Yoshihiro Kokubo
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View article: Developing a risk score for B-type natriuretic peptide (BNP) ≥ 100 pg/ml levels: the suita study
Developing a risk score for B-type natriuretic peptide (BNP) ≥ 100 pg/ml levels: the suita study Open
Our findings highlighted several CVD risk factors for BNP levels ≥ 100 pg/mL in the general Japanese population. Lifestyle modifications and regular health check-ups should be applied to reduce HF risk in vulnerable individuals.
View article: Validity of Digital Photographic Images for Dietary Assessment of Participants with Low Frequency of Home-Made Meal Intake
Validity of Digital Photographic Images for Dietary Assessment of Participants with Low Frequency of Home-Made Meal Intake Open
It is important to clarify the factors that cause errors when calculating nutrient and food group intake using dietary surveys. This study aimed to clarify the characteristics of errors in nutrient and food group intake among those who ate…
View article: Extremely Elevated High-density Lipoprotein Cholesterol and the Risk of Atrial Fibrillation: The Suita Study
Extremely Elevated High-density Lipoprotein Cholesterol and the Risk of Atrial Fibrillation: The Suita Study Open
View article: An inverse association of cerebral amyloid-β deposition and serum docosahexaenoic acid levels in cognitively normal older adults in Japan
An inverse association of cerebral amyloid-β deposition and serum docosahexaenoic acid levels in cognitively normal older adults in Japan Open
Background Alzheimer's disease (AD) is driven by amyloid-β (Aβ) plaque accumulation, but the mechanisms behind this process remain unclear. Omega-3 fatty acids, particularly docosahexaenoic acid (DHA), may offer protective effects, though …
View article: Lipoprotein(a) Levels and the Risk of Coronary Heart Disease and Stroke: The Suita Study
Lipoprotein(a) Levels and the Risk of Coronary Heart Disease and Stroke: The Suita Study Open
Lp(a) ≥ 30 mg/dL was associated with an increased risk of CHD in the Japanese population.
View article: Developing and Validating a New Atrial Fibrillation Risk Score Using Medical Examination Items in a Japanese Population ― The Suita Study ―
Developing and Validating a New Atrial Fibrillation Risk Score Using Medical Examination Items in a Japanese Population ― The Suita Study ― Open
The new risk score to predict AF uses items similar to those used in Japanese governmental health check-ups.
View article: Machine Learning Model for Predicting Coronary Heart Disease Risk: Development and Validation Using Insights From a Japanese Population–Based Study
Machine Learning Model for Predicting Coronary Heart Disease Risk: Development and Validation Using Insights From a Japanese Population–Based Study Open
Background Coronary heart disease (CHD) is a major cause of morbidity and mortality worldwide. Identifying key risk factors is essential for effective risk assessment and prevention. A data-driven approach using machine learning (ML) offer…
View article: Regular Smoking Accelerates the Decline in Masticatory Performance in Japanese Men: The Suita Study
Regular Smoking Accelerates the Decline in Masticatory Performance in Japanese Men: The Suita Study Open
Background Smoking is presumed to cause a decline in masticatory performance by worsening the intraoral environment in various ways. However, no longitudinal study has examined the relationship between smoking and masticatory performance. …
View article: Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan
Association between physical multimorbidity in middle adulthood and mortality: findings from two large cohort studies in Japan Open
View article: Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia
Green tea consumption and cerebral white matter lesions in community-dwelling older adults without dementia Open
View article: Association between decreased occlusal support and diabetes mellitus diagnosed by the oral glucose tolerance test with and without periodontal disease: The Suita Study
Association between decreased occlusal support and diabetes mellitus diagnosed by the oral glucose tolerance test with and without periodontal disease: The Suita Study Open
Decreased occlusal support was associated with DM in patients with PD.
View article: Machine Learning-Based Prediction of Coronary Heart Disease: Comprehensive Insights from the Suita Study (Preprint)
Machine Learning-Based Prediction of Coronary Heart Disease: Comprehensive Insights from the Suita Study (Preprint) Open
BACKGROUND Coronary heart disease (CHD) is a major cause of morbidity and mortality worldwide. Identifying key risk factors is essential for effective risk assessment and prevention. Machine learning (ML) offers advanced methods for analy…
View article: Risk factors for intracerebral hemorrhage by five specific bleeding sites: Japan Public Health Center-based Prospective Study
Risk factors for intracerebral hemorrhage by five specific bleeding sites: Japan Public Health Center-based Prospective Study Open
Background: Evaluating the risk factors for intracerebral hemorrhage is indispensable for primary prevention. However, the pathogenesis varies depending on the bleeding site, and few prospective studies have explored risk factors in detail…
View article: Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome
Equol Nonproducing Status as an Independent Risk Factor for Acute Cardioembolic Stroke and Poor Functional Outcome Open
Background/Objectives: Equol has protective effects against coronary artery disease and dementia by strongly binding to estrogen receptor beta, whereas the intake of soy isoflavone alone does not always confer such protective effects. Equo…
View article: Lifetime Risk of Incident Coronary Heart Disease, Stroke, and Cardiovascular Disease: The Japan Public Health Center-Based Prospective Study
Lifetime Risk of Incident Coronary Heart Disease, Stroke, and Cardiovascular Disease: The Japan Public Health Center-Based Prospective Study Open
The impact of risk accumulation on LTR of CVD was greater in men, and 1 in 4 men with ≥ 2 major risk factors at 45 years of age developed CVD in their lifetime.
View article: Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study
Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study Open
Stroke constitutes a significant public health concern due to its impact on mortality and morbidity. This study investigates the utility of machine learning algorithms in predicting stroke and identifying key risk factors using data from t…
View article: Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study
Machine Learning Approaches for Stroke Risk Prediction: Findings from the Suita Study Open
Stroke constitutes a significant public health concern due to its impact on mortality and morbidity. This study investigates the utility of machine learning algorithms in predicting stroke and identifying key risk factors using data from t…
View article: Lifestyle Behaviors of Childhood and Adolescence: Contributing Factors, Health Consequences, and Potential Interventions
Lifestyle Behaviors of Childhood and Adolescence: Contributing Factors, Health Consequences, and Potential Interventions Open
In this narrative review, we summarized evidence from peer-reviewed articles, published before February 2024, that investigated lifestyle behaviors among children (≤12 years) and adolescents (13-18 years) representing different geographic …
View article: Unveiling Coronary Heart Disease Prediction through Machine Learning Techniques: Insights from the Suita Population-Based Cohort Study
Unveiling Coronary Heart Disease Prediction through Machine Learning Techniques: Insights from the Suita Population-Based Cohort Study Open
We leveraged machine learning (ML) techniques, namely logistic regression (LR), random forest (RF), support vector machine (SVM), extreme gradient boosting (XGBoost), and LightGBM to predict coronary heart disease (CHD) and identify the ke…
View article: Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD)
Serum high-sensitivity C-reactive protein and dementia in a community-dwelling Japanese older population (JPSC-AD) Open
View article: Differential diagnosis between LQT1 and LQT2 by QT/RR relationships using 24-hour Holter monitoring: a multicenter cross-sectional study
Differential diagnosis between LQT1 and LQT2 by QT/RR relationships using 24-hour Holter monitoring: a multicenter cross-sectional study Open
Background The clinical course and therapeutic strategies in the congenital long QT syndrome (LQTS) are genotype-specific. However, accurate estimation of LQTS-genotype is often difficult from the standard 12-lead ECG. Objectives This stud…
View article: Table of Contents
Table of Contents Open
View article: The association between antenatal coffee consumption and preeclampsia: a systematic review and meta-analysis
The association between antenatal coffee consumption and preeclampsia: a systematic review and meta-analysis Open
The association between antenatal coffee consumption and preeclampsia remains inconclusive. Future prospective cohort studies are needed to better investigate this association.
View article: The association between stair climbing and modifiable cardiovascular disease risk factors: the Suita Study
The association between stair climbing and modifiable cardiovascular disease risk factors: the Suita Study Open
Stair climbing was inversely associated with obesity, smoking, physical inactivity, and stress; suggesting a potential role for cardiovascular disease prevention.
View article: Common Carotid Artery Stenosis Degree as a Predictor of Cardiovascular Disease in a General Population: The Suita Study
Common Carotid Artery Stenosis Degree as a Predictor of Cardiovascular Disease in a General Population: The Suita Study Open
Background The utility of screening for the degree of common carotid artery (CCA) stenosis as a predictor of cardiovascular disease (CVD) in a general population remains unclear. Methods and Results We studied 4775 Japanese men and women w…
View article: Fatty Liver Index and the Risk of Atrial Fibrillation in a General Japanese Population ― The Suita Study ―
Fatty Liver Index and the Risk of Atrial Fibrillation in a General Japanese Population ― The Suita Study ― Open
A U-shaped association between FLI and AF risk was detected in Japanese women. FLI could be a screening tool to detect women at high risk of developing AF.
View article: Risk and Population Attributable Fraction of Stroke Subtypes in Japan
Risk and Population Attributable Fraction of Stroke Subtypes in Japan Open
Although there are differences according to subtypes, hypertension could be regarded as the most crucial target for preventing strokes in Japan.
View article: Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease ― The Japan Public Health Center-Based Prospective Study ―
Impact of Cardiovascular Disease on the Death Certificate Diagnosis of Heart Failure, Ischemic Heart Disease, and Cerebrovascular Disease ― The Japan Public Health Center-Based Prospective Study ― Open
HF as the UCD was partly explained by CVD. The data imply that most HF deaths reported in vital statistics may be associated with underlying causes other than CVD.
View article: Prevalence of family history of cancer in the NC-CCAPH consortium of Japan
Prevalence of family history of cancer in the NC-CCAPH consortium of Japan Open
View article: Supplementary Material for: Liver enzymes and the risk of stroke among the general Japanese population: a prospective cohort study
Supplementary Material for: Liver enzymes and the risk of stroke among the general Japanese population: a prospective cohort study Open
Background: Stroke is a major cause of morbidity and mortality. Liver enzymes, alanine aminotransferase (ALT), aspartate aminotransferase (AST), and gamma-glutamyl transpeptidase (GGT), are markers of liver diseases with potential cardiova…