Yoshihiro Nishikawa
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View article: Utility of a novel tapered-tip sheath system for preoperative mapping biopsy of biliary tract cancers
Utility of a novel tapered-tip sheath system for preoperative mapping biopsy of biliary tract cancers Open
Preoperative evaluation of biliary tract cancer progression plays a critical role in assessing resectability and in selecting the appropriate surgical procedure. This study aimed to evaluate the utility of a novel tapered-tip sheath system…
View article: Abstract 2788 Chemokine Switching via ARF6-AMAP1: A Key Mechanism of Immune Evasion in Pancreatic Cancer
Abstract 2788 Chemokine Switching via ARF6-AMAP1: A Key Mechanism of Immune Evasion in Pancreatic Cancer Open
View article: Efficacy and Safety of a Novel Tapered-Tip Sheath System for Biliary-Lesion Tissue Sampling: A Randomized Controlled Trial
Efficacy and Safety of a Novel Tapered-Tip Sheath System for Biliary-Lesion Tissue Sampling: A Randomized Controlled Trial Open
The novel tapered-tip sheath system is a promising option for precisely and safely delivering biopsy forceps to target sites, thereby facilitating the diagnosis of biliary strictures.
View article: Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study
Anti-integrin αvβ6 autoantibody in primary sclerosing cholangitis: a Japanese nationwide study Open
Background Although specific biomarkers for primary sclerosing cholangitis (PSC) are required, no such biomarkers have been identified. We previously reported that patients with PSC had anti-integrin αvβ6 autoantibodies at only two hospita…
View article: Anti-integrin αvβ6 Antibodies Predict Pouchitis in Patients With Ulcerative Colitis After Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis
Anti-integrin αvβ6 Antibodies Predict Pouchitis in Patients With Ulcerative Colitis After Restorative Proctocolectomy With Ileal Pouch-Anal Anastomosis Open
Background Pouchitis is the most common complication of restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We previously reported the presence of anti-integrin αvβ6 antibodi…
View article: Anti-integrin αvβ6 antibodies predict pouchitis in patients with ulcerative colitis after restorative proctocolectomy with ileal pouch-anal anastomosis
Anti-integrin αvβ6 antibodies predict pouchitis in patients with ulcerative colitis after restorative proctocolectomy with ileal pouch-anal anastomosis Open
Background Pouchitis is the most common complication of restorative proctocolectomy (RPC) with ileal pouch-anal anastomosis (IPAA) in patients with ulcerative colitis (UC). We previously reported the presence of anti-integrin αvβ6 antibodi…
View article: Removal of a torn biliary stent fragment using a novel tapered-tip sheath system
Removal of a torn biliary stent fragment using a novel tapered-tip sheath system Open
View article: Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis
Anti-integrin αvβ6 autoantibodies are a potential biomarker for ulcerative colitis-like immune checkpoint inhibitor-induced colitis Open
View article: Pancreatic stent removal with a novel drill dilator
Pancreatic stent removal with a novel drill dilator Open
Video 1Pancreatic stent removal with a novel drill dilator.
View article: <scp>ELF3</scp> suppresses gallbladder cancer development through downregulation of the <scp>EREG</scp>/<scp>EGFR</scp>/<scp>mTOR</scp> complex 1 signalling pathway
<span>ELF3</span> suppresses gallbladder cancer development through downregulation of the <span>EREG</span>/<span>EGFR</span>/<span>mTOR</span> complex 1 signalling pathway Open
The prognosis of gallbladder cancer (GBC) remains poor, and a better understanding of GBC molecular mechanisms is important. Genome sequencing of human GBC has demonstrated that loss‐of‐function mutations of E74‐like ETS transcription fact…
View article: Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis
Anti-integrin αvβ6 autoantibodies in patients with primary sclerosing cholangitis Open
View article: An overview of the reclassification of COVID-19 of the Infectious Diseases Control Law in Japan
An overview of the reclassification of COVID-19 of the Infectious Diseases Control Law in Japan Open
Japan's responses to COVID-19 have been conducted based on the Act on the Prevention of Infectious Diseases and Medical Care for Patients with Infectious Diseases (the Infectious Diseases Control Law) and the Act on Special Measures agains…
View article: Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…
View article: Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
Supplementary Figures 1-8 and Tables 1-3
View article: Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Data from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
The acquisition of mesenchymal traits leads to immune evasion in various cancers, but the underlying molecular mechanisms remain unclear. In this study, we found that the expression levels of AT-rich interaction domain-containing protein 5…
View article: Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression
Supplementary Figures and Tables from Arid5a Promotes Immune Evasion by Augmenting Tryptophan Metabolism and Chemokine Expression Open
Supplementary Figures 1-8 and Tables 1-3
View article: Table S1-3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Table S1-3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
table S1 : recombination detection primers and qPCR primers. tableS2 : antibodies for immunohistochemistory and two chamber assay. tableS3 : list of PDAC patients
View article: Data from <i>Hes1</i> Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
Data from <i>Hes1</i> Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma Open
Intrahepatic cholangiocarcinoma (ICC) is frequently driven by aberrant KRAS activation and develops in the liver with chronic inflammation. Although the Notch signaling pathway is critically involved in ICC development, detailed mec…
View article: Supplemental Legends from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
Supplemental Legends from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors Open
Supplemental Figure legends and Table Legend
View article: Figure S6 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Figure S6 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
Cxcr4 KO inhibits liver metastasis in splenic injection model.
View article: Table S1-3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Table S1-3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
table S1 : recombination detection primers and qPCR primers. tableS2 : antibodies for immunohistochemistory and two chamber assay. tableS3 : list of PDAC patients
View article: Figure S1 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Figure S1 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
Cxcr4 is not essential for pancreatic development.
View article: Figure S2 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Figure S2 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
Cxcr4 KO does not affect Cxcr4 expression in immune cells of the spleen.
View article: Figure S5 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Figure S5 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
Myofibroblasts secrete Cola 1a1 and Cxcl12 in tumor environment.
View article: Supplementary Data from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
Supplementary Data from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors Open
Supplemental Table 1. PanNETs incidence per genotype. Figure S1: Representative images of LacZ staining in the pancreas in Pdx1-Cre;Rosa26R mice; S2: Experimental strategy for generation of Pdx1-Cre;Trp53R172H mice. S3: H&E, immunohistoche…
View article: Data from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors
Data from Rb and p53 Execute Distinct Roles in the Development of Pancreatic Neuroendocrine Tumors Open
Pancreatic neuroendocrine tumors (PanNET) were classified into grades (G) 1 to 3 by the World Health Organization in 2017, but the precise mechanisms of PanNET initiation and progression have remained unclear. In this study, we used a gene…
View article: Figure S7 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Figure S7 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
Immunohistochemistry for CXCR4 and AE1/AE3 with human PDAC specimens
View article: Table. S3 from <i>Hes1</i> Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
Table. S3 from <i>Hes1</i> Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma Open
Leading edge genes in gene set enrichment analysys using HALLMARK gene set of KRAS_SIGNALING_UP.
View article: Figure S3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma
Figure S3 from CXCR4 in Tumor Epithelial Cells Mediates Desmoplastic Reaction in Pancreatic Ductal Adenocarcinoma Open
Cxcr4 KO does not affect tumor infiltration of immune cells.
View article: Table. S2 from <i>Hes1</i> Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma
Table. S2 from <i>Hes1</i> Is Essential in Proliferating Ductal Cell–Mediated Development of Intrahepatic Cholangiocarcinoma Open
Differentially expressed genes between 48-week-old AlbcreK; Hes1WT/WT and AlbcreK; Hes1flox/flox mice.