Yoshihiro Fujikawa
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View article: Systematic mutagenesis assay promotes comprehension of the strand-bias laws for mutations induced by oxidative DNA damage
Systematic mutagenesis assay promotes comprehension of the strand-bias laws for mutations induced by oxidative DNA damage Open
We have recently developed an efficient and sensitive method for analyzing mutations caused by various environmental and endogenous factors which utilizes nucleotide-barcoded supF shuttle vector libraries with a multiplexed NGS assay, refe…
View article: Involvement of Rev1 in alkylating agent‐induced loss of heterozygosity in <i>Oryzias latipes</i>
Involvement of Rev1 in alkylating agent‐induced loss of heterozygosity in <i>Oryzias latipes</i> Open
Translesion synthesis (TLS) polymerases mediate DNA damage bypass during replication. The TLS polymerase Rev1 has two important functions in the TLS pathway, including dCMP transferase activity and acting as a scaffolding protein for other…
View article: Error-Prone and Error-Free Translesion DNA Synthesis over Site-Specifically Created DNA Adducts of Aryl Hydrocarbons (3-Nitrobenzanthrone and 4-Aminobiphenyl)
Error-Prone and Error-Free Translesion DNA Synthesis over Site-Specifically Created DNA Adducts of Aryl Hydrocarbons (3-Nitrobenzanthrone and 4-Aminobiphenyl) Open
Aryl hydrocarbons such as 3-nitrobenzanthrone (NBA), 4-aminobiphenyl (ABP), acetylaminofluorene (AAF), benzo(a)pyrene (BaP), and 1-nitropyrene (NP) form bulky DNA adducts when absorbed by mammalian cells. These chemicals are metabolically …
View article: Targeted Inactivation of DNA Photolyase Genes in Medaka Fish (<i>Oryzias latipes</i>)
Targeted Inactivation of DNA Photolyase Genes in Medaka Fish (<i>Oryzias latipes</i>) Open
Proteins of the cryptochrome/photolyase family ( CPF ) exhibit sequence and structural conservation, but their functions are divergent. Photolyase is a DNA repair enzyme that catalyzes the light‐dependent repair of ultraviolet ( UV )‐induc…