Explanipedia

Case Report: Improved hearing in a rare, adult IDH2-mutant brainstem astrocytoma successfully treated with radiation and temozolomide Open

Takuya Okada, Manabu Natsumeda, Hidemoto Fujiwara, Nayuta Higa, Toshiaki Akahane , et al. · 2025

Introduction Brain stem gliomas harboring IDH mutations can be sensitive to temozolomide (TMZ) treatment, unlike their H3K27-altered counterparts, so distinguishing the two is essential. Case presentation Here, we report an adult brainstem…

Near-Infrared Photoimmunotherapy in Brain Tumors—An Unexplored Frontier Open

Haruka Yamaguchi, Masayasu Okada, Takuya Otani, Jotaro On, Satoshi Shibuma , et al. · 2025

Near-infrared photoimmunotherapy (NIR-PIT) is a promising cancer treatment that uses near-infrared light to activate a conjugate of a monoclonal antibody (mAb) and a photoactivatable silica phthalocyanine dye (IRDye700DX: IR700). Unlike co…

Modified Lateral Approach to the Anterior Tibial Artery’s Origin With Limited Fibular Resection: A Case Report of Free Flap Reconstruction for Lateral Skin Defects in Single-vessel Lower Extremities Open

Hisataka Takeuchi, Sadaki Mitsuzawa, Koji Ikejiri, Yoshihiro Tsukamoto, Shinnosuke Yamashita , et al. · 2025

Summary: In free flap surgery for open fractures of the lower leg, selecting recipient vessels can be difficult when multiple vessels are injured. In single-vessel lower extremities, surgeons must choose between using the remaining vessel …

Improved health-related quality of life after rehabilitation in patients with brain tumors is not affected by tumor type Open

Takahiro Watanabe, Shinichi Noto, Manabu Natsumeda, Shinji Kimura, Fumie Ikarashi , et al. · 2025

These results suggest rehabilitation therapy may contribute to improved HRQOL irrespective of brain tumor type.

Risk Factors Preventing Identification of the Microorganism Causing Vertebral Osteomyelitis Open

Yushi Sakamoto, Eijiro Onishi, Sadaki Mitsuzawa, Satoshi Ota, Hisataka Takeuchi , et al. · 2025

Study Design Retrospective study. Objective To elucidate the factors influencing the identification of causative microorganisms in vertebral osteomyelitis (VO) and the effectiveness of different culture methods in increasing the identifica…

Diagnosis of Leptomeningeal Disease in Diffuse Midline Gliomas by Detection of <i>H3F3A</i> K27M Mutation in Circulating Tumor DNA of Cerebrospinal Fluid Open

Satoshi Shibuma, Jotaro On, Manabu Natsumeda, Akihide Koyama, Haruhiko Takahashi , et al. · 2025

Introduction Leptomeningeal disease (LMD) in diffuse midline gliomas (DMGs) can lead to devastating symptoms such as severe pain, urinary incontinence, and tetraparesis, with limited treatment options. We determined whether detecting H3F3A…

A new classification for dislocated and displaced proximal humeral fractures Open

Sadaki Mitsuzawa, Hisataka Takeuchi, Kousei Ijiri, Yasushi Furusho, Shinnosuke Yamashita , et al. · 2025

Association Between Trauma-Induced Vertebral Fractures and Motor Weakness in Patients With Diffuse Idiopathic Skeletal Hyperostosis Open

Ryohei Saito, Eijiro Onishi, Sadaki Mitsuzawa, Satoshi Ota, Hisataka Takeuchi , et al. · 2024

Background Diffuse idiopathic skeletal hyperostosis (DISH) is an age-related condition involving abnormal ossification of soft tissues, including ligaments and joint capsules. Patients with DISH have an increased risk of fractures, especia…

10199- ET-16 NEAR-INFRARED PHOTOIMMUNOTHERAPY FOR THE TREATMENT OF MALIGNANT BRAIN TUMORS Open

Manabu Natsumeda, Jotaro On, Satoshi Shibuma, Jun Watanabe, Yoshihiro Tsukamoto , et al. · 2024

BACKGROUND Near-infrared photoimmunotherapy (NIR-PIT) is a novel intraoperative local therapy. It involves a photosensitizer a near-infrared dye (IR700) conjugated to monoclonal antibodies targeting surface antigens of cancer cells. After …

What is the Optimal Treatment Protocol for Traumatic Popliteal Artery Injury? A Comparative Study between Two Institutions Open

Sadaki Mitsuzawa, Shinnosuke Yamashita, Yoshihiro Tsukamoto, Hisataka Takeuchi, Satoshi Ota , et al. · 2024

Introduction: While rare, popliteal artery injury is a potentially devastating complication of knee trauma. Delayed diagnosis or inadequate management of popliteal artery injury can result in limb ischemia, amputation, and long-term disabi…

Cost of medical care for malignant brain tumors at hospitals in the Japan Clinical Oncology Group brain-tumor study group Open

Kazuya Motomura, Keita Sasaki, Narushi Sugii, Shigeru Yamaguchi, Hirotaka Inoue , et al. · 2024

Background This study aimed to investigate what treatment are selected for malignant brain tumors, particularly glioblastoma (GBM) and primary central nervous system lymphoma (PCNSL), in real-world Japan and the costs involved. Methods We …

Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features Open

Daiken Satake, Manabu Natsumeda, Kaishi Satomi, Mari Tada, Taro Sato , et al. · 2024

Molecular analysis of the growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thu…

Successful Multimodal Treatment of Intracranial Growing Teratoma Syndrome with Malignant Features Open

Daiken Satake, Manabu Natsumeda, Kaishi Satomi, Mari Tada, Taro Sato , et al. · 2024

Molecular analysis of growing teratoma syndrome has not been extensively studied. Here, we report a 14-year-old boy with a growing mass during treatment for a mixed germ cell tumor of the pineal region. Tumor markers were negative; thus, g…

Missense mutation of NRAS is associated with malignant progression in neurocutaneous melanosis Open

Haruhiko Takahashi, Manabu Natsumeda, Norikazu Hara, Akihide Koyama, Hiroshi Shimizu , et al. · 2024

10091-COT-12 ELUCIDATING THE PATHOPHYSIOLOGY OF POST-OPERATIVE VENOUS THROMBOEMBOLISM IN IDH-WILDTYPE MALIGNANT GLIOMAS Open

Manabu Natsumeda, Kazuhiro Ando, Jun Watanabe, Haruhiko Takahashi, Yoshihiro Tsukamoto , et al. · 2023

BACKGROUND We have previously reported elevated expression of podoplanin and high incidence of post-operative venous thromboembolism (VTE) in IDH-wildtype gliomas (Watanabe et al., World Neurosurgery, 2019). Podoplanin binds to C-type lect…

10141-GMC-13 MULTIREGIONAL GENOMIC ANALYSIS: A NOVEL APPROACH FOR DETECTING PATHOGENIC DRIVER MUTATION ASSOCIATED WITH MALIGNANT PROGRESSION IN NEUROCUTANEOUS MELANOSIS Open

Haruhiko Takahashi, Manabu Natsumeda, Yoshihiro Tsukamoto, Masayasu Okada, Norikazu Hara , et al. · 2023

Neurocutaneous melanosis (NCM) is a rare congenital neurocutaneous syndrome characterized by congenital melanocytic nevus of skin and abnormal proliferation of leptomeningeal melanocytes. Early acquisition of post-zygotic somatic mutations…

Reliable detection of genetic alterations in cyst fluid DNA for the diagnosis of brain tumors Open

Jotaro On, Manabu Natsumeda, Haruhiko Takahashi, Akihide Koyama, Satoshi Shibuma , et al. · 2023

Purpose Liquid biopsy of cyst fluid in brain tumors has not been extensively studied to date. The present study was performed to see whether diagnostic genetic alterations found in brain tumor tissue DNA could also be detected in cell-free…

EXTH-46. SCHLAFEN11 IS A POWERFUL BIOMARKER OF CHEMOSENSITIVITY IN MEDULLOBLASTOMAS Open

Manabu Natsumeda, Satoshi Nakata, Junko Murai, Haruhiko Takahashi, Masayasu Okada , et al. · 2023

Non-biased and biased screening for prognostic factors in medulloblastomas showed that Schlafen family member 11 (SLFN11) is a powerful prognostic marker. SLFN11 is a putative DNA/RNA helicase, whose expression improves response to DNA dam…

Acute total occlusion of the common femoral artery as a consequence of COVID-19 pneumonia resulting in hip joint disarticulation: Report of an unusual case Open

Hisataka Takeuchi, Yoshihiro Tsukamoto, Rei Kato, Sadaki Mitsuzawa, Shinnosuke Yamashita , et al. · 2023

COVID-19-associated arterial thrombosis is rare but can occur in patients with mild respiratory symptoms. We present an unusual case of acute limb ischemia in a 67-year-old man with COVID-19 pneumonia, resulting in total occlusion of the l…

Clinical, imaging, and molecular features of radiation-induced glioblastomas developing more than 20 years after radiation therapy for intracranial germinomatous germ cell tumor: illustrative cases Open

Yoshihiro Tsukamoto, Manabu Natsumeda, Haruhiko Takahashi, Asuka Ueno, Kiichi Sakai , et al. · 2023

BACKGROUND Germinomatous germ cell tumor is highly sensitive to chemoradiotherapy; patients are expected to survive for decades. Many radiation-induced malignant gliomas (RIMGs) occur >10 years after radiotherapy. Standard therapy for RIMG…

Preoperative Lower-Limb Muscle Predictors for Gait Speed Improvement after Total Hip Arthroplasty for Patients with Osteoarthritis Open

Tadashi Yasuda, Satoshi Ota, Sadaki Mitsuzawa, Shinnosuke Yamashita, Yoshihiro Tsukamoto , et al. · 2023

This study aimed to identify preoperative lower-limb muscle predictors for gait speed improvement after total hip arthroplasty (THA) with hip osteoarthritis. Gait speed improvement was evaluated as the subtraction of preoperative speed fro…

Preliminary Experience of Photodynamic Therapy for Malignant Gliomas and Shooting for Next-generation Treatment Open

Manabu Natsumeda, Jotaro On, Jun Watanabe, Yoshihiro Tsukamoto, Masayasu Okada , et al. · 2023

2018年7月に当科に光線力学療法（photodynamic therapy: PDT）を導入してから2021年6月まで，当科でPDTを施行した悪性脳腫瘍症例の臨床的特徴および無増悪生存期間（progression free survival: PFS），全生存期間（overall survival: OS），主な合併症について検討した．初発膠芽腫9例におけるPFSの中央値は14ヶ月，OS中央値は未達であった．死亡例は早期に遠隔再発を来した1例のみであった．主な合併症は光過…

Diffusely Infiltrating Gliomas With Poor Prognosis, TERT Promotor Mutations, and Histological Anaplastic Pleomorphic Xanthoastrocytoma-Like Appearance Classify as Mesenchymal Type of Glioblastoma, IDH-wildtype by Methylation Analysis Open

Yoshihiro Tsukamoto, Manabu Natsumeda, Haruhiko Takahashi, Jotaro On, Hiroki Seto , et al. · 2023

BACKGROUND: Pleomorphic xanthoastrocytoma (PXA) (World Health Organization grade II) is classified as a relatively benign and circumscribed glioma; however, anaplastic PXA (APXA, World Health Organization grade III) has a poorer prognosis,…

Multidrug chemotherapy, whole-brain radiation and cytarabine therapy for primary central nervous system lymphoma in elderly patients with dose modification based on geriatric assessment: study protocol for a phase II, multicentre, non-randomised study Open

Fumiyuki Yamasaki, Hirotaka Fudaba, Kenichiro Asano, Takashi Sasayama, Manabu Natsumeda , et al. · 2023

Introduction Multidrug chemoimmunotherapy with rituximab, high-dose methotrexate, procarbazine and vincristine (R-MPV) is a standard therapy for younger patients with primary central nervous system lymphoma (PCNSL); however, prospective da…

Preoperative three-dimensional multifusion imaging aiding successful microvascular decompression of a cerebellopontine angle lipoma: associated hemifacial spasm. Illustrative case Open

Hiroki Seto, Ryosuke Ogura, Tetsuya Hiraishi, Yoshihiro Tsukamoto, Taiki Saito , et al. · 2023

BACKGROUND Cerebellopontine angle (CPA) lipoma–associated hemifacial spasm (HFS) is rare. As the removal of CPA lipomas has a high risk of worsening the neurological symptoms, surgical exploration is warranted only in selected patients. Pr…

Correction loss following short-segment posterior fixation for traumatic thoracolumbar burst fractures related to endplate and intervertebral disc destruction Open

Takumi Hashimura, Eijiro Onishi, Satoshi Ota, Yoshihiro Tsukamoto, Shinnosuke Yamashita , et al. · 2023

Background There has been widespread use of short-segment posterior fixation (SSPF) for traumatic thoracolumbar burst fractures. The relationship between the destruction of the vertebral endplate and adjacent disc and postoperative correct…

Risk Factors for the Incidence of the Volar Lunate Facet Fragments in Distal Radius Fractures Open

Sadaki Mitsuzawa, Hisataka Takeuchi, Yoshihiro Tsukamoto, Shinnosuke Yamashita, Satoshi Ota , et al. · 2023

Background The volar lip of the distal radius is the key structure for wrist joint stability. Rigid fixation of the volar lunate facet (VLF) fragment is difficult because of its unique anatomy, and a high rate of postoperative displacement…

ET-6 EFFICACY OF NEAR-INFRARED PHOTOIMMUNOTHERAPY TARGETING PODOPLANIN IN MALIGNANT GLIOMAS Open

Manabu Natsumeda, Jotaro On, Jun Watanabe, Kazuhiro Ando, Yoshihiro Tsukamoto , et al. · 2022

Background Near-infrared photoimmunotherapy (NIR-PIT) is a new cancer treatment based on a conjugate of photosensitizer IR700 and an antibody which selectively binds to the surface antigen of cancer cells. Upon exposure to near infrared li…

Correction loss following short-segment posterior fixation for traumatic thoracolumbar burst fractures related to endplate and intervertebral disc destruction Open

Takumi Hashimura, Eijiro Onishi, Satoshi Ota, Yoshihiro Tsukamoto, Shinnosuke Yamashita , et al. · 2022

Background Short-segment posterior fixation (SSPF) for traumatic thoracolumbar burst fractures has been widely used. Few studies have addressed the association between the destruction of the vertebral endplate and adjacent disc and postope…

Epigenetic upregulation of Schlafen11 renders  WNT- and SHH-activated medulloblastomas sensitive to cisplatin Open

Satoshi Nakata, Junko Murai, Masayasu Okada, Haruhiko Takahashi, Tyler H Findlay , et al. · 2022

Background Intensive chemotherapeutic regimens with craniospinal irradiation have greatly improved survival in medulloblastoma patients. However, survival markedly differs among molecular subgroups and their biomarkers are unknown. Through…

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