Yoshinori Yamagiwa
YOU?
Author Swipe
View article: Report of the AI Pathology Task Force, Non-clinical Evaluation Expert Committee, Japan Pharmaceutical Manufacturers Association: an overview of recent publications about AI pathology
Report of the AI Pathology Task Force, Non-clinical Evaluation Expert Committee, Japan Pharmaceutical Manufacturers Association: an overview of recent publications about AI pathology Open
The use of artificial intelligence (AI) in non-clinical pathology is rapidly expanding. In this study, we conducted a literature survey of articles published after 2017 that used AI to analyze the histopathological images of experimental a…
View article: Stability of Sodium Pentobarbital 5w/v% Aqueous Solution During Short‐Term Chilled and Ambient‐Temperature Storage
Stability of Sodium Pentobarbital 5w/v% Aqueous Solution During Short‐Term Chilled and Ambient‐Temperature Storage Open
The COVID‐19 pandemic made it difficult to obtain pharmaceutical‐grade injectable anaesthetics used in animal experiments in Japan. To address this problem, it is worth the effort to evaluate whether the use of non‐pharmaceutical‐grade sod…
View article: Survey of toxicity study packages and designs of intravitreal drugs approved in Japan
Survey of toxicity study packages and designs of intravitreal drugs approved in Japan Open
In contrast with standard systemic drugs, the toxicity study of ophthalmic drug has unique design and packaging characteristics. The present survey aimed to characterize the nonclinical toxicological strategy of intravitreal administration…
View article: Two cases of cartilaginous metaplasia in the sclera of Japanese White rabbits
Two cases of cartilaginous metaplasia in the sclera of Japanese White rabbits Open
Spontaneous cartilaginous metaplasia of the sclera has not been reported in rabbits. Herein, we report two cases of spontaneous cartilaginous metaplasia in the sclera of Japanese White (JW) rabbits. Case 1 was noted in a 14-week-old male K…
View article: Presumed congenital nictitating membrane dysplasia in a Japanese white rabbit
Presumed congenital nictitating membrane dysplasia in a Japanese white rabbit Open
Objective The present report characterises a spontaneous nictitating membrane abnormality in a Japanese white rabbit. Animal studied The animal was a male Japanese white rabbit ( Oryctolagus cuniculus , Kbs:JW, 10 weeks old at the time of …
View article: Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds
Time-course changes in DNA damage of corneal epithelial cells in rabbits following ocular instillation with genotoxic compounds Open
View article: In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds
In vivo comet assay in rabbit corneal epithelial cells following ocular instillation with genotoxic compounds Open
Background The in vivo comet assay is used to evaluate the genotoxic potential of compounds by detecting DNA strand breaks in cells isolated from animal tissue. The comet assay of hepatocytes is well established; however, the levels of sys…
View article: Orbital malignant schwannoma and embryonal rhabdomyosarcoma in rats caused by leakage of locally injected nickel subsulfide to the orbit
Orbital malignant schwannoma and embryonal rhabdomyosarcoma in rats caused by leakage of locally injected nickel subsulfide to the orbit Open
Nickel subsulfide (Ni3S2) is known to induce intraocular neoplasms when injected intravitreally into the eyes of rats. Here, we found two extraocular orbital neoplasms in two different rat strains, presumably due to t…
View article: Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone
Pathological Features of Corneal Phospholipidosis in Juvenile White Rabbits Induced by Ocular Instillation of Chloroquine or Amiodarone Open
Cationic amphiphilic drugs (CADs) can induce phospholipidosis (PLD) in organs/tissues. Several ophthalmic pharmaceuticals containing CADs are marketed and used in children. To investigate the effect of PLD on the developing cornea, chloroq…
View article: Anatomical and histological sex differences in the eye and its accessory tissues in Dutch belted rabbits
Anatomical and histological sex differences in the eye and its accessory tissues in Dutch belted rabbits Open
Rabbits are commonly used as laboratory animals in ocular toxicity studies. During development of ophthalmic drugs and medical devices, knowledge regarding sex differences of ocular anatomy and histology is important in the interpretation …
View article: Absence of histopathological changes in the retina of zebrafish treated with sodium iodate
Absence of histopathological changes in the retina of zebrafish treated with sodium iodate Open
In ophthalmological research, the use of zebrafish to investigate visual behaviors has been increasing, but can produce misleading, false-positive results if compounds adversely affect their motor functions or central nervous system. There…
View article: Repeated-dose ocular instillation toxicity study: a survey of its study design on the basis of common technical documents in Japan
Repeated-dose ocular instillation toxicity study: a survey of its study design on the basis of common technical documents in Japan Open
A repeated-dose ocular instillation toxicity study is a type of general toxicity study having unique design characteristics of species selection and administration methods, because the test article, an eye drop formulation, is instilled in…
View article: Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits
Characteristics of corneal phospholipidosis induced by topical ocular application of chloroquine and amiodarone in rabbits Open
Several cationic-amphiphilic drugs such as chloroquine and amiodarone are known to induce phospholipidosis in the cornea by systemic administration. However, the characteristics of ophthalmological and pathological changes when phospholipi…
View article: Ocular instillation toxicity study: current status and points to consider on study design and evaluation
Ocular instillation toxicity study: current status and points to consider on study design and evaluation Open
Ocular instillation toxicity studies (OITSs) are one of general toxicity studies. Yet, OITSs have a unique characteristic that the test article is directly administered as eye drops to the target organ. Compared with general toxicity studi…