…
View article: Plasminogen Activator Inhibitor-1 in Skin Malignancies: Therapeutic Implications of Its Inhibition
Plasminogen Activator Inhibitor-1 in Skin Malignancies: Therapeutic Implications of Its Inhibition Open
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of fibrinolysis, has emerged as a critical stromal factor that contributes to tumor progression in various malignancies, including skin cancers. Beyond its classical role in inhibi…
View article: Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene
Whole-genome sequencing reveals rare and structural variants contributing to psoriasis and identifies CERCAM as a risk gene Open
Psoriasis vulgaris (PsV) is an immune-mediated inflammatory skin disorder with complex genetic architecture. Most genome-wide association studies (GWASs) of PsV have been limited to analyzing common single-nucleotide variants in Europeans,…
View article: Plasminogen Activator Inhibitor-1 in Systemic Sclerosis: A Nexus of Fibrosis, Vasculopathy, and Senescence
Plasminogen Activator Inhibitor-1 in Systemic Sclerosis: A Nexus of Fibrosis, Vasculopathy, and Senescence Open
Plasminogen activator inhibitor-1 (PAI-1), a key regulator of the fibrinolytic system, has emerged as a multifaceted contributor to the pathogenesis of systemic sclerosis (SSc). Beyond its classical role in inhibiting plasminogen activatio…
View article: Recent Advances in Immunotherapy for Melanoma: Perspectives on the Development of Novel Treatments: A Mini Review
Recent Advances in Immunotherapy for Melanoma: Perspectives on the Development of Novel Treatments: A Mini Review Open
It has been more than a decade since anti-PD-1 and anti-CTLA-4 antibodies were first introduced for the treatment of unresectable melanoma. The advent of these immunotherapies has dramatically transformed the treatment landscape. In recent…
View article: A case of psoriasis and atopic dermatitis-like rash induced by interleukin-17 and interleukin-23 inhibitors successfully controlled with upadacitinib
A case of psoriasis and atopic dermatitis-like rash induced by interleukin-17 and interleukin-23 inhibitors successfully controlled with upadacitinib Open
View article: Adamantinoid basal cell carcinoma: clinical, histological and dermoscopic findings
Adamantinoid basal cell carcinoma: clinical, histological and dermoscopic findings Open
View article: The Evolving Landscape of Systemic Sclerosis Pathogenesis: From Foundational Mechanisms to Organ-Specific Modifiers
The Evolving Landscape of Systemic Sclerosis Pathogenesis: From Foundational Mechanisms to Organ-Specific Modifiers Open
Systemic sclerosis (SSc) is a multifaceted autoimmune disease in which the complex interplay of genetic predisposition and environmental factors triggers aberrant immune responses, ultimately leading to vasculopathy and fibrosis. This revi…
View article: A Super-Aged Patient with Primary Cutaneous Gamma-Delta T-Cell Lymphoma Treated with Palliative Radiotherapy: A Short-Term Follow-Up Case
A Super-Aged Patient with Primary Cutaneous Gamma-Delta T-Cell Lymphoma Treated with Palliative Radiotherapy: A Short-Term Follow-Up Case Open
Introduction: Primary cutaneous gamma-delta T-cell lymphoma (PCGDTL) is a rare and aggressive subtype of cutaneous T-cell lymphoma, often associated with poor prognosis and resistance to conventional therapies. Case Presentation: We presen…
View article: Wound, pressure ulcer, and burn guidelines – 3: Guidelines for the diagnosis and treatment of diabetic ulcers and gangrene, second edition
Wound, pressure ulcer, and burn guidelines – 3: Guidelines for the diagnosis and treatment of diabetic ulcers and gangrene, second edition Open
The Japanese Dermatological Association aimed to prepare a second edition of guidelines for the management of diabetic ulcer/gangrene with emphasis on the diagnosis and treatment of skin symptoms. This new edition serves as a tool to impro…
View article: The Evolving Landscape of Systemic Sclerosis Pathogenesis: From Foundational Mechanisms to Organ-Specific Modifiers
The Evolving Landscape of Systemic Sclerosis Pathogenesis: From Foundational Mechanisms to Organ-Specific Modifiers Open
Systemic sclerosis (SSc) is a multifaceted autoimmune disease in which the complex interplay of genetic predisposition and environmental factors triggers aberrant immune responses, ultimately leading to vasculopathy and fibrosis. This revi…
View article: Two cases of advanced melanoma with <scp>BRAF L597</scp> mutation: Options for systemic treatment
Two cases of advanced melanoma with <span>BRAF L597</span> mutation: Options for systemic treatment Open
The combination of BRAF and MEK kinase inhibitors is a well‐established treatment for BRAF V600‐mutated advanced melanoma. However, the efficacy of these therapies against less common BRAF mutations, such as BRAF L597, remains unclear. We …
View article: Nationwide epidemiological and clinical survey of juvenile‐onset morphea in Japan
Nationwide epidemiological and clinical survey of juvenile‐onset morphea in Japan Open
Juvenile‐onset morphea can severely impact activities of daily living by causing functional disability. This study was performed to clarify the epidemiological and clinical characteristics of juvenile‐onset morphea in Japan. We conducted a…
View article: Clinical Images: Multiple blisters on the upper and lower extremities in granulomatosis with polyangiitis
Clinical Images: Multiple blisters on the upper and lower extremities in granulomatosis with polyangiitis Open
View article: An Evaluation of Prognostic Factors in Cutaneous Squamous Cell Carcinoma: A Single-Center Study of 237 Japanese Cases
An Evaluation of Prognostic Factors in Cutaneous Squamous Cell Carcinoma: A Single-Center Study of 237 Japanese Cases Open
Background/Objectives: Cutaneous squamous cell carcinoma (cSCC) is a common cutaneous malignancy with diverse etiologies, including actinic keratosis, burns, and hidradenitis suppurativa (HS). Methods: We reviewed 237 cases diagnosed as cS…
View article: Successful Treatment of Poikilodermatous Mycosis Fungoides with 308-nm Excimer Laser
Successful Treatment of Poikilodermatous Mycosis Fungoides with 308-nm Excimer Laser Open
Introduction: Among the spectrum of mycosis fungoides (MF), poikilodermatous MF (PMF) is a rare clinical variant of patch-stage MF, which is characterized by cutaneous atrophy, mottled-reticular pigmentation, and telangiectasia. Given its …
View article: Impact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene
Impact of Hyaluronic Acid on the Cutaneous T-Cell Lymphoma Microenvironment: A Novel Anti-Tumor Mechanism of Bexarotene Open
Background: Cutaneous T-cell lymphoma (CTCL) is a type of non-Hodgkin’s lymphoma that primarily affects the skin, rich in hyaluronic acid (HA). HA is a component of the extracellular matrix in the dermis and likely affects the development …
View article: Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases
Deep learning-based histopathological assessment of tubulo-interstitial injury in chronic kidney diseases Open
DLRS-derived tubulo-interstitial injury scores are concordant with nephrologists' evaluations and correlated with eGFR across different populations and institutions. The effectiveness of DLRS-derived scores for predicting annual eGFR decli…
View article: Comprehensive Analysis of the Chemokine/Cytokine Profiles in Advanced Mycosis Fungoides and Atopic Dermatitis
Comprehensive Analysis of the Chemokine/Cytokine Profiles in Advanced Mycosis Fungoides and Atopic Dermatitis Open
Mycosis fungoides (MF) is an indolent form of cutaneous T‐cell lymphoma. Its early lesions are important to be distinguished from atopic dermatitis (AD) because of their similar immune microenvironment. We have previously demonstrated that…
View article: Semaphorin3A Knockdown Upregulates miR-20b-5p to Suppress Cyclin D1 expression and Cell Proliferation in High Bone-Metastatic Lung Cancer Cell
Semaphorin3A Knockdown Upregulates miR-20b-5p to Suppress Cyclin D1 expression and Cell Proliferation in High Bone-Metastatic Lung Cancer Cell Open
View article: Efficacy of corneal squamous cell carcinoma antigen-1 in early infancy in predicting atopic dermatitis and food allergy: A prospective study
Efficacy of corneal squamous cell carcinoma antigen-1 in early infancy in predicting atopic dermatitis and food allergy: A prospective study Open
The findings suggest that non-invasive measurements of corneal SCCA1 at 2 months of age is useful for predicting atopic dermatitis and food allergy in infants at risk for atopic dermatitis and subsequent food allergy.
View article: Impact of Fli1 deletion on B cell populations: A focus on age-associated B cells and transcriptional dynamics
Impact of Fli1 deletion on B cell populations: A focus on age-associated B cells and transcriptional dynamics Open
These findings suggest complex modulations of B cell populations and immune-related gene expression due to Fli1 deficiency, shedding light on its involvement in autoimmune processes.
View article: Atypical bilateral hyperpigmented macules on the lower legs possibly due to cyclophosphamide.
Atypical bilateral hyperpigmented macules on the lower legs possibly due to cyclophosphamide. Open
Introduction: Chemotherapeutic agents occasionally induce various cutaneous adverse events, but hyperpigmentation due to cyclophosphamide is extremely rare. Case presentation: A case of atypical bilateral hyperpigmented macules on the lowe…
View article: Erythematous Plaques on the Dorsum of both Hands and Forearm: A Quiz
Erythematous Plaques on the Dorsum of both Hands and Forearm: A Quiz Open
View article: Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia
Characterization of a Cancer-Induced Bone Pain Model for Use as a Model of Cancer Cachexia Open
Cancer cachexia is a debilitating syndrome characterized by progressive weight loss, muscle wasting, and systemic inflammation. Despite the prevalence and severe consequences of cancer cachexia, effective treatments for this syndrome remai…