Yoshihisa Arao
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View article: Employment Status of Patients With Liver Disease: A Nationwide Questionnaire Survey in Japan
Employment Status of Patients With Liver Disease: A Nationwide Questionnaire Survey in Japan Open
Aim Patients with chronic liver disease often experience significant physical, psychological, and financial burdens. These burdens result from repeated long‐term hospital visits or admissions caused by progression to decompensated cirrhosi…
View article: Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice
Maid gene dysfunction promotes hyperobesity via the reduction of adipose tissue inflammation in Mc4r gene-deficient mice Open
View article: Maid gene dysfunction promotes hyperobesity via the reduction of anti-inflammatory macrophages in Mc4r gene-deficient mice
Maid gene dysfunction promotes hyperobesity via the reduction of anti-inflammatory macrophages in Mc4r gene-deficient mice Open
The onset and progression mechanisms of metabolic dysfunction-associated steatotic liver disease (MASLD) and metabolic dysfunction-associated steatohepatitis (MASH) are being studied. We developed and analyzed a new mouse model of obesity …
View article: Which nonhepatology departments are in urgent need of measures for treating patients positive for hepatitis virus?
Which nonhepatology departments are in urgent need of measures for treating patients positive for hepatitis virus? Open
In eight regional core centers for liver disease management, we evaluated the status of HBs antigen (HBsAg) and anti-hepatitis C virus antibody (anti-HCV) testing from 2016 to 2020. Among nonhepatology departments, ophthalmology had the hi…
View article: Present status of hepatitis medical care coordinators in regional core centers for liver disease management in Japan (second report)
Present status of hepatitis medical care coordinators in regional core centers for liver disease management in Japan (second report) Open
Hepatitis medical care coordinators (HMCCs) in Japan are trained by local governments and regional core centers, and are expected to play an active role in various aspects of hepatitis countermeasures. A 2019 survey revealed varied activit…
View article: A rare cause of esophageal stenosis: Compression due to a thoracic osteophyte
A rare cause of esophageal stenosis: Compression due to a thoracic osteophyte Open
Several cases of esophageal stenosis caused by cervical vertebral osteophytes have been reported; however, few reports of esophageal stenosis caused by thoracic osteophytes are available. We describe the case of an 86‐year‐old man with eso…
View article: Machine learning prediction model for treatment responders in patients with primary biliary cholangitis
Machine learning prediction model for treatment responders in patients with primary biliary cholangitis Open
Background and Aim Treatment response to ursodeoxycholic acid may predict the prognosis of patients with primary biliary cholangitis (PBC). Recent studies have suggested the benefits of using machine learning (ML) to forecast complex medic…
View article: Massive Empyema With <i>Edwardsiella tarda</i> in a Patient With Liver Cirrhosis
Massive Empyema With <i>Edwardsiella tarda</i> in a Patient With Liver Cirrhosis Open
Although infection caused by Edwardsiella tarda is rare in humans, it can be fatal if contracted. A 78-year-old man with liver cirrhosis who ate raw fish on a regular basis was emergently admitted for treatment of septic shock. Computed to…
View article: Cumulative risk of developing a new symptom in patients with primary biliary cholangitis and its impact on prognosis
Cumulative risk of developing a new symptom in patients with primary biliary cholangitis and its impact on prognosis Open
Background and Aim Symptoms of primary biliary cholangitis (PBC) frequently impair one's quality of life (QOL). Nonetheless, with improved treatment, the prognosis of PBC also improves. QOL plays an important role in patients with PBC. In …
View article: Longitudinal increase in albumin–bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis
Longitudinal increase in albumin–bilirubin score is associated with non-malignancy-related mortality and quality of life in patients with liver cirrhosis Open
Due to the developments in the treatment for hepatitis, it is possible to prevent the progression of liver fibrosis and improve patients’ prognosis even if it has already led to liver cirrhosis (LC). Consequently, a two-step study was cond…
View article: Liver cirrhosis with ruptured splenic artery aneurysm leading to hepatitis C treatment: A case report
Liver cirrhosis with ruptured splenic artery aneurysm leading to hepatitis C treatment: A case report Open
症例は50代の女性.30代でC型肝炎ウイルスへの感染を指摘されていたが治療に至らず,継続的な受診も行っていなかった.腹痛と意識消失を主訴に救急搬送され,脾動脈瘤破裂による出血性ショックと診断された.当院で脾動脈瘤塞栓術を施行し,術後経過は良好であった.外来にて直接作用型抗ウイルス薬を導入し,ウイルス学的著効を達成した.CT検査の普及により,脾動脈瘤の偶然の発見も増加していると報告されていて,今後本例のように肝臓以外の疾患での受診を契機に,ウイルス性肝炎や肝硬変の診断から治療…
View article: Advances in the Treatment of Gastrointestinal Bleeding: Safety and Efficiency of Transnasal Endoscopy
Advances in the Treatment of Gastrointestinal Bleeding: Safety and Efficiency of Transnasal Endoscopy Open
Acute upper gastrointestinal bleeding (UGIB) is a common disorder and a gastroenterological emergency. With the development of new techniques and devices, the survivability after gastrointestinal bleeding is improving. However, at the same…
View article: The prognosis and incidence of hepatic encephalopathy of patients with liver cirrhosis treated with proton pump inhibitors
The prognosis and incidence of hepatic encephalopathy of patients with liver cirrhosis treated with proton pump inhibitors Open
Gastrointestinal bleeding, hepatic encephalopathy (HE), and hepatocarcinogenesis are associated with the prognosis of patients with liver cirrhosis (LC). Proton pump inhibitors (PPIs) have been used to prevent bleeding, however the effects…
View article: Novel Strategy for Diagnosis of Focal Nodular Hyperplasia Using Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid: Enhanced Magnetic Resonance Imaging and Magnetic Resonance Elastography
Novel Strategy for Diagnosis of Focal Nodular Hyperplasia Using Gadolinium Ethoxybenzyl Diethylenetriaminepentaacetic Acid: Enhanced Magnetic Resonance Imaging and Magnetic Resonance Elastography Open
Focal nodular hyperplasia (FNH) is the second most frequent benign liver tumor, and it is a fiber-rich stiff lesion. Typically, FNH can be diagnosed by imaging without biopsy. However, liver biopsy and diagnostic resection may be required …
View article: Present status of hepatitis medical care coordinators in regional core centers in Japan
Present status of hepatitis medical care coordinators in regional core centers in Japan Open
In Japan, each prefecture in collaboration with regional core centers is required to train hepatitis medical care coordinators (HMCCs). In this study, we surveyed the present status of HMCCs in 17 of the 71 regional core centers. The findi…
View article: Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and Its Role in Multidisciplinary Therapy
Efficacy and Safety of the Radiotherapy for Liver Cancer: Assessment of Local Controllability and Its Role in Multidisciplinary Therapy Open
This study investigated the efficacy and safety of radiotherapy as part of multidisciplinary therapy for advanced hepatocellular carcinoma (HCC). Clinical data of 49 HCC patients treated with radiotherapy were assessed retrospectively. The…
View article: Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review
Esophageal Ulcers Associated with Ulcerative Colitis: A Case Series and Literature Review Open
Ulcerative colitis, a chronic and recurrent inflammatory disease, is localized to the colonic mucosa but can affect other organs and lead to various complications. Gastroduodenitis associated with ulcerative colitis has been reported. Howe…
View article: Ten years' experience in Niigata Prefecture Liver Disease Consultation Center
Ten years' experience in Niigata Prefecture Liver Disease Consultation Center Open
平成21年に設立された新潟大学医歯学総合病院肝疾患相談センターは令和元年に10年目を迎え，236万人の新潟県民や医療従事者に対するウイルス性肝炎の情報の提供，啓発活動，助成制度のサポート等を新潟県健康対策課，厚生労働省健康局がん・疾病対策課肝炎対策室，国立国際医療センター肝炎情報センターとともに行ってきた．新潟県内の各種肝炎ウイルスの発生動向の報告，助成対象人数の把握や非受検者に対する啓発活動を各年度で行ってきた．C型肝炎については他県と同じく新規治療者数については減少段階…
View article: Rare case of circumferential esophageal peeling
Rare case of circumferential esophageal peeling Open
This report highlights the easy peeling of the esophageal epithelium with Nikolsky phenomenon after swallowing the foreign body and the healing status of the esophagus only 3 days later in a patient of pemphigus vulgaris.
View article: Daily Monitoring of Serum <i>Wisteria floribunda</i> Agglutinin-Positive Mac-2 Binding Protein Is Useful for Predicting Therapeutic Effect of Tolvaptan in Cirrhotic Ascites
Daily Monitoring of Serum <i>Wisteria floribunda</i> Agglutinin-Positive Mac-2 Binding Protein Is Useful for Predicting Therapeutic Effect of Tolvaptan in Cirrhotic Ascites Open
Wisteria floribunda agglutinin (WFA) is a lectin that binds to the sugar chain of Mac-2 binding protein (M2BP), and WFA-positive M2BP (WFA+-M2BP) has been reported as a useful marker for assessing liver fibrosis in chronic liver…
View article: Pulmonary tumor thrombotic microangiopathy of hepatocellular carcinoma: A case report and review of literature
Pulmonary tumor thrombotic microangiopathy of hepatocellular carcinoma: A case report and review of literature Open
PTTM is caused by tumor thrombi in the arteries and thickening of the pulmonary arterial endothelium leading to the symptoms of dyspnea in terminal staged patients. Therefore, supportive management of symptoms is necessary in the cases wit…
View article: A Rare Duodenal Carcinosarcoma: A Case Report and Literature Review
A Rare Duodenal Carcinosarcoma: A Case Report and Literature Review Open
Carcinosarcoma is a biphasic malignant tumor comprising both carcinomatous and sarcomatous components; its occurrence in the duodenum is very rare. We herein report the case of a 96-year-old woman with duodenal carcinosarcoma showing rapid…
View article: Utility of Over-the-Scope Clipping for Closure of a Persistent Post-Percutaneous Endoscopic Gastrostomy Fistula under Long-Term Steroid Therapy
Utility of Over-the-Scope Clipping for Closure of a Persistent Post-Percutaneous Endoscopic Gastrostomy Fistula under Long-Term Steroid Therapy Open
A 50-year-old woman had a percutaneous endoscopic gastrostomy (PEG) tube placed after surgery for pharyngeal cancer. After 21 months, the PEG tube was removed due to improvement of per-oral ingestion. She had taken prednisolone for 31 year…