Yasushi Ishida
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View article: Development of a questionnaire for evaluating supporters’ skills in Hikikomori support
Development of a questionnaire for evaluating supporters’ skills in Hikikomori support Open
Enhancing the skills of hikikomori supporters inherently contributes to improving the quality of support provided. However, a comprehensive skills assessment tool for these supporters has not yet been developed. This study aimed to develop…
View article: Characteristics of psychiatric patients with nightmares after suvorexant administration: A retrospective study
Characteristics of psychiatric patients with nightmares after suvorexant administration: A retrospective study Open
Aim Suvorexant is an orexin receptor antagonist (ORA) for the treatment of insomnia. The antagonistic action of suvorexant on orexin receptors is associated with an increase in rapid eye movement (REM) sleep, which can potentially lead to …
View article: Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity
Development of radioiodine-labeled mequitazine for evaluation of hepatic CYP2D activity Open
Background: As drug-metabolizing enzyme activities are affected by a variety of factors, such as drug-drug interactions, a method to evaluate drug-metabolizing enzyme activities in real time is needed. In this study, we developed a novel S…
View article: Brief Behavioral Activation Intervention for Inpatient Depression by Psychiatric Nurses: A Single-Group Study
Brief Behavioral Activation Intervention for Inpatient Depression by Psychiatric Nurses: A Single-Group Study Open
Introduction Behavioral Activation (BA) is a short-term cognitive behavioral therapy modality that stimulates activities that increase patients’ reinforcement experiences. Recent research verified the effect of brief BA. However, despite t…
View article: Differential Contribution of 5-HT<sub>4</sub>, 5-HT<sub>5</sub>, and 5-HT<sub>6</sub> Receptors to Acute Pruriceptive Processing Induced by Chloroquine and Histamine in Mice
Differential Contribution of 5-HT<sub>4</sub>, 5-HT<sub>5</sub>, and 5-HT<sub>6</sub> Receptors to Acute Pruriceptive Processing Induced by Chloroquine and Histamine in Mice Open
The involvement of serotonin (5-HT) and/or noradrenaline in acute pruriceptive processing in the central nervous system (CNS) has been reported using antidepressants, such as milnacipran, a serotonin and noradrenaline reuptake inhibitor, a…
View article: A case of intractable trigeminal neuralgia improved by a combination of venlafaxine and cognitive behavioral therapy
A case of intractable trigeminal neuralgia improved by a combination of venlafaxine and cognitive behavioral therapy Open
難治化した三叉神経痛にベンラファキシンを使用し良好な経過を得た1例を経験した。症例は72歳女性,三叉神経痛に対して複数の薬剤による投薬治療や神経ブロック,神経血管減圧術が施行されるも疼痛は再燃を繰り返していた。ペインクリニックを経て当科を受診し,ベンラファキシンと認知行動療法を併用し疼痛は軽減した。慢性疼痛は身体的要因に加え心理社会的要因が絡むことでより難治化する傾向にあり,薬物療法と非薬物療法を効果的に組み合わせて治療を行う事が肝要であると考えた。本邦ではベンラファキシン…
View article: A case study of the utilization of clozapine treatment for treatment‐resistant schizophrenia associated with 22q11.2 deletion syndrome
A case study of the utilization of clozapine treatment for treatment‐resistant schizophrenia associated with 22q11.2 deletion syndrome Open
Background The optimal treatment strategy for patients with treatment‐resistant schizophrenia (TRS) associated with 22q11.2 deletion syndrome (DS) remains a subject of debate. Case Presentation We present the case of a 40‐year‐old female p…
View article: Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study
Characteristics of psychiatric patients with hypokalemia after yokukansan administration: A retrospective study Open
Aim Yokukansan is a Japanese herbal medicine used in psychiatry to treat behavioral and psychological symptoms of dementia and other psychiatric symptoms. However, the glycyrrhizic acid included in this medicine can cause pseudoaldosteroni…
View article: Frailty Improvement by Multicomponent Drug, Ninjin’Yoeito, in Mild Cognitive Impairment and Mild Alzheimer’s Disease Patients: An Open-Label Exploratory Study (FRAMINGO)
Frailty Improvement by Multicomponent Drug, Ninjin’Yoeito, in Mild Cognitive Impairment and Mild Alzheimer’s Disease Patients: An Open-Label Exploratory Study (FRAMINGO) Open
Background: Alzheimer’s disease (AD) and dementia have increasingly been conceived of as “complex diseases of aging”, determined by multiple, simultaneous, interacting pathophysiological processes. The condition known as frailty is a pheno…
View article: A case of schizophrenia in which psychotropic medication reduction and dental treatment contributed to the treatment of pneumonia and lung abscess
A case of schizophrenia in which psychotropic medication reduction and dental treatment contributed to the treatment of pneumonia and lung abscess Open
統合失調症では,複合的な要因で嚥下障害を呈することがあり,適切な対処が求められる。今回,減薬と口腔ケアが肺炎および肺化膿症の治療に寄与した統合失調症の一例を報告する。症例は破瓜型統合失調症の35歳女性。支離滅裂で衝動的な行動が目立ち,単科精神科病院に長期入院していた。肺炎を繰り返すようになり,精査目的で当科へ転院後,肺化膿症と診断された。抗菌薬治療と併せて,向精神薬の調整や口腔ケアを行った。全身状態が改善するにつれて,精神状態が安定し意味のある発語も見られるようになり,入院…
View article: Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled O-Desmethylvenlafaxine
Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-Labeled O-Desmethylvenlafaxine Open
Drug metabolizing enzyme activity is affected by various factors such as drug–drug interactions, and a method to quantify drug metabolizing enzyme activity in real time is needed. In this study, we developed a novel radiopharmaceutical for…
View article: A nationwide survey of late effects in survivors of juvenile myelomonocytic leukemia in Japan
A nationwide survey of late effects in survivors of juvenile myelomonocytic leukemia in Japan Open
We conducted a cross-sectional study using a questionnaire to explore the late effects in survivors of juvenile myelomonocytic leukemia (JMML). The attending pediatric hematologist oncologists completed the questionnaires. All survivors (N…
View article: Spatial statistical analysis of regional disparities in suicide among policy units in Japan: Using the Bayesian hierarchical model
Spatial statistical analysis of regional disparities in suicide among policy units in Japan: Using the Bayesian hierarchical model Open
Suicide prevention is a crucial policy issue in Japan to be addressed nationally. Nevertheless, if there are regional differences in suicide, even in adjacent sub-regions, measures may need to be taken at the sub-regional level. Previous s…
View article: Hospital Support for Siblings of Children With Illness in Japan
Hospital Support for Siblings of Children With Illness in Japan Open
Recent years have seen increased attention to the needs and support of siblings of children with chronic illness, and reports of intervention studies on siblings are gradually increasing worldwide. In Japan, the basic policy approved by th…
View article: Psychosocial interventions for community-dwelling individuals with schizophrenia: study protocol for a systematic review and meta-analysis
Psychosocial interventions for community-dwelling individuals with schizophrenia: study protocol for a systematic review and meta-analysis Open
Introduction Despite the recent global mental health movement of the transition from hospital-centred to integrated community-based services, comprehensive evidence of psychosocial interventions focusing on community-dwelling individuals w…
View article: Reasons for Suicide During the COVID-19 Pandemic in Japan
Reasons for Suicide During the COVID-19 Pandemic in Japan Open
In this study, observed suicides corresponding to all 7 categories of reasons exceeded the monthly estimates (based on data from before or during the COVID-19 pandemic), except for school-related reasons in men. This study can be used as a…
View article: Case of reversible Mobitz type II atrioventricular block after the use of injectable antipsychotics
Case of reversible Mobitz type II atrioventricular block after the use of injectable antipsychotics Open
Although Mobitz type II atrioventricular block is typically an arrhythmia arising from a permanent organic disorder of the His‐Purkinje system, reversible factors should also be considered. Here, we report the association between a rare re…
View article: A case of reversible Mobitz type II atrioventricular block after the use of injectable antipsychotics
A case of reversible Mobitz type II atrioventricular block after the use of injectable antipsychotics Open
Although Mobitz type II atrioventricular block is an arrhythmia based on a permanent organic disorder of the His-Purkinje system, reversible factors should be considered. Here, we report the association between a rare reversible Mobitz typ…
View article: Time course of effects of venlafaxine on migraine and generalized pruritus in a patient with depression
Time course of effects of venlafaxine on migraine and generalized pruritus in a patient with depression Open
Venlafaxine has potential as a therapeutic option for patients with depressive disorder, migraine, and pruritus unresponsive to antihistamines.
View article: Impact of age on catheter ablation of premature ventricular contractions
Impact of age on catheter ablation of premature ventricular contractions Open
Funding Acknowledgements Type of funding sources: None. Introduction Catheter ablation (CA) of frequent premature ventricular contractions (PVC) is increasingly performed in older patients as the population ages. Purpose The purpose of thi…
View article: Differential onset time of mirtazapine on pruritus and depression in a patient receiving hemodialysis
Differential onset time of mirtazapine on pruritus and depression in a patient receiving hemodialysis Open
A 63-year-old male receiving hemodialysis for renal insufficiency developed severe and widespread pruritus, which was unresponsive to antihistamines and severe depression with insomnia, agitation, and anxiety. The oral administration of 7.…
View article: Association Between Autistic Symptoms and Self-Stigma in Patients with Schizophrenia Spectrum Disorders
Association Between Autistic Symptoms and Self-Stigma in Patients with Schizophrenia Spectrum Disorders Open
Hiroshi Komatsu,1 Takashi Ono,2 Yoshinori Maita,3 Yusuke Ishida,4 Tatsuo Kikuchi,2 Takahiro Maki,5 Satoshi Hase,6 Hisakazu Sakurai,6 Akiko Oba,5 Osamu Teshirogi,6 Akira Suzuki,3 Yasuko Mori,3 Chikako Shoji,3 Akira Fujita,3 Sachiko Takahash…
View article: Clinical effectiveness of metacognitive training as a transdiagnostic program in routine clinical settings: A single-group pre-post study
Clinical effectiveness of metacognitive training as a transdiagnostic program in routine clinical settings: A single-group pre-post study Open
Objective To evaluate the clinical effectiveness of metacognitive training (MCT) as a transdiagnostic program, on a diverse population with mental disorders in routine day-care settings through a single-group pre-post-design. Results Thirt…
View article: How was cognitive behavioural therapy for mood disorder implemented in Japan? A retrospective observational study using the nationwide claims database from FY2010 to FY2015
How was cognitive behavioural therapy for mood disorder implemented in Japan? A retrospective observational study using the nationwide claims database from FY2010 to FY2015 Open
Objectives To clarify the dissemination status of cognitive behavioural therapy (CBT) in Japan under the national health insurance scheme. Design Retrospective observational study. Setting National Database of Health Insurance Claims and S…
View article: Development of the School Teachers Job Stressor Scale (STJSS)
Development of the School Teachers Job Stressor Scale (STJSS) Open
Aim Japanese teachers are not only responsible for students but also for tasks outside the classroom, including engagement with parents and the community, and maintaining safety. They work longer hours and have lower self‐efficacy than tea…
View article: PF407 TREATMENT‐FREE REMISSION IN PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA FOLLOWING FIRST‐LINE DASATINIB, 1ST DADI/IMIDAS4
PF407 TREATMENT‐FREE REMISSION IN PATIENTS WITH CHRONIC MYELOGENOUS LEUKEMIA FOLLOWING FIRST‐LINE DASATINIB, 1ST DADI/IMIDAS4 Open
Background: The main treatment goal for patients with chronic phase chronic myelogenous leukemia (CML‐CP) is discontinuation of tyrosine kinase inhibitor (TKI) therapy. In the previous DAsatinib Discontinuation (DADI) trial, we showed that…
View article: Characteristics of facial muscle activity during voluntary facial expressions: Imaging analysis of facial expressions based on myogenic potential data
Characteristics of facial muscle activity during voluntary facial expressions: Imaging analysis of facial expressions based on myogenic potential data Open
Purpose Facial expressions are formed by the coordination of facial muscles and reflect changes in emotion. Nurses observe facial expressions as way of understanding patients. This study conducted basic research using facial myogenic poten…