Yoshitaka Okamoto
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View article: Effect of heat-killed Lacticaseibacillus paracasei KW3110 on mild to moderate seasonal allergic rhinitis symptoms in Japanese adults: a randomized, double-blind, placebo-controlled parallel-group study
Effect of heat-killed Lacticaseibacillus paracasei KW3110 on mild to moderate seasonal allergic rhinitis symptoms in Japanese adults: a randomized, double-blind, placebo-controlled parallel-group study Open
Background In recent years, the prevalence of seasonal allergic rhinitis has increased rapidly in Japan, becoming a social problem. Therefore, we evaluated the effect of tablets containing Lacticaseibacillus paracasei KW3110 ( L. paracasei…
View article: Toward a topological description of Legendrian contact homology of unit conormal bundles
Toward a topological description of Legendrian contact homology of unit conormal bundles Open
View article: Legendrian non-isotopic unit conormal bundles in high dimensions
Legendrian non-isotopic unit conormal bundles in high dimensions Open
For any compact connected submanifold $K$ of $\mathbb{R}^n$, let $Λ_K$ denote its unit conormal bundle, which is a Legendrian submanifold of the unit cotangent bundle of $\mathbb{R}^n$. In this paper, we give examples of pairs $(K_0,K_1)$ …
View article: Safety of 300IR house dust mite sublingual tablet from pooled clinical trial and post-marketing data
Safety of 300IR house dust mite sublingual tablet from pooled clinical trial and post-marketing data Open
View article: Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study
Poor Rhinitis and Asthma Control Is Associated With Decreased Health-Related Quality of Life and Utilities: A MASK-air Study Open
Poor AR or asthma control are associated with reduced quality of life. The estimates obtained from mobile health data may provide valuable insights for health technology assessment studies.
View article: Efficacy of 300 <scp>IR</scp> house dust mite immunotherapy as a function of disease activity: Tertile analysis in clinical trials
Efficacy of 300 <span>IR</span> house dust mite immunotherapy as a function of disease activity: Tertile analysis in clinical trials Open
Background The symptoms of house dust mite (HDM)‐induced allergic rhinitis (AR) vary with changes in exposure related to the weather or the domestic environment. In allergen immunotherapy (AIT) studies, a certain level of AR disease activi…
View article: Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study
Factors contributing to the diagnosis and onset prediction of perennial allergic rhinitis in high-risk children: A sub-analysis of the CHIBA study Open
Rhinitis findings and nasal eosinophilia are useful auxiliary diagnostic items for pediatric PAR. Sensitization to HDM and nasal eosinophilia were the most influential factors associated with future PAR onset. A combination of these factor…
View article: Safety and Effectiveness of a 300 IR House Dust Mite Sublingual Tablet: Descriptive 4-Year Final Analysis of a Post-Marketing Surveillance in Japan
Safety and Effectiveness of a 300 IR House Dust Mite Sublingual Tablet: Descriptive 4-Year Final Analysis of a Post-Marketing Surveillance in Japan Open
Background: Data are limited for clinical outcomes with house dust mite (HDM) allergen immunotherapy beyond 2 years' observation. Materials & methods: A post-marketing drug-use survey assessed the safety and effectiveness of …
View article: Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study
Impairment of EQ-5D-5L Domains According to Allergic Rhinitis and Asthma Control: A MASK-air Real-World Study Open
View article: Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study
Adherence to inhaled corticosteroids and long-acting β2-agonists in asthma: A MASK-air study Open
In asthma patients adherent to the MASK-air app, adherence to ICS+LABA was high. ICS+F users reported lower adherence but also a lower SABA use and a similar level of control.
View article: Global expert views on the diagnosis, classification and pharmacotherapy of allergic rhinitis in clinical practice using a modified Delphi panel technique
Global expert views on the diagnosis, classification and pharmacotherapy of allergic rhinitis in clinical practice using a modified Delphi panel technique Open
View article: Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype
Differences in the expression of multidrug resistance proteins in chronic rhinosinusitis according to endotype Open
MRP is associated with treatment resistance and is expressed in nasal polyps. The expression pattern had different features based on chronic rhinosinusitis endotype. Therefore, drug resistance factors can be associated with therapeutic out…
View article: Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study
Association of umbilical cord serum TARC/CCL17 with childhood allergies: A birth cohort study Open
cTARC was associated with the development of allergic diseases and allergen sensitization in early childhood. These results suggest that, infantile AD-mediated atopic march starts during fetal life, and this immune status is reflected in t…
View article: Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The <scp>ARIA‐EAACI</scp> approach – ARIA‐EAACI Task Force Report
Patient‐centered digital biomarkers for allergic respiratory diseases and asthma: The <span>ARIA‐EAACI</span> approach – ARIA‐EAACI Task Force Report Open
Biomarkers for the diagnosis, treatment and follow‐up of patients with rhinitis and/or asthma are urgently needed. Although some biologic biomarkers exist in specialist care for asthma, they cannot be largely used in primary care. There ar…
View article: Rhinitis associated with asthma is distinct from rhinitis alone: The <scp>ARIA‐MeDALL</scp> hypothesis
Rhinitis associated with asthma is distinct from rhinitis alone: The <span>ARIA‐MeDALL</span> hypothesis Open
Asthma, rhinitis, and atopic dermatitis (AD) are interrelated clinical phenotypes that partly overlap in the human interactome. The concept of “one‐airway‐one‐disease,” coined over 20 years ago, is a simplistic approach of the links betwee…
View article: Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air<sup>®</sup>approach
Digitally‐enabled, patient‐centred care in rhinitis and asthma multimorbidity: The ARIA‐MASK‐air<sup>®</sup>approach Open
MASK‐air ® , a validated mHealth app (Medical Device regulation Class IIa) has enabled large observational implementation studies in over 58,000 people with allergic rhinitis and/or asthma. It can help to address unmet patient needs in rhi…
View article: Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology – secondary publication
Current situation of anaphylaxis in Japan: Data from the anaphylaxis registry of training and teaching facilities certified by the Japanese Society of Allergology – secondary publication Open
The present survey revealed the most common triggers and treatments for anaphylaxis in Japan. Self-management and adrenaline administration as first-line treatment may not be done sufficiently. Therefore, it is necessary to thoroughly educ…
View article: Efficacy of Japanese cedar pollen sublingual immunotherapy tablets for Japanese cypress pollinosis
Efficacy of Japanese cedar pollen sublingual immunotherapy tablets for Japanese cypress pollinosis Open
View article: Cutoff Values of MASK-air Patient-Reported Outcome Measures
Cutoff Values of MASK-air Patient-Reported Outcome Measures Open
View article: Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The <scp>MASK</scp>‐air® longitudinal study
Consistent trajectories of rhinitis control and treatment in 16,177 weeks: The <span>MASK</span>‐air® longitudinal study Open
Introduction Data from mHealth apps can provide valuable information on rhinitis control and treatment patterns. However, in MASK‐air®, these data have only been analyzed cross‐sectionally, without considering the changes of symptoms over …
View article: Complement Factor H Is an Early Predictive Biomarker of the Therapeutic Efficacy of Sublingual Immunotherapy for Japanese Cedar Pollinosis
Complement Factor H Is an Early Predictive Biomarker of the Therapeutic Efficacy of Sublingual Immunotherapy for Japanese Cedar Pollinosis Open
Sublingual immunotherapy for Japanese cedar pollinosis can improve the symptoms of allergic rhinitis and modify its natural course. However, sublingual immunotherapy requires a long treatment period and some patients do not respond to trea…
View article: Knowledge and Attitude Among Patients and Physicians on Allergic Rhinitis (KAPPA): An International Survey
Knowledge and Attitude Among Patients and Physicians on Allergic Rhinitis (KAPPA): An International Survey Open
Patient and physician perceptions of AR mostly differed between and within countries, although there was generally agreement that AR could be controlled with treatment. Differing attitudes towards AR among patients and physicians suggests …
View article: Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities
Real‐world data using mHealth apps in rhinitis, rhinosinusitis and their multimorbidities Open
Digital health is an umbrella term which encompasses eHealth and benefits from areas such as advanced computer sciences. eHealth includes mHealth apps, which offer the potential to redesign aspects of healthcare delivery. The capacity of a…
View article: Same dose of Japanese cedar pollen sublingual immunotherapy tablets is optimal for allergic rhinitis caused by either Japanese cedar or Japanese cypress pollen
Same dose of Japanese cedar pollen sublingual immunotherapy tablets is optimal for allergic rhinitis caused by either Japanese cedar or Japanese cypress pollen Open
Japanese cedar (JC) pollinosis is the most prevalent and important tree pollen allergy in Japan,1, 2 and about 70% of JC pollinosis patients also have a symptomatic allergy to Japanese cypress (JCY) pollen.1 Consequently, combined JC/JCY p…
View article: Academic Productivity of Young People With Allergic Rhinitis: A MASK-air Study
Academic Productivity of Young People With Allergic Rhinitis: A MASK-air Study Open
View article: Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion
Single-cell immunoprofiling after immunotherapy for allergic rhinitis reveals functional suppression of pathogenic TH2 cells and clonal conversion Open
View article: Comparative Survey of Children and Adults with Japanese Cedar Pollinosis Using a Self-written Questionnaire on Sublingual Immunotherapy in Clinical Practice
Comparative Survey of Children and Adults with Japanese Cedar Pollinosis Using a Self-written Questionnaire on Sublingual Immunotherapy in Clinical Practice Open
スギ花粉症への錠剤による舌下免疫療法は年齢制限がないが2018年5月までは液剤により施行され, 適応は12歳以上であった. 過去の報告では小児と成人における服薬アドヒアランス, 臨床効果, 副反応等の臨床的検討が十分になされていない. 過去の調査で使われたアンケート結果より臨床上重要となる小児と成人の服薬アドヒアランス, 臨床効果, 副反応等の違いについて新たに統計学的解析を行ったので報告する. 対象は2014～2018年にシダトレン® を開始し, 治療を継続中のスギ花粉症…
View article: Comparison of rhinitis treatments using <scp>MASK</scp>‐air® data and considering the minimal important difference
Comparison of rhinitis treatments using <span>MASK</span>‐air® data and considering the minimal important difference Open
Background Different treatments exist for allergic rhinitis (AR), including pharmacotherapy and allergen immunotherapy (AIT), but they have not been compared using direct patient data (i.e., “real‐world data”). We aimed to compare AR pharm…
View article: Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK‐air<sup>®</sup> real‐world data
Behavioural patterns in allergic rhinitis medication in Europe: A study using MASK‐air<sup>®</sup> real‐world data Open
Background Co‐medication is common among patients with allergic rhinitis (AR), but its dimension and patterns are unknown. This is particularly relevant since AR is understood differently across European countries, as reflected by rhinitis…
View article: Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model
Allergen immunotherapy in MASK‐air users in real‐life: Results of a Bayesian mixed‐effects model Open
Background Evidence regarding the effectiveness of allergen immunotherapy (AIT) on allergic rhinitis has been provided mostly by randomised controlled trials, with little data from real‐life studies. Objective To compare the reported contr…