Yoshiyuki Akiyama
YOU?
Author Swipe
View article: Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis
Molecular characterization of chronic inflammatory diseases of the urinary bladder based on next-generation RNA sequencing and digital image analysis Open
This study aimed to elucidate distinct cellular and immunological characteristics associated with chronic inflammatory conditions of the urinary bladder, including Hunner-type interstitial cystitis (HIC), bacillus Calmette-Guérin (BCG)-rel…
View article: Long‐Term Clinical Outcomes of Transurethral Resection of Hunner Lesions Combined With Bladder Hydrodistension for Patients With Interstitial Cystitis at a Tertiary Referral Center in Japan
Long‐Term Clinical Outcomes of Transurethral Resection of Hunner Lesions Combined With Bladder Hydrodistension for Patients With Interstitial Cystitis at a Tertiary Referral Center in Japan Open
Objectives To report the long‐term clinical outcomes of transurethral resection of Hunner lesions with bladder hydrodistension in patients with Hunner lesion interstitial cystitis (HIC) at a tertiary referral center in Japan. Methods A ret…
View article: A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters
A Case of Interstitial Cystitis With Hunner Lesions Involving Bilateral Ureters Open
Introduction Interstitial cystitis with Hunner lesion (IC/HL) is an enigmatic, chronic inflammatory disease of the urinary bladder. Few documented cases have reported the IC/HL involving the upper urinary tract. Case Presentation A 51‐year…
View article: Lipidomic analysis coupled with machine learning identifies unique urinary lipid signatures in patients with interstitial cystitis/bladder pain syndrome
Lipidomic analysis coupled with machine learning identifies unique urinary lipid signatures in patients with interstitial cystitis/bladder pain syndrome Open
Purpose To identify biomarkers for diagnosis and classification of interstitial cystitis/bladder pain syndrome (IC/BPS) by urinary lipidomics coupled with machine learning. Methods Urine samples from 138 patients with IC/BPS, including 116…
View article: Physical, but not laboratory, treatment‐related adverse events are associated with favorable outcomes of enfortumab vedotin for advanced urothelial carcinoma: A landmark analysis
Physical, but not laboratory, treatment‐related adverse events are associated with favorable outcomes of enfortumab vedotin for advanced urothelial carcinoma: A landmark analysis Open
Background While the occurrence of immune‐related adverse events has been recognized as a prognostic marker in patients receiving immune checkpoint inhibitors, the prognostic significance of treatment‐related adverse events (trAEs) in pati…
View article: Survival improvement over time in renal cell carcinoma treated with nephrectomy: A longitudinal propensity score‐matched study
Survival improvement over time in renal cell carcinoma treated with nephrectomy: A longitudinal propensity score‐matched study Open
Objective Surgical treatment for renal cell carcinoma (RCC) has drastically evolved for the past 30 years. However, survival outcomes of RCC according to times have not been fully elucidated, especially in the real‐world setting. This stud…
View article: Clinical manifestations of interstitial cystitis and bladder pain syndrome: Analysis of a patient registry in Japan
Clinical manifestations of interstitial cystitis and bladder pain syndrome: Analysis of a patient registry in Japan Open
Objective To describe clinical manifestations of patients with interstitial cystitis and bladder pain syndrome (IC/BPS) using a patient registry in Japan. Methods This retrospective cohort study utilized a patient registry supported by the…
View article: <scp>APRIL</scp> / <scp>BAFF</scp> upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis
<span>APRIL</span> / <span>BAFF</span> upregulation is associated with clonal B‐cell expansion in Hunner‐type interstitial cystitis Open
Hunner‐type interstitial cystitis (HIC) is a chronic inflammatory disease of the urinary bladder with an unknown etiology. We conducted comprehensive immunogenomic profiling of bladder specimens obtained by biopsy and cystectomy from 37 pa…
View article: Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases
Oncologic and Functional Outcomes of Salvage Robot-Assisted Radical Prostatectomy: Report of the First 10 Cases Open
Background: Salvage robot-assisted radical prostatectomy (sRARP) after PSA failure in patients who underwent initial radiotherapy or focal therapy has rarely been reported in Japan. We aimed to report the oncologic and functional outcomes …
View article: Novel clipping procedure for preventing post‐operative inguinal hernia in robot‐assisted radical prostatectomy
Novel clipping procedure for preventing post‐operative inguinal hernia in robot‐assisted radical prostatectomy Open
Objectives Inguinal hernia (IH) is a common postoperative complication after robot‐assisted radical prostatectomy (RARP). We developed a novel clipping technique for the prevention of IH developing after RARP. Methods This cohort included …
View article: Physical, but not laboratory, treatment-related adverse events are associated with favorable outcomes of enfortumab vedotin for advanced urothelial carcinoma: A landmark analysis
Physical, but not laboratory, treatment-related adverse events are associated with favorable outcomes of enfortumab vedotin for advanced urothelial carcinoma: A landmark analysis Open
Background While the occurrence of immune-related adverse events has been recognized as a prognostic marker in patients receiving immune checkpoint inhibitors, the prognostic significance of treatment-related adverse events (trAEs) in pati…
View article: Comparison of PDD-TURBT alone versus white light TURBT plus intravesical BCG therapy: A propensity-score matching study
Comparison of PDD-TURBT alone versus white light TURBT plus intravesical BCG therapy: A propensity-score matching study Open
PDD-TURBT alone is insufficient to control the long-term recurrence of bladder cancer but can be effective in selected cases such as primary and single tumors.
View article: Upper extremity contact pressure measurement in robot-assisted pelvic surgery
Upper extremity contact pressure measurement in robot-assisted pelvic surgery Open
View article: Development of risk-score model in patients with negative surgical margin after robot-assisted radical prostatectomy
Development of risk-score model in patients with negative surgical margin after robot-assisted radical prostatectomy Open
A total of 739 patients underwent RARP as initial treatment for PCa from November 2011 to October 2018. Data on BCR status, clinical and pathological parameters were collected from the clinical records. After excluding cases with neoadjuva…
View article: Upper extremity contact pressure measurement in robot-assisted pelvic surgery
Upper extremity contact pressure measurement in robot-assisted pelvic surgery Open
Upper extremity complications are often a problem in robot-assisted pelvic surgery (RAPS) with the lithotomy-Trendelenburg position (LT-position). This study focused on upper extremity contact pressure (UEP) and examined the relationship b…
View article: Six-year outcomes of robot-assisted radical prostatectomy versus volumetric modulated arc therapy for localized prostate cancer: A propensity score-matched analysis
Six-year outcomes of robot-assisted radical prostatectomy versus volumetric modulated arc therapy for localized prostate cancer: A propensity score-matched analysis Open
Background Although robot-assisted radical prostatectomy (RARP) and intensity-modulated radiotherapy are the leading respective techniques of prostatectomy and radiotherapy for localized prostate cancer, almost no study has directly compar…
View article: Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis
Th1/17 polarization and potential treatment by an anti-interferon-γ DNA aptamer in Hunner-type interstitial cystitis Open
Hunner-type interstitial cystitis (HIC) is a rare, enigmatic inflammatory disease of the urinary bladder with no curative treatments. In this study, we aimed to characterize the unique cellular and immunological factors specifically involv…
View article: Prostate-specific antigen doubling time predicts the efficacy of site-directed therapy for oligoprogressive castration-resistant prostate cancer
Prostate-specific antigen doubling time predicts the efficacy of site-directed therapy for oligoprogressive castration-resistant prostate cancer Open
View article: Efficacy and safety of intravesical dimethyl sulfoxide treatment for patients with refractory Hunner‐type interstitial cystitis: Real‐world data postofficial approval in Japan
Efficacy and safety of intravesical dimethyl sulfoxide treatment for patients with refractory Hunner‐type interstitial cystitis: Real‐world data postofficial approval in Japan Open
Objectives To examine real‐world data regarding intravesical dimethyl sulfoxide (DMSO) therapy after official approval as a treatment for Hunner‐type interstitial cystitis (HIC) in Japan. Methods This single institution, retrospective obse…
View article: Enfortumab vedotin versus platinum rechallenge in post‐platinum, post‐pembrolizumab advanced urothelial carcinoma: A multicenter propensity score‐matched study
Enfortumab vedotin versus platinum rechallenge in post‐platinum, post‐pembrolizumab advanced urothelial carcinoma: A multicenter propensity score‐matched study Open
Objective Enfortumab vedotin (EV) was approved for advanced urothelial carcinoma (UC) in 2021 after the EV‐301 trial showed its superiority to non‐platinum‐based chemotherapy as later‐line treatment after platinum‐based chemotherapy and im…
View article: Efficacy and Safety of Low-dose Oral Prednisolone for Patients with Refractory Hunner-type Interstitial Cystitis
Efficacy and Safety of Low-dose Oral Prednisolone for Patients with Refractory Hunner-type Interstitial Cystitis Open
View article: Surgical resection of retinoblastoma-associated bladder leiomyosarcoma during pregnancy: a case report
Surgical resection of retinoblastoma-associated bladder leiomyosarcoma during pregnancy: a case report Open
Background Management of a bladder tumor during pregnancy is an uncommon clinical situation. Leiomyosarcoma of the urinary bladder is a rare histological type of bladder tumor and a rare secondary cancer in survivors of retinoblastoma (RB)…
View article: UROFLOWMETRY FINDINGS BEFORE AND AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY AND ITS RELATIONSHIP WITH RECOVERY OF URINARY CONTINENCE
UROFLOWMETRY FINDINGS BEFORE AND AFTER ROBOT-ASSISTED RADICAL PROSTATECTOMY AND ITS RELATIONSHIP WITH RECOVERY OF URINARY CONTINENCE Open
View article: Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis
Genome-wide association study identifies risk loci within the major histocompatibility complex region for Hunner-type interstitial cystitis Open
Hunner-type interstitial cystitis (HIC) is a rare, chronic inflammatory disease of the urinary bladder with unknown etiology and genetic background. Here, we conduct a genome-wide association study of 144 patients with HIC and 41,516 contr…
View article: Low hemoglobin and PSA kinetics are prognostic factors of overall survival in metastatic castration-resistant prostate cancer patients
Low hemoglobin and PSA kinetics are prognostic factors of overall survival in metastatic castration-resistant prostate cancer patients Open
View article: Usefulness of lysophosphatidylcholine measurement in the cerebrospinal fluid for differential diagnosis of neuropathic pain: Possible introduction into clinical laboratory testing
Usefulness of lysophosphatidylcholine measurement in the cerebrospinal fluid for differential diagnosis of neuropathic pain: Possible introduction into clinical laboratory testing Open
LPC measurement in the CSF is useful for the differential diagnosis of neuropathic pain, especially for surgical decision-making, which is expected for clinical introduction.
View article: Deep Learning Models for Cystoscopic Recognition of Hunner Lesion in Interstitial Cystitis
Deep Learning Models for Cystoscopic Recognition of Hunner Lesion in Interstitial Cystitis Open
In this diagnostic study, we developed a deep learning system for cystoscopic recognition of Hunner lesions in patients with interstitial cystitis. The mean area under the curve of the constructed system reached 0.919 with mean sensitivity…
View article: Comparison of full-dose gemcitabine/cisplatin, dose-reduced gemcitabine/cisplatin, and gemcitabine/carboplatin in real-world patients with advanced urothelial carcinoma
Comparison of full-dose gemcitabine/cisplatin, dose-reduced gemcitabine/cisplatin, and gemcitabine/carboplatin in real-world patients with advanced urothelial carcinoma Open
View article: Left–right reversal of the testes within the scrotum: An extremely rare variant of testicular ectopia
Left–right reversal of the testes within the scrotum: An extremely rare variant of testicular ectopia Open
Introduction Testicular ectopia refers to abnormal positioning of testis, which includes a wide variety of variants. An ectopic testis is located off the normal path of male gonadal descent, unlike conventional undescended testis. Case pre…
View article: AUTOTRANSPLANTATION FOR IATROGENIC URETERAL INJURY FOLLOWING GYNECOLOGICAL SURGERY
AUTOTRANSPLANTATION FOR IATROGENIC URETERAL INJURY FOLLOWING GYNECOLOGICAL SURGERY Open
A 48-year-old woman underwent total hysterectomy and oophorectomy for uterine fibroids and bilateral ovarian cysts. Postoperatively, her renal function worsened, and the histological specimen contained ureteral tissue. She was referred to …