Yuichiro Izumi
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View article: Alvespimycin is identified as a novel therapeutic agent for diabetic kidney disease by chemical screening targeting extracellular vesicles
Alvespimycin is identified as a novel therapeutic agent for diabetic kidney disease by chemical screening targeting extracellular vesicles Open
Extracellular vesicles (EVs) are important mediators of intercellular communication and play key roles in the regulation of pathophysiological processes. In diabetic kidney disease (DKD), it has been reported that macrophages recruited in …
View article: Rituximab as an Effective Treatment for New-onset Evans Syndrome and Systemic Lupus Erythematosus with Lupus Nephritis
Rituximab as an Effective Treatment for New-onset Evans Syndrome and Systemic Lupus Erythematosus with Lupus Nephritis Open
Evans syndrome (ES) is characterized by the development of autoimmune hemolytic anemia and immune thrombocytopenic purpura and is often linked to autoimmune diseases, such as systemic lupus erythematosus (SLE). Standard treatment includes …
View article: Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review
Recurrent Helicobacter cinaedi bacteremia cured with long-term oral minocycline treatment in a patient undergoing hemodialysis: a case report and literature review Open
Background Helicobacter cinaedi is a Gram-negative spiral bacillus that inhabits the intestines of animals. First reported in 1984 as the causative agent of proctitis in a homosexual man, it causes bacteremia, cellulitis, and infections in…
View article: A case of acute abdomen caused by visceral disseminated varicella-zoster virus infection causes diagnostic challenges during the course of systemic lupus erythematosus
A case of acute abdomen caused by visceral disseminated varicella-zoster virus infection causes diagnostic challenges during the course of systemic lupus erythematosus Open
Visceral disseminated varicella-zoster virus (VD-VZV) infection, resulting from primary infection by, or reactivation of, VZV, is a rare and severe complication in immunosuppressed patients. Because VD-VZV often develops alongside acute ab…
View article: Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections
Bacteria-specific modified nucleoside is released and elevated in urine of patients with bacterial infections Open
Over 170 types of chemical modifications have been identified in cellular RNAs across the three domains of life. Modified RNA is eventually degraded to constituent nucleosides, and in mammals, modified nucleosides are released into the ext…
View article: Mouse embryonic kidney transplantation identifies maturation defects in the medulla
Mouse embryonic kidney transplantation identifies maturation defects in the medulla Open
Kidney organoids are connected to the host circulation and mature after transplantation. However, they are still immature compared to the adult kidneys, and their precise maturation stages remain unclear. By transplanting the mouse embryon…
View article: Effects of supportive hemodialysis on the management of a pregnant woman with advanced chronic kidney disease: a case report and literature review
Effects of supportive hemodialysis on the management of a pregnant woman with advanced chronic kidney disease: a case report and literature review Open
Background Pregnancy in women with chronic kidney disease (CKD) is associated with an increased risk of adverse maternal and fetal outcomes, including worsening renal function, hypertension, proteinuria, preeclampsia, preterm delivery, sti…
View article: Renoprotective Effects of Daprodustat in Patients with Chronic Kidney Disease and Renal Anemia
Renoprotective Effects of Daprodustat in Patients with Chronic Kidney Disease and Renal Anemia Open
Many large-scale studies revealed that exogenous erythropoietin, erythropoiesis-stimulating agents, have no renoprotective effects. We reported the renoprotective effects of endogenous erythropoietin production on renal function in ischemi…
View article: WCN24-721 Clinicopathological features of tubulointerstitial nephritis (TIN) associated with irAE, COVID-19 infection, and COVID-19 vaccination in comparison with classical allergic TIN
WCN24-721 Clinicopathological features of tubulointerstitial nephritis (TIN) associated with irAE, COVID-19 infection, and COVID-19 vaccination in comparison with classical allergic TIN Open
In recent decades, there has been a significant increase in the frequency of immune-related adverse event (irAE)–associated renal injury due to the dramatic advances of anti-cancer immunotherapy. Of these, the most popular renal lesion is …
View article: Identification and verification of novel therapeutic agents for diabetic kidney disease based on exosome-targeted high-throughput chemical screening
Identification and verification of novel therapeutic agents for diabetic kidney disease based on exosome-targeted high-throughput chemical screening Open
Exosomes are important mediators of intercellular communication and play key roles in the regulation of pathophysiological processes. In diabetic kidney disease (DKD), it has been reported that macrophages recruited in the mesangial region…
View article: Tubular Endogenous Erythropoietin Protects Renal Function against Ischemic Reperfusion Injury
Tubular Endogenous Erythropoietin Protects Renal Function against Ischemic Reperfusion Injury Open
Many large-scale studies show that exogenous erythropoietin, erythropoiesis-stimulating agents, lack any renoprotective effects. We investigated the effects of endogenous erythropoietin on renal function in kidney ischemic reperfusion inju…
View article: Tubular Endogenous Erythropoietin Protects Renal Function against Ischemic Reperfusion Injury
Tubular Endogenous Erythropoietin Protects Renal Function against Ischemic Reperfusion Injury Open
Many large-scale studies revealed that exogenous erythropoietin, erythropoie-sis-stimulating agents, have no renoprotective effects. We investigated the effects of en-dogenous erythropoietin on renal function in ischemic reperfusion injury…
View article: Association between prognostic nutritional index and peritoneal dialysis discontinuation: a retrospective cohort study
Association between prognostic nutritional index and peritoneal dialysis discontinuation: a retrospective cohort study Open
Background Malnutrition is associated with discontinuing peritoneal dialysis (PD). The prognostic nutritional index (PNI), composed of serum albumin level and total lymphocyte count, has been suggested as a prognostic marker for mortality …
View article: A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats
A Serine Protease Inhibitor, Camostat Mesilate, Suppresses Urinary Plasmin Activity and Alleviates Hypertension and Podocyte Injury in Dahl Salt-Sensitive Rats Open
In proteinuric renal diseases, the serine protease (SP) plasmin activates the epithelial sodium channel (ENaC) by cleaving its γ subunit. We previously demonstrated that a high-salt (HS) diet provoked hypertension and proteinuria in Dahl s…
View article: Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice
Suppression of Indoxyl Sulfate Accumulation Reduces Renal Fibrosis in Sulfotransferase 1a1-Deficient Mice Open
Renal fibrosis is the final manifestation of chronic kidney disease (CKD); its prevention is vital for controlling CKD progression. Indoxyl sulfate (IS), a typical sulfate-conjugated uremic solute, is produced in the liver via the enzyme s…
View article: Progress in the Detection of Erythropoietin in Blood, Urine, and Tissue
Progress in the Detection of Erythropoietin in Blood, Urine, and Tissue Open
Detection of erythropoietin (Epo) was difficult until a method was developed by the World Anti-Doping Agency (WADA). WADA recommended the Western blot technique using isoelectric focusing (IEF)-PAGE to show that natural Epo and injected er…
View article: Supplementary data of "Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice"_112523
Supplementary data of "Characterization of gene expression in the kidney of renal tubular cell-specific NFAT5 knockout mice"_112523 Open
Kidney from renal tubular cell-specific NFAT5 knockout mice was analyzed TSS-Seq.
View article: The serine protease plasmin plays detrimental roles in epithelial sodium channel activation and podocyte injury in Dahl salt-sensitive rats
The serine protease plasmin plays detrimental roles in epithelial sodium channel activation and podocyte injury in Dahl salt-sensitive rats Open
Salt-sensitive hypertension is associated with poor clinical outcomes. The epithelial sodium channel (ENaC) in the kidney plays pivotal roles in sodium reabsorption and blood pressure regulation, in which its γ subunit is activated by extr…
View article: Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels
Camostat mesilate, a serine protease inhibitor, exerts aquaretic effects and decreases urinary exosomal AQP2 levels Open
Serine proteases (SPs) play physiological roles in the kidney. We previously reported that a synthetic SP inhibitor, camostat mesilate (CM), suppressed sodium reabsorption in the renal tubule and showed natriuretic effects in aldosterone-i…
View article: Usefulness of peripherally inserted central catheter port system (PICC-PORT) implantation in the sitting position: a new technique for cases unsuitable for conventional implantation
Usefulness of peripherally inserted central catheter port system (PICC-PORT) implantation in the sitting position: a new technique for cases unsuitable for conventional implantation Open
Purpose Totally implantable central venous access port implantation is typically performed in the supine position. However, some patients cannot adopt the supine position due to severe pain and/or dyspnea. The present study evaluated the t…
View article: A Case of Successful Endovascular Treatment for Arteriovenous Malformation That Developed after Rectal Cancer Surgery
A Case of Successful Endovascular Treatment for Arteriovenous Malformation That Developed after Rectal Cancer Surgery Open
症例は79歳の男性で，10年前に直腸癌に対して開腹低位前方切除術を施行されていた．今回は血便があり当院を受診した．腹部造影CTで骨盤内に動静脈奇形（arteriovenous malformation；以下，AVMと略記）を認めた．下部消化管内視鏡検査では吻合部よりoozingを認めた．出血は鎮静化したため経過観察をしたが再度出血したため，血管内治療（interventional radiology；以下，IVRと略記）を施行した．右総腸骨動脈より造影を行うと内腸骨動脈領域…
View article: Effects of Roxadustat on Erythropoietin Production in the Rat Body
Effects of Roxadustat on Erythropoietin Production in the Rat Body Open
Anemia is a major complication of chronic renal failure. To treat this anemia, prolylhydroxylase domain enzyme (PHD) inhibitors as well as erythropoiesis-stimulating agents (ESAs) have been used. Although PHD inhibitors rapidly stimulate e…
View article: POS-328 SUPPRESSION OF ER-ASSOCIATED DEGRADATION BY INTRAGLOMERULAR CROSS-COMMUNICATION BETWEEN MESANGIAL CELLS AND PODOCYTES CAUSES PODOCYTE INJURY IN DIABETIC KIDNEY DISEASE
POS-328 SUPPRESSION OF ER-ASSOCIATED DEGRADATION BY INTRAGLOMERULAR CROSS-COMMUNICATION BETWEEN MESANGIAL CELLS AND PODOCYTES CAUSES PODOCYTE INJURY IN DIABETIC KIDNEY DISEASE Open
Mesangial lesions and podocyte injury are essential manifestations of the progression of diabetic kidney disease (DKD). Although cross-communication between mesangial cells (MCs) and podocytes has recently been suggested by the results of …
View article: Salt-Sensitive Hypertension of the Renal Tubular Cell–Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice
Salt-Sensitive Hypertension of the Renal Tubular Cell–Specific NFAT5 (Nuclear Factor of Activated T-Cells 5) Knockout Mice Open
The kidney plays a crucial role in blood pressure (BP) regulation by controlling sodium reabsorption along the nephron. NFAT5 (nuclear factor of activated T-cells 5) is a transcription factor that is expressed in various tissues including …
View article: Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice
Osteocrin, a bone-derived humoral factor, exerts a renoprotective role in ischemia–reperfusion injury in mice Open
Background Osteocrin (OSTN), a bone-derived humoral factor, was reported to act on heart and bone by potentiating the natriuretic peptide (NP) system. Ostn gene polymorphisms have been associated with renal function decline, but its pathop…
View article: Effects of Angiotensin II on Erythropoietin Production in the Kidney and Liver
Effects of Angiotensin II on Erythropoietin Production in the Kidney and Liver Open
The kidney is a main site of erythropoietin production in the body. We developed a new method for the detection of Epo protein by deglycosylation-coupled Western blotting. Detection of deglycosylated Epo enables the examination of small ch…
View article: A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats
A serine protease inhibitor camostat mesilate prevents podocyte apoptosis and attenuates podocyte injury in metabolic syndrome model rats Open
Metabolic syndrome (MetS) is associated with chronic kidney disease and proteinuria. Previously, we reported that a synthetic serine protease inhibitor, camostat mesilate (CM), mitigated hypertension and proteinuria in rodent disease model…