Yosuke Fukunaga
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View article: Quality of life after laparoscopic surgery for very low rectal cancer: A sub‐analysis of the ultimate trial
Quality of life after laparoscopic surgery for very low rectal cancer: A sub‐analysis of the ultimate trial Open
Aim Laparoscopic low anterior resection is widely used for treating rectal cancer; however, postoperative complications frequently result in a marked deterioration in the patients' quality of life (QOL). This study aimed to investigate the…
View article: Machine learning prediction of anastomotic leak after low anterior resection: Nationwide database analysis
Machine learning prediction of anastomotic leak after low anterior resection: Nationwide database analysis Open
Predicting anastomotic leak preoperatively in patients undergoing low anterior resection for rectal cancer remains a significant challenge. This study aims to develop and validate a predictive model for anastomotic leaks using a machine le…
View article: Patient‐Reported Outcomes and Surgical Results of Hand‐Sewn Versus Stapled Anastomosis for Lower Rectal Cancer Located 4–5 cm From the Anal Verge: A Subanalysis of the Ultimate Study
Patient‐Reported Outcomes and Surgical Results of Hand‐Sewn Versus Stapled Anastomosis for Lower Rectal Cancer Located 4–5 cm From the Anal Verge: A Subanalysis of the Ultimate Study Open
Background Preserving anorectal function while achieving oncological success is crucial in the treatment of lower rectal cancer near the anal canal. Despite advancements in laparoscopic surgery that facilitate anal preservation, post‐opera…
View article: Standardization of the surgical technique and reporting for radical right colectomy with central vascular ligation and complete mesocolic excision (RRoC-STAR): Delphi consensus
Standardization of the surgical technique and reporting for radical right colectomy with central vascular ligation and complete mesocolic excision (RRoC-STAR): Delphi consensus Open
Background Complete mesocolic excision refers to a radical right hemicolectomy for cancer following embryologically defined anatomical planes. However, heterogeneity in definitions and techniques is a barrier to research. The aim of the Ra…
View article: A multicentre prospective study of anal function after laparoscopic ultra‐low rectal cancer surgery using a mixed‐effects model
A multicentre prospective study of anal function after laparoscopic ultra‐low rectal cancer surgery using a mixed‐effects model Open
Aim Abdominoperineal resection with permanent colostomy has historically been performed for very low rectal cancer located near the anal canal. Anus‐preserving surgeries, such as intersphincteric resection (ISR) and low anterior resection …
View article: Longitudinal follow‐up of sexual function after surgery for ultra‐low rectal cancers located within 5 cm of the anal verge: A multicentre collaborative study
Longitudinal follow‐up of sexual function after surgery for ultra‐low rectal cancers located within 5 cm of the anal verge: A multicentre collaborative study Open
Aim The effect of laparoscopic surgery on sexual function in patients with ultra‐low rectal cancer remains unexplored. This multicentre study evaluated postoperative sexual function in male patients with rectal cancer located within 5 cm o…
View article: Short- and Long-term Outcomes of One-stage Radical Resection and Anastomosis without Preoperative Decompression and Diverting Stoma between Incomplete Obstructive and Non-obstructive Left-sided Colorectal Cancer: A Retrospective Observational Study
Short- and Long-term Outcomes of One-stage Radical Resection and Anastomosis without Preoperative Decompression and Diverting Stoma between Incomplete Obstructive and Non-obstructive Left-sided Colorectal Cancer: A Retrospective Observational Study Open
The outcomes regarding anastomotic leakage and long-term survival for one-stage resection and anastomosis without preoperative decompression in cases of incomplete obstructive colorectal cancer are promising. This management strategy appea…
View article: Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study
Prognostic Impact of Potentially Curative Resection for Synchronous Peritoneal Carcinomatosis with Lavage Cytology Positivity in Colorectal Cancer: A Retrospective Observational Study Open
In resectable cases, the resection of synchronous peritoneal carcinomatosis from colorectal cancer can be considered even if intraoperative lavage cytology is positive.
View article: Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub‐analysis of the ultimate trial
Late anastomotic complication after laparoscopic surgery for clinical stage I low rectal cancers located within 5 cm of the anal verge: Sub‐analysis of the ultimate trial Open
Background Although extensive research has been conducted on early anastomotic leakage (AL) after sphincter‐sparing surgery, the status of late anastomotic complications (post‐30 days) has received limited attention. These late complicatio…
View article: Curative Resection of Locally Advanced Colon Cancer that Invading the Common Iliac Artery by Creating an Extra-Anatomical Arterial Bypass: A Case Report
Curative Resection of Locally Advanced Colon Cancer that Invading the Common Iliac Artery by Creating an Extra-Anatomical Arterial Bypass: A Case Report Open
This case demonstrates the potential of systemic chemotherapy followed by radical resection with extra-anatomical arterial bypass in achieving favorable long-term outcomes and satisfactory short-term results.
View article: Bowel preparation and surgical site infections in laparoscopic and robot‐assisted right‐sided colon cancer surgery with intracorporeal anastomosis: A retrospective study
Bowel preparation and surgical site infections in laparoscopic and robot‐assisted right‐sided colon cancer surgery with intracorporeal anastomosis: A retrospective study Open
Aim Previous studies have examined bowel preparation as a measure to reduce surgical site infection (SSI) rates. This retrospective study aimed to identify the risk factors for SSI in right‐sided colon cancer surgery using intracorporeal a…
View article: Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases
Longitudinal phosphoproteomics reveals the PI3K-PAK1 axis as a potential target for recurrent colorectal liver metastases Open
The resistance of colorectal cancer liver metastases (CRLMs) to 5-fluorouracil (5-FU) chemotherapy remains a significant global health challenge. We investigated the phosphoproteomic dynamics of serial tissue sections obtained from initial…
View article: Clinical Outcomes and Prognostic Factors for R0 Resected Colorectal Cancer with Synchronous Peritoneal Metastasis: A Retrospective Study
Clinical Outcomes and Prognostic Factors for R0 Resected Colorectal Cancer with Synchronous Peritoneal Metastasis: A Retrospective Study Open
R0 resection of colorectal cancer with synchronous peritoneal metastasis should be considered for improving long-term survival. The laparoscopic approach for this disease is another promising method to prolong survival in patients with R0 …
View article: Integrating surgical intervention and watch-and-wait approach in dMMR metastatic rectal cancer with pembrolizumab: a case report
Integrating surgical intervention and watch-and-wait approach in dMMR metastatic rectal cancer with pembrolizumab: a case report Open
Background Treating rectal cancer presents challenges due to postoperative complications and reduced quality of life (QOL). Recent evidence supports the watch-and-wait (WW) approach for patients with a clinical complete response (cCR) foll…
View article: Cytoreductive surgery without intra-peritoneal chemotherapy for metachronous colorectal peritoneal metastases
Cytoreductive surgery without intra-peritoneal chemotherapy for metachronous colorectal peritoneal metastases Open
View article: Long-Term Outcomes of Additional Surgery After Endoscopic Resection Versus Primary Surgery for T1 Colorectal Cancer
Long-Term Outcomes of Additional Surgery After Endoscopic Resection Versus Primary Surgery for T1 Colorectal Cancer Open
INTRODUCTION: There is considerable concern about whether endoscopic resection (ER) before additional surgery (AS) for T1 colorectal cancer (CRC) has oncologically potential adverse effects. Therefore, the aim of this study was to compare …
View article: Feasibility of robotic-assisted surgery in advanced rectal cancer: a multicentre prospective phase II study (VITRUVIANO trial)
Feasibility of robotic-assisted surgery in advanced rectal cancer: a multicentre prospective phase II study (VITRUVIANO trial) Open
Background The potential benefits of robotic-assisted compared with laparoscopic surgery for locally advanced cancer have not been sufficiently proven by prospective studies. One factor is speculated to be the lack of strict surgeon criter…
View article: Long-term Survival and Functional Outcomes of Laparoscopic Surgery for Clinical Stage I Ultra-low Rectal Cancers Located Within 5 cm of the Anal Verge
Long-term Survival and Functional Outcomes of Laparoscopic Surgery for Clinical Stage I Ultra-low Rectal Cancers Located Within 5 cm of the Anal Verge Open
Objective: To clarify the long-term oncological outcomes and postoperative anal, urinary, and sexual functions after laparoscopic surgery for clinical stage I very low rectal carcinoma located near the anal canal. Background: Laparoscopic …
View article: Implementable assay for monitoring minimum residual disease after radical treatment for colorectal cancer
Implementable assay for monitoring minimum residual disease after radical treatment for colorectal cancer Open
Considering the cost and invasiveness of monitoring postoperative minimal residual disease (MRD) of colorectal cancer (CRC) after adjuvant chemoradiotherapy (ACT), we developed a favorable approach based on methylated circulating tumor DNA…
View article: Treatment Decision for Locally Resected T1 Colorectal Carcinoma–Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes
Treatment Decision for Locally Resected T1 Colorectal Carcinoma–Verification of the Japanese Guideline Criteria for Additional Surgery Based on Long-Term Clinical Outcomes Open
INTRODUCTION: To verify the value of the pathological criteria for additional treatment in locally resected pT1 colorectal carcinoma (CRC) which have been used in the Japanese Society for Cancer of the Colon and Rectum (JSCCR) guidelines s…
View article: Risk factors for and prognostic impact of lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: A single-center retrospective analysis of 214 cases with radial resection
Risk factors for and prognostic impact of lateral pelvic lymph node metastasis in patients with rectal neuroendocrine tumors: A single-center retrospective analysis of 214 cases with radial resection Open
Background Lateral pelvic lymph node (LPLN) metastasis of rectal neuroendocrine tumors (NETs) is rare, and its oncologic features are unknown. We aimed to investigate the oncologic impact of LPLN metastasis in patients with rectal NETs. Me…
View article: ASO Visual Abstract: Risk Factors for Lymph Node Metastasis of Rectal Neuroendocrine Tumor and its Prognostic Impact—A Single-Center Retrospective Analysis of 195 Cases with Radical Resection
ASO Visual Abstract: Risk Factors for Lymph Node Metastasis of Rectal Neuroendocrine Tumor and its Prognostic Impact—A Single-Center Retrospective Analysis of 195 Cases with Radical Resection Open
View article: Geriatric Nutritional Risk Index after Neoadjuvant Chemoradiotherapy and Survival in Older Patients with Advanced Rectal Cancer
Geriatric Nutritional Risk Index after Neoadjuvant Chemoradiotherapy and Survival in Older Patients with Advanced Rectal Cancer Open
Purpose To investigate the clinical impact of malnutrition on survival in older patients with advanced rectal cancer undergoing neoadjuvant chemoradiotherapy. Methods We investigated the clinical significance of the geriatric nutrition ris…
View article: Mucinous tumors arising from ovarian teratomas as another source of pseudomyxoma peritoneii: MR findings comparison with ovarian metastases from appendiceal mucinous tumors
Mucinous tumors arising from ovarian teratomas as another source of pseudomyxoma peritoneii: MR findings comparison with ovarian metastases from appendiceal mucinous tumors Open
Objective: The origin of pseudomyxoma peritoneii (PMP) has been established as low-grade appendiceal mucinous tumors (AMT). However, intestinal-type ovarian mucinous tumors are known as another source of PMP. Recently, it is advocated that…
View article: Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer
Estrogen Receptor-β Gene Cytosine-Adenine (ESR2-CA) Repeat Polymorphism in Postmenopausal Colon Cancer Open
The pathobiological role of estrogen is controversial in colorectal cancer. Cytosine-adenine (CA) repeat in the estrogen receptor (ER)-β gene (ESR2-CA) is a microsatellite, as well as representative of ESR2 polymorphism. Though its functio…
View article: Tumor-informed or tumor-agnostic circulating tumor DNA as a biomarker for risk of recurrence in resected colorectal cancer patients
Tumor-informed or tumor-agnostic circulating tumor DNA as a biomarker for risk of recurrence in resected colorectal cancer patients Open
Introduction Circulating tumor DNA (ctDNA) has been increasingly recognized as a promising minimally-invasive biomarker that could identify patients with minimal residual disease and a high risk of recurrence after definitive treatment. In…
View article: Transcriptomic Analyses of Pretreatment Tumor Biopsy Samples, Response to Neoadjuvant Chemoradiotherapy, and Survival in Patients With Advanced Rectal Cancer
Transcriptomic Analyses of Pretreatment Tumor Biopsy Samples, Response to Neoadjuvant Chemoradiotherapy, and Survival in Patients With Advanced Rectal Cancer Open
Importance Neoadjuvant chemoradiotherapy (CRT) is the standard of care for advanced rectal cancer. Yet, estimating response to CRT remains an unmet clinical challenge. Objective To investigate and better understand the transcriptomic facto…
View article: Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study
Nomogram as a novel predictive tool for lymph node metastasis in T1 colorectal cancer treated with endoscopic resection: a nationwide, multicenter study Open
This is the first nomogram to include submucosal invasion depth and tumor budding for use in routine pathologic diagnosis based on data from a nationwide multi-institutional study. This nomogram, developed with real-world data, should impr…
View article: Interventional management for postoperative arterial bleeding in gastrointestinal surgery
Interventional management for postoperative arterial bleeding in gastrointestinal surgery Open
Postoperative arterial bleeding after gastrointestinal surgery is a potentially fatal complication. Transcatheter arterial embolization is considered the first-line treatment because of efficacy and less invasiveness despite the risk of or…
View article: Incidence and risk factors of bowel dysfunction after minimally invasive rectal cancer surgery
Incidence and risk factors of bowel dysfunction after minimally invasive rectal cancer surgery Open
Purpose Bowel dysfunction after sphincter-preserving-surgery (SPS) has a negative impact on the quality of life. Wexner and low anterior resection syndrome (LARS) scores are well-established instruments for assessing postoperative bowel dy…